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  1. Article ; Online: A different way to diagnosis acute appendicitis: machine learning.

    Harmantepe, Ahmet Tarik / Dikicier, Enis / Gönüllü, Emre / Ozdemir, Kayhan / Kamburoğlu, Muhammet Burak / Yigit, Merve

    Polski przeglad chirurgiczny

    2024  Volume 96, Issue 2, Page(s) 38–43

    Abstract: ... Indroduction: ... Machine learning is a branch of artificial intelligence based on the idea that systems can learn from data, identify patterns, and make decisions with minimal human intervention ... ... Aim: ... Our aim is to predict acute ... ...

    Abstract
    Indroduction:
    Machine learning is a branch of artificial intelligence based on the idea that systems can learn from data, identify patterns, and make decisions with minimal human intervention.

    Aim:
    Our aim is to predict acute appendicitis, which is the most common indication for emergency surgery, using machine learning algorithms with an easy and inexpensive method.

    Materials and methods:
    Patients who were treated surgically with a prediagnosis of acute appendicitis in a single center between 2011 and 2021 were analyzed. Patients with right lower quadrant pain were selected. A total of 189 positive and 156 negative appendectomies were found. Gender and hemogram were used as features. Machine learning algorithms and data analysis were made in Python (3.7) programming language.

    Results:
    Negative appendectomies were found in 62% (n = 97) of the women and in 38% (n = 59) of the men. Positive appendectomies were present in 38% (n = 72) of the women and 62% (n = 117) of the men. The accuracy in the test data was 82.7% in logistic regression, 68.9% in support vector machines, 78.1% in k-nearest neighbors, and 83.9% in neural networks. The accuracy in the voting classifier created with logistic regression, k-nearest neighbor, support vector machines, and artificial neural networks was 86.2%. In the voting classifier, the sensitivity was 83.7% and the specificity was 88.6%.

    Conclusions:
    The results of our study show that machine learning is an effective method for diagnosing acute appendicitis. This study presents a practical, easy, fast, and inexpensive method to predict the diagnosis of acute appendicitis.
    .
    MeSH term(s) Male ; Humans ; Female ; Appendicitis/diagnosis ; Appendicitis/surgery ; Artificial Intelligence ; Machine Learning ; Abdominal Pain ; Acute Disease
    Language English
    Publishing date 2024-04-17
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 128732-1
    ISSN 2299-2847 ; 0032-373X
    ISSN (online) 2299-2847
    ISSN 0032-373X
    DOI 10.5604/01.3001.0053.5994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: ANALYSIS OF DIAGNOSTIC EXCISIONAL LYMPH NODE BIOPSY RESULTS: 12-YEAR EXPERIENCE OF A SINGLE CENTER.

    Bayhan, Zulfu / Ozdemir, Kayhan / Gonullu, Emre / Harmantepe, Ahmet Tarik / Capoglu, Recayi / Akin, Emrah / Aziret, Mehmet / Altintoprak, Fatih

    Acta clinica Croatica

    2024  Volume 62, Issue 1, Page(s) 58–64

    Abstract: Lymph node biopsy is indicated in patients with suspected malignancy or lymphadenopathy due to unclarified reasons. Lymph node biopsy can be performed as fine needle aspiration biopsy, core biopsy, or excisional lymph node biopsy. In particular, the ... ...

