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  1. Article: [Promotion of HBeAg seroconversion/loss in patients with chronic hepatitis B following the switch from nucleoside drugs to telbivudine and adefovir].

    Cui, Sunan / Wang, Mingming / Gong, Yanxue

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2014  Volume 22, Issue 10, Page(s) 776–778

    MeSH term(s) Adenine/analogs & derivatives ; Adenine/therapeutic use ; Drug Combinations ; Hepatitis B e Antigens/blood ; Hepatitis B, Chronic/drug therapy ; Humans ; Nucleic Acid Synthesis Inhibitors/therapeutic use ; Nucleosides/antagonists & inhibitors ; Nucleosides/biosynthesis ; Organophosphonates/therapeutic use ; Thymidine/analogs & derivatives ; Thymidine/therapeutic use
    Chemical Substances Drug Combinations ; Hepatitis B e Antigens ; Nucleic Acid Synthesis Inhibitors ; Nucleosides ; Organophosphonates ; telbivudine (2OC4HKD3SF) ; adefovir (6GQP90I798) ; Adenine (JAC85A2161) ; Thymidine (VC2W18DGKR)
    Language Chinese
    Publishing date 2014-10
    Publishing country China
    Document type Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dual Antiplatelet Therapy after Intravenous Thrombolysis for Acute Minor Ischemic Stroke.

    Zhao, Guangjian / Lin, Fanzhen / Wang, Ziran / Shao, Xiaolin / Gong, Yanxue / Zhang, Shirui / Cui, Yansen / Yang, Daiqun / Lei, Hongyan / Cheng, Zhongrong / Wang, Liquan / Guo, Dongdong / Zhang, Qinghua

    European neurology

    2020  Volume 82, Issue 4-6, Page(s) 93–98

    Abstract: Objective: To verify the efficacy and safety of dual antiplatelet therapy after intravenous thrombolysis for acute minor ischemic stroke (AMIS).: Methods: AMIS patients who received recombinant tissue plasminogen activator (rt-PA) intravenous ... ...

    Abstract Objective: To verify the efficacy and safety of dual antiplatelet therapy after intravenous thrombolysis for acute minor ischemic stroke (AMIS).
    Methods: AMIS patients who received recombinant tissue plasminogen activator (rt-PA) intravenous thrombolysis from January to October 2018 were retrospectively analyzed and divided into the aspirin (ASP) and ASP + clopidogrel (ASP-CLO) groups based on the type of antiplatelet therapy to compare the rates of good clinical outcome, symptomatic intracranial hemorrhage (SICH) after thrombolysis, and mortality in 90 days.
    Results: A total of 207 patients were included (group ASP, 105 patients; group ASP-CLO, 102 patients). There was no significant difference in the baseline clinical data between the 2 groups. The -90-day modified Rankin scale scores (66.7 vs. 82.4%, p = 0.009) showed a statistically significant difference, but SICH (1.0 vs. 1.0%, p = 0.917) and 90-day mortality (1.9 vs. 1.0%, p = 0.585) showed no significant difference between the 2 groups.
    Conclusions: Short-term (21 days) dual antiplatelet therapy after rt-PA intravenous thrombolysis for AMIS can improve the prognosis, reduce the risk of stroke recurrence, without increasing the risk of bleeding and mortality.
    MeSH term(s) Administration, Intravenous ; Aged ; Aspirin/therapeutic use ; Brain Ischemia/drug therapy ; Clopidogrel/therapeutic use ; Dual Anti-Platelet Therapy/methods ; Female ; Humans ; Male ; Middle Aged ; Platelet Aggregation Inhibitors/therapeutic use ; Prognosis ; Retrospective Studies ; Stroke/drug therapy ; Thrombolytic Therapy/methods ; Tissue Plasminogen Activator/therapeutic use ; Treatment Outcome
    Chemical Substances Platelet Aggregation Inhibitors ; Clopidogrel (A74586SNO7) ; Tissue Plasminogen Activator (EC 3.4.21.68) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2020-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 209426-5
    ISSN 1421-9913 ; 0014-3022
    ISSN (online) 1421-9913
    ISSN 0014-3022
    DOI 10.1159/000505241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 575: Show issues Location:
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  3. Article: [Clinical efficacy of telbivudine in retreatment and native treatment of chronic hepatitis B for 24 months].

