LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 19

Search options

  1. Article ; Online: Heterozygous knockout of cytosolic phospholipase A

    Qu, Baoxi / Gong, Yunhua / Gill, Jassica M / Kenney, Kimbra / Diaz-Arrastia, Ramon

    Brain research

    2017  Volume 1670, Page(s) 248–252

    Abstract: Cytosolic phospholipase A2α (cPLA2α) is a key enzyme in regulation of inflammation process and neuromembrane homeostasis, both of which are critical in pathogenesis of Alzheimer's diseases. By hybride APP/PS1 Tg-AD mice with cPLA2α knockout mice, three ... ...

    Abstract Cytosolic phospholipase A2α (cPLA2α) is a key enzyme in regulation of inflammation process and neuromembrane homeostasis, both of which are critical in pathogenesis of Alzheimer's diseases. By hybride APP/PS1 Tg-AD mice with cPLA2α knockout mice, three lines of APP/PS1 Tg-AD mice were produced with genotypes of cPLA2α
    Language English
    Publishing date 2017-09-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2017.06.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 161: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: cPLA2α knockout mice exhibit abnormalities in the architecture and synapses of cortical neurons

    Qu, Bao-Xi / Gong, Yunhua / Sinclair, David / Fu, Min / Perl, Daniel / Diaz-Arrastia, Ramon

    Brain research. 2013 Feb. 25, v. 1497

    2013  

    Abstract: Cytosolic phospholipase A2α (cPLA2α) affects membrane fluidity and permeability by catalyzing the hydrolysis of membrane phospholipids. We hypothesize that cPLA2α deficiency induces rigidity and architectural changes in cell membranes, especially in ... ...

    Abstract Cytosolic phospholipase A2α (cPLA2α) affects membrane fluidity and permeability by catalyzing the hydrolysis of membrane phospholipids. We hypothesize that cPLA2α deficiency induces rigidity and architectural changes in cell membranes, especially in large cortical neurons. These membrane changes are discernible using light and electron microscopy. Through careful comparison with wild-type counterparts, we observed significant morphological changes in cortical neurons of cPLA2α knockout mice. These changes included the following: (1) increased numbers of nucleoli and enlarged nuclei, (2) narrower spaces between the inner and outer nuclear membranes, (3) reduced numbers of nuclear pores and altered nuclear pore structure, and (4) morphological changes in synaptic clefts. These results further suggest that cPLA2α and its cleaved arachidonic acids play important roles in cortical neuronal maturation and in normal neurochemical processes.
    Keywords arachidonic acid ; brain ; cell nucleolus ; electron microscopy ; hydrolysis ; membrane fluidity ; mice ; neurons ; nuclear membrane ; permeability ; phospholipids
    Language English
    Dates of publication 2013-0225
    Size p. 101-105.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2012.12.018
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 88/503: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: pH-induced outward movement of star centers within coumarin-centered star-block polymer micelles

    Jiang, Jinqiang / Liu, Yan / Gong, Yunhua / Shu, Qiaozhen / Yin, Ming / Liu, Xiaoya / Chen, Mingqing

    Chemical communications. 2012 Oct. 10, v. 48, no. 88

    2012  

    Abstract: A novel coumarin-centered amphiphilic star-block polymer of C-(PDMAEMA₈₀-b-PS₈)₃ has been designed to investigate the pH-induced accompanying outward movement of hydrophobic coumarin centers within the polymer micelles upon protonation. ...

    Abstract A novel coumarin-centered amphiphilic star-block polymer of C-(PDMAEMA₈₀-b-PS₈)₃ has been designed to investigate the pH-induced accompanying outward movement of hydrophobic coumarin centers within the polymer micelles upon protonation.
    Keywords chemical communication ; coumarin ; hydrophobicity ; micelles ; polymers ; protonation
    Language English
    Dates of publication 2012-1010
    Size p. 10883-10885.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c2cc35680e
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: cPLA2α knockout mice exhibit abnormalities in the architecture and synapses of cortical neurons.

