LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 10 von insgesamt 14

Suchoptionen

  1. Artikel ; Online: Predictive value of Controlling Nutritional Status score and Prognostic Nutritional Index for systemic inflammatory response syndrome/sepsis after percutaneous nephrolithotomy.

    Arslan, Burak / Kinik, Abdullah Harun / Gonultas, Serkan / Kose, Mustafa Gökhan / Kardas, Sina / Cetin, Buğra / Kecebas, Arif / Altay, Doğan / Ozdemir, Enver

    International urology and nephrology

    2023  Band 55, Heft 5, Seite(n) 1101–1107

    Abstract: Purpose: Our aim was to investigate the predictive value of Controlling Nutritional Status (CONUT) score and Prognostic Nutritional Index (PNI) for systemic inflammatory response syndrome (SIRS)/sepsis after percutaneous nephrolithotomy (PNL).: ... ...

    Abstract Purpose: Our aim was to investigate the predictive value of Controlling Nutritional Status (CONUT) score and Prognostic Nutritional Index (PNI) for systemic inflammatory response syndrome (SIRS)/sepsis after percutaneous nephrolithotomy (PNL).
    Methods: Demographic and clinical data of 422 patients who underwent PNL were evaluated. The CONUT score was calculated from lymphocyte count, serum albumin, and cholesterol, while the PNI was calculated using lymphocyte count and serum albumin. Spearman's correlation coefficient was used to evaluate the relationship between nutritional scores and systemic inflammation markers. Logistic regression analysis was performed to determine the risk factors for SIRS/sepsis development after PNL.
    Results: Patients with SIRS/sepsis had a significantly higher preoperative CONUT score and lower PNI compared with the SIRS/sepsis (-) group. A positive significant correlation between CONUT score and CRP (rho = 0.75), CONUT score and procalcitonin (rho = 0.36), and CONUT score and WBC (rho = 0.23) were determined. Additionally, a negative significant correlation was shown between PNI and procalcitonin (rho = - 0.30) and PNI and CRP (rho = - 0.64). The ROC curve analysis showed that the cut-off values for the CONUT score and PNI were 4 (AUC = 0.827) and 42 (AUC = 0.734), respectively. Age, stone size, history of pyelonephritis, residual stone, presence of infection stone, CONUT score ≥ 4, and PNI ≤ 42 were found to be independent predictors for postoperative SIRS/sepsis in multivariate analysis.
    Conclusion: Our results demonstrated that preoperative CONUT score and PNI are potential predictive factors for SIRS/sepsis development after PNL. Therefore, patients with CONUT score ≥ 4 and PNI ≤ 42 are suggested to be closely monitoring due to the risk of post-PNL SIRS/sepsis.
    Mesh-Begriff(e) Humans ; Nutritional Status ; Nutrition Assessment ; Prognosis ; Nephrolithotomy, Percutaneous/adverse effects ; Procalcitonin ; Retrospective Studies ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/etiology ; Sepsis/etiology ; Sepsis/complications ; Serum Albumin
    Chemische Substanzen Procalcitonin ; Serum Albumin
    Sprache Englisch
    Erscheinungsdatum 2023-03-20
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-023-03559-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  2. Artikel: COVID-19 and animals: What do we know?

    Gönültaş, Serkan / Karabağlı, Murat / Baştuğ, Yavuz / Çilesiz, Nusret Can / Kadıoğlu, Ateş

    Turkish journal of urology

    2020  

    Abstract: Coronaviruses, which were generally considered harmless to humans before 2003, have appeared again with a pandemic threatening the world since December 2019 after the epidemics of SARS and MERS. It is known that transmission from person to person is the ... ...