    Cui, Su-nan / Wang, Ming-ming / Guo, Nan / Gong, Yan-xue

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2013  Volume 21, Issue 2, Page(s) 142–143

    MeSH term(s) Adult ; Aged ; Female ; Hepatitis B e Antigens/blood ; Hepatitis B, Chronic/blood ; Hepatitis B, Chronic/drug therapy ; Humans ; Male ; Middle Aged ; Thymidine/analogs & derivatives ; Thymidine/therapeutic use ; Treatment Outcome ; Young Adult
    Chemical Substances Hepatitis B e Antigens ; telbivudine (2OC4HKD3SF) ; Thymidine (VC2W18DGKR)
    Language Chinese
    Publishing date 2013-02
    Publishing country China
    Document type Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Diagnostic value of human neutrophil peptide in spontaneous bacterial peritonitis].

    Gong, Yan-xue / Cui, Su-nan / Li, Li / Wang, Ming-ming / Guo, Nan

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2013  Volume 21, Issue 12, Page(s) 944–948

    Abstract: Objective: To investigate the correlation between human neutrophil peptide (HNP) and spontaneous bacterial peritonitis (SBP) in order to assess the diagnostic value of quantitative measurement of these alpha-defensins.: Methods: Seventy-seven ... ...

    Abstract Objective: To investigate the correlation between human neutrophil peptide (HNP) and spontaneous bacterial peritonitis (SBP) in order to assess the diagnostic value of quantitative measurement of these alpha-defensins.
    Methods: Seventy-seven patients with cirrhosis and ascites were divided into two groups according to diagnosis of SBP (n = 45 with SBP and n = 32 without SBP). Twenty-eight healthy individuals were analyzed as controls. HNP was detected by double-antibody sandwich assay. Peripheral white blood cell (WBC) counts, neutrophil ratio, and levels of procalcitonin (PCT) and C-reactive protein (CRP) were determined by standard methods. Receiver operating characteristic (ROC) curves were used to compare the diagnostic values of HNP, PCT and CRP in SBP.
    Results: There were no significant differences between the three groups (SBP, non-SBP, and healthy controls) for WBC count ((6.01+/-2.25)*109 /L, (4.85+/-1.94)*109 /L, and (5.49+/-1.76)*109 /L; F = 2.91, P more than 0.05) and neutrophil ratio (70.70%+/-10.42%, (68.20%+/-8.97%, and 69.50%+/-8.69%; F = 3.07, P more than 0.05). However, compared to the non-SBP group and the healthy controls, the SBP group showed significantly higher levels of HNP ((9.99+/-3.33) ng/ml and (8.92+/-2.30) ng/ml vs. (17.66+/-6.40) ng/ml; q = 3.20 vs. 3.52, P less than 0.05), serum CRP ((15.08+/-9.95) ng/ml and (5.96+/-2.91) ng/ml vs. (31.32+/-18.65) mg/L; q = 11.03 vs. 3.69, P less than 0.05), and positive rate of PCT (25.0% and 10.0% vs. 62.2%; X2 = 10.41 vs. 15.40, P less than 0.0125). The areas under the curve (AUC) showed the following descending trend: HNP more than PCT more than CRP (0.719, 0.707, and 0.629 respectively). Using cut-off points of 10 ng/ml for HNP, 0.5 ng/ml for PCT, and 8 mg/L for CRP, the respective sensitivities for diagnosis of SBP were 71.1%, 62.2%, and 73.3%, the respective specificities were 71.9%, 75.0%, and 56.3%, and the respective Youden's indexes were 0.430, 0.372, and 0.296.
    Conclusion: HNP is closely related to SBP and can diagnose SBP as reliably as PCT. CRP may help to diagnose SBP, but the results from routine blood testing did not show sufficient statistical significance for diagnosing SBP.
    MeSH term(s) Adult ; Aged ; Bacterial Infections/blood ; Bacterial Infections/diagnosis ; C-Reactive Protein/metabolism ; Calcitonin/blood ; Calcitonin Gene-Related Peptide ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Peritonitis/blood ; Peritonitis/diagnosis ; Peritonitis/microbiology ; Protein Precursors/blood ; alpha-Defensins/blood
    Chemical Substances CALCA protein, human ; Protein Precursors ; alpha-Defensins ; human neutrophil peptide 1 ; Calcitonin Gene-Related Peptide (83652-28-2) ; Calcitonin (9007-12-9) ; C-Reactive Protein (9007-41-4)
    Language Chinese
    Publishing date 2013-12
    Publishing country China
    Document type Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.issn.1007-3418.2013.12.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Geng et al. reply.

