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  1. AU="Gonakoti, Sriram"
  2. AU="Wulf, J"
  3. AU="Mardsen, D"
  4. AU="James, David B A"
  5. AU="Montabone, Erika"
  6. AU="Susan J. Burke"
  7. AU="Chen, Yuguang"
  8. AU="Zhao, Zhenghuan"
  9. AU="De Chiara, Anna Rosaria"
  10. AU="Savage, Anne"
  11. AU="Salamanca, Albert"
  12. AU="Zhong, Xiao-Song"
  13. AU="Deguchi, Masashi"
  14. AU="Żmuda, J"
  15. AU="Liao, Yanyan"
  16. AU="Zhu, Jin-Wei"
  17. AU="Khan, Azkia"
  18. AU="Folkman, Judah"
  19. AU=Bhatia Rajesh
  20. AU="Thobois, Stéphane"
  21. AU="Lai, Chien-Chih"
  22. AU="Ahn, Bo Young"
  23. AU="Jeje, Olamide"
  24. AU="Fine, Samson W"
  25. AU="Riemann, Burkhard"
  26. AU="Nazir, Ahsan"
  27. AU="Kawakita, Emi"
  28. AU="Wang, Junnian"
  29. AU="Nie, Chong"

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  1. Artikel: Protein-Energy Malnutrition Increases Mortality in Patients Hospitalized With Bacterial Pneumonia: A Retrospective Nationwide Database Analysis.

    Gonakoti, Sriram / Osifo, Iyobosa F

    Cureus

    2021  Band 13, Heft 1, Seite(n) e12645

    Abstract: Background Malnutrition is a less commonly recognized risk factor for various infections. It encompasses both undernutrition or protein-energy malnutrition (PEM) and overnutrition, including obesity. This study aimed to evaluate whether PEM impacts ... ...

    Abstract Background Malnutrition is a less commonly recognized risk factor for various infections. It encompasses both undernutrition or protein-energy malnutrition (PEM) and overnutrition, including obesity. This study aimed to evaluate whether PEM impacts bacterial pneumonia (BP) and, if so, to quantify the degree of impact on inpatient outcomes. Methods This was a retrospective cohort study involving adult hospitalizations for BP using the nationwide inpatient database. Outcomes included comparing inpatient mortality, total hospital charges, length of hospital stay, as well as complications from bacterial pneumonia. Results The in-hospital mortality for adults with BP was 2.62%. Patients with PEM had a higher adjusted odds ratio (aOR) of inpatient mortality (adjusted odds ratio (aOR): 2.31, 95% confidence interval (CI): 2.14 - 2.48, p<0.001) as compared to non-PEM patients. PEM was also associated with higher odds of sepsis (aOR: 2.24, 95% CI: 2.04 - 2.46, p<0.001), septic shock (aOR: 3.29, 95% CI: 2.82 - 3.85, p<0.001), requiring mechanical ventilation (aOR: 2.51, 95% CI: 2.31 - 2.71, p<0.001), requiring vasopressors (aOR: 2.90, 95% CI: 2.20 - 3.83, p<0.001), acute respiratory distress syndrome (ARDS) (aOR: 1.63, 95% CI: 1.33 - 2.00, p<0.001), acute kidney failure (AKI) (aOR: 1.24, 95% CI: 1.18 - 1.29, p<0.001), deep vein thrombosis (DVT) (aOR: 1.80, 95% CI: 1.62 - 2.00, p<0.001), and pulmonary embolism (PE) (aOR: 1.25, 95% CI: 1.08 - 1.45, p=0.003). Conclusion The study concluded that PEM was an independent mortality predictor for those with BP, with an increased risk of systemic complications, as well as increased healthcare utilization costs.
    Sprache Englisch
    Erscheinungsdatum 2021-01-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.12645
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Should CD4 Levels be Monitored in a Patient on Temozolomide?

    Gonakoti, Sriram / Parra-Rodriguez, Luis

    European journal of case reports in internal medicine

    2021  Band 8, Heft 3, Seite(n) 2276

    Abstract: Introduction: Temozolomide is an alkylating agent, indicated in the treatment of refractory anaplastic astrocytoma and newly diagnosed glioblastoma. We describe a case of : Case: A 67-year-old woman presented with acute onset of bilateral knee pain ... ...