    Abstract Coronaviruses, which were generally considered harmless to humans before 2003, have appeared again with a pandemic threatening the world since December 2019 after the epidemics of SARS and MERS. It is known that transmission from person to person is the most important way to spread. However, due to the widespread host diversity, a detailed examination of the role of animals in this pandemic is essential to effectively fight against the outbreak. Although coronavirus infections in pets are known to be predominantly related to the gastrointestinal tract, it has been observed that there are human-to-animal transmissions in this outbreak and some animals have similar symptoms to humans. Although animal-to-animal transmission has been shown to be possible, there is no evidence of animal-to-human transmission.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-15
    Erscheinungsland Turkey
    Dokumenttyp Journal Article
    ISSN 2149-3235
    ISSN 2149-3235
    DOI 10.5152/tud.2020.140520
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  3. Artikel ; Online: Controlling nutritional status score in predicting International Society of Urological Pathology score upgrading and biochemical recurrence after radical prostatectomy.

    Arslan, Burak / Ekinci, Suat / Avci, Mustafa Asım / Ozalevli, Mehmet / Bulut, Berk / Kecebas, Arif Burak / Kinik, Abdullah Harun / Kardas, Sina / Gonultas, Serkan / Ozdemir, Enver

    Asia-Pacific journal of clinical oncology

    2023  

    Abstract: Aim: The aim of our study was to assess the predictive value of controlling nutritional status (CONUT) score for the prognosis of prostate cancer.: Methods: A total of 257 patients' characteristics, prostate-specific antigen (PSA) values, biopsy, and ...

    Abstract Aim: The aim of our study was to assess the predictive value of controlling nutritional status (CONUT) score for the prognosis of prostate cancer.
    Methods: A total of 257 patients' characteristics, prostate-specific antigen (PSA) values, biopsy, and pathological specimen features were all recorded. The CONUT score was calculated for each patient from three blood parameters: total lymphocyte count (TLC), serum albumin, and cholesterol concentrations. Spearman's correlation coefficient was used to assess the correlation between the total CONUT score and the variables including age, body mass index, prostate volume, PSA, biopsy and pathological specimen features, and PSA-recurrence free survival (PSA-RFS) time. The Kaplan-Meier method and log-rank test were used for PSA-RFS analysis. Regression analyses were performed to assess the association between clinicopathological factors, the International Society of Urological Pathology (ISUP) upgrading, and biochemical recurrence (BCR).
    Results: Statistically significant differences were determined in pathologic ISUP grade, and total tumor volume between low and high CONUT score groups. Additionally, the high CONUT score group had a significantly higher BCR rate and lower PSA-RFS when compared with the low CONUT score group. A strong positive correlation between total CONUT score and pathologic ISUP grade and a moderate negative correlation between total CONUT score and PSA-RFS was determined. In multivariate analysis, a total CONUT score ≥2 had a statistically significant association with ISUP upgrading (odds ratio [OR] = 3.05) and BCR (3.52).
    Conclusion: Preoperative CONUT score is an independent predictive factor for ISUP score upgrading and BCR in patients who undergo radical prostatectomy.
    Sprache Englisch
    Erscheinungsdatum 2023-04-07
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 2187409-8
    ISSN 1743-7563 ; 1743-7555
    ISSN (online) 1743-7563
    ISSN 1743-7555
    DOI 10.1111/ajco.13951
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  4. Artikel ; Online: Frequency of etiological factors among patients with acquired premature ejaculation: prospective, observational, single-center study.

    Culha, Mehmet Gokhan / Tuken, Murat / Gonultas, Serkan / Cakir, Omer Onur / Serefoglu, Ege Can

    International journal of impotence research

    2019  Band 32, Heft 3, Seite(n) 352–357

    Abstract: Although premature ejaculation (PE) is a common male sexual dysfunction, its pathophysiology has not been fully elucidated. Several medical problems such as erectile dysfunction, depression, anxiety, hormonal disorders and chronic prostatitis may play a ... ...

