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Article ; Online: Deepening on breast cancer metastasis: the ERα-mediated modulation of KISS/KISS1R system.

González, Celestino

2013 Volume 154, Issue 6, Page(s) 1959–1961

MeSH term(s)	Animals ; Cell Movement ; Epithelial Cells/metabolism ; Estrogen Receptor alpha/metabolism ; Female ; Humans ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Kisspeptin-1
Chemical Substances	Estrogen Receptor alpha ; KISS1R protein, human ; Receptors, G-Protein-Coupled ; Receptors, Kisspeptin-1
Language	English
Publishing date	2013-06
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	427856-2
ISSN	1945-7170 ; 0013-7227
ISSN (online)	1945-7170
ISSN	0013-7227
DOI	10.1210/en.2013-1285
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Article ; Online: Long-term outcomes of nummular headache: A series of 168 patients and 1198 patient-years of follow-up.

García-Iglesias, Cristina / González-Celestino, Ana / Sierra Mencía, Álvaro / González Osorio, Yésica / Recio García, Andrea / Martínez-Badillo, Cristina / Echavarría Íñiguez, Ana / Varona-Galán, Berta / García-Azorín, David / Guerrero-Peral, Ángel Luis

Cephalalgia : an international journal of headache

2023 Volume 43, Issue 9, Page(s) 3331024231201576

Abstract: Background: Since the first description of nummular headache (NH), more than 500 cases have been described, delineating its clinical phenotype and response to treatment. However, data on the natural history of NH and outcomes during long-term follow-up ... ...

Abstract	Background: Since the first description of nummular headache (NH), more than 500 cases have been described, delineating its clinical phenotype and response to treatment. However, data on the natural history of NH and outcomes during long-term follow-up are not currently available. The present study aimed to describe the long-term outcomes and follow-up of a large series of patients with NH. Methods: A descriptive observational ambisective study with a series of cases was conducted. The study population included adult patients with primary NH and a minimum of 12 months of follow-up. Demographic variables, previous medical history, clinical phenotype, diagnosis and treatment of NH, temporal pattern, and long-term evolution were analysed. Results: In total, 168 patients were enrolled and followed for a median [interquartile range (IQR)] of 80.5 (55-118.5) months. The temporal pattern after NH onset was chronic in 67.9% and, at diagnosis, the median (IQR) number of pain days per month was 20 [10-30] days with 138 (82.1%) patients with ≥8 days of pain per month. Preventive treatment was needed by 112 (66.7%) patients. The most frequently used drugs were gabapentin (69/112; 61.6%), onabotulinumtoxinA (38/112; 33.9%), amitriptyline (31/112; 27.7%) and lamotrigine (21/112; 18.7%). Response to preventive treatment was at least partial in 91/112 (81.3%) patients. At the end of follow-up, 81 (48.2%) patients had inactive NH. Of patients with active NH, the median (IQR) number of headache days per month was 3 (1-12) days and patients had ≥8 days of pain in 35 (20.8%) cases. Conclusions: Long-term outcomes of NH were positive in most patients. After a median of 6.7 years of follow-up, 48% of cases were inactive. Two-thirds of patients required preventive treatment, and 80% of them were treatment-responsive. In NH cases that remained symptomatic, the headache frequency was lower, and the proportion of patients with chronic NH decreased from 68% to 11%.
MeSH term(s)	Adult ; Humans ; Amitriptyline ; Follow-Up Studies ; Headache/drug therapy ; Headache/epidemiology ; Headache Disorders ; Pain
Chemical Substances	Amitriptyline (1806D8D52K)
Language	English
Publishing date	2023-09-20
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	604567-4
ISSN	1468-2982 ; 0333-1024
ISSN (online)	1468-2982
ISSN	0333-1024
DOI	10.1177/03331024231201576
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Article: Estrogen receptor targeting to the plasma membrane. Preface.

