Article ; Online: Five successive waves of SARS-CoV-2 infection in the Central African Republic: a prospective observational study from 2020-2022.
The Pan African medical journal
2023 Volume 46, Page(s) 120
Abstract: Introduction: the National Laboratory of Clinical Biology and Public Health (NLBPH) in Bangui in the Central African Republic (CAR) carries out the vast majority of molecular screening tests for SARS-CoV-2 infection nationwide. This study aimed to show ... ...
| Abstract | Introduction: the National Laboratory of Clinical Biology and Public Health (NLBPH) in Bangui in the Central African Republic (CAR) carries out the vast majority of molecular screening tests for SARS-CoV-2 infection nationwide. This study aimed to show the contribution of molecular diagnosis and genomic surveillance in monitoring the evolution of longitudinal variations of the SARS-CoV-2 infection epidemic in CAR between 2020 and the end of 2022. Methods: this is an observational study on the variations in the prevalence of detection of SARS-CoV-2 by RT-PCR at the NLCBPH from nasopharyngeal samples taken prospectively over a period of 3 years since the beginning of the COVID-19 epidemic. A subgroup of SARS-CoV-2 positive samples was selected for molecular sequencing performed by Illumina® and MinIon® at the National Institute for Biomedical Research in Kinshasa, Democratic Republic of the Congo. Results: from March 2020 to December 31 Conclusion: this prospective study over a period of 3 years, marked by 5 successive waves, made it possible to report that age, sex and the presence of clinical symptoms are associated with RT-PCR positivity. Among the different variants identified during successive waves, the Omicron variant predominated during the last two waves. |
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| MeSH term(s) | Adult ; Humans ; Central African Republic/epidemiology ; COVID-19/diagnosis ; COVID-19/epidemiology ; Democratic Republic of the Congo ; Prospective Studies ; SARS-CoV-2 ; Male ; Female ; Middle Aged ; Aged ; Aged, 80 and over |
| Language | English |
| Publishing date | 2023-12-28 |
| Publishing country | Uganda |
| Document type | Observational Study ; Journal Article |
| ZDB-ID | 2514347-5 |
| ISSN | 1937-8688 ; 1937-8688 |
| ISSN (online) | 1937-8688 |
| ISSN | 1937-8688 |
| DOI | 10.11604/pamj.2023.46.120.39511 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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