    Abstract Although premature ejaculation (PE) is a common male sexual dysfunction, its pathophysiology has not been fully elucidated. Several medical problems such as erectile dysfunction, depression, anxiety, hormonal disorders and chronic prostatitis may play a role in the etiology of acquired PE. This study aims to evaluate the frequency of these etiologic factors among patients with acquired PE. Between May and July 2016, 53 men with acquired PE were included in the study. Self-estimated intravaginal ejaculation latency time (IELT) of these patients was recorded along with their medical history and physical examination findings. Moreover, 5-item version of the International Index of Erectile Function (IIEF-5), premature ejaculation profile (PEP), anxiety and depression scales (STAI-1, STAI-2, and BECK), and chronic prostatitis symptom index (NIH-CPSI) were administered. Fasting plasma glucose, follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, total and free testosterone, total prostate specific antigen, thyroid and thyroid stimulating hormone levels were measured. Urine analysis and 2 cup tests were also studied. Mean age of the patients was 42.41 ± 11.14 (22-60). Mean duration of the PE complaint was 34.18 ± 36.76 (3-144) months. Mean IELT time of the patients was 38.28 ± 30.79 (3-180) s. Of the patients; 69.81%, 62.26%, 56.60%, 45.28%, 30.19%, 24.53%, 16.98%, 15.09%, and 7.55% had depression, chronic prostatitis, erectile dysfunction, anxiety, diabetes mellitus, abnormal FSH or LH, hypoprolactinemia, hyperthyroidism, and high testosterone levels, respectively. The results of our study revealed that anxiety disorders, depression, erectile dysfunction, and chronic prostatitis are common among patients with acquired PE and may play role in the etiology of this problem. There is a need for further researches related to the exact pathophysiology of acquired PE with larger number of patients.
    Mesh-Begriff(e) Ejaculation ; Erectile Dysfunction/epidemiology ; Erectile Dysfunction/etiology ; Humans ; Male ; Premature Ejaculation/epidemiology ; Premature Ejaculation/etiology ; Prospective Studies ; Prostatitis/complications ; Prostatitis/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2019-09-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1034295-3
    ISSN 1476-5489 ; 0955-9930
    ISSN (online) 1476-5489
    ISSN 0955-9930
    DOI 10.1038/s41443-019-0188-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  5. Artikel ; Online: Outcomes of intravesical chondroitin-sulfate and combined hyaluronic-acid/chondroitin-sulfate therapy on female sexual function in bladder pain syndrome.

    Arslan, Burak / Gönültaş, Serkan / Gökmen, Ersin / Özman, Oktay / Avci, Mustafa Asım / Özdemir, Enver

    International urogynecology journal

    2019  Band 30, Heft 11, Seite(n) 1857–1862

    Abstract: Introduction and hypothesis: Our aim was to determine the efficacy of intravesical chondroitin sulfate (CS) and combined hyaluronic acid/chondroitin sufate (HA/CS) treatment and their effects on sexual function of females with interstitial cystitis/ ... ...

    Abstract Introduction and hypothesis: Our aim was to determine the efficacy of intravesical chondroitin sulfate (CS) and combined hyaluronic acid/chondroitin sufate (HA/CS) treatment and their effects on sexual function of females with interstitial cystitis/bladder pain syndrome (IC/BPS).
    Methods: A total of 68 female patients with IC/BPS between 2012 and 2018 were reviewed. Thirty-three patients were treated with combined HA/CS and 28 patients were treated with CS. Instillations were performed weekly for the first month, biweekly for the second month, and monthly in the third and fourth months. Before and after the sixth month of the treatment, all patients were evaluated with the Female Sexual Function Index (FSFI), visual analog pain scale (VAS), interstitial cystitis symptom index (ICSI), interstitial cystitis problem index (ICPI), and voiding diary, and changes were recorded.
    Results: A statistically significant improvement was determined for FSFI, VAS, ICSI, and ICPI scores after treatment in both groups. Among baseline characteristics, a weak but significant negative correlation was determined only between the ICSI score improvement and age (rho: -0.38; p = 0.03) on statistical analysis. Compared with CS, combined HA/CS treatment was superior in terms of ICSI, ICPI, and daytime and nighttime frequency improvement (0.042, 0.038, 0.039, and 0.045; respectively). All domains of the sexual function index were significantly improved at the sixth month of intravesical therapy in both groups. A statistical difference was not found between the two groups.
    Conclusions: Although it seems that intravesical HA/CS combination is superior to CS alone in terms of symptom reduction, both of them have beneficial effects on sexual function.
    Mesh-Begriff(e) Administration, Intravesical ; Adult ; Chondroitin Sulfates/administration & dosage ; Cystitis, Interstitial/complications ; Cystitis, Interstitial/drug therapy ; Drug Combinations ; Female ; Humans ; Hyaluronic Acid/administration & dosage ; Middle Aged ; Retrospective Studies ; Sexual Dysfunction, Physiological/drug therapy ; Sexual Dysfunction, Physiological/etiology ; Treatment Outcome ; Young Adult
    Chemische Substanzen Drug Combinations ; Hyaluronic Acid (9004-61-9) ; Chondroitin Sulfates (9007-28-7)
    Sprache Englisch
    Erscheinungsdatum 2019-06-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1050631-7
    ISSN 1433-3023 ; 0937-3462
    ISSN (online) 1433-3023
    ISSN 0937-3462
    DOI 10.1007/s00192-019-04036-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  6. Artikel: COVID-19 and animals: What do we know?

