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Article ; Online: Common and distinct patterns underlying different linguistic tasks: multivariate disconnectome symptom mapping in poststroke patients.

Jiang, Yaya / Gong, Gaolang

Cerebral cortex (New York, N.Y. : 1991)

2024 Volume 34, Issue 2

Abstract: Numerous studies have been devoted to neural mechanisms of a variety of linguistic tasks (e.g. speech comprehension and production). To date, however, whether and how the neural patterns underlying different linguistic tasks are similar or differ remains ...

Abstract	Numerous studies have been devoted to neural mechanisms of a variety of linguistic tasks (e.g. speech comprehension and production). To date, however, whether and how the neural patterns underlying different linguistic tasks are similar or differ remains elusive. In this study, we compared the neural patterns underlying 3 linguistic tasks mainly concerning speech comprehension and production. To address this, multivariate regression approaches with lesion/disconnection symptom mapping were applied to data from 216 stroke patients with damage to the left hemisphere. The results showed that lesion/disconnection patterns could predict both poststroke scores of speech comprehension and production tasks; these patterns exhibited shared regions on the temporal pole of the left hemisphere as well as unique regions contributing to the prediction for each domain. Lower scores in speech comprehension tasks were associated with lesions/abnormalities in the superior temporal gyrus and middle temporal gyrus, while lower scores in speech production tasks were associated with lesions/abnormalities in the left inferior parietal lobe and frontal lobe. These results suggested an important role of the ventral and dorsal stream pathways in speech comprehension and production (i.e. supporting the dual stream model) and highlighted the applicability of the novel multivariate disconnectome-based symptom mapping in cognitive neuroscience research.
MeSH term(s)	Humans ; Brain Mapping/methods ; Magnetic Resonance Imaging/methods ; Linguistics ; Stroke/complications ; Stroke/diagnostic imaging ; Comprehension
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1077450-6
ISSN	1460-2199 ; 1047-3211
ISSN (online)	1460-2199
ISSN	1047-3211
DOI	10.1093/cercor/bhae008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Determination, exposure and risk assessment of PAHs in natural vitamin E isolated from vegetable oil industry.

Gong, Guangyi / Wu, Shimin

Food additives & contaminants. Part B, Surveillance

2023 Volume 16, Issue 2, Page(s) 130–142

Abstract: Natural vitamin E, which is mainly extracted from vegetable oil deodoriser distillate (VODD), is likely contaminated by carcinogenic polycyclic aromatic hydrocarbons (PAHs). A total of 26 commercial vitamin E products from six countries were investigated ...

Abstract	Natural vitamin E, which is mainly extracted from vegetable oil deodoriser distillate (VODD), is likely contaminated by carcinogenic polycyclic aromatic hydrocarbons (PAHs). A total of 26 commercial vitamin E products from six countries were investigated for 16 EPA PAHs using QuEChERS combined with gas chromatography triple quadrupole mass spectrometry (GC-QQQ-MS). The concentrations of total PAHs in the samples ranged from 46.5 μg kg
MeSH term(s)	Polycyclic Aromatic Hydrocarbons/analysis ; Plant Oils/analysis ; Food Contamination/analysis ; Gas Chromatography-Mass Spectrometry/methods ; Risk Assessment
Chemical Substances	Polycyclic Aromatic Hydrocarbons ; Plant Oils
Language	English
Publishing date	2023-03-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2447868-4
ISSN	1939-3229 ; 1939-3210
ISSN (online)	1939-3229
ISSN	1939-3210
DOI	10.1080/19393210.2023.2182833
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Prediction of pCR based on clinical-radiomic model in patients with locally advanced ESCC treated with neoadjuvant immunotherapy plus chemoradiotherapy.

Wang, Xiaohan / Gong, Guanzhong / Sun, Qifeng / Meng, Xue

Frontiers in oncology

2024 Volume 14, Page(s) 1350914

Abstract: Background: The primary objective of this research is to devise a model to predict the pathologic complete response in esophageal squamous cell carcinoma (ESCC) patients undergoing neoadjuvant immunotherapy combined with chemoradiotherapy (nICRT).: ... ...