Gonzalez, Celestino

Infectious disorders drug targets

2008 Volume 8, Issue 1, Page(s) 1

MeSH term(s)	Cell Membrane/metabolism ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/metabolism ; Estrogens/physiology ; Humans
Chemical Substances	Estrogen Receptor alpha ; Estrogen Receptor beta ; Estrogens
Language	English
Publishing date	2008-05-08
Publishing country	United Arab Emirates
Document type	Introductory Journal Article
ZDB-ID	2234298-9
ISSN	2212-3989 ; 1871-5265
ISSN (online)	2212-3989
ISSN	1871-5265
DOI	10.2174/187152608784139604
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Article: Dietary Xenobiotics Derived from Food Processing: Association with Fecal Mutagenicity and Gut Mucosal Damage

Ruiz-Saavedra, Sergio / Zapico, Aida / del Rey, Carmen González / Gonzalez, Celestino / Suárez, Adolfo / Díaz, Ylenia / de los Reyes-Gavilán, Clara G. / González, Sonia

Nutrients. 2022 Aug. 24, v. 14, no. 17

2022

Abstract: Whereas the mechanisms underlying the association of toxic dietary xenobiotics and cancer risk are not well established, it is plausible that dietary pattern may affect the colon environment by enhancing or reducing exposure to mutagens. This work aimed ... ...

Abstract	Whereas the mechanisms underlying the association of toxic dietary xenobiotics and cancer risk are not well established, it is plausible that dietary pattern may affect the colon environment by enhancing or reducing exposure to mutagens. This work aimed to investigate the association between xenobiotics intake and different stages of intestinal mucosal damage and colorectal cancer (CRC) screening and examine whether these associations may be mediated by altered intestinal mutagenicity. This was a case control study with 37 control subjects, 49 patients diagnosed with intestinal polyps, and 7 diagnosed with CRC. Lifestyle, dietary, and clinical information was registered after colonoscopy. For xenobiotics intake estimation the European Prospective Investigation into Cancer (EPIC) and the Computerized Heterocyclic Amines Resource for Research in Epidemiology of Disease (CHARRED) databases were used. The mutagenicity of fecal supernatants was assayed by the Ames test and light microscopy was used for the presence of aberrant crypt formation. Among all the potential carcinogens studied, the polyp group showed higher intakes of ethanol and dibenzo (a) anthracene (DiB(a)A). Besides, intakes between 0.75 and 1.29 µg/d of total polycyclic aromatic hydrocarbons (PAHs) were related with a higher risk of belonging to the polyp group. On the contrary, an intake of wholegrain cereals greater than 50 g/d was associated with a reduction in the relative risk of belonging to the polyp group. Heterocyclic amines (HAs) such as 2-amino-1-methyl-6-phenylimidazo (4,5,b) pyridine (PhIP) were associated with an increased level of mutagenicity in polyps. This study is of great interest for the identification of possible therapeutic targets for the early prevention of colon cancer through diet.
Keywords	Ames test ; anthracenes ; case-control studies ; colon ; colonoscopy ; colorectal neoplasms ; diet ; eating habits ; ethanol ; lifestyle ; light microscopy ; mutagenicity ; prospective studies ; pyridines ; relative risk ; xenobiotics
Language	English
Dates of publication	2022-0824
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14173482
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Treatment of Primary Nummular Headache

Cristina García-Iglesias / Francesca Puledda / Ana Echavarría-Íñiguez / Yesica González-Osorio / Álvaro Sierra-Mencía / Andrea Recio-García / Ana González-Celestino / Gonzalo Valle-Peñacoba / Pablo Irimia / Ángel Luis Guerrero-Peral / David García-Azorín

Journal of Clinical Medicine, Vol 12, Iss 1, p

A Series of 183 Patients from the NUMITOR Study

2022 Volume 122

Abstract: Nummular headache (NH) is a primary headache characterized by superficial coin-shaped pain. NUMITOR (NCT 05475769) is an observational study evaluating the responder rate of preventive drugs in NH patients. The treatment response was assessed between ... ...

Abstract	Nummular headache (NH) is a primary headache characterized by superficial coin-shaped pain. NUMITOR (NCT 05475769) is an observational study evaluating the responder rate of preventive drugs in NH patients. The treatment response was assessed between weeks 8 and 12 compared with the baseline. Patients were included between February 2002 and October 2022. Demographic and clinical variables were assessed; treatment response was estimated by 50%, 30%, and 75% responder rates and treatment discontinuation due to inadequate tolerability. A total of 183 out of 282 patients fulfilled eligibility criteria and completed the study. Patients were aged 49.5 (standard deviation (SD): 16.8) years, and 60.7% were female. NH phenotype was a parietal circular pain of four centimeters’ diameter, moderate intensity, and oppressive quality. At baseline, patients had 25 (interquartile range) pain days per month. Preventive treatment was used by 114 (62.3%) patients. The highest 50% and 75% responder rates corresponded to onabotulinumtoxinA (62.5%, 47.5%), followed by gabapentin (43.7%, 35.2%). Oral preventive drugs were not tolerated by 12.9–25%. The present study provides class IV evidence of the effectiveness of oral preventive drugs and onabotulinumtoxinA in the treatment of primary NH. OnabotulinumtoxinA was the most effective and best-tolerated drug, positioning it as first-line treatment of NH.
Keywords	headache disorders ; nummular headache ; epicranial headache ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Neuroprotective role of estrogens: relationship with insulin/IGF-1 signaling.

Alonso, Ana / Gonzalez, Celestino

Frontiers in bioscience (Elite edition)

2012 Volume 4, Issue 2, Page(s) 607–619

Abstract: Postmenopausal women have an elevated risk of developing a neurodegenerative disease. These clinical observation supported by basic research, suggest that estrogens are neuroprotective. Insulin resistance represents an independent factor in the etiology ... ...

Abstract	Postmenopausal women have an elevated risk of developing a neurodegenerative disease. These clinical observation supported by basic research, suggest that estrogens are neuroprotective. Insulin resistance represents an independent factor in the etiology of age-associated disease and metabolic syndrome should be considered as a contributing factor to the higher post-menopausal vulnerability to neurological disorders. Elucidating the relationship between insulin resistance associated with aging in females, and the cross-talk between estradiol, insulin, and insulin-like growth factor (IGF-1) signaling pathways, will lead to a more complete understanding of the mechanism underlying estradiol-mediated neuroprotection. In past decades, estrogen replacement therapy (ERT) was commonly used as a palliative therapy during menopause, but the mid-term and long-term effects of estrogen as possible promoters of breast cancer and the increased risk of coronary illness or stroke, has limited current usage. A deeper understanding of the molecular mechanisms common to all forms of neurodegenerative diseases may hasten the development of protective strategies against chronic age-related deterioration and acute illness, ultimately providing a better quality of life for the elderly.
MeSH term(s)	Brain/metabolism ; Estrogens/metabolism ; Estrogens/physiology ; Estrogens/therapeutic use ; Humans ; Insulin/metabolism ; Insulin Resistance ; Insulin-Like Growth Factor I/metabolism ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/metabolism ; Neuroprotective Agents/therapeutic use ; Signal Transduction
Chemical Substances	Estrogens ; Insulin ; Neuroprotective Agents ; Insulin-Like Growth Factor I (67763-96-6)
Language	English
Publishing date	2012-01-01
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	2565080-4
ISSN	1945-0508 ; 1945-0494
ISSN (online)	1945-0508
ISSN	1945-0494
DOI	10.2741/403
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Article ; Online: Immunometabolic Profile Associated with Progressive Damage of the Intestinal Mucosa in Adults Screened for Colorectal Cancer: Association with Diet.

González, Celestino / Ruiz-Saavedra, Sergio / Gómez-Martín, María / Zapico, Aida / López-Suarez, Patricia / Suárez, Ana / Suárez González, Adolfo / Del Rey, Carmen González / Díaz, Elena / Alonso, Ana / de Los Reyes-Gavilán, Clara G / González, Sonia

International journal of molecular sciences

2023 Volume 24, Issue 22

Abstract: Environmental factors such as diet and lifestyle have been shown to influence the development of some intestinal mucosal lesions that may be precursors of colorectal cancer (CRC). The presence of these alterations seems to be associated with misbalanced ... ...

Abstract	Environmental factors such as diet and lifestyle have been shown to influence the development of some intestinal mucosal lesions that may be precursors of colorectal cancer (CRC). The presence of these alterations seems to be associated with misbalanced immunological parameter levels. However, it is still unclear as to which immunological parameters are altered in each phase of CRC development. In this work, we aimed to study the potential relationships of immunological and metabolic parameters with diet in a CRC-related lesion context. Dietary information was obtained using an annual semi-quantitative food-frequency questionnaire (FFQ) from 93 volunteers classified via colonoscopy examination according to the presence of intestinal polyps or adenocarcinoma. Cytokines, chemokines, and adipokines were determined from serum samples. We observed a reduction in adiponectin according to the damage to the mucosa, accompanied by an increase and decrease in C-X-C motif chemokine ligand 10 (CXCL10) and resistin, respectively, in CRC cases. The presence of aberrant crypt foci (ACF) in the polyp group was associated with higher tumor necrosis factor-alpha (TNF-α) concentrations. Vegetables were directly correlated with adiponectin and resistin levels, while the opposite occurred with red meat. A bioactive compound, soluble pectin, showed a negative association with TNF-α. Future dietary strategies could be developed to modulate specific immunological parameters in the context of CRC.
MeSH term(s)	Humans ; Adult ; Resistin ; Colorectal Neoplasms/metabolism ; Adiponectin ; Tumor Necrosis Factor-alpha ; Diet ; Intestinal Mucosa/metabolism
Chemical Substances	Resistin ; Adiponectin ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2023-11-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242216451
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Article ; Online: Dietary Xenobiotics Derived from Food Processing: Association with Fecal Mutagenicity and Gut Mucosal Damage.

Ruiz-Saavedra, Sergio / Zapico, Aida / Del Rey, Carmen González / Gonzalez, Celestino / Suárez, Adolfo / Díaz, Ylenia / de Los Reyes-Gavilán, Clara G / González, Sonia

Nutrients

2022 Volume 14, Issue 17

Abstract	Whereas the mechanisms underlying the association of toxic dietary xenobiotics and cancer risk are not well established, it is plausible that dietary pattern may affect the colon environment by enhancing or reducing exposure to mutagens. This work aimed to investigate the association between xenobiotics intake and different stages of intestinal mucosal damage and colorectal cancer (CRC) screening and examine whether these associations may be mediated by altered intestinal mutagenicity. This was a case control study with 37 control subjects, 49 patients diagnosed with intestinal polyps, and 7 diagnosed with CRC. Lifestyle, dietary, and clinical information was registered after colonoscopy. For xenobiotics intake estimation the European Prospective Investigation into Cancer (EPIC) and the Computerized Heterocyclic Amines Resource for Research in Epidemiology of Disease (CHARRED) databases were used. The mutagenicity of fecal supernatants was assayed by the Ames test and light microscopy was used for the presence of aberrant crypt formation. Among all the potential carcinogens studied, the polyp group showed higher intakes of ethanol and dibenzo (a) anthracene (DiB(a)A). Besides, intakes between 0.75 and 1.29 µg/d of total polycyclic aromatic hydrocarbons (PAHs) were related with a higher risk of belonging to the polyp group. On the contrary, an intake of wholegrain cereals greater than 50 g/d was associated with a reduction in the relative risk of belonging to the polyp group. Heterocyclic amines (HAs) such as 2-amino-1-methyl-6-phenylimidazo (4,5,b) pyridine (PhIP) were associated with an increased level of mutagenicity in polyps. This study is of great interest for the identification of possible therapeutic targets for the early prevention of colon cancer through diet.
MeSH term(s)	Amines/toxicity ; Carcinogens ; Case-Control Studies ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/etiology ; Diet/adverse effects ; Food Handling ; Humans ; Mutagenicity Tests ; Mutagens/toxicity ; Prospective Studies ; Xenobiotics/toxicity
Chemical Substances	Amines ; Carcinogens ; Mutagens ; Xenobiotics
Language	English
Publishing date	2022-08-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14173482
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Article: Relationship between non-genomic actions of estrogens and insulin resistace.

Alonso, Ana / González, Celestino

Infectious disorders drug targets

2008 Volume 8, Issue 1, Page(s) 48–51

Abstract: Numerous experimental and clinical data show that the physiological actions of insulin and sexual steroids interact in target tissues for these hormones. In the other hand, sexual steroids has effects on peripheral tissues, and since the skeletal muscle ... ...

Abstract	Numerous experimental and clinical data show that the physiological actions of insulin and sexual steroids interact in target tissues for these hormones. In the other hand, sexual steroids has effects on peripheral tissues, and since the skeletal muscle is the main responsible for peripheral glucose uptake, it would be possible that the sexual steroids induce directly in the muscle a decrease of the sensibility of this tissue to insulin action. Some of the biological actions of the estrogens are too fast like to be compatible with this classical mechanism of action, and this mechanism has been called not classical, non-genomic or rapid actions of the estrogens. Moreover, some experiments have shown that low concentrations of estradiol, induce an increase in the rate of IRS-1 phosphorylation, promotes the association between IRS-1 and the subunit of PI3-k, p85alpha, causes a decrease in the rate of IRS-1 serine phosphorylation and increases the rate of Akt phosphorylation. Therefore, the evidences suggest the existence of a narrow interrelation between the estrogens and insulin sensitivity, but relatively few studies have tried to resolve the molecular base of this relation in insulin-dependent tissues. The resolution of these unknown questions would be able to have a great long-term therapeutic repercussion. In this sense, we should not forget that insulin resistance is the underlying cause of several associated pathologies to the female aging, as Type 2 diabetes, cardio-circulatory pathology or neurodegenerative disease.
MeSH term(s)	Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/physiopathology ; Diabetes Mellitus, Type 2/etiology ; Diabetes Mellitus, Type 2/physiopathology ; Estradiol/pharmacology ; Estradiol/physiology ; Estrogens/pharmacology ; Estrogens/physiology ; Female ; Humans ; Insulin Receptor Substrate Proteins ; Insulin Resistance ; Male ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/physiopathology ; Phosphorylation
Chemical Substances	Adaptor Proteins, Signal Transducing ; Estrogens ; IRS1 protein, human ; Insulin Receptor Substrate Proteins ; Estradiol (4TI98Z838E)
Language	English
Publishing date	2008-05-08
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2234298-9
ISSN	2212-3989 ; 1871-5265
ISSN (online)	2212-3989
ISSN	1871-5265
DOI	10.2174/187152608784139596
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Article ; Online: Effects of estradiol and genistein on the insulin signaling pathway in the cerebral cortex of aged female rats.

Morán, Javier / Garrido, Pablo / Cabello, Estefanía / Alonso, Ana / González, Celestino

Experimental gerontology

2014 Volume 58, Page(s) 104–112

Abstract: Menopause leads to a decrease in estrogen production that increases central insulin resistance, contributing to the development of neurodegenerative diseases. We have evaluated the influence of aging and estradiol or genistein treatments on some key ... ...

Abstract	Menopause leads to a decrease in estrogen production that increases central insulin resistance, contributing to the development of neurodegenerative diseases. We have evaluated the influence of aging and estradiol or genistein treatments on some key stages of the insulin signaling pathway in the cerebral cortex. Young and aged female Wistar rats were ovariectomized and treated acutely with 17β-estradiol (1.4μg/kg body weight), two doses of genistein (10 or 40mg/kg body weight), or vehicle. The cortical expression of several key insulin signaling pathway components was analyzed by western blotting. Our results showed an age-related deterioration in the interactions between the regulatory subunit of phosphatidylinositol 3-kinase (p85α) and the activated form of insulin receptor substrate 1 (p-IRS1tyr612), as well as between p85α and the 46kDa isoform of the estrogen receptor α (ERα46). Moreover, aging also decreased the translocation of glucose transporter-4 (GLUT4) to the plasma membrane. 17β-Estradiol but not genistein reduced the negative impact of aging on central insulin sensitivity by favoring this GLUT4 translocation, and therefore could be neuroprotective against the associated neurodegenerative diseases. However, protein kinase B (Akt) activation by genistein suggests that other possible mechanisms are involved in the neuroprotective effects of this phytoestrogen during the aging process.
MeSH term(s)	Age Factors ; Aging ; Animals ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Cerebral Cortex/drug effects ; Cerebral Cortex/metabolism ; Class Ia Phosphatidylinositol 3-Kinase/metabolism ; Enzyme Activation ; Estradiol/pharmacology ; Estrogen Receptor alpha/agonists ; Estrogen Receptor alpha/metabolism ; Female ; Genistein/pharmacology ; Glucose Transporter Type 4/drug effects ; Glucose Transporter Type 4/metabolism ; Hormone Replacement Therapy ; Insulin/metabolism ; Insulin Receptor Substrate Proteins/metabolism ; Ovariectomy ; Phosphorylation ; Phytoestrogens/pharmacology ; Protein Transport ; Proto-Oncogene Proteins c-akt/metabolism ; Rats, Wistar ; Signal Transduction/drug effects
Chemical Substances	Estrogen Receptor alpha ; Glucose Transporter Type 4 ; Insulin ; Insulin Receptor Substrate Proteins ; Irs1 protein, rat ; Phytoestrogens ; Slc2a4 protein, rat ; Estradiol (4TI98Z838E) ; Genistein (DH2M523P0H) ; Class Ia Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2014-10
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390992-x
ISSN	1873-6815 ; 0531-5565
ISSN (online)	1873-6815
ISSN	0531-5565
DOI	10.1016/j.exger.2014.07.018
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