    Gönültas, Serkan / Karabagli, Murat / Bastug, Yavuz / Çilesiz, Nusret Can / Kadioglu, Ates

    Abstract: Coronaviruses, which were generally considered harmless to humans before 2003, have appeared again with a pandemic threatening the world since December 2019 after the epidemics of SARS and MERS. It is known that transmission from person to person is the ... ...

    Abstract Coronaviruses, which were generally considered harmless to humans before 2003, have appeared again with a pandemic threatening the world since December 2019 after the epidemics of SARS and MERS. It is known that transmission from person to person is the most important way to spread. However, due to the widespread host diversity, a detailed examination of the role of animals in this pandemic is essential to effectively fight against the outbreak. Although coronavirus infections in pets are known to be predominantly related to the gastrointestinal tract, it has been observed that there are human-to-animal transmissions in this outbreak and some animals have similar symptoms to humans. Although animal-to-animal transmission has been shown to be possible, there is no evidence of animal-to-human transmission.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #32420863
    Datenquelle COVID19

    Kategorien

  7. Artikel: Are There Relationships between Seminal Parameters and the Neutrophil-to-Lymphocyte Ratio or the Platelet-to-Lymphocyte Ratio?

    Aykan, Serdar / Canat, Lütfi / Gönültaş, Serkan / Atalay, Hasan Anıl / Altunrende, Fatih

    The world journal of men's health

    2017  Band 35, Heft 1, Seite(n) 51–56

    Abstract: Purpose: The aim of this study was to evaluate the relationship of seminal parameters with the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), which are inflammatory markers, in men with an abnormal semen analysis and ... ...

    Abstract Purpose: The aim of this study was to evaluate the relationship of seminal parameters with the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), which are inflammatory markers, in men with an abnormal semen analysis and men with normozoospermia.
    Materials and methods: Fifty-seven men with abnormal semen analyses and 59 men with normozoospermia were included in this cross-sectional study. A complete blood count was recorded, and the NLR and PLR were calculated from the hematologic parameters.
    Results: The NLR was 1.84±0.78 in the normozoospermic group and 1.80±0.75 in the abnormal semen analysis group. The PLR was 95.32±35.47 in the normozoospermic group and 93.57±28.09 in the abnormal semen analysis group. No significant differences were found between the normozoospermic and the abnormal semen analysis group in the NLR (p=0.828) or the PLR (p=0.768). In addition, no seminal parameters were correlated with the NLR or the PLR (p>0.05).
    Conclusions: We do not recommend using the NLR or the PLR as markers to screen for abnormal semen parameters or male infertility.
    Sprache Englisch
    Erscheinungsdatum 2017-05-01
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2719786-4
    ISSN 2287-4690 ; 2287-4208
    ISSN (online) 2287-4690
    ISSN 2287-4208
    DOI 10.5534/wjmh.2017.35.1.51
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  8. Artikel ; Online: Does YouTube include high-quality resources for training on laparoscopic and robotic radical prostatectomy?