    Abstract Introduction: Temozolomide is an alkylating agent, indicated in the treatment of refractory anaplastic astrocytoma and newly diagnosed glioblastoma. We describe a case of
    Case: A 67-year-old woman presented with acute onset of bilateral knee pain and swelling. She had a medical history of glioblastoma multiforme treated with temozolomide. Synovial fluid analysis and blood cultures revealed S. typhimurium, confirming a diagnosis of
    Conclusion: We conclude that chemotherapy with temozolomide and corticosteroid use will increase an individual's susceptibility to a wide variety of opportunistic infections akin to HIV-associated acquired immunodeficiency syndrome (AIDS). Furthermore, we hypothesize a possible benefit of monitoring CD4 levels and prophylaxis against opportunistic infections (based on the CD4 levels) in individuals receiving temozolomide-based chemotherapy, similar to HIV-AIDS.
    Learning points: Chemotherapy with temozolomide and corticosteroid use will increase an individual's susceptibility to a wide variety of opportunistic infections akin to HIV-associated acquired immunodeficiency syndrome (AIDS).There may be a benefit in monitoring CD4 levels in patients who are receiving temozolomide.Given selective CD4 lymphopenia while on temozolomide, there may be a possible benefit of prophylaxis against opportunistic infections in individuals based on their CD4 levels, similar to HIV-AIDS (current guidelines recommend considering
    Sprache Englisch
    Erscheinungsdatum 2021-03-11
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2021_002276
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  3. Artikel ; Online: Intracranial thrombosis associated with MSSA bacteraemia in the setting of influenza A.

    Raghavan, Sairam / Gonakoti, Sriram / Parra-Rodriguez, Luis

    BMJ case reports

    2021  Band 14, Heft 4

    Abstract: The authors present a case of a 42-year-old previously healthy man who presented in sepsis, with right lateral gaze palsy. He was found to have bilateral cavernous sinus thrombosis (CST) and bilateral internal jugular thrombosis in the setting ... ...

    Abstract The authors present a case of a 42-year-old previously healthy man who presented in sepsis, with right lateral gaze palsy. He was found to have bilateral cavernous sinus thrombosis (CST) and bilateral internal jugular thrombosis in the setting of
    Mesh-Begriff(e) Adult ; Bacteremia/complications ; Bacteremia/drug therapy ; Cavernous Sinus Thrombosis ; Exotoxins ; Humans ; Influenza, Human/complications ; Influenza, Human/drug therapy ; Leukocidins ; Male ; Staphylococcal Infections/complications ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus
    Chemische Substanzen Exotoxins ; Leukocidins
    Sprache Englisch
    Erscheinungsdatum 2021-04-22
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-239359
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Prevalence and Characteristics of Long COVID 7-12 Months After Hospitalization Among Patients From an Urban Safety-Net Hospital: A Pilot Study.

    Hua, Miao Jenny / Gonakoti, Sriram / Shariff, Ruhi / Corpuz, Carlos / Acosta, R Alfonso Hernandez / Chang, Hillary / Asemota, Iriagbonse / Gobbi, Elizabeth / Rezai, Katayoun

    AJPM focus

    2023  Band 2, Heft 3, Seite(n) 100091

    Abstract: Introduction: Little is known about the burden of long COVID among Black and Hispanic patients in the U.S. We surveyed adult patients hospitalized for COVID-19 at John H. Roger, Jr. Hospital of Cook County, a safety-net hospital predominantly serving ... ...

    Abstract Introduction: Little is known about the burden of long COVID among Black and Hispanic patients in the U.S. We surveyed adult patients hospitalized for COVID-19 at John H. Roger, Jr. Hospital of Cook County, a safety-net hospital predominantly serving Black and Hispanic patients in Chicago, for persistent symptoms after hospitalization to assess prevalence and identify risk factors.
    Methods: Cross-sectional data were obtained over 6 months after discharge from patients hospitalized at John H. Roger, Jr. Hospital of Cook County who tested positive for SARS-CoV-2 between October 1, 2020 and January 12, 2021. Multivariable logistic regression was used to analyze the associations between patient characteristics and symptom persistence.
    Results: Of 145 patients surveyed at a median follow-up period of 255 days (IQR=238-302), 80% were Black or Hispanic, and 50 (34%) reported at least 1 symptom. In multivariable logistic regression, the risk of long COVID was associated with the severity of acute COVID-19 illness, consistent with findings from population-based cohort studies.
    Conclusions: Long COVID prevalence remains high 7 months to a year after an initial illness in a majority Black and Hispanic hospitalized cohort. There is a long-term and ongoing need to assess and address the burden of long COVID, especially among minority communities disproportionately affected by acute COVID-19.
    Sprache Englisch
    Erscheinungsdatum 2023-03-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2773-0654
    ISSN (online) 2773-0654
    DOI 10.1016/j.focus.2023.100091
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Heparin-Induced Thrombocytopenia in COVID-19.

