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Book ; Online: Physical Metallurgy of Metals and Alloys

Gong, Pan / Li, Maojun / Han, Guangchao / Wang, Xin

2023

Keywords	Technology: general issues ; History of engineering & technology ; Fe-rich Al-Si alloy ; β-Al5FeSi phase ; cooling rate ; melt spinning ; microstructure ; strengthening mechanisms ; Zn-Mg-Ti alloy ; biodegradable metals ; mechanical properties ; cytotoxicity ; Fe-B-W alloy ; manganese ; aluminum ; molten zinc ; microanalysis ; corrosion ; hydrogenated-dehydrogenated titanium powder ; laser directed energy deposition ; mechanical property ; radio frequency plasma technique ; high entropy alloy ; bulk metallic glass ; similar element substitution/addition ; glass forming ability ; lattice distortion ; sapphire ; surface metallization ; deposition mechanism ; wettability ; low-temperature joining ; silver alloy bonding wire ; bonding strength ; vulcanization resistance ; cathodic passivation ; Mg-Nd alloy ; precipitate ; eutectic growth ; modelling and simulation ; recrystallization ; microstructure-property characterization simulation and modeling ; heat treatment and surface treatment ; TC4 alloy ; EBCHM ; aging treatment ; glass-forming ability ; corrosion behavior ; amorphous alloy ; phase transformation ; mechanical behavior ; corrosion wear resistance ; gear grinding ; white layer ; grinding temperature ; surface integrity ; AlSi10Mg alloy ; friction stir processing ; grain boundary ; texture ; dynamic recrystallization ; silver wire ; wire bonding ; chloride ions ; ion migration ; galvanic corrosion ; Cu-15Ni-8Sn alloys ; grain size ; solution treatment ; microalloying ; microstructural evolution ; laser-powder bed fusion ; MgAl2O4 ; TiB2 ; metallothermic reduction ; SHS powder metallurgy ; combustion wave propagation ; HSLA steel ; microstructural characterization ; laser welding ; thick plate ; corrosion resistance ; high entropy alloys ; lightweight ; magnesium alloys ; ultrasound treatment ; solution ; aging ; Mg17Al12 ; converter ; vortex ; flow field analysis ; numerical simulation ; steel ball ; skew rolling ; cold forming ; stainless steel ; copper-scandium CuSc ; copper alloy ; differential scanning calorimetry DSC ; precipitation kinetics ; cold-working ; cold-rolling ; activation energy ; Kissinger method
Language	English
Size	1 electronic resource (324 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030381955
ISBN	9783036578057 ; 3036578056
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Scopolamine regulates the osteogenic differentiation of human periodontal ligament stem cells through lactylation modification of RUNX2 protein.

Wu, Ying / Gong, Pan

Pharmacology research & perspectives

2023 Volume 12, Issue 1, Page(s) e1169

Abstract: Periodontal ligament stem cells (PDLSCs) are important mesenchymal stem cells contributing to regenerating lost periodontal tissues and repairing bone defects. Studies on the molecular mechanism affecting the osteogenic differentiation of PDLSCs are ... ...

Abstract	Periodontal ligament stem cells (PDLSCs) are important mesenchymal stem cells contributing to regenerating lost periodontal tissues and repairing bone defects. Studies on the molecular mechanism affecting the osteogenic differentiation of PDLSCs are necessary. Scopolamine (SCO) is known as a regulator of neural cell damage. The focus of the current study is on unveiling the role of SCO-mediated molecular mechanism in the osteogenic differentiation of PDLSCs. Through CCK-8 assay and LDH detection, we confirmed that SCO enhanced the viability of PDLSCs. Moreover, we determined that SCO induced the PDLSCs osteogenic differentiation, according to data of ALP activity measurement and ARS staining. Mechanistically, we performed western blot and identified that SCO could promote the lactylation of runt-related transcription factor 2 (RUNX2). We also found through rescue assays that knockdown of RUNX2 could reverse the effect of SCO treatment on the osteogenic differentiation of PDLSCs. Further mechanism investigation revealed that lactylation of RUNX2 at K176 site enhances the protein stability of RUNX2 through deubiquitination. Collectively, our present study unveils that SCO stabilizes RUNX2 to promote the osteogenic differentiation of PDLSCs through the lactylation modification of RUNX2.
MeSH term(s)	Humans ; Periodontal Ligament ; Core Binding Factor Alpha 1 Subunit/genetics ; Osteogenesis ; Stem Cells ; Scopolamine
Chemical Substances	Core Binding Factor Alpha 1 Subunit ; Scopolamine (DL48G20X8X) ; RUNX2 protein, human
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2740389-0
ISSN	2052-1707 ; 2052-1707
ISSN (online)	2052-1707
ISSN	2052-1707
DOI	10.1002/prp2.1169
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Computationally Efficient Direction-of-Arrival Estimation Algorithms for a Cubic Coprime Array.

