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  1. Article ; Online: An integral genomic signature approach for tailored cancer therapy using genome-wide sequencing data

    Xiao-Song Wang / Sanghoon Lee / Han Zhang / Gong Tang / Yue Wang

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 17

    Abstract: Predicting drug responses in cancer patients requires robust computational frameworks. Here, the authors develop an integral genomic signature —iGenSig— approach to predict drug responses using multi-omics data from tumour samples, and validate this ... ...

    Abstract Predicting drug responses in cancer patients requires robust computational frameworks. Here, the authors develop an integral genomic signature —iGenSig— approach to predict drug responses using multi-omics data from tumour samples, and validate this approach using genomic datasets from multiple clinical studies.
    Keywords Science ; Q
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Factors Associated with the Development of Gastrointestinal Symptoms in Patients Hospitalized with Covid-19.

    Aroniadis, Olga C / Wang, Xianling / Gong, Tang / Forbes, Nauzer / Yang, Jeong Yun / Canakis, Andrew / Elmunzer, Badih Joseph / Yadav, Dhiraj

    Digestive diseases and sciences

    2021  Volume 67, Issue 8, Page(s) 3860–3871

    Abstract: Background and aims: The most common symptoms of Covid-19 are respiratory; however, gastrointestinal symptoms are present in up to 50% of patients. We aimed to determine characteristics associated with the development of gastrointestinal symptoms in ... ...

    Abstract Background and aims: The most common symptoms of Covid-19 are respiratory; however, gastrointestinal symptoms are present in up to 50% of patients. We aimed to determine characteristics associated with the development of gastrointestinal symptoms in patients with Covid-19.
    Methods: A case-control study of adults hospitalized for Covid-19 was conducted across a geographically diverse alliance of 36 US and Canadian medical centers. Data were manually abstracted from electronic health records and analyzed using regression analyses to determine characteristics associated with any gastrointestinal symptoms and diarrhea specifically.
    Results: Of 1406 patients, 540 (38%) reported at least one gastrointestinal symptom and 346 (25%) reported diarrhea. Older patients (≥ 80 years) had significantly lower rates of any gastrointestinal symptoms and diarrhea (vs. patients 18-79 years, OR 0.41, p < 0.01 and OR 0.43 p = 0.01, respectively), while those with IBS (OR 7.70, p = 0.02 and OR 6.72, p < 0.01, respectively) and on immunosuppressive therapy (OR = 1.56, p = 0.02) had higher rates of any gastrointestinal symptom and diarrhea. Patients with constitutional symptoms exhibited significantly higher rates (OR 1.91, p < 0.01), while those with pulmonary disease alone had lower rates of gastrointestinal symptoms (OR 0.23, p = 0.01). A significant interaction between constitutional symptoms and pre-existing pulmonary conditions was observed.
    Conclusions: Several patient- and disease-specific characteristics associate with gastrointestinal symptoms in patients with Covid-19. Knowledge of these may provide insights into associated pathophysiologic mechanisms, and help health care professionals provide targeted attention to reduce morbidity related to Covid-19.
    MeSH term(s) Adult ; COVID-19/complications ; Canada ; Case-Control Studies ; Diarrhea/epidemiology ; Diarrhea/etiology ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Diseases/epidemiology ; Gastrointestinal Diseases/etiology ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-021-07286-7
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  3. Article ; Online: Maternal Factors Associated with Mode of Delivery in a Population with a High Cesarean Section Rate

    Tamala Gondwe / Kalpana Betha / G.N. Kusneniwar / Clareann H. Bunker / Gong Tang / Hyagriv Simhan / P.S. Reddy / Catherine L. Haggerty

    Journal of Epidemiology and Global Health, Vol 9, Iss

    2019  Volume 4

    Abstract: We sought to identify factors associated with mode of delivery in a peri-urban Indian population with a high cesarean section rate. Poisson regression with robust error variance was applied to model factors associated with cesarean compared to vaginal ... ...