    Abstract Lymph node biopsy is indicated in patients with suspected malignancy or lymphadenopathy due to unclarified reasons. Lymph node biopsy can be performed as fine needle aspiration biopsy, core biopsy, or excisional lymph node biopsy. In particular, the diagnosis of malignant lymphoma is considered insufficient for oncological treatment unless classified into subgroups. Core biopsy and excisional biopsy can be performed to diagnose lymphoma and classify it into subgroups. Core biopsy may also be limited in some cases for the diagnosis of lymphoma. Therefore, patients are referred to surgical departments for excisional lymph node biopsy. It was aimed herein to analyze the results of excisional lymph node biopsies performed for diagnostic purposes in our department. Data on 73 patients having undergone diagnostic excisional lymph node biopsy at Sakarya University Medical Faculty Training and Research Hospital between January 2008 and January 2020 were retrospectively analyzed. Patients were evaluated in terms of age, gender, biopsy site, pathological diagnosis, number and diameter of lymph nodes excised. Patients younger than 18 years of age, those with sentinel lymph node biopsies, and lymph node dissections performed for any known malignancy were excluded from the study. Statistical data analysis was done using SPSS statistical software. There were 37 (50.7%) female and 36 (49.3%) male patients, mean age 52.07 (18-90) years. Axillary lymph node biopsy was performed in 32 patients, inguinal lymph node biopsy in 29 patients, cervical lymph node biopsy in 3 patients, intra-abdominal lymph node biopsy in 6 patients, mediastinal lymph node biopsy in 1 patient, and supraclavicular lymph node biopsy in 2 patients. All of the lymph node biopsies were performed as excisional biopsy. Malignancy was detected in 36 (49.3%) patients. In 37 (50.3%) patients, the causes of lymphadenopathy were found to be benign pathologies. When the causes of malignant disease were examined, it was observed that 23 (31.5%) patients were diagnosed with lymphoma. Hodgkin lymphoma was detected in 5 patients diagnosed with lymphoma, and non-Hodgkin lymphoma was found in 18 patients. Metastatic lymphadenopathy was observed in 13 (17.8%) patients. Reactive lymphoid hyperplasia (26%) and lymphadenitis (20.5%) were found among the causes of benign lymphadenopathy. The number of excised lymph nodes was between 1 and 4, and their diameter was between 9 and 75 mm (mean: 29.53±15.56 mm). There was no statistically significant difference between benign and malignant patients according to gender, age, lymph node diameter, number of lymph nodes excised, and excisional lymph node biopsy site. For diagnostic lymph node biopsy, fine-needle aspiration biopsy and core biopsy should be performed primarily. If lymphoma is suspected in the diagnosis, fine-needle aspiration biopsy is not necessary. In this case, it is believed that it is more appropriate to perform core biopsy first. If the core biopsy is insufficient for diagnosis, it is more appropriate to perform surgical biopsy in order to cause no delay in diagnosis and treatment. Excisional biopsy is a method that can be safely performed and does not cause severe morbidity in palpable peripheral lymphadenopathies. Although it does not cause severe morbidity because it is an invasive procedure, excisional biopsy should be performed in a selected patient group.
    MeSH term(s) Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Lymph Nodes/pathology ; Biopsy ; Lymphadenopathy/pathology ; Lymphoma/diagnosis ; Lymphoma/surgery ; Lymphoma/pathology ; Hodgkin Disease/pathology ; Biopsy, Fine-Needle
    Language English
    Publishing date 2024-01-18
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 1478635-7
    ISSN 1333-9451 ; 0353-9466
    ISSN (online) 1333-9451
    ISSN 0353-9466
    DOI 10.20471/acc.2023.62.01.07
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comparison of treatment methods in plastron appendicitis: a tertiary center experience.

    Ozdemir, Kayhan / Harmantepe, Ahmet Tarik / Dulger, Ugur Can / Gonullu, Emre / Dikicier, Enis / Bayhan, Zulfu / Altintoprak, Fatih

    Malawi medical journal : the journal of Medical Association of Malawi

    2024  Volume 35, Issue 4, Page(s) 224–227

    Abstract: Background: It is controversial which treatment method is superior in plastron appendicitis and the research is still going on. The aim of this study is to compare treatment methods for plastron appendicitis in the adult population with our experience.!# ...