Gong, Pan / Chen, Xixin

Sensors (Basel, Switzerland)

2021 Volume 22, Issue 1

Abstract: In this paper, we investigate the problem of direction-of-arrival (DOA) estimation for massive multi-input multi-output (MIMO) radar, and propose a total array-based multiple signals classification (TA-MUSIC) algorithm for two-dimensional direction-of- ... ...

Abstract	In this paper, we investigate the problem of direction-of-arrival (DOA) estimation for massive multi-input multi-output (MIMO) radar, and propose a total array-based multiple signals classification (TA-MUSIC) algorithm for two-dimensional direction-of-arrival (DOA) estimation with a coprime cubic array (CCA). Unlike the conventional multiple signal classification (MUSIC) algorithm, the TA-MUSIC algorithm employs not only the auto-covariance matrix but also the mutual covariance matrix by stacking the received signals of two sub cubic arrays so that full degrees of freedom (DOFs) can be utilized. We verified that the phase ambiguity problem can be eliminated by employing the coprime property. Moreover, to achieve lower complexity, we explored the estimation of signal parameters via the rotational invariance technique (ESPRIT)-based multiple signal classification (E-MUSIC) algorithm, which uses a successive scheme to be computationally efficient. The Cramer-Rao bound (CRB) was taken as a theoretical benchmark for the lower boundary of the unbiased estimate. Finally, numerical simulations were conducted in order to demonstrate the effectiveness and superiority of the proposed algorithms.
Language	English
Publishing date	2021-12-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22010136
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Curcumin Promotes Diabetic Foot Ulcer Wound Healing by Inhibiting miR-152-3p and Activating the FBN1/TGF-β Pathway.

Cao, Mei / Duan, Zhisheng / Wang, Xianting / Gong, Pan / Zhang, Limei / Ruan, Bin

Molecular biotechnology

2024

Abstract: The objective of this study was to investigate the mechanism of curcumin in diabetic foot ulcer (DFU) wound healing. A DFU rat model was established, and fibroblasts were cultured in a high-glucose (HG) environment to create a cell model. Various ... ...

Abstract	The objective of this study was to investigate the mechanism of curcumin in diabetic foot ulcer (DFU) wound healing. A DFU rat model was established, and fibroblasts were cultured in a high-glucose (HG) environment to create a cell model. Various techniques, including Western blot, RT‒qPCR, flow cytometry, Transwell, cell scratch test and H&E staining, were employed to measure the levels of relevant genes and proteins, as well as to assess cell proliferation, apoptosis, migration, and pathological changes. The results showed that miR-152-3p was overexpressed in DFU patients, while FBN1 was underexpressed. Curcumin was found to inhibit fibroblast apoptosis, promote proliferation, migration, and angiogenesis in DFU rats, and accelerate wound healing in DFU rats. In addition, overexpression of miR-152-3p weakened the therapeutic effect of curcumin, while overexpression of FBN1 reversed the effects of the miR-152-3p mimic. Further investigations into the underlying mechanisms revealed that curcumin expedited wound healing in DFU rats by restoring the FBN1/TGF-β pathway through the inhibition of miR-152-3p. In conclusion, curcumin can suppress the activity of miR-152-3p, which, in turn, leads to the rejuvenation of the FBN1/TGF-β pathway and accelerates DFU wound healing.
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1193057-3
ISSN	1559-0305 ; 1073-6085
ISSN (online)	1559-0305
ISSN	1073-6085
DOI	10.1007/s12033-023-01027-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Microstructure and Friction Properties of AlCrTiVNb

Li, Baowei / Zhang, Zihao / Luo, Xiaoling / Chen, Kangmin / Zhang, Jiaqi / Gong, Pan / Peng, Zhen

Materials (Basel, Switzerland)

2024 Volume 17, Issue 4

Abstract: To enhance the friction and wear properties of alloys, ... ...