    Qu, Bao-Xi / Gong, Yunhua / Sinclair, David / Fu, Min / Perl, Daniel / Diaz-Arrastia, Ramon

    Brain research

    2013  Volume 1497, Page(s) 101–105

    Abstract: Cytosolic phospholipase A2α (cPLA2α) affects membrane fluidity and permeability by catalyzing the hydrolysis of membrane phospholipids. We hypothesize that cPLA2α deficiency induces rigidity and architectural changes in cell membranes, especially in ... ...

    Abstract Cytosolic phospholipase A2α (cPLA2α) affects membrane fluidity and permeability by catalyzing the hydrolysis of membrane phospholipids. We hypothesize that cPLA2α deficiency induces rigidity and architectural changes in cell membranes, especially in large cortical neurons. These membrane changes are discernible using light and electron microscopy. Through careful comparison with wild-type counterparts, we observed significant morphological changes in cortical neurons of cPLA2α knockout mice. These changes included the following: (1) increased numbers of nucleoli and enlarged nuclei, (2) narrower spaces between the inner and outer nuclear membranes, (3) reduced numbers of nuclear pores and altered nuclear pore structure, and (4) morphological changes in synaptic clefts. These results further suggest that cPLA2α and its cleaved arachidonic acids play important roles in cortical neuronal maturation and in normal neurochemical processes.
    MeSH term(s) Animals ; Arachidonic Acids/metabolism ; Cell Nucleolus/pathology ; Cell Nucleolus/ultrastructure ; Cerebral Cortex/abnormalities ; Cerebral Cortex/pathology ; Group IV Phospholipases A2/deficiency ; Group IV Phospholipases A2/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microscopy, Electron, Transmission ; Neurons/pathology ; Neurons/ultrastructure ; Nuclear Pore/genetics ; Nuclear Pore/pathology ; Synapses/ultrastructure
    Chemical Substances Arachidonic Acids ; Group IV Phospholipases A2 (EC 3.1.1.4)
    Language English
    Publishing date 2013-02-25
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2012.12.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 161: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Phosphodiesterase-5 inhibition potentiates cerebrovascular reactivity in chronic traumatic brain injury.

    Kenney, Kimbra / Amyot, Franck / Moore, Carol / Haber, Margalit / Turtzo, L Christine / Shenouda, Christian / Silverman, Erika / Gong, Yunhua / Qu, Bao-Xi / Harburg, Leah / Wassermann, Eric M / Lu, Hanzhang / Diaz-Arrastia, Ramon

    Annals of clinical and translational neurology

    2018  Volume 5, Issue 4, Page(s) 418–428

    Abstract: Background: Traumatic cerebrovascular injury (TCVI), a common consequence of traumatic brain injury (TBI), presents an attractive therapeutic target. Because phosphodiesterase-5 (PDE5) inhibitors potentiate the action of nitric oxide (NO) produced by ... ...

    Abstract Background: Traumatic cerebrovascular injury (TCVI), a common consequence of traumatic brain injury (TBI), presents an attractive therapeutic target. Because phosphodiesterase-5 (PDE5) inhibitors potentiate the action of nitric oxide (NO) produced by endothelial cells, they are candidate therapies for TCVI. This study aims to: (1) measure cerebral blood flow (CBF), cerebrovascular reactivity (CVR), and change in CVR after a single dose of sildenafil (ΔCVR) in chronic TBI compared to uninjured controls; (2) examine the safety and tolerability of 8-week sildenafil administration in chronic symptomatic moderate/severe TBI patients; and as an exploratory aim, (3) assess the effect of an 8-week course of sildenafil on chronic TBI symptoms.
    Methods: Forty-six subjects (31 chronic TBI, 15 matched healthy volunteers) were enrolled. Baseline CBF and CVR before and after administration of sildenafil were measured. Symptomatic TBI subjects then completed an 8-week double-blind, placebo-controlled, crossover trial of sildenafil. A neuropsychological battery and neurobehavioral symptom questionnaires were administered at each study visit.
    Results: After a single dose of sildenafil, TBI subjects showed a significant increase in global CVR compared to healthy controls (
    Findings: Single-dose sildenafil improves regional CVR deficits in chronic TBI patients. CVR and ΔCVR are potential predictive and pharmacodynamic biomarkers of PDE5 inhibitor therapy for TCVI. Sildenafil is a potential therapy for TCVI.
    Language English
    Publishing date 2018-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2740696-9
    ISSN 2328-9503
    ISSN 2328-9503
    DOI 10.1002/acn3.541
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Imaging of Cerebrovascular Function in Chronic Traumatic Brain Injury.