    Abstract Background: It is controversial which treatment method is superior in plastron appendicitis and the research is still going on. The aim of this study is to compare treatment methods for plastron appendicitis in the adult population with our experience.
    Materials and methods: The data of 92 patients who were diagnosed with plastron appendicitis in university hospital between 2015 and 2021 were analyzed retrospectively. Data were taken from the hospital database. The patients were divided into three groups: those treated with primary surgery, with interval appendectomy and only with conservative method.
    Results: Interval appendectomy resulted in a lower rate of conversion to open surgery compared to primary surgery, shorter operative time, and lower complication rates. Surgical procedures were found to be superior in detecting neoplasms compared to conservative treatment. After conservative treatment, one of three patients was retreated with the diagnosis of acute appendicitis.
    Conclusion: In plastron appendicitis, routine interval appendectomy can be performed due to its advantages over other treatments such as the frequency of attacks after conservative treatment, the risk of the tumor being overlooked in conservative treatment, and the high rate of complications and conversion to open surgery in the primary surgery group.
    MeSH term(s) Adult ; Humans ; Retrospective Studies ; Appendicitis/surgery ; Appendicitis/complications ; Appendicitis/diagnosis ; Length of Stay ; Appendectomy/adverse effects ; Appendectomy/methods ; Acute Disease ; Treatment Outcome
    Language English
    Publishing date 2024-02-01
    Publishing country Malawi
    Document type Journal Article
    ISSN 1995-7270 ; 1995-7262
    ISSN (online) 1995-7270
    ISSN 1995-7262
    DOI 10.4314/mmj.v35i4.5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Coexisting of small bowel perforation and abdominal cocoon syndrome: A case report.

    Akın, Emrah / Altıntoprak, Fatih / Gönüllü, Emre / Yılmaz, Fahri / Alper Yıldız, Yasin

    Turkish journal of surgery

    2023  Volume 39, Issue 3, Page(s) 274–277

    Abstract: Abdominal cocoon syndrome (ACS) is a rare situation and has an unknown etiology. Patients are characterized by the development of intraabdominal fibrotic tissue surrounding the small intestine as a result of chronic inflammation of the peritoneum. Small ... ...

    Abstract Abdominal cocoon syndrome (ACS) is a rare situation and has an unknown etiology. Patients are characterized by the development of intraabdominal fibrotic tissue surrounding the small intestine as a result of chronic inflammation of the peritoneum. Small bowel perforations due to foreign bodies are not frequent in clinical practice. The coexistence of these two rare situations are extremely uncommon. In this article, the radiological findings and treatment process of the patient who presented with acute abdomen syndrome findings and the association of these two rare conditions are presented.
    Language English
    Publishing date 2023-09-27
    Publishing country Turkey
    Document type Case Reports
    ISSN 2564-6850
    ISSN 2564-6850
    DOI 10.47717/turkjsurg.2022.4687
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Analysis of Ambulatory Proctologic Surgery for Simple Anal Fistulas in Terms of Recovery, Complications, Recurrence, and Cost.

    Demir, Hakan / Capoglu, Recayi / Yigit, Merve / Harmantepe, Tarik / Gonullu, Emre / Karaman, Kerem

    Cureus

    2023  Volume 15, Issue 7, Page(s) e42110

    Abstract: Background Ambulatory anorectal surgeries have increased in the last few years. This clinical study aimed to compare general operating room conditions with outpatient procedures for simple anal fistulas in terms of healing success, recurrence, cost, ... ...

    Abstract Background Ambulatory anorectal surgeries have increased in the last few years. This clinical study aimed to compare general operating room conditions with outpatient procedures for simple anal fistulas in terms of healing success, recurrence, cost, complications, and sustainability. Methodology Only primary fistulotomy and seton application for simple anal fistulas were retrospectively analyzed. Results Two-hundred fifty patients (73.7%) were male, and 89 (26.3%) were female. Sixty patients (17.7%) were treated in the operating room, and 279 (82.3%) were treated in the outpatient clinic conditions. Of the ambulatory surgeries, 160 patients underwent fistulotomy and 119 patients loose seton. On the other hand, 34 patients underwent fistulotomy and 26 patients loose seton in operating room conditions. No significant difference was found between the groups according to the distribution of age, gender, complications, and recurrence (
    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.42110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: FAR Ratio as Prognostic Biomarker in AMI.

    Muhtaroğlu, Ali / Çapoğlu, Recayi / Uygur, Furkan Ali / Harmantepe, Ahmet Tarık / Bayhan, Zülfü / Gönüllü, Emre

    SN comprehensive clinical medicine

    2023  Volume 5, Issue 1, Page(s) 109

    Abstract: Acute mesenteric ischemia (AMI) is a vascular emergency resulting from decreased blood flow caused by the occlusion of the mesenteric vessels, hypoperfusion, or vasospasm. This study aimed to investigate the prognostic value of the fibrinogen-to-albumin ( ...