    Lingamaneni, Prasanth / Gonakoti, Sriram / Moturi, Krishna / Vohra, Ishaan / Zia, Maryam

    Journal of investigative medicine high impact case reports

    2020  Band 8, Seite(n) 2324709620944091

    Abstract: COVID-19 (coronavirus disease-2019) infection is a highly prothrombotic state, resulting from a dysregulation of the coagulation cascade. Therefore, thromboprophylaxis is strongly recommended in these patients, with some experts even advocating for ... ...

    Abstract COVID-19 (coronavirus disease-2019) infection is a highly prothrombotic state, resulting from a dysregulation of the coagulation cascade. Therefore, thromboprophylaxis is strongly recommended in these patients, with some experts even advocating for therapeutic dosing to prevent thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a well-known complication of heparin therapy. In this article, we report a case of HIT in a patient with COVID-19. A 63-year-old male presented with 1 week of dry cough and diarrhea. He had a positive nasopharyngeal COVID-19 reverse-transcriptase-polymerase chain reaction. On admission, the platelet count and liver function tests were within normal limits. During his hospitalization, he developed a right femoral deep venous thrombosis and was started on therapeutic anticoagulation. Due to worsening respiratory failure, he was intubated and mechanically ventilated. Between days 11 and 12 of hospitalization, platelet count dropped from 304 000 to 96 000 cells/µL. He had a high pretest probability for HIT with a 4T score of 6 and a positive anti-PF4/heparin antibody. Heparin drip was discontinued and was switched to argatroban. The serotonin release assay eventually returned positive, which confirmed the diagnosis of HIT. We also discuss potential overdiagnosis of HIT in COVID-19 through 4 cases with false-positive HIT antibodies.
    Mesh-Begriff(e) Anticoagulants/adverse effects ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Heparin/adverse effects ; Humans ; Leg/blood supply ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2 ; Thrombocytopenia/chemically induced ; Venous Thrombosis/drug therapy ; Venous Thrombosis/etiology
    Chemische Substanzen Anticoagulants ; Heparin (9005-49-6)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-07-28
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2710326-2
    ISSN 2324-7096 ; 2324-7096
    ISSN (online) 2324-7096
    ISSN 2324-7096
    DOI 10.1177/2324709620944091
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  6. Artikel ; Online: A Case of Systemic Lupus Erythematosus Flare Triggered by Severe Coronavirus Disease 2019.

    Raghavan, Sairam / Gonakoti, Sriram / Asemota, Iriagbonse Rotimi / Mba, Benjamin

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

    2020  Band 26, Heft 6, Seite(n) 234–235

    Mesh-Begriff(e) COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Disease Progression ; Emergency Service, Hospital ; Fatal Outcome ; Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Severe Acute Respiratory Syndrome/complications ; Severe Acute Respiratory Syndrome/diagnosis
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-08-20
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article ; Review
    ZDB-ID 1283266-2
    ISSN 1536-7355 ; 1076-1608
    ISSN (online) 1536-7355
    ISSN 1076-1608
    DOI 10.1097/RHU.0000000000001531
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Heparin-Induced Thrombocytopenia in COVID-19

    Lingamaneni, Prasanth / Gonakoti, Sriram / Moturi, Krishna / Vohra, Ishaan / Zia, Maryam

    Journal of Investigative Medicine High Impact Case Reports

    2020  Band 8, Seite(n) 232470962094409

    Abstract: COVID-19 (coronavirus disease-2019) infection is a highly prothrombotic state, resulting from a dysregulation of the coagulation cascade. Therefore, thromboprophylaxis is strongly recommended in these patients, with some experts even advocating for ... ...

    Abstract COVID-19 (coronavirus disease-2019) infection is a highly prothrombotic state, resulting from a dysregulation of the coagulation cascade. Therefore, thromboprophylaxis is strongly recommended in these patients, with some experts even advocating for therapeutic dosing to prevent thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a well-known complication of heparin therapy. In this article, we report a case of HIT in a patient with COVID-19. A 63-year-old male presented with 1 week of dry cough and diarrhea. He had a positive nasopharyngeal COVID-19 reverse-transcriptase–polymerase chain reaction. On admission, the platelet count and liver function tests were within normal limits. During his hospitalization, he developed a right femoral deep venous thrombosis and was started on therapeutic anticoagulation. Due to worsening respiratory failure, he was intubated and mechanically ventilated. Between days 11 and 12 of hospitalization, platelet count dropped from 304 000 to 96 000 cells/µL. He had a high pretest probability for HIT with a 4T score of 6 and a positive anti-PF4/heparin antibody. Heparin drip was discontinued and was switched to argatroban. The serotonin release assay eventually returned positive, which confirmed the diagnosis of HIT. We also discuss potential overdiagnosis of HIT in COVID-19 through 4 cases with false-positive HIT antibodies.
    Schlagwörter covid19
    Sprache Englisch
    Verlag SAGE Publications
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 2710326-2
    ISSN 2324-7096
    ISSN 2324-7096
    DOI 10.1177/2324709620944091
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel: Heparin-Induced Thrombocytopenia in COVID-19

