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  1. Article: Assessment of Clinical Pharmacists' Assistance for Patients With Established Cardiovascular Diseases During the COVID-19 Pandemic: Insights From Southern India.

    Gona, Oliver Joel / Madhan, Ramesh / Shambu, Sunil Kumar

    Frontiers in cardiovascular medicine

    2020  Volume 7, Page(s) 599807

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2020-12-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2020.599807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The ambulatory blood pressure monitoring among obese and nonobese diabetes mellitus patients.

    Mathews, Hella Fiona / Kumar, Sunil / Madhu, B / Gona, Oliver Joel / Srinath, K M

    Annals of African medicine

    2022  Volume 21, Issue 3, Page(s) 255–261

    Abstract: Background: Obesity and diabetes mellitus are two major factors related with the risk of metabolic syndrome and cardiovascular diseases. Co-existing hypertension with diabetes mellitus and obesity has poor prognosis for cardiovascular diseases. ... ...

    Abstract Background: Obesity and diabetes mellitus are two major factors related with the risk of metabolic syndrome and cardiovascular diseases. Co-existing hypertension with diabetes mellitus and obesity has poor prognosis for cardiovascular diseases. Ambulatory blood pressure monitoring (ABPM) correlates more closely to target organ damage than clinic blood pressure.
    Objectives: The objective of the study is to assess and compare ABPM pattern among obese and nonobese diabetes mellitus patients.
    Materials and methods: A cross-sectional study was conducted among fifty obese and fifty nonobese diabetic patients who were classified based on their body mass index as per the WHO criterion. The clinical blood pressure measurements were measured on each subject using a digital sphygmomanometer, and 24 h ABPM was done and ABPM parameters such as dipping pattern, 24 h systolic blood pressure (SBP), diastolic blood pressure (DBP), Mean SBP, mean DBP, diurnal variability of SBP, DBP, Mean arterial pressure, pulse pressure, SD systole (Standard Deviation systole), SD diastole, white coat hypertension was derived and compared between the two groups.
    Results: Around 37 (74%) obese and 18 (36%) nonobese showed non dipping pattern in SBP and 28 (66.7%) of obese and 14 (33.3%) of nonobese showed a nondipping pattern in DBP and was found to be statistically significant (P < 0.001). On comparison between normotensive obese and normotensive nonobese, it was found that SBP non dipping pattern18 (67%) versus 9 (29%) and DBP nondipping pattern 12 (45%) versus 5 (16%) was statistically significant with P = 0.004, 0.016, respectively.
    Conclusion: Obese diabetes mellitus subjects had altered ABPM parameters and increased prevalence of nondipping status. In addition, obese diabetic patients who did not give prior history of hypertension were also found to have higher nondipping SBP and DBP patterns.
    MeSH term(s) Blood Pressure/physiology ; Blood Pressure Monitoring, Ambulatory ; Cardiovascular Diseases ; Circadian Rhythm/physiology ; Cross-Sectional Studies ; Diabetes Mellitus/epidemiology ; Humans ; Hypertension/complications ; Hypertension/epidemiology ; Obesity/complications ; Obesity/epidemiology ; Risk Factors
    Language English
    Publishing date 2022-10-06
    Publishing country India
    Document type Journal Article
    ZDB-ID 2165792-0
    ISSN 0975-5764 ; 0975-5764
    ISSN (online) 0975-5764
    ISSN 0975-5764
    DOI 10.4103/aam.aam_65_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Impact of Updated 2016 ASE/EACVI VIS-À-VIS 2009 ASE Recommendation on the Prevalence of Diastolic Dysfunction and LV Filling Pressures in Patients with Preserved Ejection Fraction.

    S, Sunil Kumar / Desai, Nagaraj / Gona, Oliver Joel / K, Vinay Kumar / B, Madhu

    Journal of cardiovascular imaging

    2021  Volume 29, Issue 1, Page(s) 31–43

    Abstract: Background: Assessment of diastolic dysfunction (DD) and left ventricular filling pressures (LVFP) by echocardiography is complex in patients with preserved ejection fraction (EF). The American Society of Echocardiography and the European Association of ...

    Abstract Background: Assessment of diastolic dysfunction (DD) and left ventricular filling pressures (LVFP) by echocardiography is complex in patients with preserved ejection fraction (EF). The American Society of Echocardiography and the European Association of Cardiovascular Imaging (ASE/EACVI) jointly published recommendations in 2016 to simplify the diagnosis and classification of DD and the assessment of LVFP. We aimed to study the impact of the updated 2016 ASE/EACVI guidelines vis-à-vis the 2009 ASE recommendations on prevalence of DD and LVFP in patients with preserved EF.
    Methods: Five hundred patients referred to the echocardiography laboratory from March 2020 to May 2020 were analyzed. Patients with left ventricular ejection fraction (LVEF) < 50% were excluded. All patients underwent comprehensive transthoracic echocardiography. DD and LVFP were assessed by the 2016 ASE/EACVI and 2009 ASE recommendations. The concordance between the guidelines was analyzed by kappa coefficient and overall proportion of agreement.
    Results: Mean age was 53 ± 13 years and 63.4% were men. Prevalence of DD and abnormal LVFP were significantly lower with the 2016 recommendations than with the 2009 recommendations (9.4% vs. 16.8%, p < 0.001 and 8.4% vs. 12.8%, p < 0.05). Patients with Grade 1 DD (100%) and Grade 2 DD (46.4%) were reclassified by the 2016 recommendations. Indeterminate diastolic function (9.8%) was strikingly high according to the 2016 recommendations. The concordance between the two recommendations was moderate (kappa = 0.569). The overall proportion of agreement was 85.4%.
    Conclusions: Prevalence of DD and abnormal LV filling pressures were lower with application of the 2016 ASE/EACVI recommendations in patients with preserved EF. There was moderate agreement between the 2009 and 2016 recommendations.
    Language English
    Publishing date 2021-01-28
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3020035-0
    ISSN 2586-7296 ; 2586-7210
    ISSN (online) 2586-7296
    ISSN 2586-7210
    DOI 10.4250/jcvi.2020.0117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Study of correlation between epicardial fat thickness and severity of coronary artery disease.

