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Article ; Online: The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition.

Sacco, Michael Dominic / Hu, Yanmei / Gongora, Maura Verenice / Meilleur, Flora / Kemp, Michael Trent / Zhang, Xiujun / Wang, Jun / Chen, Yu

Cell research

2022  Volume 32, Issue 5, Page(s) 498–500

MeSH term(s) COVID-19 ; Catalysis ; Humans ; Mutation/genetics ; Peptide Hydrolases ; SARS-CoV-2
Chemical Substances Peptide Hydrolases (EC 3.4.-)
Language English
Publishing date 2022-03-15
Publishing country England
Document type Letter ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID 1319303-x
ISSN 1748-7838 ; 1001-0602
ISSN (online) 1748-7838
ISSN 1001-0602
DOI 10.1038/s41422-022-00640-y
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