Abstract	Background: The primary objective of this research is to devise a model to predict the pathologic complete response in esophageal squamous cell carcinoma (ESCC) patients undergoing neoadjuvant immunotherapy combined with chemoradiotherapy (nICRT). Methods: We retrospectively analyzed data from 60 ESCC patients who received nICRT between 2019 and 2023. These patients were divided into two cohorts: pCR-group (N = 28) and non-pCR group (N = 32). Radiomic features, discerned from the primary tumor region across plain, arterial, and venous phases of CT, and pertinent laboratory data were documented at two intervals: pre-treatment and preoperation. Concurrently, related clinical data was amassed. Feature selection was facilitated using the Extreme Gradient Boosting (XGBoost) algorithm, with model validation conducted via fivefold cross-validation. The model's discriminating capability was evaluated using the area under the receiver operating characteristic curve (AUC). Additionally, the clinical applicability of the clinical-radiomic model was appraised through decision curve analysis (DCA). Results: The clinical-radiomic model incorporated seven significant markers: postHALP, ΔHB, post-ALB, firstorder_Skewness, GLCM_DifferenceAverage, GLCM_JointEntropy, GLDM_DependenceEntropy, and NGTDM_Complexity, to predict pCR. The XGBoost algorithm rendered an accuracy of 0.87 and an AUC of 0.84. Notably, the joint omics approach superseded the performance of solely radiomic or clinical model. The DCA further cemented the robust clinical utility of our clinical-radiomic model. Conclusion: This study successfully formulated and validated a union omics methodology for anticipating the therapeutic outcomes of nICRT followed by radical surgical resection. Such insights are invaluable for clinicians in identifying potential nICRT responders among ESCC patients and tailoring optimal individualized treatment plans.
Language	English
Publishing date	2024-03-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1350914
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Article ; Online: ROS: Executioner of regulating cell death in spinal cord injury.

Yin, Zhaoyang / Wan, Bowen / Gong, Ge / Yin, Jian

Frontiers in immunology

2024 Volume 15, Page(s) 1330678

Abstract: The damage to the central nervous system and dysfunction of the body caused by spinal cord injury (SCI) are extremely severe. The pathological process of SCI is accompanied by inflammation and injury to nerve cells. Current evidence suggests that ... ...

Abstract	The damage to the central nervous system and dysfunction of the body caused by spinal cord injury (SCI) are extremely severe. The pathological process of SCI is accompanied by inflammation and injury to nerve cells. Current evidence suggests that oxidative stress, resulting from an increase in the production of reactive oxygen species (ROS) and an imbalance in its clearance, plays a significant role in the secondary damage during SCI. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is a crucial regulatory molecule for cellular redox. This review summarizes recent advancements in the regulation of ROS-Nrf2 signaling and focuses on the interaction between ROS and the regulation of different modes of neuronal cell death after SCI, such as apoptosis, autophagy, pyroptosis, and ferroptosis. Furthermore, we highlight the pathways through which materials science, including exosomes, hydrogels, and nanomaterials, can alleviate SCI by modulating ROS production and clearance. This review provides valuable insights and directions for reducing neuronal cell death and alleviating SCI through the regulation of ROS and oxidative stress.
MeSH term(s)	Humans ; Reactive Oxygen Species/metabolism ; NF-E2-Related Factor 2/metabolism ; Spinal Cord Injuries/pathology ; Apoptosis ; Oxidative Stress
Chemical Substances	Reactive Oxygen Species ; NF-E2-Related Factor 2
Language	English
Publishing date	2024-01-23
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1330678
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Article ; Online: Determination, exposure and risk assessment of PAHs in natural vitamin E isolated from vegetable oil industry

Gong, Guangyi / Wu, Shimin

Food Additives & Contaminants: Part B. 2023 Apr. 03, v. 16, no. 2 p.130-142

2023

Abstract	Natural vitamin E, which is mainly extracted from vegetable oil deodoriser distillate (VODD), is likely contaminated by carcinogenic polycyclic aromatic hydrocarbons (PAHs). A total of 26 commercial vitamin E products from six countries were investigated for 16 EPA PAHs using QuEChERS combined with gas chromatography triple quadrupole mass spectrometry (GC-QQQ-MS). The concentrations of total PAHs in the samples ranged from 46.5 μg kg⁻¹ to 215 μg kg⁻¹, while the concentrations of PAH4 (BaA, Chr, BbF and BaP) ranged from 4.43 μg kg⁻¹ to 20.1 μg kg⁻¹. Risk assessment indicates that maximum intake of PAHs is 0.2 mg day⁻¹, which is less than the LD₅₀ and no observed adverse effect levels (NOAEL) of PAHs. However, chronic carcinogenicity of PAHs needs to be considered. The results suggested that PAH concentrations as well as toxicity equivalent should be considered as important indicator of risk of vitamin E products.
Keywords	carcinogenicity ; gas chromatography ; industry ; mass spectrometry ; risk ; risk assessment ; vegetable oil ; vitamin E ; Natural tocopherol ; PAHs ; GC-MS
Language	English
Dates of publication	2023-0403
Size	p. 130-142.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2447868-4
ISSN	1939-3229 ; 1939-3210
ISSN (online)	1939-3229
ISSN	1939-3210
DOI	10.1080/19393210.2023.2182833
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Heterogeneous impacts of financial development on carbon emissions: evidence from China's provincial data.