    Amyot, Franck / Kenney, Kimbra / Moore, Carol / Haber, Margalit / Turtzo, L Christine / Shenouda, Christian / Silverman, Erika / Gong, Yunhua / Qu, Bao-Xi / Harburg, Leah / Lu, Hanzhang Y / Wassermann, Eric M / Diaz-Arrastia, Ramon

    Journal of neurotrauma

    2018  Volume 35, Issue 10, Page(s) 1116–1123

    Abstract: Traumatic cerebrovascular injury (TCVI) is a common pathologic mechanism of traumatic brain injury (TBI) and presents an attractive target for intervention. The aims of this study were to assess cerebral blood flow (CBF) and cerebrovascular reactivity ( ... ...

    Abstract Traumatic cerebrovascular injury (TCVI) is a common pathologic mechanism of traumatic brain injury (TBI) and presents an attractive target for intervention. The aims of this study were to assess cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) using magnetic resonance imaging (MRI) to assess their value as biomarkers of TCVI in chronic TBI, characterize the spatial distribution of TCVI, and assess the relationships between each biomarker and neuropsychological and clinical assessments. Forty-two subjects (27 chronic TBI, 15 age- and gender-matched healthy volunteers) were studied cross-sectionally. CBF was measured by arterial spin labeling and CVR by assessing the MRI-blood oxygen level-dependent signal with hypercapnia challenge. A focused neuropsychological battery adapted from the TBI Common Data Elements and neurobehavioral symptom questionnaires were administered at the time of the imaging session. Chronic TBI subjects showed a significant reduction in mean global, gray matter (GM), and white matter (WM) CVR, compared with healthy volunteers (p < 0.001). Mean GM CVR had the greatest effect size (Cohen's d = 0.9). CVR maps in chronic TBI subjects showed patchy, multifocal CVR deficits. CBF discriminated poorly between TBI subjects and healthy volunteers and did not correlate with CVR. Mean global CVR correlated best with chronic neurobehavioral symptoms among TBI subjects. Global, GM, and WM CVR are reliable and potentially useful biomarkers of TCVI in the chronic stage after moderate-to-severe TBI. CBF is less useful as biomarker of TCVI. CVR correlates best with chronic TBI symptoms. CVR has potential as a predictive and pharmacodynamic biomarker for interventions targeting TCVI.
    MeSH term(s) Adult ; Brain Injuries, Traumatic/diagnostic imaging ; Brain Injuries, Traumatic/physiopathology ; Brain Injury, Chronic/diagnostic imaging ; Brain Injury, Chronic/physiopathology ; Cerebrovascular Circulation/physiology ; Cross-Sectional Studies ; Female ; Humans ; Image Interpretation, Computer-Assisted ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged
    Language English
    Publishing date 2018-03-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 645092-1
    ISSN 1557-9042 ; 0897-7151
    ISSN (online) 1557-9042
    ISSN 0897-7151
    DOI 10.1089/neu.2017.5114
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2016: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: [Effectiveness of integrated schistosomiasis control strategy in marshlands of Qixia District, Nanjing City].

    Zhang, Ke / Liu, Ning / Hou, Kai / Hou, Ning / Gong, Yun-hua / Zhang, Qiu-ping / Ye, Jia-ming / Wang, Biao / Sun, Ji-ji

    Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control

    2015  Volume 27, Issue 4, Page(s) 428–430

    Abstract: Objective: To evaluate the effectiveness of integrated schistosomiasis control strategy in marshlands of Qixia District from 2004 to 2013.: Methods: The endemic situation and integrated control data of schistosomiasis in Qixia District from 2004 to ... ...

