Article ; Online: MAP-2:CD55 chimeric construct effectively modulates complement activation.
2023 Volume 37, Issue 11, Page(s) e23256
Abstract: The complement system is a complex, tightly regulated protein cascade involved in pathogen defense and the pathogenesis of several diseases. Thus, the development of complement modulators has risen as a potential treatment for complement-driven ... ...
| Abstract | The complement system is a complex, tightly regulated protein cascade involved in pathogen defense and the pathogenesis of several diseases. Thus, the development of complement modulators has risen as a potential treatment for complement-driven inflammatory pathologies. The enzymatically inactive MAP-2 has been reported to inhibit the lectin pathway by competing with its homologous serine protease MASP-2. The membrane-bound complement inhibitor CD55 acts on the C3/C5 convertase level. Here, we fused MAP-2 to the four N-terminal domains of CD55 generating a targeted chimeric inhibitor to modulate complement activation at two different levels of the complement cascade. Its biological properties were compared in vitro with the parent molecules. While MAP-2 and CD55 alone showed a minor inhibition of the three complement pathways when co-incubated with serum (IC50 |
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| MeSH term(s) | Animals ; Sheep ; Complement Activation ; Complement System Proteins ; CD55 Antigens/pharmacology ; Lectins/metabolism ; Transcription Factors ; Complement Inactivating Agents ; Mannose-Binding Protein-Associated Serine Proteases/metabolism | ||||||||||
| Chemical Substances | Complement System Proteins (9007-36-7) ; CD55 Antigens ; Lectins ; Transcription Factors ; Complement Inactivating Agents ; Mannose-Binding Protein-Associated Serine Proteases (EC 3.4.21.-) | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2023-10-12 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 639186-2 | ||||||||||
| ISSN | 1530-6860 ; 0892-6638 | ||||||||||
| ISSN (online) | 1530-6860 | ||||||||||
| ISSN | 0892-6638 | ||||||||||
| DOI | 10.1096/fj.202300571R | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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