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  1. AU="González-Mansilla, Ana"
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  1. Artikel ; Online: 1-Step Percutaneous Treatment of Heavily Calcified Left-Heart Valve Stenoses.

    Sanz-Ruiz, Ricardo / González-Mansilla, Ana / Rivera-Juárez, Allan / Bermejo, Javier / Fernández-Avilés, Francisco

    JACC. Cardiovascular interventions

    2021  Band 14, Heft 24, Seite(n) e335–e337

    Mesh-Begriff(e) Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Constriction, Pathologic ; Heart Valve Diseases ; Heart Valves ; Humans ; Mitral Valve Stenosis/surgery ; Transcatheter Aortic Valve Replacement ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2021-11-24
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2021.09.026
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Stasis imaging predicts the risk of cardioembolic events related to acute myocardial infarction.

    Rodríguez-González, Elena / Martínez-Legazpi, Pablo / Mombiela, Teresa / González-Mansilla, Ana / Delgado-Montero, Antonia / Guzmán-De-Villoria, Juan A / Díaz-Otero, Fernando / Prieto-Arévalo, Raquel / Juárez, Miriam / García Del Rey, María Del Carmen / Fernández-García, Pilar / Flores, Óscar / Postigo, Andrea / Yotti, Raquel / García-Villalba, Manuel / Fernández-Avilés, Francisco / Álamo, Juan C Del / Bermejo, Javier

    Revista espanola de cardiologia (English ed.)

    2024  

    Abstract: Introduction and objectives: In the setting of ST-segment elevation myocardial infarction (STEMI), imaging-based biomarkers could be useful for guiding oral anticoagulation to prevent cardioembolism. Our objective was to test the efficacy of ... ...

    Abstract Introduction and objectives: In the setting of ST-segment elevation myocardial infarction (STEMI), imaging-based biomarkers could be useful for guiding oral anticoagulation to prevent cardioembolism. Our objective was to test the efficacy of intraventricular blood stasis imaging in predicting a composite primary endpoint of cardioembolic risk during the first 6 months after STEMI.
    Methods: We designed a prospective clinical study, Imaging Silent Brain Infarct in Acute Myocardial Infarction (ISBITAMI, NCT02917213), including patients with a first STEMI, an ejection fraction ≤ 45% and without atrial fibrillation to assess the performance of stasis metrics to predict cardioembolism. Patients underwent ultrasound-based stasis imaging at enrollment followed by heart and brain magnetic resonance at 1-week and 6-month visits. From the stasis maps, we calculated the average residence time, R
    Results: A total of 66 patients were assigned to the primary endpoint. Of them, 17 patients had 1 or more events: 3 strokes, 5 silent brain infarctions, and 13 mural thromboses. No systemic embolisms were observed. R
    Conclusions: In patients with STEMI and left ventricular systolic dysfunction in sinus rhythm, the risk of cardioembolism may be assessed by echocardiography by combining stasis and strain imaging.
    Sprache Spanisch
    Erscheinungsdatum 2024-05-08
    Erscheinungsland Spain
    Dokumenttyp Journal Article
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2024.04.007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Assessment of Blood Flow Transport in the Left Ventricle Using Ultrasound. Validation Against 4-D Flow Cardiac Magnetic Resonance.

    Postigo, Andrea / Viola, Federica / Chazo, Christian / Martínez-Legazpi, Pablo / González-Mansilla, Ana / Rodríguez-González, Elena / Fernández-Avilés, Francisco / Del Álamo, Juan C / Ebbers, Tino / Bermejo, Javier

    Ultrasound in medicine & biology

    2022  Band 48, Heft 9, Seite(n) 1822–1832

    Abstract: Four-dimensional flow cardiac magnetic resonance (CMR) is the reference technique for analyzing blood transport in the left ventricle (LV), but similar information can be obtained from ultrasound. We aimed to validate ultrasound-derived transport in a ... ...