Abstract	To enhance the friction and wear properties of alloys, AlCrTiVNb
Language	English
Publishing date	2024-02-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17040812
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Development and evaluation of acceptance scale for artificial intelligence in digestive endoscopy by subjects.

Long, Xiuyan / Deng, Haijun / Zhang, Zinan / Liu, Tao / Yu, Xiaoyu / Gong, Pan / Tian, Li

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

2024 Volume 48, Issue 12, Page(s) 1844–1853

Abstract: Objectives: Digestive endoscopy is an important diagnostic and therapeutic tool for digestive system diseases. The artificial intelligence (AI)-assisted system in endoscopy (hereinafter referred to as AI in digestive endoscopy) has broad application ... ...

Title translation	受检者对消化内镜人工智能接受度量表的编制及评价.
Abstract	Objectives: Digestive endoscopy is an important diagnostic and therapeutic tool for digestive system diseases. The artificial intelligence (AI)-assisted system in endoscopy (hereinafter referred to as AI in digestive endoscopy) has broad application prospects in the field of digestive endoscopy. The trust and acceptance of endoscopic subjects are the cornerstone of the research, application, and promotion of AI in digestive endoscopy. Currently, the tools for measuring the acceptance of AI in digestive endoscopy by subjects are limited at home and abroad. This study aims to develop a scale for measuring the acceptance of AI in digestive endoscopy by subjects, then to evaluate its reliability and validity. Methods: By conducting literature research, an item pool and dimensions were constructed, and a preliminary scale was constructed using Delphi method. Through the first stage of the survey on the subjects, the reliability and validity of the scale were tested, and the revised scale was used for the second stage of survey on the subjects to further verify the structural validity of the scale. Results: The acceptance scale for AI in digestive endoscopy included 11 items in 3 dimensions: accuracy, ethics, benefit and willingness. In the first stage of the survey, 351 valid questionnaires were collected, and the Cronbach's α was 0.864. The correlation coefficient between the total score of the scale and the score of the test item was 0.636, and the Kaiser-Meyer-Olkin (KMO) value in exploratory factor analysis was 0.788. In the second stage of the survey, 335 valid questionnaires were collected, and in confirmatory factor analysis, the Conclusions: Acceptance scale for AI in digestive endoscopy by subjects developed in this study has good reliability and validity.
MeSH term(s)	Humans ; Artificial Intelligence ; Reproducibility of Results ; Endoscopy, Gastrointestinal ; Factor Analysis, Statistical
Language	Chinese
Publishing date	2024-03-06
Publishing country	China
Document type	Journal Article
ZDB-ID	2168533-2
ISSN	1672-7347
ISSN	1672-7347
DOI	10.11817/j.issn.1672-7347.2023.230225
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chloroplast immunity: A cornerstone of plant defense.

Liu, Jie / Gong, Pan / Lu, Ruobin / Lozano-Durán, Rosa / Zhou, Xueping / Li, Fangfang

Molecular plant

2024

Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2393618-6
ISSN	1752-9867 ; 1674-2052
ISSN (online)	1752-9867
ISSN	1674-2052
DOI	10.1016/j.molp.2024.03.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Natural Geranylated Sulfur-Containing Amides with Inhibitory Effect on Th17 Differentiation.

Ji, Kai-Long / Tang, Yan-Qing / Guo, Zheng-Yang / GongPan, Pian-Chou / Sun, Peng / Lu, Jian-Mei / Dai, Meng-Yuan / Li, Ting

Chemistry & biodiversity

2023 Volume 20, Issue 6, Page(s) e202300373

Abstract: Chemical investigation of medicinal plant Glycosmis lucida Wall. ex C. C. Huang leaves led to the production of ten compounds (1-10), including two previously unreported geranylated sulfur-containing amides (1 and 2) and eight known ones (3-10). ... ...