    Shambu, Sunil Kumar / Desai, Nagaraj / Sundaresh, Nikhil / Babu, M Suresh / Madhu, B / Gona, Oliver Joel

    Indian heart journal

    2020  Volume 72, Issue 5, Page(s) 445–447

    Abstract: Epicardial fat thickness (EFT) reflects visceral adiposity and is associated with coronary artery disease (CAD). This study aimed to assess the correlation of echocardiographic EFT with the severity of CAD and to determine the EFT cut-off to predict CAD. ...

    Abstract Epicardial fat thickness (EFT) reflects visceral adiposity and is associated with coronary artery disease (CAD). This study aimed to assess the correlation of echocardiographic EFT with the severity of CAD and to determine the EFT cut-off to predict CAD. EFT was measured in 503 patients undergoing coronary angiogram. Mean EFT was significantly higher in the CAD group than control group (5.55 ± 1.21 mm vs 3.25 ± 1.15 mm, p < 0.0001). EFT correlated with Gensini score (r = 0.906, p < 0.001). EFT cut-off ≥ 4.75 mm had 87% sensitivity and 63% specificity for prediction of significant CAD (AUC: 0.831, p < 0.001).
    MeSH term(s) Adipose Tissue/diagnostic imaging ; Coronary Angiography/methods ; Coronary Artery Disease/diagnosis ; Cross-Sectional Studies ; Echocardiography/methods ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Pericardium/diagnostic imaging ; Retrospective Studies ; Risk Factors ; Severity of Illness Index
    Language English
    Publishing date 2020-07-17
    Publishing country India
    Document type Journal Article ; Observational Study
    ZDB-ID 604366-5
    ISSN 2213-3763 ; 0019-4832
    ISSN (online) 2213-3763
    ISSN 0019-4832
    DOI 10.1016/j.ihj.2020.07.014
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  5. Article: Implementation and Evaluation of Virtual Anticoagulation Clinic Care to Provide Incessant Care During COVID-19 Times in an Indian Tertiary Care Teaching Hospital.

    Shambu, Sunil Kumar / B, Shyam Prasad Shetty / Gona, Oliver Joel / Desai, Nagaraj / B, Madhu / Madhan, Ramesh / V, Revanth

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 648265

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.648265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Safety and efficacy of pharmacotherapy used for the management of COVID 19: A systematic review and meta-analysis of randomized control trials

    Sah, Sujit Kumar / Undela, Krishna / Chand, Dr. Sharad / Ramesh, Madhan / R, Subramanian / Gona, Oliver Joel / George, Sophia M. / UP, Nandakumar / Aryal, Santosh / P, Niharika / Shastry, C.S.

    medRxiv

    Abstract: Background: COVID-19 is a novel coronavirus, which is highly contagious and a threat to human health, spreading across nearly 235 countries, affecting 33.8 million and causing 1.01 million fatalities as of 22 September 2020. Researchers have invested ... ...

    Abstract Background: COVID-19 is a novel coronavirus, which is highly contagious and a threat to human health, spreading across nearly 235 countries, affecting 33.8 million and causing 1.01 million fatalities as of 22 September 2020. Researchers have invested tremendous efforts to develop vaccines or effective drug therapy but have not yet been fruitful. Hence, we planned to conduct this systematic review and meta-analysis to supplement the readers with comprehensive data and credible information on the safety and efficacyof essential pharmacotherapy during the pharmacological management of COVID-19. Methods: Theprotocol will be designed based on the updated PRISMA-P 2015 guidelines. An elaborate search of electronic databases such as PubMed/Medline, Web of Science, Scopus, The Cochrane Library, ClinicalTrials.gov, Google Scholar, Medrxiv and other potential databases for articles published during January 2020 to 10 October 2020 is planned to be conducted. Following this,randomized control trials published in English language that assess the safety and efficacy of pharmacotherapy versusplacebo or standard of care or usual care will be evaluated for inclusion. The primary outcomes will include time to clinical recovery and the probability for the negative conversion of COVID-19. Secondary outcomes will quantifythe proportion of patients relieved of symptoms, the all-cause mortality, morbidity, detection of viral RNA, time needed to achieve a negative viral load, ordinal scale changes, ventilatorand oxygen requirements,length of hospital stayand the incidence of adverse and serious adverse events.RevMan V.5.3 computer software packages will be utilised to conduct an accurate statistical analysis of the study. Thebinary random-effects model will be used at a 95 % confidence interval to estimate the weighted effect size ofdichotomous data and continuous data studies. The results of statistical analysis will be considered statistically significant whena p-value <0.05 is attained. Results: Selected studies will be used to evaluate the safety and efficacy of pharmacotherapy used during the management of the novel COVID-19. Conclusion: This study will be a qualitative and quantitative pool of comprehensive evidence regarding the safety and efficacy of pharmacotherapy on COVID-19.
    Keywords covid19
    Language English
    Publishing date 2020-10-05
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.10.02.20206045
    Database COVID19

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