    Abstract We sought to identify factors associated with mode of delivery in a peri-urban Indian population with a high cesarean section rate. Poisson regression with robust error variance was applied to model factors associated with cesarean compared to vaginal delivery in a prospective, preconception pregnancy cohort study in Telangana State, India. Adjusted relative risks and 95% confidence intervals from multivariable models are presented. Among 1164 singleton births between 2010 and 2015, 46% were delivered by cesarean. In multiparous women (n = 674), prior cesarean delivery (4.2, 3.2–5.6), prior twin delivery (1.4, 1.1–1.9), diagnosis of hypertension (1.4, 1.0–2.0), or preeclampsia (3.5, 2.1–5.7) in a prior pregnancy independently increased the risk of cesarean. Prepregnancy overweight/obesity (1.4, 1.0–1.9), a composite of prenatal complications (1.3, 1.0–1.7), a composite of labor complications (1.5, 1.0–2.3), nonreassuring fetal heart rate (2.3, 1.3–4.1), and breech position (2.6, 1.4–5.0) also increased the cesarean risk. Among nulliparous women (n = 233), cephalo–pelvic disproportion (1.9, 1.2–3.0), a composite of labor complications (2.9, 1.8–4.9), and breech position (3.4, 1.9–6.2) increased the risk of cesarean. The high rate of cesarean delivery in this peri-urban Indian population is attributed to history of pregnancy complications, history of prior cesarean, prepregnancy body mass index, and medical indications at delivery.
    Keywords Global health ; India ; cesarean section ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher Springer
    Document type Article ; Online
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  4. Article ; Online: Computed tomography based scoring system in a prospectively ascertained cohort of patients with chronic pancreatitis.

    Dasyam, Anil K / Vipperla, Kishore / Slivka, Adam / Gong, Tang / Papachristou, Georgios I / Whitcomb, David C / Yadav, Dhiraj

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

    2019  Volume 19, Issue 8, Page(s) 1027–1033

    Abstract: Objective: No standardized system is currently used to report the presence or severity of parenchymal and ductal features of chronic pancreatitis (CP) on CT scan. We report a modification to the previously proposed Cambridge classification to serve this ...

    Abstract Objective: No standardized system is currently used to report the presence or severity of parenchymal and ductal features of chronic pancreatitis (CP) on CT scan. We report a modification to the previously proposed Cambridge classification to serve this purpose.
    Methods: Contrast-enhanced CT scans of 158 well-phenotyped patients with CP enrolled in the North American Pancreatitis Studies (NAPS2) during 2000-2014 from the University of Pittsburgh were retrospectively reviewed by a subspecialty trained abdominal radiologist. Presence and severity (score scale 0-4) of pancreatic duct (PD) dilation, obstruction and contour irregularity, pancreatic calcifications, atrophy and extent of pancreatic involvement were recorded to grade the morphological severity of CP and stratify patients into distinct morphologic patterns. Findings were also correlated with clinical features.
    Results: Pancreatic atrophy, calcifications, PD dilation and PD irregularity were observed in 80%, 68%, 65%, 58% cases, respectively. An obstructive stone or PD stricture was present in 63%, and 86% had diffuse pancreatic involvement. Using these features, CP was noted to be moderate or severe in 61%, and classified morphologically as obstructive with/without calcifications, calcific but non-obstructive and non-calcific/non-obstructive in 65%, 20%, 15%, respectively. Functional abnormalities but not the presence of pain generally correlated with imaging findings.
    Conclusion: A structured scoring system can provide qualitative and quantitative assessment of imaging findings in CP and an opportunity for adoption into clinical practice and research for initial evaluation and longitudinal follow-up. Our findings need validation in a prospective cohort before widespread adoption.
    MeSH term(s) Adult ; Aged ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Pancreas/diagnostic imaging ; Pancreas/pathology ; Pancreatitis, Chronic/diagnostic imaging ; Pancreatitis, Chronic/pathology ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2019-10-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2056680-3
    ISSN 1424-3911 ; 1424-3903
    ISSN (online) 1424-3911
    ISSN 1424-3903
    DOI 10.1016/j.pan.2019.09.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5553: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: [Risk factors for the kidney stones: a hospital-based case-control study in a distric hospital in Beijing].

    Wang, Jiao / Luo, Gong-tang / Niu, Wei-jing / Gong, Man-man / Liu, Lu / Zhou, Jie / Zhou, Xue-wei / He, Li-hua

    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

    2013  Volume 45, Issue 6, Page(s) 971–974

    Abstract: Objective: To explore the risk and protective factors of kidney calculi in order to put forward theoretical basis for preventive and control measures.: Methods: A 1:1 matched case-control study was performed using data from a hospital in Beijing. The ...

