Article: Phospholipase A secreted by Legionella pneumophila destroys alveolar surfactant phospholipids.
2000 Volume 188, Issue 2, Page(s) 129–133
Abstract: Destruction of alveolar surfactant phospholipids by bacterial phospholipases is suggested to be a major virulence factor involved in bacterial pneumonia. Since Legionella pneumophila secretes phospholipase A, we analyzed phospholipid degradation in ... ...
| Abstract | Destruction of alveolar surfactant phospholipids by bacterial phospholipases is suggested to be a major virulence factor involved in bacterial pneumonia. Since Legionella pneumophila secretes phospholipase A, we analyzed phospholipid degradation in natural bovine surfactant by L. pneumophila. Phospholipids were reduced in amount after incubation with bacteria or culture supernatant of L. pneumophila serogroup 6. Free fatty acids and lysophosphatidylcholine were formed, the latter is known to be highly cytotoxic. Surface tension of surfactant as determined by pulsating bubble surfactometer increased significantly compared to the control. Phospholipase A activity seems to be a powerful agent of legionellae in causing lung disease. |
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| MeSH term(s) | Animals ; Cattle ; Fatty Acids/analysis ; Legionella pneumophila/enzymology ; Legionella pneumophila/growth & development ; Lysophosphatidylcholines/analysis ; Magnetic Resonance Spectroscopy ; Phosphatidylcholines/analysis ; Phosphatidylglycerols/analysis ; Phospholipases A/metabolism ; Pulmonary Surfactants/analysis ; Pulmonary Surfactants/chemistry ; Pulmonary Surfactants/metabolism ; Surface Tension ; Time Factors | |||||
| Chemical Substances | Fatty Acids ; Lysophosphatidylcholines ; Phosphatidylcholines ; Phosphatidylglycerols ; Pulmonary Surfactants ; Phospholipases A (EC 3.1.1.32) | |||||
| Language | English | |||||
| Publishing date | 2000-07-15 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 752343-9 | |||||
| ISSN | 1574-6968 ; 0378-1097 | |||||
| ISSN (online) | 1574-6968 | |||||
| ISSN | 0378-1097 | |||||
| DOI | 10.1111/j.1574-6968.2000.tb09183.x | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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