    Abstract Acute mesenteric ischemia (AMI) is a vascular emergency resulting from decreased blood flow caused by the occlusion of the mesenteric vessels, hypoperfusion, or vasospasm. This study aimed to investigate the prognostic value of the fibrinogen-to-albumin (FAR) ratio in patients with acute mesenteric ischemia. A total of 91 patients were enrolled in the study. Patients' demographics such as age and gender, pre- and postoperative hemoglobin, CRP, white blood cell (WBC), neutrophils, preoperative lymphocyte, alanine transaminase (ALT), aspartate transaminase (AST), thrombocytes, and postoperative D-dimer values were recorded. In addition, pre- and postoperative fibrinogen and albumin levels were recorded, and FAR was calculated. Patients were divided into two groups, survivors and non-survivors. The mean pre- and postoperative fibrinogen levels were statistically significantly higher in the non-survivor group than in the survivor group (
    Language English
    Publishing date 2023-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2947211-8
    ISSN 2523-8973 ; 2523-8973
    ISSN (online) 2523-8973
    ISSN 2523-8973
    DOI 10.1007/s42399-023-01451-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Should multifocality be an indication for prophylactic central neck dissection in papillary thyroid cancer?

    Ozdemir, Kayhan / Harmantepe, Ahmet Tarik / Gonullu, Emre / Kocer, Belma / Bayhan, Zulfu

    Updates in surgery

    2023  Volume 75, Issue 3, Page(s) 701–706

    Abstract: Although multifocality is common in patients with papillary thyroid cancer, its effects on lymphatic metastasis and the necessity of central dissection in the presence of multifocality are still controversial. In our clinic, 258 patients who underwent ... ...

    Abstract Although multifocality is common in patients with papillary thyroid cancer, its effects on lymphatic metastasis and the necessity of central dissection in the presence of multifocality are still controversial. In our clinic, 258 patients who underwent thyroidectomy between 2015 and 2020 and were found to have papillary thyroid cancer in postoperative pathology reports were analyzed. The tumor characteristics contributing to central lymph node metastasis positivity were evaluated. Lymph node metastases were not significantly increased in the presence of multifocality. In cases with bilateral multifocal tumors, compared to cases with unilateral multifocal tumors, capsular invasion (p = 0.02), vascular invasion (p = 0.01) and cervical lymphatic metastasis (p = 0.004) were observed to increase. Bilateral multifocal tumors have more aggressive clinicopathological features than unilateral tumors. We found that the risk of central lymph node metastasis increased significantly in bilateral multifocal tumors in our study. Prophylactic central lymph node dissection may be considered in patients with no preoperative or intraoperative lymph node metastasis but thought to have a multifocal tumor.
    MeSH term(s) Humans ; Thyroid Cancer, Papillary/surgery ; Thyroid Cancer, Papillary/pathology ; Neck Dissection ; Lymphatic Metastasis/pathology ; Thyroid Neoplasms/surgery ; Thyroid Neoplasms/pathology ; Carcinoma, Papillary/surgery ; Carcinoma, Papillary/pathology ; Retrospective Studies ; Carcinoma/surgery ; Thyroidectomy ; Lymph Nodes/pathology ; Risk Factors
    Language English
    Publishing date 2023-03-05
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-023-01479-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The unexpected effect of parathyroid adenoma on inflammation.

    Harmantepe, Ahmet Tarik / Kocer, Belma / Bayhan, Zulfu / Gonullu, Emre / Dulger, Ugur Can

    Updates in surgery

    2023  Volume 76, Issue 2, Page(s) 589–593

    Abstract: Primary hyperparathyroidism (PHPT) is an endocrinological disease that affects systemic inflammation. This study is aimed to investigate the preoperative and postoperative effect of PHPT on systemic inflammation. A total of 203 patients who were ... ...