Liu, Hongyan / Gong, Guofei

Environmental science and pollution research international

2022 Volume 29, Issue 25, Page(s) 37565–37581

Abstract: The effect of financial development on carbon emissions is a hot topic. Although some researches study the heterogeneous impacts of financial development on carbon emissions at the country level, few paper has investigated their heterogeneous relations ... ...

Abstract	The effect of financial development on carbon emissions is a hot topic. Although some researches study the heterogeneous impacts of financial development on carbon emissions at the country level, few paper has investigated their heterogeneous relations within the same country. This paper, applying geographically and temporally weighted regression (GTWR), studies the spatial-temporal heterogeneity of the impacts of financial development on carbon emissions across China's 30 provinces from 2003 to 2017. The results show that financial development proxied by bank credit indicators curbs carbon emissions in most provinces most of the time, while that proxied by stock market indicator exhibits nonlinear relationships in most provinces, such as U-shaped, inverse U-shaped, and inverse N-shaped. The paper concludes first that financial development proxied by different indicators may exert varied impacts on carbon emissions. Second, the impact of financial development on carbon emissions shows great heterogeneity among different provinces and different years: it may be curbing or increasing, and even it is curbing, its curbing effects differ greatly across provinces and years. Third, the impact of financial development on CO2 is not always monotonic; instead, it may be nonlinear. Regional segmentation of financial markets may explain the heterogeneity. Some policy suggestions are also given.
MeSH term(s)	Carbon/analysis ; Carbon Dioxide/analysis ; China ; Economic Development ; Policy ; Spatial Regression
Chemical Substances	Carbon Dioxide (142M471B3J) ; Carbon (7440-44-0)
Language	English
Publishing date	2022-01-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-18209-4
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Article: [Prediction of microvascular invasion in hepatocellular carcinoma with magnetic resonance imaging using models combining deep attention mechanism with clinical features].

Gong, G / Cao, S / Xiao, H / Fang, W / Que, Y / Liu, Z / Chen, C

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

2023 Volume 43, Issue 5, Page(s) 839–851

Abstract: Objective: To investigate the consistency and diagnostic performance of magnetic resonance imaging (MRI) for detecting microvascular invasion (MVI) of hepatocellular carcinoma (HCC) and the validity of deep learning attention mechanisms and clinical ... ...

Abstract	Objective: To investigate the consistency and diagnostic performance of magnetic resonance imaging (MRI) for detecting microvascular invasion (MVI) of hepatocellular carcinoma (HCC) and the validity of deep learning attention mechanisms and clinical features for MVI grade prediction. Methods: This retrospective study was conducted among 158 patients with HCC treated in Shunde Hospital Affiliated to Southern Medical University between January, 2017 and February, 2020. The imaging data and clinical data of the patients were collected to establish single sequence deep learning models and fusion models based on the EfficientNetB0 and attention modules. The imaging data included conventional MRI sequences (T Results: The fusion model based on T1mapping-20min sequence and clinical features outperformed other fusion models with an accuracy of 0.8376, a sensitivity of 0.8378, a specificity of 0.8702, and an AUC of 0.8501 for detecting MVI. The deep fusion models were also capable of displaying the high-risk areas of MVI. Conclusion: The fusion models based on multiple MRI sequences can effectively detect MVI in patients with HCC, demonstrating the validity of deep learning algorithm that combines attention mechanism and clinical features for MVI grade prediction.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular ; Retrospective Studies ; Liver Neoplasms ; Magnetic Resonance Imaging ; Algorithms
Language	Chinese
Publishing date	2023-05-25
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2250951-3
ISSN	1673-4254
ISSN	1673-4254
DOI	10.12122/j.issn.1673-4254.2023.05.21
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Article ; Online: Evaluation of Oxygen Consumption Rates In Situ.

Li, Anqi / Qin, Yuan / Zhang, Ying / Zhen, Xiaoqun / Gong, Guohua

Methods in molecular biology (Clifton, N.J.)

2024 Volume 2755, Page(s) 215–226

Abstract: An analysis of the mitochondrial respiration function represented by the oxygen consumption rate is necessary to assess mitochondrial bioenergetics and redox function. This protocol describes two alternative techniques to evaluate mitochondrial ... ...

Abstract	An analysis of the mitochondrial respiration function represented by the oxygen consumption rate is necessary to assess mitochondrial bioenergetics and redox function. This protocol describes two alternative techniques to evaluate mitochondrial respiration function in situ: (1) measure oxygen consumption rates via an electrode; (2) measure oxygen consumption rates via a seahorse instrument. These in situ approaches provide more physiological access to mitochondria to evaluate mitochondrial respiration function in a relatively integrated cellular system.
MeSH term(s)	Oxygen Consumption ; Respiration ; Mitochondria ; Electrodes ; Respiratory Function Tests
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3633-6_16
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Research progress in brain-targeted nasal drug delivery.