    Abstract Objective: To evaluate the effectiveness of integrated schistosomiasis control strategy in marshlands of Qixia District from 2004 to 2013.
    Methods: The endemic situation and integrated control data of schistosomiasis in Qixia District from 2004 to 2013 were collected, and the morbidity and Oncomelania hupensis snail status before and after the implementa- tion of integrated schistosomiasis control strategy were compared.
    Results: Following 10-year integrated schistosomiasis control, the human schistosome infection rate gradually decreased in Qixia District, and no infection was detected since 2007. A gradual reduction was observed in the infection rate of domestic animals, and all bovine was eliminated from the regions along the Yangtze River since 2006. In addition, the snail area and the density of living snails in 2013 reduced by 42.25% and 82.56% as compared to those in 2004, and no infected snails were found since 2009. In 2010, the district achieved schistoso- miasis transmission control.
    Conclusion: The integrated schistosomiasis control strategy is effective to accelerate schistoso- miasis control process and achieve the criteria of schistosomiasis transmission control rapidly.
    MeSH term(s) Animals ; Cattle ; China ; Disease Reservoirs ; Humans ; Schistosomiasis/prevention & control ; Schistosomiasis/transmission ; Snails/parasitology ; Time Factors
    Language Chinese
    Publishing date 2015-08
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1005-6661
    ISSN 1005-6661
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Preservation and enumeration of endothelial progenitor and endothelial cells from peripheral blood for clinical trials.

    Bogoslovsky, Tanya / Maric, Dragan / Gong, Yunhua / Qu, Baoxi / Yang, Kelly / Spatz, Maria / Hallenbeck, John / Diaz-Arrastia, Ramon

    Biomarkers in medicine

    2015  Volume 9, Issue 7, Page(s) 625–637

    Abstract: Aims: Endothelial progenitor cells (EPCs) are markers of vascular repair. Increased numbers of circulating endothelial cells (ECs) are associated with endothelial damage.: Materials & methods: We enumerated EPC-EC by using Enrichment kit with ... ...

    Abstract Aims: Endothelial progenitor cells (EPCs) are markers of vascular repair. Increased numbers of circulating endothelial cells (ECs) are associated with endothelial damage.
    Materials & methods: We enumerated EPC-EC by using Enrichment kit with addition of anti-human CD146-PE/Cy7 from peripheral blood mononuclear cell (PBMC) isolated either by red blood cell (RBC) lysing solution or by Ficoll centrifugation, and from fresh and preserved samples. PBMCs were quantified by flow cytometry.
    Results: RBC lysis yielded higher percentage of PBMC (p = 0.0242) and higher numbers of PBMC/ml (p = 0.0039) than Ficoll. Absolute numbers of CD34(+)CD133(+)VEGFR2(+) and CD146(+)CD34(+)VEGFR2(+) were higher (p = 0.0117 for both), when isolated by RBC lysis than by Ficoll, when no difference in other subsets was found. Cryopreservation at -160°C and -80°C and short-term preservation at room temperature decreased EPC-EC.
    Conclusions: Our data support use of fresh samples and isolation of PBMC from human blood by RBC lysis for enumeration of EPC and EC.
    MeSH term(s) AC133 Antigen ; Adult ; Aged ; Antigens, CD/metabolism ; Antigens, CD34/metabolism ; CD146 Antigen/metabolism ; Cryopreservation ; Endothelial Cells/cytology ; Erythrocytes/cytology ; Female ; Ficoll/chemistry ; Flow Cytometry ; Glycoproteins/metabolism ; Humans ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/metabolism ; Male ; Middle Aged ; Peptides/metabolism ; Stem Cells/cytology ; Stem Cells/metabolism ; Vascular Endothelial Growth Factor Receptor-2/metabolism
    Chemical Substances AC133 Antigen ; Antigens, CD ; Antigens, CD34 ; CD146 Antigen ; Glycoproteins ; PROM1 protein, human ; Peptides ; Ficoll (25702-74-3) ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1)
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/bmm.15.34
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6985: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: pH-induced outward movement of star centers within coumarin-centered star-block polymer micelles.