    Wang, Xinyi / Sun, Guangqiang / Feng, Teng / Zhang, Jing / Huang, Xun / Wang, Tao / Xie, Zuoquan / Chu, Xingkun / Yang, Jun / Wang, Huan / Chang, Shuaishuai / Gong, Yanxue / Ruan, Lingfei / Zhang, Guanqun / Yan, Siyuan / Lian, Wen / Du, Chen / Yang, Dabing / Zhang, Qingli /
    Lin, Feifei / Liu, Jia / Zhang, Haiyan / Ge, Changrong / Xiao, Shifu / Ding, Jian / Geng, Meiyu

    Cell research

    2020  Volume 30, Issue 9, Page(s) 820

    MeSH term(s) Alzheimer Disease ; Amino Acids ; Disease Progression ; Gastrointestinal Microbiome ; Humans ; Sodium
    Chemical Substances Amino Acids ; Sodium (9NEZ333N27)
    Keywords covid19
    Language English
    Publishing date 2020-07-13
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-020-0377-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5283: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression.

    Wang, Xinyi / Sun, Guangqiang / Feng, Teng / Zhang, Jing / Huang, Xun / Wang, Tao / Xie, Zuoquan / Chu, Xingkun / Yang, Jun / Wang, Huan / Chang, Shuaishuai / Gong, Yanxue / Ruan, Lingfei / Zhang, Guanqun / Yan, Siyuan / Lian, Wen / Du, Chen / Yang, Dabing / Zhang, Qingli /
    Lin, Feifei / Liu, Jia / Zhang, Haiyan / Ge, Changrong / Xiao, Shifu / Ding, Jian / Geng, Meiyu

    Cell research

    2019  Volume 29, Issue 10, Page(s) 787–803

    Abstract: Recently, increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease (AD) progression, yet the role of gut microbiota in AD pathogenesis remains obscure. Herein, we provide a potential mechanistic link between gut ... ...

    Abstract Recently, increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease (AD) progression, yet the role of gut microbiota in AD pathogenesis remains obscure. Herein, we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression. Using AD mouse models, we discovered that, during AD progression, the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine, which stimulates the differentiation and proliferation of pro-inflammatory T helper 1 (Th1) cells. The brain-infiltrated peripheral Th1 immune cells are associated with the M1 microglia activation, contributing to AD-associated neuroinflammation. Importantly, the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment (MCI) due to AD. Furthermore, GV-971, a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China, suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation, harnesses neuroinflammation and reverses the cognition impairment. Together, our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota.
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Amino Acids/metabolism ; Animals ; Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Bacteria/isolation & purification ; Bacteria/metabolism ; Clinical Trials, Phase III as Topic ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/pathology ; Disease Models, Animal ; Disease Progression ; Gastrointestinal Microbiome/drug effects ; Humans ; Isoleucine/metabolism ; Mannose/analogs & derivatives ; Mannose/pharmacology ; Mannose/therapeutic use ; Maze Learning/drug effects ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microglia/metabolism ; Oligosaccharides/pharmacology ; Oligosaccharides/therapeutic use ; Phenylalanine/metabolism ; Th1 Cells/immunology ; Th1 Cells/metabolism
    Chemical Substances Amino Acids ; Anti-Bacterial Agents ; GV-971 ; Oligosaccharides ; Isoleucine (04Y7590D77) ; Phenylalanine (47E5O17Y3R) ; Mannose (PHA4727WTP)
    Language English
    Publishing date 2019-09-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-019-0216-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5283: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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