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  1. Article ; Online: Unmasking tricuspid regurgitation.

    Fernández-Golfín, Covadonga / González-Gómez, Ariana

    International journal of cardiology

    2023  Volume 398, Page(s) 131609

    MeSH term(s) Humans ; Tricuspid Valve Insufficiency/diagnostic imaging ; Tricuspid Valve Insufficiency/surgery ; Echocardiography ; Cardiac Catheterization
    Language English
    Publishing date 2023-11-28
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2023.131609
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    Zs.A 1673: Show issues Location:
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  2. Article ; Online: Immediate right chambers remodelling after orthotopic transcatheter valve tricuspid replacement.

    Sanchez-Recalde, Angel / Fernandez-Golfin, Covadonga / Gonzalez-Gomez, Ariana / Rodriguez-Roda, Jorge / Zamorano, José L

    European heart journal. Cardiovascular Imaging

    2023  Volume 24, Issue 8, Page(s) e207

    MeSH term(s) Humans ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/surgery ; Heart Valve Prosthesis Implantation/adverse effects ; Tricuspid Valve Insufficiency/diagnostic imaging ; Tricuspid Valve Insufficiency/surgery ; Treatment Outcome ; Cardiac Catheterization
    Language English
    Publishing date 2023-05-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jead114
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    Zs.A 5614: Show issues Location:
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  3. Article ; Online: Circulating miRNA in functional tricuspid regurgitation. Unveiling novel links to heart failure: A pilot study.

    Hinojar, Rocio / Moreno-Gómez-Toledano, Rafael / Conde, Elisa / Gonzalez-Gomez, Ariana / García-Martin, Ana / González-Portilla, Paz / Fernández-Golfín, Covadonga / García-Bermejo, Maria Laura / Zaragoza, Carlos / Zamorano, Jose Luis

    ESC heart failure

    2024  

    Abstract: Aim: Severe functional tricuspid regurgitation (FTR) is associated with high risk of cardiovascular events, particularly heart failure (HF) and mortality. MicroRNAs (miRNAs) have been recently identified as novel biomarkers in different cardiovascular ... ...

    Abstract Aim: Severe functional tricuspid regurgitation (FTR) is associated with high risk of cardiovascular events, particularly heart failure (HF) and mortality. MicroRNAs (miRNAs) have been recently identified as novel biomarkers in different cardiovascular conditions, but no studies have focused on FTR. We sought to (1) to identify and validate circulating miRNAs as regulators of FTR and (2) to test association of miRNA with heart failure and mortality in FTR.
    Methods and results: Consecutive patients with isolated severe FTR (n = 100) evaluated in the outpatient Heart Valve Clinic and age- and gender-matched subjects with no TR (controls, n = 50) were prospectively recruited. The experimental design included (1) a screening phase to identify candidate miRNA differentially expressed in FTR (n = 8) compared with controls (n = 8) through miRNA array profiling of 192 miRNAs using quantitative reverse transcription PCR arrays [qRT-PCR]) and (2) a validation phase in which candidate miRNAs identified in the initial screening were selected for further validation by qRT-PCR in a prospectively recruited cohort of FTR (n = 92) and controls (n = 42). Bioinformatics analysis was used to predict their potential target genes and functional pathways elicited. A combined endpoint of hospital admission due to heart failure (HF) and all-cause mortality was defined. Initial screening identified 16 differentially expressed miRNAs in FTR compared with controls, subsequently confirmed in the validation phase (n = 16 were excluded due to significant haemolysis). miR-186-5p, miR-30e-5p, and miR-152-3p identified FTR with high predictive value [AUC of 0.93 (0.88-0.97), 0.83 (0.75-0.91) and 0.84 (0.76-0.92), respectively]. During a median follow-up of 20.4 months (IQR 8-35 months), 32% of FTR patients reached the combined endpoint. Patients with low relative expression of miR-15a-5p, miR-92a-3p, miR101-3p, and miR-363-3p, miR-324-3p, and miR-22-3p showed significantly higher rates of events (log-rank test for all P < 0.01). Both miR-15a-5p [hazard ratio: 0.21 (0.06-0.649, P = 0.007) and miR-92a-3p (0.27 (0.09-0.76), P = 0.01] were associated with outcomes after adjusting for age, gender, and New York Heart Association functional class.
    Conclusions: Circulating miRNAs are novel diagnostic and prognostic biomarkers in severe FTR. The quantification of miR-186-5p, miR-30e-5p, and miR-152-3p held strong diagnostic value, and the quantification of miR-15a-5p and miR-92a-3p are independently associated with outcomes. The recognition of specific miRNAs offers a novel perspective for TR evaluation.
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.14765
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  4. Article ; Online: Dynamic compression of the left main coronary artery by the left atrium.

    Pardo Sanz, Ana / Salido Tahoces, Luisa / González Gómez, Ariana / Zamorano Gómez, José Luis / Sánchez Recalde, Ángel

    European heart journal. Cardiovascular Imaging

    2022  Volume 23, Issue 8, Page(s) e292

    MeSH term(s) Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/surgery ; Coronary Vessels/diagnostic imaging ; Heart Atria/diagnostic imaging ; Humans ; Pulmonary Artery
    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeac065
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  5. Article ; Online: Telemedicine for patients with valvular heart disease or aortic disease in the era of COVID-19.

    González Gómez, Ariana / Méndez Santos, Irene / Moñivas Palomero, Vanessa / Calvo Iglesias, Francisco

    Revista espanola de cardiologia (English ed.)

    2020  Volume 74, Issue 4, Page(s) 361–362

    MeSH term(s) Aortic Diseases/diagnosis ; COVID-19 ; Heart Valve Diseases/diagnosis ; Humans ; SARS-CoV-2 ; Telemedicine
    Language Spanish
    Publishing date 2020-12-23
    Publishing country Spain
    Document type Letter ; Comment
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2020.11.009
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  6. Article ; Online: La consulta telemática para el paciente con valvulopatías o enfermedad aórtica en tiempos de la COVID-19.

    González Gómez, Ariana / Méndez Santos, Irene / Moñivas Palomero, Vanessa / Calvo Iglesias, Francisco

    Revista espanola de cardiologia

    2020  Volume 74, Issue 4, Page(s) 361–362

    Title translation Telemedicine for patients with valvular heart disease or aortic disease in the era of COVID-19.
    Keywords covid19
    Language Spanish
    Publishing date 2020-11-11
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 128925-1
    ISSN 1579-2242 ; 0300-8932
    ISSN (online) 1579-2242
    ISSN 0300-8932
    DOI 10.1016/j.recesp.2020.11.001
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    Zs.B 215: Show issues Location:
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  7. Article ; Online: Clinical utility and prognostic value of right atrial function in severe tricuspid regurgitation: one more piece of the puzzle.

    Hinojar, Rocio / Fernández-Golfín, Covadonga / González Gómez, Ariana / García-Martin, Ana / Monteagudo, Juan Manuel / García Lunar, Inés / García Sebastian, Cristina / Rivas, Sonia / Sanchez Recalde, Angel / Zamorano, Jose Luis

    European heart journal. Cardiovascular Imaging

    2023  Volume 24, Issue 8, Page(s) 1092–1101

    Abstract: Aims: The optimal management of severe tricuspid regurgitation (TR) remains controversial. While right ventricular systolic function is an established prognostic marker of outcomes, the potential role of right atrial (RA) function is unknown. This study ...

    Abstract Aims: The optimal management of severe tricuspid regurgitation (TR) remains controversial. While right ventricular systolic function is an established prognostic marker of outcomes, the potential role of right atrial (RA) function is unknown. This study aimed to describe RA function by 2D speckle-tracking echocardiography (STE) in at least severe TR and to evaluate its potential association with cardiovascular outcomes.
    Methods and results: Consecutive patients with at least (≥) severe TR (severe, massive, or torrential TR) evaluated in the Heart Valve Clinic following a comprehensive clinical protocol were included. Consecutive control subjects and patients with permanent isolated atrial fibrillation (AF) were included for comparison (control and AF group, respectively). RA function was measured with 2D-STE and two components of RA function were calculated: reservoir (RASr) and contractile (RASct) strain (AutoStrain, Philips Medical Systems the EPIQ system). A combined endpoint of hospital admission due to heart failure (HF) or all-cause mortality was defined. Patients with ≥ severe TR (n = 140) showed lower RASr compared with controls (n = 20) and with the AF group (n = 20) (P < 0.001). Atrial TR showed lower RASr compared with other aetiologies of TR (P < 0.001). After a median follow-up of 2.2 years (IQR: 12-41 months), RASr remained an independent predictor of mortality and HF. A cut-off value of RASr of <9.4% held the best accuracy to predict outcomes.
    Conclusion: RA function by 2D-STE independently predicts mortality and HF hospitalizations in patients with ≥ severe TR.
    MeSH term(s) Humans ; Tricuspid Valve Insufficiency/diagnostic imaging ; Atrial Fibrillation/diagnostic imaging ; Prognosis ; Atrial Function, Right ; Echocardiography ; Heart Failure ; Retrospective Studies
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jead052
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  8. Article ; Online: Prognostic Impact of Right Ventricular Strain in Isolated Severe Tricuspid Regurgitation.