    Jiang, Jinqiang / Liu, Yan / Gong, Yunhua / Shu, Qiaozhen / Yin, Ming / Liu, Xiaoya / Chen, Mingqing

    Chemical communications (Cambridge, England)

    2012  Volume 48, Issue 88, Page(s) 10883–10885

    Abstract: A novel coumarin-centered amphiphilic star-block polymer of C-(PDMAEMA(80)-b-PS(8))(3) has been designed to investigate the pH-induced accompanying outward movement of hydrophobic coumarin centers within the polymer micelles upon protonation. ...

    Abstract A novel coumarin-centered amphiphilic star-block polymer of C-(PDMAEMA(80)-b-PS(8))(3) has been designed to investigate the pH-induced accompanying outward movement of hydrophobic coumarin centers within the polymer micelles upon protonation.
    Language English
    Publishing date 2012-11-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c2cc35680e
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Beta-amyloid auto-antibodies are reduced in Alzheimer's disease.

    Qu, Bao-Xi / Gong, Yunhua / Moore, Carol / Fu, Min / German, Dwight C / Chang, Ling-Yu / Rosenberg, Roger / Diaz-Arrastia, Ramon

    Journal of neuroimmunology

    2014  Volume 274, Issue 1-2, Page(s) 168–173

    Abstract: Accumulation and cytotoxicity of amyloid beta (Aβ) are understood as the major cause of Alzheimer's disease (AD). There is evidence that naturally occurring antibodies against amyloid beta (Aβ) protein play a role in Aβ-clearance, and such a mechanism ... ...

    Abstract Accumulation and cytotoxicity of amyloid beta (Aβ) are understood as the major cause of Alzheimer's disease (AD). There is evidence that naturally occurring antibodies against amyloid beta (Aβ) protein play a role in Aβ-clearance, and such a mechanism appears to be impaired in AD. In the present study, the anti-Aβ antibodies in the serum from individuals with and without late onset AD were measured using ELISA and dot-blot methods. Aβ auto-antibodies in serum were mainly targeted to Aβ1-15 epitope and its titer was significantly lower in AD patients than elderly non-AD controls (NC). The dot-blot analysis further demonstrated that auto-antibodies against fibrillar Aβ42, Aβ1-15 and Aβ16-30 epitopes were all in a lower level in AD than in NC. The isotypes of the auto-antibodies were mainly non-inflammatory IgG2 type. We also analyzed the relationship of auto-Aβ antibody levels with the genotypes of apolipoprotein E (ApoE) and ANKK1/DRD2 gene.
    MeSH term(s) Aged ; Aged, 80 and over ; Alzheimer Disease/genetics ; Alzheimer Disease/immunology ; Amyloid beta-Peptides/immunology ; Apolipoproteins E/genetics ; Autoantibodies/blood ; Autoantibodies/immunology ; Enzyme-Linked Immunosorbent Assay ; Female ; Genotype ; Humans ; Immune System/immunology ; Male ; Middle Aged ; Peptide Fragments/immunology ; Protein-Serine-Threonine Kinases/genetics ; Receptors, Dopamine D2/genetics
    Chemical Substances Amyloid beta-Peptides ; Apolipoproteins E ; Autoantibodies ; DRD2 protein, human ; Peptide Fragments ; Receptors, Dopamine D2 ; amyloid beta-protein (1-15) ; amyloid beta-protein (1-42) ; ANKK1 protein, human (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2014-06-27
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 8335-5
    ISSN 1872-8421 ; 0165-5728
    ISSN (online) 1872-8421
    ISSN 0165-5728
    DOI 10.1016/j.jneuroim.2014.06.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1646: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top