Abstract	Chemical investigation of medicinal plant Glycosmis lucida Wall. ex C. C. Huang leaves led to the production of ten compounds (1-10), including two previously unreported geranylated sulfur-containing amides (1 and 2) and eight known ones (3-10). Structural characterization was carried out using comprehensive spectroscopic methods including NMR, MS and CD. The inhibitory effects of all isolates on Th17 differentiation were evaluated, of which compounds 1 and 6 significantly inhibited Th17 differentiation with IC
MeSH term(s)	Amides/pharmacology ; Amides/chemistry ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; Sulfur ; Cell Differentiation
Chemical Substances	Amides ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; Sulfur (70FD1KFU70)
Language	English
Publishing date	2023-05-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202300373
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Phosphoproteomics Reveals Novel Insights into the Pathogenesis and Identifies New Therapeutic Kinase Targets of Ulcerative Colitis.

Tao, Sifan / Long, Xiuyan / Gong, Pan / Yu, Xiaoyu / Tian, Li

Inflammatory bowel diseases

2023

Abstract: Background: Ulcerative colitis (UC) is a chronic recurrent inflammatory disease with unclear etiology. Currently, safe and effective treatment options for UC remain to be developed. Kinases, which catalyze the phosphorylation of substrates, have emerged ...

Abstract	Background: Ulcerative colitis (UC) is a chronic recurrent inflammatory disease with unclear etiology. Currently, safe and effective treatment options for UC remain to be developed. Kinases, which catalyze the phosphorylation of substrates, have emerged as promising therapeutic targets for inflammatory diseases. We clarified the kinase activity profile and phosphorylation network in UC and aimed to reveal new pathogenic mechanisms and potential therapeutic targets. Methods: We first performed the phosphoproteomic analysis of rectal tissues from UC patients and healthy individuals. Further bioinformatic analyses revealed the remodeling of key kinases and signaling pathways. Then, we conducted a screening of kinases to identify new potential therapeutic targets through in vivo and in vitro experiments. Results: Phosphoproteomics revealed a drastic remodeling of signaling pathways in UC, such as pathways related to tight junction, adhesion junction, and necroptosis. Additionally, the activity of kinases such as CDK2, CLK1 and AURKB were significantly changed. Additional screening of these kinases identified CDK2 as a potential therapeutic target for UC, as inhibiting CDK2 effectively alleviated dextran sulfate sodium-induced colitis in mice. Further research revealed that suppressing CDK2 remarkably inhibited RIPK1, RIPK3, and MLKL phosphorylation, as well as MLKL oligomerization, thereby inhibiting epithelial necroptosis and protecting the intestinal barrier. Conclusions: Our research deepened the understanding of UC pathogenesis through the lens of phosphorylation. Moreover, we identified CDK2 as a new potential therapeutic target for UC, revealing a novel role for CDK2 in necroptosis.
Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1093/ibd/izad291
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4530: Show issues

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Article: Grinding Force and Surface Formation Mechanisms of 17CrNi2MoVNb Alloy When Grinding with CBN and Alumina Wheels.

Jiang, Xiaoyang / Liu, Ke / Si, Mingda / Li, Maojun / Gong, Pan

Materials (Basel, Switzerland)

2023 Volume 16, Issue 4

Abstract: The 17CrNi2MoVNb alloy is widely used for manufacturing heavy-duty gears in vehicles' transmission systems, where grinding is a significant process affecting gears' working performance and service life. This work comprehensively analyzed the grinding ... ...

Abstract	The 17CrNi2MoVNb alloy is widely used for manufacturing heavy-duty gears in vehicles' transmission systems, where grinding is a significant process affecting gears' working performance and service life. This work comprehensively analyzed the grinding force, surface morphology, and surface roughness when grinding 17CrNi2MoVNb alloy using alumina and CBN grinding wheels. Results showed that the maximum normal grinding force from the CBN wheel was only ~67% of the one from the alumina wheel. Due to the small size and limited cutting depth of CBN grains, the grinding force increased by about 20% when the grinding depth increased from 0.02 to 0.03 mm for CBN grinding wheels. Surface defects, including cavities and material tearing, were mainly found on the ground surface when using an alumina grinding wheel. The surface roughness Ra recorded from the CBN grinding wheel mainly ranged from 0.263 to 0.410 μm, accounting for less than 40% of the one from the alumina grinding wheel. The information from this work could provide benchmark data and references for optimizing grinding tools and parameters when manufacturing gears in the vehicle industry.
Language	English
Publishing date	2023-02-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16041720
Database	MEDical Literature Analysis and Retrieval System OnLINE

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