    Abstract Objective: To explore the risk and protective factors of kidney calculi in order to put forward theoretical basis for preventive and control measures.
    Methods: A 1:1 matched case-control study was performed using data from a hospital in Beijing. The case group included 100 inpatients who were diagnosed kidney calculi using B ultrasonic, X-ray and intravenous pyelography during the survey while other 100 urolithiasis and endocrine disease excluded inpatients who shared the same sex, within five years gap to the case group inpatients were for the control group. A face-to-face survey was conducted with self-made questionnaires which covered demographic characteristics, water issues, dietary habits, genetic and medical history. Epidata 3.0 was used to build the database and SPSS 19.0 for the statistical analysis.
    Results: In the univariate Logistic regression analysis, ten variables were found showing statistical significance. For the multivariate Logistic regression analysis, variables left in the model were labor intensity (OR=0.622, 95%CI: 0.435-0.889), preferring to drink after dinner (OR=0.316, 95%CI: 0.122-0.815), loving drinking (OR=0.232, 95%CI: 0.084-0.642), drinking tea regularly (OR=1.463, 95%CI: 1.033-2.071), eating more vegetables (OR=0.571, 95%CI: 0.328-0.993), the history of the urolithiasis (OR=2.127, 95%CI: 1.065-90.145).
    Conclusion: Drinking tea regularly, urolithiasis history and brain work are the risk factors of kidney calculi while loving drinking and eating more vegetables for the protection.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Alcohol Drinking ; Beverages ; Case-Control Studies ; China/epidemiology ; Drinking ; Drinking Behavior ; Feeding Behavior ; Female ; Humans ; Kidney Calculi/epidemiology ; Kidney Calculi/etiology ; Logistic Models ; Male ; Middle Aged ; Risk Factors ; Surveys and Questionnaires ; Tea ; Urolithiasis/complications ; Vegetables ; Young Adult
    Chemical Substances Tea
    Language Chinese
    Publishing date 2013-12-18
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1671-167X
    ISSN 1671-167X
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  6. Article ; Online: Steroids in the treatment of IgA nephropathy to the improvement of renal survival

    Yu-Hao Zhou / Li-Gong Tang / Shi-Lei Guo / Zhi-Chao Jin / Mei-Jing Wu / Jia-Jie Zang / Jin-Fang Xu / Chun-Fang Wu / Ying-Yi Qin / Qing Cai / Qing-Bin Gao / Shan-Shan Zhang / Dand-Hui Yu / Jia He

    PLoS ONE, Vol 6, Iss 4, p e

    a systematic review and meta-analysis.

    2011  Volume 18788

    Abstract: BACKGROUND: Studies have shown that steroids can improve kidney survival and decrease the risk of proteinuria in patients with Immunoglobulin A nephropathy, but the overall benefit of steroids in the treatment of Immunoglobulin A nephropathy remains ... ...

    Abstract BACKGROUND: Studies have shown that steroids can improve kidney survival and decrease the risk of proteinuria in patients with Immunoglobulin A nephropathy, but the overall benefit of steroids in the treatment of Immunoglobulin A nephropathy remains controversial. The aim of this study was to evaluate the benefits and risks of steroids for renal survival in adults with Immunoglobulin A nephropathy. METHODOLOGY AND PRINCIPAL FINDINGS: We searched the Cochrane Renal Group Specialized Register, Cochrane Controlled Trial Registry, MEDLINE and EMBASE databases. All eligible studies were measuring at least one of the following outcomes: end-stage renal failure, doubling of serum creatinine and urinary protein excretion. Fifteen relevant trials (n = 1542) that met our inclusion criteria were identified. In a pooled analysis, steroid therapy was associated with statistically significant reduction of the risk in end-stage renal failure (RR: 0.46, 95% CI: 0.27 to 0.79), doubling of serum creatinine (RR = 0.34, 95%CI = 0.15 to 0.77) and reduced urinary protein excretion (MD = -0.47 g/day, 95%CI = -0.64 to -0.31). CONCLUSIONS/SIGNIFICANCE: We identified that steroid therapy was associated with a decrease of proteinuria and with a statistically significant reduction of the risk in end-stage renal failure. Moreover, subgroup analysis also suggested that long-term steroid therapy had a higher efficiency than standard and short term therapy.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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