    Abstract Primary hyperparathyroidism (PHPT) is an endocrinological disease that affects systemic inflammation. This study is aimed to investigate the preoperative and postoperative effect of PHPT on systemic inflammation. A total of 203 patients who were successfully operated for PHPT and 98 healthy controls were included in the study. The blood tests of the patients in the last month preoperatively and in the postoperative 6th month were compared. In addition, preoperative and postoperative tests were compared with the healthy control group. When the preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic inflammation index (SII) values of the patients who were operated for parathyroid adenoma were compared with the control group (p values were < 0.05, 0.01, 0.19, < 0.05), the NLR, PLR, and SII values were significantly lower in the patient group with parathyroid adenoma than in the control group. When the preoperative and postoperative 6th month NLR, PLR, LMR, and SII values of the patients were compared (p values: 0.026, 0.56, 0.023, 0.016, respectively), there was a significant increase in NLR and SII values after excision, while a significant decrease was observed in the LMR value. When the postoperative 6th month NLR, PLR, LMR, SII values were compared with the healthy control group (p values: 0.22, 0.29, 0.19, 0.29, respectively), no significant difference was observed between all values. We found that the immune system was suppressed in PHPT and this returned to normal levels after a successful surgery.
    MeSH term(s) Humans ; Parathyroid Neoplasms/complications ; Parathyroid Neoplasms/surgery ; Retrospective Studies ; Lymphocytes ; Blood Platelets ; Inflammation
    Language English
    Publishing date 2023-12-17
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-023-01734-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Oversewing the Staple Line: Does It Safe to Prevent Leakage?

    Gönüllü, Emre / Yüksel, Adem / Coşkun, Murat / Harmantepe, Tarık / Fırtına, Gizem / Karaman, Kerem

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2023  Volume 34, Issue 2, Page(s) 120–126

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Humans ; Obesity, Morbid/surgery ; Surgical Stapling ; Laparoscopy ; Gastrectomy/adverse effects ; Sutures
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1381909-4
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2023.0284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Comparison of scoring systems regarding the gender as a parameter with the traditional scoring systems for predicting appendicitis.

    Capoglu, Recayi / Gonullu, Emre / Bayhan, Zulfu / Coskun, Murat / Harmantepe, Tarık / Kucuk, Furkan

    Updates in surgery

    2022  Volume 74, Issue 3, Page(s) 1035–1042

    Abstract: Although acute appendicitis remains the most common cause of acute abdomen in General Surgery practice, negative appendectomy rates are still high in particularly female patients. Appendicitis scoring systems considering gender can help the clinician to ... ...

    Abstract Although acute appendicitis remains the most common cause of acute abdomen in General Surgery practice, negative appendectomy rates are still high in particularly female patients. Appendicitis scoring systems considering gender can help the clinician to reduce negative appendectomy rates in females. This present study aims to compare the Lintula, Ripasa, Fenyo-Lindberg scoring systems, which use gender as a variable, with the Alvarado, Karaman, scoring systems to evaluate which CSS is more successful in the differential diagnosis of appendicitis in females. We analyzed the records of the patients operated on with a prediagnosis of acute appendicitis in our clinic between 2020 and 2021, retrospectively. Alvarado, adult appendicitis score (AAS), appendicitis inflammatory response score (AIRS), Ripasa, Karaman, Lintula, and Fenyo Lindberg scores were calculated for each patient. The patients were divided into two groups as male and female, according to gender. Receiver operator characteristic (ROC) curve analysis was used to identify the best cut-off value and assess the performance of the test score for appendicitis. Three hundred and sixty-three patients were included in the study. One hundred seventy-two (47.4%) of the patients were male, and 191 (52.6%) were female. Alvarado and AAS were the most valuable score in female (AUC: 0.805, sensitivity: 0.63, specificity: 0.83; and area under curve (AUC): 0.794, Sensitivity 0.71, Specificity: 0.76, respectively), male group (AUC: 0.828, Sensitivity: 0.71, Specificity: 0.83; and AUC: 0.834, Sensitivity 0.74, Specificity: 0.77, respectively), and when patients were not categorized by gender (AUC: 0.818, Sensitivity: 0.67 Specificity: 0.83; and AUC: 0.794, Sensitivity 0.71, Specificity: 0.76, respectively). Although the Alvarado scoring system is the first defined appendicitis scoring system, it seems as superior to the many scoring systems defined after it in predicting appendicitis, even in female patients.
    MeSH term(s) Acute Disease ; Adult ; Appendectomy ; Appendicitis/diagnosis ; Appendicitis/surgery ; Female ; Humans ; Male ; Prospective Studies ; Retrospective Studies ; Sensitivity and Specificity
    Language English
    Publishing date 2022-04-21
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-022-01272-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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