    Arslan, Burak / Gönültaş, Serkan / Gökmen, Ersin / Özman, Oktay / Onuk, Özkan / Yazıcı, Gökhan / Göv, Taha / Özdemir, Enver

    World journal of urology

    2019  Band 38, Heft 5, Seite(n) 1195–1199

    Abstract: Purpose: Our aim was to assess the educational quality of the YouTube video content related to laparoscopic and robotic radical prostatectomy (RP).: Methods: An objective scoring tool named as Prostatectomy Assessment and Competency Evaluation (PACE) ...

    Abstract Purpose: Our aim was to assess the educational quality of the YouTube video content related to laparoscopic and robotic radical prostatectomy (RP).
    Methods: An objective scoring tool named as Prostatectomy Assessment and Competency Evaluation (PACE) score was used to measure and quantify seven critical steps in RP including bladder drop, preparation of the prostate, bladder neck dissection, posterior/seminal vesicle dissection, neurovascular bundle preservation, apical dissection, and urethro-vesical anastomosis. A five-point scale was used for grading the seven steps, where a score of 1 and 5 represented the lowest and ideal performance, respectively. Additionally, descriptive statistics including the upload time, video length, view count, number of comments, likes, and dislikes were all recorded.
    Results: Of the 1688 videos (551 from laparoscopic RP, 567 from robotic RP, and 570 from robot-assisted RP), 226 videos were analyzed after excluding duplicate and irrelevant videos. Robotic/robot-assisted RP videos were found to be statistically longer than laparoscopic RP videos (p = 0.016). The PACE score of urethro-vesical anastomosis step in robotic RP videos was statistically higher than laparoscopic RP videos (p = 0.021). A weak but significant positive correlation between the video length and total PACE score (rho: 0.51; p = 0.04 for laparoscopic RP and rho: 0.43; p = 0.03 for robotic/robot-assisted RP) was found. A weak but positive correlation was also determined between number of likes and total PACE score (rho: 0.39; p = 0.02) for robotic/robot-assisted RP videos.
    Conclusions: Although YouTube website includes high-quality videos for both laparoscopic and robotic/robot-assisted RP, there is no objective parameter to predict the educational quality of the videos.
    Mesh-Begriff(e) Humans ; Laparoscopy/education ; Male ; Prostatectomy/education ; Prostatectomy/methods ; Robotic Surgical Procedures/education ; Social Media ; Webcasts as Topic/standards
    Sprache Englisch
    Erscheinungsdatum 2019-08-09
    Erscheinungsland Germany
    Dokumenttyp Evaluation Study ; Journal Article
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s00345-019-02904-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  9. Artikel: Neutrophil-to-lymphocyte ratio is elevated in recurringnonmuscle invasive bladder cancer.

    Yürük, Emrah / Saitz, Theodore Robert / Gönültaş, Serkan / Şerefoğlu, Ege Can / Müslümanoğlu, Ahmet Yaser

    Turkish journal of medical sciences

    2017  Band 47, Heft 1, Seite(n) 234–239

    Abstract: Background/aim: Although it has been shown that the neutrophil-to-lymphocyte ratio (NLR) may predict the progression of nonmuscle invasive bladder cancer (NMIBC), its association with the recurrence of NMIBC has been poorly studied. The aim of this ... ...