    Hinojar, Rocio / Zamorano, Jose Luis / González Gómez, Ariana / García-Martin, Ana / Monteagudo, Juan Manuel / García Lunar, Inés / Sanchez Recalde, Angel / Fernández-Golfín, Covadonga

    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

    2023  Volume 36, Issue 6, Page(s) 615–623

    Abstract: Background: Right ventricular (RV) systolic function is an established marker of outcomes in patients with severe tricuspid regurgitation (TR). Timely detection of RV dysfunction using conventional two-dimensional echocardiography is challenging. RV ... ...

    Abstract Background: Right ventricular (RV) systolic function is an established marker of outcomes in patients with severe tricuspid regurgitation (TR). Timely detection of RV dysfunction using conventional two-dimensional echocardiography is challenging. RV strain has emerged as an accurate and sensitive tool for the evaluation of RV function, with the capability to detect subclinical RV dysfunction. The aim of this study was to evaluate the prognostic value of RV strain parameters in early stages of severe TR.
    Methods: Consecutive patients with at least severe TR (severe, massive, or torrential) and the absence of a formal indication for tricuspid valve intervention in secondary TR evaluated in the Heart Valve Clinic were prospectively included. RV systolic function was measured using conventional echocardiographic indices (RV fractional area change, tricuspid annular plane systolic excursion, and Doppler tissue imaging S wave [S']) and speckle-tracking echocardiography-derived automatic peak global longitudinal strain and free wall longitudinal strain (FWLS) using an automated two-dimensional strain analytic software. A combined end point of hospital admission due to heart failure or all-cause mortality was defined.
    Results: A total of 266 patients were enrolled in the study, and 151 were ultimately included. Strain parameters detected a higher percentage of abnormal RV values compared with conventional indices. During a median follow-up period of 26 months (interquartile range, 13-42 months), 35% of the patients reached the combined end point. Cumulative event-free survival was significantly worse in patients with impaired RV global longitudinal strain and RV FWLS. Conventional indices of RV systolic function were not associated with outcomes (P > .05 for all). On multivariate analysis, RV FWLS was independently associated with mortality and heart failure (adjusted hazard ratio for abnormal RV FWLS, 5.90; 95% CI, 3.17-10.99; P < .001).
    Conclusion: In early stages of severe TR, RV FWLS is more frequently impaired compared with conventional indices of RV function. Among all parameters, RV FWLS is the strongest predictor of mortality and heart failure, independent of additional prognostic markers.
    MeSH term(s) Humans ; Prognosis ; Tricuspid Valve Insufficiency/diagnostic imaging ; Echocardiography/adverse effects ; Heart Ventricles/diagnostic imaging ; Ventricular Function, Right ; Heart Failure ; Ventricular Dysfunction, Right/diagnostic imaging ; Ventricular Dysfunction, Right/etiology
    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1035622-8
    ISSN 1097-6795 ; 0894-7317
    ISSN (online) 1097-6795
    ISSN 0894-7317
    DOI 10.1016/j.echo.2023.02.009
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  9. Article ; Online: Concomitant Transcatheter Tricuspid Annuloplasty and Edge-to-Edge Repair in Torrential Tricuspid Regurgitation.

    Sánchez-Recalde, Ángel / Salido-Tahoces, Luisa / García-Martín, Ana / Carrión-Sánchez, Irene / González-Gomez, Ariana / Pardo-Sanz, Ana / García-Sebastian, Cristina / Hinojar-Baydes, Rocío / Fernández-Golfín, Covadonga / Zamorano, José L

    JACC. Cardiovascular interventions

    2023  Volume 17, Issue 1, Page(s) 99–100

    MeSH term(s) Humans ; Tricuspid Valve Insufficiency/diagnostic imaging ; Tricuspid Valve Insufficiency/surgery ; Treatment Outcome ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/surgery ; Mitral Valve/surgery ; Heart Valve Prosthesis Implantation/adverse effects ; Cardiac Catheterization
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2023.10.066
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    Zs.A 6669: Show issues Location:
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  10. Article ; Online: Tricuspid Annulus Reduction Mechanism After Transcatheter Annuloplasty and its Impact on Right Ventricular Remodeling.

    Sánchez-Recalde, Ángel / Pardo-Sanz, Ana / Hinojar-Baydes, Rocío / Salido-Tahoces, Luisa / García-Sebastian, Cristina / González-Gomez, Ariana / García-Martín, Ana / Fernández-Golfín, Covadonga / Zamorano, José Luis

    JACC. Cardiovascular interventions

    2023  Volume 17, Issue 1, Page(s) 108–110

    MeSH term(s) Humans ; Ventricular Remodeling ; Treatment Outcome ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/surgery ; Mitral Valve/surgery ; Tricuspid Valve Insufficiency/diagnostic imaging ; Tricuspid Valve Insufficiency/surgery ; Cardiac Valve Annuloplasty/adverse effects
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Letter
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2023.10.067
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