    Abstract Four-dimensional flow cardiac magnetic resonance (CMR) is the reference technique for analyzing blood transport in the left ventricle (LV), but similar information can be obtained from ultrasound. We aimed to validate ultrasound-derived transport in a head-to-head comparison against 4D flow CMR. In five patients and two healthy volunteers, we obtained 2D + t and 3D + t (4D) flow fields in the LV using transthoracic echocardiography and CMR, respectively. We compartmentalized intraventricular blood flow into four fractions of end-diastolic volume: direct flow (DF), retained inflow (RI), delayed ejection flow (DEF) and residual volume (RV). Using ultrasound we also computed the properties of LV filling waves (percentage of LV penetration and percentage of LV volume carried by E/A waves) to determine their relationships with CMR transport. Agreement between both techniques for quantifying transport fractions was good for DF and RV (R
    Mesh-Begriff(e) Heart Ventricles/diagnostic imaging ; Hemodynamics ; Humans ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Spectroscopy ; Reproducibility of Results ; Ventricular Function, Left
    Sprache Englisch
    Erscheinungsdatum 2022-06-25
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2022.05.007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Prognostic implications of systolic function in patients with cirrhosis.

    González-Mansilla, Ana / Castellote-Domínguez, Irene / Fernández-Quintanilla, Sara / Martínez-Legazpi, Pablo / Ripoll, Cristina / Vega Catalina, Maria / Rincón, Diego / Fernández-Avilés, Francisco / Bañares, Rafael / Bermejo, Javier

    Gastroenterologia y hepatologia

    2022  Band 46, Heft 6, Seite(n) 446–454

    Abstract: Introduction: LV intrinsic systolic cardiac function in cirrhotic patients is conditioned by the degree of sympathetic activation and the use of non-selective beta-blockers (NSBBs). Systolic function can be non-invasively measured by ultrasound using ... ...

    Abstract Introduction: LV intrinsic systolic cardiac function in cirrhotic patients is conditioned by the degree of sympathetic activation and the use of non-selective beta-blockers (NSBBs). Systolic function can be non-invasively measured by ultrasound using Ejection Intraventricular Pressure Differences in the LV (EIVPD). We aimed to address the relationship between systolic function and long-term clinical outcomes using EIVPD.
    Methods: We studied 45 Child-Pugh B or C patients (13 female, 24 on NSBBs) using echocardiography. The primary endpoint was the combination of any-cause mortality or liver transplantation. After a follow-up of 7 years (796 person-months) and a median period of 17 (10-42) months, 41 patients (91%) reached the primary endpoint: 13 (29%) died and 28 (62%) underwent transplantation.
    Results: By univariable analysis the primary endpoint was related exclusively to MELD score. However, in a multivariable proportional-hazards analysis, adjusted for age, sex and MELD score, EIVPD was inversely related to the primary endpoint, showing interaction with NSBBs. In patients without NSBBs, EIVPD inversely predicted the primary endpoint, whereas in patients with NSBBs, EIVPD was unrelated to outcomes. These relationships were undetected by myocardial strain or conventional cardiac indices.
    Conclusions: LV intrinsic systolic function, as noninvasively measured by EIVPD is a predictor of long-term outcomes in patients with cirrhosis. The prognostic value of EIVPD is present along any degree of liver dysfunction but blunted by NSBBs. Because NSBBs have a deep effect on myocardial contractility, these drugs need to be considered when assessing the prognostic implications of cardiac function in these patients.
    Mesh-Begriff(e) Humans ; Female ; Prognosis ; Liver Cirrhosis/complications ; Liver Transplantation ; Echocardiography
    Sprache Spanisch
    Erscheinungsdatum 2022-10-19
    Erscheinungsland Spain
    Dokumenttyp Journal Article
    ZDB-ID 632502-6
    ISSN 0210-5705
    ISSN 0210-5705
    DOI 10.1016/j.gastrohep.2022.10.011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Telecardiología en tiempos de la pandemia de COVID-19.

    Postigo, Andrea / González-Mansilla, Ana / Bermejo, Javier / Elízaga, Jaime / Fernández-Avilés, Francisco / Martínez-Sellés, Manuel

    Revista espanola de cardiologia

    2020  Band 73, Heft 8, Seite(n) 674–676

    Titelübersetzung Telecardiology in times of the COVID-19 pandemic.
    Schlagwörter covid19
    Sprache Spanisch
    Erscheinungsdatum 2020-05-04
    Erscheinungsland Spain
    Dokumenttyp Case Reports
    ZDB-ID 128925-1
    ISSN 1579-2242 ; 0300-8932
    ISSN (online) 1579-2242
    ISSN 0300-8932
    DOI 10.1016/j.recesp.2020.04.026
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Telecardiology in times of the COVID-19 pandemic.

    Postigo, Andrea / González-Mansilla, Ana / Bermejo, Javier / Elízaga, Jaime / Fernández-Avilés, Francisco / Martínez-Sellés, Manuel

    Revista espanola de cardiologia (English ed.)

    2020  Band 73, Heft 8, Seite(n) 674–675

    Mesh-Begriff(e) Aged ; COVID-19 ; Cardiology Service, Hospital/organization & administration ; Clinical Protocols ; Coronavirus Infections/prevention & control ; Female ; Heart Diseases/diagnosis ; Heart Diseases/therapy ; Humans ; Male ; Middle Aged ; Outpatient Clinics, Hospital/organization & administration ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Telemedicine/methods ; Telemedicine/organization & administration
    Schlagwörter covid19
    Sprache Spanisch
    Erscheinungsdatum 2020-05-23
    Erscheinungsland Spain
    Dokumenttyp Letter
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2020.04.018
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Personalized Evaluation of Atrial Complexity of Patients Undergoing Atrial Fibrillation Ablation: A Clinical Computational Study

    Sánchez de la Nava, Ana María / González Mansilla, Ana / González-Torrecilla, Esteban / Ávila, Pablo / Datino, Tomás / Bermejo, Javier / Arenal, Ángel / Fernández-Avilés, Francisco / Atienza, Felipe

    Biology. 2021 Aug. 28, v. 10, no. 9

    2021  

    Abstract: Current clinical guidelines establish Pulmonary Vein (PV) isolation as the indicated treatment for Atrial Fibrillation (AF). However, AF can also be triggered or sustained due to atrial drivers located elsewhere in the atria. We designed a new simulation ...

    Abstract Current clinical guidelines establish Pulmonary Vein (PV) isolation as the indicated treatment for Atrial Fibrillation (AF). However, AF can also be triggered or sustained due to atrial drivers located elsewhere in the atria. We designed a new simulation workflow based on personalized computer simulations to characterize AF complexity of patients undergoing PV ablation, validated with non-invasive electrocardiographic imaging and evaluated at one year after ablation. We included 30 patients using atrial anatomies segmented from MRI and simulated an automata model for the electrical modelling, consisting of three states (resting, excited and refractory). In total, 100 different scenarios were simulated per anatomy varying rotor number and location. The 3 states were calibrated with Koivumaki action potential, entropy maps were obtained from the electrograms and compared with ECGi for each patient to analyze PV isolation outcome. The completion of the workflow indicated that successful AF ablation occurred in patients with rotors mainly located at the PV antrum, while unsuccessful procedures presented greater number of driving sites outside the PV area. The number of rotors attached to the PV was significantly higher in patients with favorable long-term ablation outcome (1-year freedom from AF: 1.61 ± 0.21 vs. AF recurrence: 1.40 ± 0.20; p-value = 0.018). The presented workflow could improve patient stratification for PV ablation by screening the complexity of the atria.
    Schlagwörter action potentials ; atrial fibrillation ; computers ; electrocardiography ; entropy ; models ; patients
    Sprache Englisch
    Erscheinungsverlauf 2021-0828
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology10090838
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Artikel: Personalized Evaluation of Atrial Complexity of Patients Undergoing Atrial Fibrillation Ablation: A Clinical Computational Study.

    Sánchez de la Nava, Ana María / González Mansilla, Ana / González-Torrecilla, Esteban / Ávila, Pablo / Datino, Tomás / Bermejo, Javier / Arenal, Ángel / Fernández-Avilés, Francisco / Atienza, Felipe

    Biology

    2021  Band 10, Heft 9

    Abstract: Current clinical guidelines establish Pulmonary Vein (PV) isolation as the indicated treatment for Atrial Fibrillation (AF). However, AF can also be triggered or sustained due to atrial drivers located elsewhere in the atria. We designed a new simulation ...