    Abstract Background/aim: Although it has been shown that the neutrophil-to-lymphocyte ratio (NLR) may predict the progression of nonmuscle invasive bladder cancer (NMIBC), its association with the recurrence of NMIBC has been poorly studied. The aim of this study is to evaluate the association between NLR and disease recurrence in patients with NMIBC.
    Materials and methods: The medical records of 428 consecutive initially diagnosed NMIBC patients who underwent transurethral resection between January 2010 and July 2014 were retrospectively reviewed. Patients without a preoperative NLR (n = 6), without a minimum of 6 months of follow-up (n = 56), who were lost to follow-up (n = 38), or who had progressive disease during follow-up (n = 42) were excluded. The demographics, tumor characteristics, and NLRs of patients with and without tumor recurrence were compared.
    Results: Of 286 patients who met the inclusion criteria, 68 (17.43%) had recurrent disease. Tumor size (P = 0.198), tumor type (P = 0.929), and the presence of carcinoma in situ (P = 0.373) were also similar between groups. Patients with recurrent disease had a higher mean NLR (2.62 ± 0.99 vs. 2.2 ± 0.96, P = 0.002).
    Conclusion: Our results show that NLR may be used as a predictor of recurrence in patients with NMIBC; however, prospective studies are required to validate these findings.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Lymphocyte Count/statistics & numerical data ; Lymphocytes/cytology ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Neutrophils/cytology ; Retrospective Studies ; Urinary Bladder Neoplasms/blood ; Urinary Bladder Neoplasms/epidemiology ; Urinary Bladder Neoplasms/immunology ; Urinary Bladder Neoplasms/pathology ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2017-02-27
    Erscheinungsland Turkey
    Dokumenttyp Journal Article
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.3906/sag-1509-73
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  10. Artikel ; Online: Tissue neutrophil elastase contributes to extracorporeal shock wave lithotripsy-induced kidney damage and the neutrophil elastase inhibitor, sivelestat, attenuates kidney damage with gratifying immunohistopathological and biochemical findings: an experimental study.

    Colakerol, Aykut / Suzan, Serhat / Temiz, Mustafa Zafer / Gonultas, Serkan / Aykan, Serdar / Ozsoy, Sule / Kucuk, Suat Hayri / Yuruk, Emrah / Kandırali, Engin / Semercioz, Atilla

    Urolithiasis

    2021  Band 50, Heft 1, Seite(n) 103–112

    Abstract: Although the efficacy of extracorporeal shock wave lithotripsy (ESWL) has been well established within the literature, debate continues on the safety of the procedure while focusing on cellular injury and its long-term consequences. Here, we describe the ...

    Abstract Although the efficacy of extracorporeal shock wave lithotripsy (ESWL) has been well established within the literature, debate continues on the safety of the procedure while focusing on cellular injury and its long-term consequences. Here, we describe the role of neutrophil elastase (NE) in ESWL-related rat kidney damage and investigate the protective effects of sivelestat, an inhibitor of NE, during the early and late phases. Four groups including control, ESWL alone, ESWL with sivelestat 50 mg/kg and ESWL with treatment of 100 mg/kg, each consisting of ten rats were created. Biochemical parameters of kidney function and damage and immunohistopathological findings were compared in the early (72 h after ESWL) and late (1 week after ESWL) periods between the groups. During the early period, serum and urine creatinine levels and urine kidney injury molecule-1 (KIM-1) levels and the KIM-1/creatinine ratio increased in rats treated with ESWL compared to the control group. Furthermore, increased tissue inflammation, ductal dilatation and hemorrhage, and glomerular, tubular, and interstitial damage with increased NE staining were also detected in the ESWL treatment group. During the late phase, although urine KIM-1 levels remained stable at high levels, other parameters showed significant improvements. On the other hand, the administration of sivelestat 50 mg/kg decreased serum creatinine and urine KIM-1 and KIM-1/creatinine levels significantly in rats treated with ESWL, during the early and late periods. Significant decreases in tissue inflammation, tubular, and interstitial tissue damage were also observed during the early period. In conclusion, ESWL-related kidney tissue damage occurs primarily during the early period, and NE is involved in this process. On the other hand, the NE inhibitor sivelestat attenuated this ESWL-induced kidney damage.
    Mesh-Begriff(e) Animals ; Glycine/analogs & derivatives ; Kidney ; Kidney Calculi/therapy ; Leukocyte Elastase ; Lithotripsy/adverse effects ; Proteinase Inhibitory Proteins, Secretory ; Rats ; Sulfonamides
    Chemische Substanzen Proteinase Inhibitory Proteins, Secretory ; Sulfonamides ; sivelestat (DWI62G0P59) ; Leukocyte Elastase (EC 3.4.21.37) ; Glycine (TE7660XO1C)
    Sprache Englisch
    Erscheinungsdatum 2021-11-15
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2703553-0
    ISSN 2194-7236 ; 2194-7228
    ISSN (online) 2194-7236
    ISSN 2194-7228
    DOI 10.1007/s00240-021-01287-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang