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  1. Article: Metataxonomic Analysis of Milk Samples From SARS-CoV-2-Positive and SARS-CoV-2-Negative Women.

    Gómez-Torres, Natalia / Sánchez-García, Laura / Castro, Irma / Arroyo, Rebeca / Cabañas, Fernando / González-Sánchez, Raquel / López-Azorín, Manuela / Moral-Pumarega, M Teresa / Escuder-Vieco, Diana / Cabañes-Alonso, Esther / Rodríguez, Juan Miguel / Alba, Claudio / Pellicer, Adelina

    Frontiers in nutrition

    2022  Volume 9, Page(s) 853576

    Abstract: Objective: To assess the impact of SARS-CoV-2 viral infection on the metataxonomic profile and its evolution during the first month of lactation.: Methods: Milk samples from 37 women with full-term pregnancies and mild SARS-CoV-2 infection and from ... ...

    Abstract Objective: To assess the impact of SARS-CoV-2 viral infection on the metataxonomic profile and its evolution during the first month of lactation.
    Methods: Milk samples from 37 women with full-term pregnancies and mild SARS-CoV-2 infection and from 63 controls, collected in the first and fifth postpartum weeks, have been analyzed. SARS-CoV-2 RNA was assessed by reverse transcription polymerase chain reaction (RT-PCR) both in cases and controls. After DNA extraction, the V3-V4 hypervariable region of the gene 16S rRNA was amplified and sequenced using the MiSeq system of Illumina. Data were submitted for statistical and bioinformatics analyses after quality control.
    Results: All the 1st week and 5th week postpartum milk samples were negative for SARS-CoV-2 RNA. Alpha diversity showed no differences between milk samples from the study and control group, and this condition was maintained along the observation time. Analysis of the beta-diversity also indicated that the study and control groups did not show distinct bacterial profiles.
    Conclusion: These results support that in the non-severe SARS-CoV-2 pregnant woman infection the structure of the bacterial population is preserved and does not negatively impact on the human milk microbiota.
    Language English
    Publishing date 2022-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2022.853576
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Immediate Pre-Partum SARS-CoV-2 Status and Immune Profiling of Breastmilk: A Case-Control Study.

    Sánchez García, Laura / Gómez-Torres, Natalia / Cabañas, Fernando / González-Sánchez, Raquel / López-Azorín, Manuela / Moral-Pumarega, M Teresa / Escuder-Vieco, Diana / Cabañes-Alonso, Esther / Castro, Irma / Alba, Claudio / Rodríguez Gómez, Juan Miguel / Pellicer, Adelina

    Frontiers in immunology

    2021  Volume 12, Page(s) 720716

    Abstract: Objetive: To address the prevalence of SARS-CoV-2 and the evolutionary profile of immune compounds in breastmilk of positive mothers according to time and disease state.: Methods: Forty-five women with term pregnancies with confirmed non-severe SARS- ... ...

    Abstract Objetive: To address the prevalence of SARS-CoV-2 and the evolutionary profile of immune compounds in breastmilk of positive mothers according to time and disease state.
    Methods: Forty-five women with term pregnancies with confirmed non-severe SARS-CoV-2 infection (case group), and 96 SARS-CoV-2 negative women in identical conditions (control group) were approached, using consecutive sample. Weekly (1st to 5th week postpartum) reverse transcription polymerase chain reaction (RT-PCR) in nasopharyngeal swabs (cases) and breastmilk (cases and controls) were obtained. Concentration of cytokines, chemokines, and growth factors in breastmilk (cases and controls) were determined at 1st and 5th week post-partum.
    Results: Thirty-seven (study group) and 45 (control group) women were enrolled. Symptomatic infection occurred in 56.8% of women in the study group (48% fever, 48% anosmia, 43% cough). SARS-CoV-2 RNA was not found in breastmilk samples. Concentrations of cytokines (IFN-γ, IL-1ra, IL-4, IL-6, IL-9, IL-13, and TNF-α) chemokines (eotaxin, IP-10, MIP-1α, and RANTES) and growth factors (FGF, GM-CSF, IL7, and PDGF-BB) were higher in breastmilk of the study compared with the control group at 1st week postpartum. Immune compounds concentrations decreased on time, particularly in the control group milk samples. Time of nasopharyngeal swab to become negative influenced the immune compound concentration pattern. Severity of disease (symptomatic or asymptomatic infection) did not affect the immunological profile in breast milk.
    Conclusions: This study confirms no viral RNA and a distinct immunological profile in breastmilk according to mother's SARS-CoV-2 status. Additional studies should address whether these findings indicate efficient reaction against SARS-CoV-2 infection, which might be suitable to protect the recipient child.
    MeSH term(s) Adult ; Breast Feeding ; COVID-19 ; Case-Control Studies ; Chemokines/analysis ; Cytokines/analysis ; Female ; Humans ; Infant, Newborn ; Intercellular Signaling Peptides and Proteins/analysis ; Milk, Human/chemistry ; Milk, Human/immunology ; Mothers ; Pregnancy ; Prospective Studies ; RNA, Viral
    Chemical Substances Chemokines ; Cytokines ; Intercellular Signaling Peptides and Proteins ; RNA, Viral
    Language English
    Publishing date 2021-07-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.720716
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mother's Bed Incline and Desaturation Episodes in Healthy Term Newborns during Early Skin-to-Skin Contact: A Multicenter Randomized Controlled Trial.

    Rodríguez-López, Jesús / De la Cruz Bértolo, Javier / García-Lara, Nadia Raquel / Núñez Vecino, José Luis / Soriano-Ramos, María / Asla Elorriaga, Izaskun / Román Echevarría, Lourdes / Pellicer, Adelina / Marín Huarte, Natalia / Vento, Máximo / Parra-Llorca, Anna / Cabañas, Fernando / González Sánchez, Raquel / García-Algar, Óscar / Martín-Ancel, Ana / Copons Fernández, Cristina / González Carrasco, Ersilia / Beato, Maite / Pallás-Alonso, Carmen Rosa

    Neonatology

    2021  Volume 118, Issue 6, Page(s) 702–709

    Abstract: Introduction: Early skin-to-skin contact (ESSC) is associated with rare, sudden, unexpected postnatal collapse episodes. Placing the newborn in ESSC closer to an upright position may reduce the risk of airway obstruction and improve respiratory ... ...

    Abstract Introduction: Early skin-to-skin contact (ESSC) is associated with rare, sudden, unexpected postnatal collapse episodes. Placing the newborn in ESSC closer to an upright position may reduce the risk of airway obstruction and improve respiratory mechanics. This study assessed whether a greater inclination of the mother's bed during ESSC would reduce the proportion of healthy term newborns (HTNs) who experienced episodes of pulse oximeter saturation (SpO2) <91%.
    Methods: We conducted a multicenter randomized controlled trial comparing the effect of the mother's bed incline, 45° versus 15°, on desaturation in HTNs during ESSC. Before delivery on 1,271 dyads, randomization was conducted, and stringent criteria to select healthy mothers and term newborns were monitored until after birth. Preductal SpO2 was continuously monitored between 10 min and 2 h after birth. The primary outcome was the occurrence of at least one episode of SpO2 <91%.
    Results: 254 (20%) mother-infant dyads were eligible for analysis (45°, n = 126; 15°, n = 128). Overall, 57% (95% confidence interval [CI]: 51%-63%) of newborns showed episodes of SpO2 <91%. The proportion of infants with SpO2 <91% episodes was 52% in 45° and 62% in 15° (relative risk: 0.80; 95% CI: 0.6-1.07).
    Conclusions: We did not show that a high mother bed inclination during ESSC led to significantly fewer HTNs who experienced episodes of SpO2 <91%. Desaturation episodes from 10 min to 2 h after birth occurred in more than half of HTNs.
    MeSH term(s) Breast Feeding ; Female ; Humans ; Infant ; Infant, Newborn ; Mother-Child Relations ; Mothers ; Oxygen ; Skin
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2021-10-25
    Publishing country Switzerland
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2266911-5
    ISSN 1661-7819 ; 1661-7800
    ISSN (online) 1661-7819
    ISSN 1661-7800
    DOI 10.1159/000519387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Neonatal Infection Due to SARS-CoV-2: An Epidemiological Study in Spain.

    Fernández Colomer, Belén / Sánchez-Luna, Manuel / de Alba Romero, Concepción / Alarcón, Ana / Baña Souto, Ana / Camba Longueira, Fátima / Cernada, María / Galve Pradell, Zenaida / González López, María / López Herrera, M Cruz / Ribes Bautista, Carmen / Sánchez García, Laura / Zamora Flores, Elena / Pellicer, Adelina / Alonso Díaz, Clara / Herraiz Perea, Cristina / Romero Ramírez, Dolores Sabina / de Las Cuevas Terán, Isabel / Pescador Chamorro, Isabel /
    Fernández Trisac, José Luis / Arruza Gómez, Luis / Cardo Fernández, Luis Miguel / García García, Mª Jesús / Nicolás López, Marta / Hortelano López, Miryam / Riaza Gómez, Mónica / Hernández González, Natalio / González Sánchez, Raquel / Zambudio Sert, Sílvia / Larrosa Capacés, Susana / Matías Del Pozo, Vanesa

    Frontiers in pediatrics

    2020  Volume 8, Page(s) 580584

    Abstract: Objective: ...

    Abstract Objective:
    Keywords covid19
    Language English
    Publishing date 2020-10-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2020.580584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Neonatal Infection Due to SARS-CoV-2

    Fernández Colomer, Belén / Sánchez-Luna, Manuel / de Alba Romero, Concepción / Alarcón, Ana / Baña Souto, Ana / Camba Longueira, Fátima / Cernada, María / Galve Pradell, Zenaida / González López, María / López Herrera, M. Cruz / Ribes Bautista, Carmen / Sánchez García, Laura / Zamora Flores, Elena / Pellicer, Adelina / Alonso Díaz, Clara / Herraiz Perea, Cristina / Romero Ramírez, Dolores Sabina / de las Cuevas Terán, Isabel / Pescador Chamorro, Isabel /
    Fernández Trisac, José Luis / Arruza Gómez, Luis / Cardo Fernández, Luis Miguel / García García, M� Jesús / Nicolás López, Marta / Hortelano López, Miryam / Riaza Gómez, Mónica / Hernández González, Natalio / González Sánchez, Raquel / Zambudio Sert, Sílvia / Larrosa Capacés, Susana / Matías del Pozo, Vanesa

    Frontiers in Pediatrics

    An Epidemiological Study in Spain

    2020  Volume 8

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2020.580584
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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