Huang, Qingqing / Chen, Xin / Yu, Sixun / Gong, Gu / Shu, Haifeng

Frontiers in aging neuroscience

2024 Volume 15, Page(s) 1341295

Abstract: The unique anatomical and physiological connections between the nasal cavity and brain provide a pathway for bypassing the blood-brain barrier to allow for direct brain-targeted drug delivery through nasal administration. There are several advantages of ... ...

Abstract	The unique anatomical and physiological connections between the nasal cavity and brain provide a pathway for bypassing the blood-brain barrier to allow for direct brain-targeted drug delivery through nasal administration. There are several advantages of nasal administration compared with other routes; for example, the first-pass effect that leads to the metabolism of orally administered drugs can be bypassed, and the poor compliance associated with injections can be minimized. Nasal administration can also help maximize brain-targeted drug delivery, allowing for high pharmacological activity at lower drug dosages, thereby minimizing the likelihood of adverse effects and providing a highly promising drug delivery pathway for the treatment of central nervous system diseases. The aim of this review article was to briefly describe the physiological structures of the nasal cavity and brain, the pathways through which drugs can enter the brain through the nose, the factors affecting brain-targeted nasal drug delivery, methods to improve brain-targeted nasal drug delivery systems through the application of related biomaterials, common experimental methods used in intranasal drug delivery research, and the current limitations of such approaches, providing a solid foundation for further in-depth research on intranasal brain-targeted drug delivery systems (see Graphical Abstract).
Language	English
Publishing date	2024-01-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2023.1341295
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Article ; Online: Key biological processes and essential genes for Proteus mirabilis biofilm development inhibition by protocatechuic acid.

Tian, Lu / Gao, Chang / Lu, Jiaxing / Liao, Sichen / Gong, Guoli

International journal of food microbiology

2024 Volume 412, Page(s) 110570

Abstract: Proteus mirabilis is an opportunistic pathogen linked to human urinary tract infections, and is potentially present as a foodborne pathogen within poultry products, including broiler chickens. This report outlines the inhibitory impacts of protocatechuic ...

Abstract	Proteus mirabilis is an opportunistic pathogen linked to human urinary tract infections, and is potentially present as a foodborne pathogen within poultry products, including broiler chickens. This report outlines the inhibitory impacts of protocatechuic acid (PCA) on P. mirabilis isolated from a broiler slaughterhouse in China as well as its biofilm. This investigation encompasses assays related to motility and adhesion, bacterial metabolic activity, extracellular polymer (EPS) production, and scavenging capacity. The findings demonstrated that PCA reduced biofilm formation by 61 %. Transcriptomics findings identified that PCA limited the expression of genes like PstS that promote adhesin formation, rbsA and RcsB that alter bacterial chemotaxis, lipopolysaccharide synthesis genes LpxA and EptB, and cell wall synthesis genes MurF and MrdA, and affects the Regulator of Capsule Synthesis (RCS) two-component modulation system. Weighted gene co-expression network analysis (WGCNA) was conducted to identify the core genes. Furthermore, the binding sites of PCA to cytochrome oxidases cydA and cydB, two subunits of ATP synthase atpI and atpH, and ftsZ, which regulate bacterial division, were predicted via molecular docking. Metabolome analysis determined that PCA critically influenced coenzyme A biosynthesis, nucleotide metabolism, alanine, aspartic acid, and glutamate metabolic pathways of P. mirabilis. Therefore, PCA impacts metabolism within bacteria via various pathways, limiting the levels of extracellular polymer and bacterial viability to hinder biofilm formation. Additionally, we prepared an antibacterial plastic film containing protocatechuic acid using PVA as the monomer and CNC as the reinforcing agent. We examined the mechanical and antibacterial properties of this film. When used to wrap chicken, it reduced the total number of colonies, slowed the deterioration of chicken, and maintained the freshness of chicken. In conclusion, the information outlined in this study complements our comprehension of P. mirabilis inhibition by PCA and provides clues for the reduction of foodborne infections associated with P. mirabilis.
MeSH term(s)	Animals ; Humans ; Proteus mirabilis/genetics ; Genes, Essential ; Molecular Docking Simulation ; Chickens/genetics ; Anti-Bacterial Agents/pharmacology ; Biofilms ; Polymers ; Hydroxybenzoates
Chemical Substances	protocatechuic acid (36R5QJ8L4B) ; Anti-Bacterial Agents ; Polymers ; Hydroxybenzoates
Language	English
Publishing date	2024-01-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	87122-9
ISSN	1879-3460 ; 0168-1605
ISSN (online)	1879-3460
ISSN	0168-1605
DOI	10.1016/j.ijfoodmicro.2024.110570
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