    Lingamaneni, Prasanth / Gonakoti, Sriram / Moturi, Krishna / Vohra, Ishaan / Zia, Maryam

    J Investig Med High Impact Case Rep

    Abstract: COVID-19 (coronavirus disease-2019) infection is a highly prothrombotic state, resulting from a dysregulation of the coagulation cascade. Therefore, thromboprophylaxis is strongly recommended in these patients, with some experts even advocating for ... ...

    Abstract COVID-19 (coronavirus disease-2019) infection is a highly prothrombotic state, resulting from a dysregulation of the coagulation cascade. Therefore, thromboprophylaxis is strongly recommended in these patients, with some experts even advocating for therapeutic dosing to prevent thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a well-known complication of heparin therapy. In this article, we report a case of HIT in a patient with COVID-19. A 63-year-old male presented with 1 week of dry cough and diarrhea. He had a positive nasopharyngeal COVID-19 reverse-transcriptase-polymerase chain reaction. On admission, the platelet count and liver function tests were within normal limits. During his hospitalization, he developed a right femoral deep venous thrombosis and was started on therapeutic anticoagulation. Due to worsening respiratory failure, he was intubated and mechanically ventilated. Between days 11 and 12 of hospitalization, platelet count dropped from 304 000 to 96 000 cells/µL. He had a high pretest probability for HIT with a 4T score of 6 and a positive anti-PF4/heparin antibody. Heparin drip was discontinued and was switched to argatroban. The serotonin release assay eventually returned positive, which confirmed the diagnosis of HIT. We also discuss potential overdiagnosis of HIT in COVID-19 through 4 cases with false-positive HIT antibodies.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #688920
    Datenquelle COVID19

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  9. Artikel: A Case of Systemic Lupus Erythematosus Flare Triggered by Severe Coronavirus Disease 2019

    Raghavan, Sairam / Gonakoti, Sriram / Asemota, Iriagbonse Rotimi / Mba, Benjamin

    J Clin Rheumatol

    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #725370
    Datenquelle COVID19

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  10. Artikel ; Online: A case of H3N2 complicated by acute kidney injury secondary to rhabdomyolysis.

    Gonakoti, Sriram / Bahirwani, Janak / Maddala, Raja Naga Mahesh / Vidyasagar, Sudha

    BMJ case reports

    2018  Band 2018

    Abstract: H3N2 was first detected in July 2011 in the USA. It is responsible for sporadic cases of influenza and localised outbreaks and has not yet taken over on an epidemic or pandemic scale. An 84-year-old man presented with a dry cough, fever and myalgia for 3 ...

    Abstract H3N2 was first detected in July 2011 in the USA. It is responsible for sporadic cases of influenza and localised outbreaks and has not yet taken over on an epidemic or pandemic scale. An 84-year-old man presented with a dry cough, fever and myalgia for 3 days. On examination, he had a pulse of 98 bpm and blood pressure of 124/88 mm Hg. The patient was tachypnoeic, SpO
    Mesh-Begriff(e) Acute Kidney Injury/drug therapy ; Acute Kidney Injury/etiology ; Acute Kidney Injury/physiopathology ; Aged, 80 and over ; Antiviral Agents/therapeutic use ; Bronchodilator Agents/therapeutic use ; Cough ; Fever ; Humans ; Influenza A Virus, H3N2 Subtype/isolation & purification ; Influenza, Human/complications ; Influenza, Human/virology ; Male ; Methylprednisolone/therapeutic use ; Myalgia ; Oseltamivir/therapeutic use ; Respiratory Distress Syndrome, Adult/physiopathology ; Respiratory Distress Syndrome, Adult/therapy ; Respiratory Distress Syndrome, Adult/virology ; Rhabdomyolysis/complications ; Rhabdomyolysis/drug therapy ; Rhabdomyolysis/physiopathology ; Treatment Outcome
    Chemische Substanzen Antiviral Agents ; Bronchodilator Agents ; Oseltamivir (20O93L6F9H) ; Methylprednisolone (X4W7ZR7023)
    Sprache Englisch
    Erscheinungsdatum 2018-04-18
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2018-224334
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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