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  1. Article: Expression Analysis of hsa-miR-181a-5p, hsa-miR-143-3p, hsa-miR-132-3p and hsa-miR-23a-3p as Biomarkers in Colorectal Cancer-Relationship to the Body Mass Index.

    Tesolato, Sofía Elena / González-Gamo, Daniel / Barabash, Ana / Claver, Paula / de la Serna, Sofía Cristina / Domínguez-Serrano, Inmaculada / Dziakova, Jana / de Juan, Carmen / Torres, Antonio José / Iniesta, Pilar

    Cancers

    2023  Volume 15, Issue 13

    Abstract: This work aims to investigate the expression levels of four preselected miRNAs previously linked to cancer and/or obesity, with the purpose of finding potential biomarkers in the clinical management of CRC developed by patients showing different BMI ... ...

    Abstract This work aims to investigate the expression levels of four preselected miRNAs previously linked to cancer and/or obesity, with the purpose of finding potential biomarkers in the clinical management of CRC developed by patients showing different BMI values. We analyzed samples from a total of 65 subjects: 43 affected by CRC and 22 without cancer. Serum and both subcutaneous and omental adipose tissues (SAT and OAT) were investigated, as well as tumor and non-tumor colorectal tissues in the case of the CRC patients. The relative expression (2
    Language English
    Publishing date 2023-06-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15133324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Obesity and telomere status in the prognosis of patients with colorectal cancer submitted to curative intention surgical treatment.

    García-Martínez, Sergio / González-Gamo, Daniel / Fernández-Marcelo, Tamara / Tesolato, Sofía / De La Serna, Sofía / Domínguez-Serrano, Inmaculada / Cano-Valderrama, Oscar / Barabash, Ana / De Juan, Carmen / Torres-García, Antonio / Iniesta, Pilar

    Molecular and clinical oncology

    2021  Volume 15, Issue 3, Page(s) 184

    Abstract: The risk of colorectal cancer (CRC) development has been associated with telomere dysfunction and obesity. However, clinical relevance of these parameters in CRC prognosis is not clear. Therefore, the aim of the present study was to evaluate the impact ... ...

    Abstract The risk of colorectal cancer (CRC) development has been associated with telomere dysfunction and obesity. However, clinical relevance of these parameters in CRC prognosis is not clear. Therefore, the aim of the present study was to evaluate the impact of obesity and telomere status in the prognosis of patients affected by CRC and submitted to curative surgical treatment. According to published data, this is the first work in which obesity and telomere status are jointly considered in relation to CRC prognosis. A prospective study including 162 patients with CRC submitted to curative surgical treatment was performed. Subjects were classified according to their BMI. Telomere status was established through telomere length and telomerase activity evaluation. Statistical analyses were performed using the SPSS software package version 22. Telomere shortening was inversely associated with BMI in patients with CRC. Notably, among patients with CRC, subjects with obesity exhibited less shortening of tumor telomeres than non-obese patients (P=0.047). Patients with shorter telomeres, both in the tumor (median telomere length <6.5 kb) and their non-tumor paired tissues (median telomere length <7.1 kb), had the best clinical evolution, regardless of the Dukes' stage of cancers (P=0.025, for tumor samples; P=0.003, for non-tumor samples). Additionally, subjects with a BMI >31.85 kg/m
    Language English
    Publishing date 2021-07-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2796865-0
    ISSN 2049-9469 ; 2049-9450
    ISSN (online) 2049-9469
    ISSN 2049-9450
    DOI 10.3892/mco.2021.2346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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