    Abstract Current clinical guidelines establish Pulmonary Vein (PV) isolation as the indicated treatment for Atrial Fibrillation (AF). However, AF can also be triggered or sustained due to atrial drivers located elsewhere in the atria. We designed a new simulation workflow based on personalized computer simulations to characterize AF complexity of patients undergoing PV ablation, validated with non-invasive electrocardiographic imaging and evaluated at one year after ablation. We included 30 patients using atrial anatomies segmented from MRI and simulated an automata model for the electrical modelling, consisting of three states (resting, excited and refractory). In total, 100 different scenarios were simulated per anatomy varying rotor number and location. The 3 states were calibrated with Koivumaki action potential, entropy maps were obtained from the electrograms and compared with ECGi for each patient to analyze PV isolation outcome. The completion of the workflow indicated that successful AF ablation occurred in patients with rotors mainly located at the PV antrum, while unsuccessful procedures presented greater number of driving sites outside the PV area. The number of rotors attached to the PV was significantly higher in patients with favorable long-term ablation outcome (1-year freedom from AF: 1.61 ± 0.21 vs. AF recurrence: 1.40 ± 0.20;
    Sprache Englisch
    Erscheinungsdatum 2021-08-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology10090838
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Increased Chamber Resting Tone Is a Key Determinant of Left Ventricular Diastolic Dysfunction.

    Tamargo, María / Martínez-Legazpi, Pablo / Espinosa, M Ángeles / Lyon, Aurore / Méndez, Irene / Gutiérrez-Ibañes, Enrique / Fernández, Ana I / Prieto-Arévalo, Raquel / González-Mansilla, Ana / Arts, Theo / Delhaas, Tammo / Mombiela, Teresa / Sanz-Ruiz, Ricardo / Elízaga, Jaime / Yotti, Raquel / Tschöpe, Carsten / Fernández-Avilés, Francisco / Lumens, Joost / Bermejo, Javier

    Circulation. Heart failure

    2023  Band 16, Heft 12, Seite(n) e010673

    Abstract: Background: Twitch-independent tension has been demonstrated in cardiomyocytes, but its role in heart failure (HF) is unclear. We aimed to address twitch-independent tension as a source of diastolic dysfunction by isolating the effects of chamber ... ...

    Abstract Background: Twitch-independent tension has been demonstrated in cardiomyocytes, but its role in heart failure (HF) is unclear. We aimed to address twitch-independent tension as a source of diastolic dysfunction by isolating the effects of chamber resting tone (RT) from impaired relaxation and stiffness.
    Methods: We invasively monitored pressure-volume data during cardiopulmonary exercise in 20 patients with hypertrophic cardiomyopathy, 17 control subjects, and 35 patients with HF with preserved ejection fraction. To measure RT, we developed a new method to fit continuous pressure-volume measurements, and first validated it in a computational model of loss of cMyBP-C (myosin binding protein-C).
    Results: In hypertrophic cardiomyopathy, RT (estimated marginal mean [95% CI]) was 3.4 (0.4-6.4) mm Hg, increasing to 18.5 (15.5-21.5) mm Hg with exercise (
    Conclusions: Augmented RT is the major cause of LV diastolic chamber dysfunction in hypertrophic cardiomyopathy and HF with preserved ejection fraction. RT transients determine diastolic pressures, pulmonary pressures, and functional capacity to a greater extent than relaxation and stiffness abnormalities. These findings support antimyosin agents for treating HF.
    Mesh-Begriff(e) Humans ; Heart Failure/diagnosis ; Stroke Volume ; Ventricular Dysfunction, Left/diagnosis ; Heart ; Cardiomyopathy, Hypertrophic/diagnosis ; Ventricular Function, Left
    Sprache Englisch
    Erscheinungsdatum 2023-12-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2429459-7
    ISSN 1941-3297 ; 1941-3289
    ISSN (online) 1941-3297
    ISSN 1941-3289
    DOI 10.1161/CIRCHEARTFAILURE.123.010673
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Telecardiología en tiempos de la pandemia de COVID-19

    Postigo, Andrea / González-Mansilla, Ana / Bermejo, Javier / Elízaga, Jaime / Fernández-Avilés, Francisco / Martínez-Sellés, Manuel

    Revista Española de Cardiología

    2020  Band 73, Heft 8, Seite(n) 674–676

    Schlagwörter Cardiology and Cardiovascular Medicine ; covid19
    Sprache Spanisch
    Verlag Elsevier BV
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 128925-1
    ISSN 0300-8932
    ISSN 0300-8932
    DOI 10.1016/j.recesp.2020.04.026
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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