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Article ; Online: The authors reply.

Villar, Jesús / González-Martin, Jesús M / Szakmany, Tamas

2024 Volume 52, Issue 2, Page(s) e106–e107

Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/CCM.0000000000006115
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Zs.A 1261: Show issues

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Article ; Online: Attitudes and beliefs of Spanish healthcare professionals during the COVID-19 pandemic.

Santana López, Borja Nicolás / Santana-Padilla, Yeray G / González-Martín, Jesús M / Santana-Cabrera, Luciano

Science progress

2021 Volume 104, Issue 2, Page(s) 368504211003775

Abstract: During the COVID-19 pandemic, healthcare professionals are taking the risk of becoming infected or infecting their families. Spain is the country with the highest number of infected healthcare professionals worldwide. Our aim was to study the attitudes ... ...

Abstract	During the COVID-19 pandemic, healthcare professionals are taking the risk of becoming infected or infecting their families. Spain is the country with the highest number of infected healthcare professionals worldwide. Our aim was to study the attitudes and beliefs of these professionals during the current pandemic. Descriptive study conducted by using an online questionnaire-based on an earlier one-which was sent to healthcare professionals at the national level, during the week March 20-27, 2020. Healthcare professionals returned 971 completed questionnaires. A total of 803 (82.7%) participants thought that they did not have suitable PPEs (Personal Protective Equipment) to protect them from infection with COVID-19. In addition, even 229 (23.58%) agreed to go on working even if they were not. In spite of this, 606 (62.4%) of them were ready to work, even with a higher-than-usual risk of becoming infected at work and getting ill. Remarkably high professional commitment has been observed among Spanish healthcare workers in the current pandemic. They were ready to work even when many of them considered that they did not have suitable PPEs, and were thus taking a higher than usual infection risk. However, they put the health of their relatives before their duties at work.
MeSH term(s)	Adult ; Attitude of Health Personnel ; COVID-19/epidemiology ; COVID-19/virology ; Female ; Humans ; Male ; Pandemics ; Personal Protective Equipment ; SARS-CoV-2/isolation & purification ; Spain/epidemiology ; Surveys and Questionnaires
Language	English
Publishing date	2021-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	128412-5
ISSN	2047-7163 ; 0036-8504 ; 0302-1785
ISSN (online)	2047-7163
ISSN	0036-8504 ; 0302-1785
DOI	10.1177/00368504211003775
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Zs.B 731: Show issues

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Article ; Online: Noticias sobre suicidio en medios digitales de España: Características y adhesión a las recomendaciones de la OMS.

Rodríguez Rodríguez-Caro, Carlos J / Acosta Artiles, Francisco J / Cejas Méndez, María R / Fernández-Garcimartin, Helena / González Martín, Jesús M

Revista espanola de salud publica

2021 Volume 95

Abstract: Objective: News about suicide may cause a contagion effect or a protective effect. For this reason, the World Health Organization (WHO) has published recommendations on responsible media coverage of suicide. Certain characteristics of suicide news ... ...

Title translation	News articles in the spanish digital press media: characteristics of the sample and adherence to World Health Organization guidelines.
Abstract	Objective: News about suicide may cause a contagion effect or a protective effect. For this reason, the World Health Organization (WHO) has published recommendations on responsible media coverage of suicide. Certain characteristics of suicide news articles and their frequency have been associated to such effects. Despite their importance, these aspects have been scarcely studied in the Spanish media. The objective of this study was to identify the characteristics of suicide news articles in the Spanish digital media. Methods: We identified the adherence to WHO recommendations, avoidability, frequency, and typology of suicide news articles in the four main spanish digital media (El País, El Mundo, El Confidencial and ABC), according to Alexa (a website traffic statistics). Adherence was evaluated from a dichotomous and continuous perspective by using an ad hoc scale, and avoidability was conceptually defined. The evaluation period was 6 months (11/1/2016-04/30/2017). The statistical program used was R Core Team (2017). Results: We analysed 141 suicide news articles. Of these, 99.12% did not adhere to the recommendations, the degree of adherence was 2.97 (95% CI, 2.19-3.75; range between +22 and -22), 34.51% were avoidable, 34.04% were about "suicide after murder", and 90.04% about death by suicide. Conclusions: Adherence to WHO recommendations is very low in suicide news articles. Furthermore, almost one third of them are avoidable. The identified profile points out the need for interventions aimed at the media. Besides, it allows adjusting their contents to the identified specific needs.
MeSH term(s)	Guideline Adherence/statistics & numerical data ; Guidelines as Topic ; Humans ; Internet ; Mass Media/standards ; Mass Media/statistics & numerical data ; Spain ; Suicide ; World Health Organization
Language	Spanish
Publishing date	2021-04-21
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1288657-9
ISSN	2173-9110 ; 0034-8899 ; 1135-5727
ISSN (online)	2173-9110
ISSN	0034-8899 ; 1135-5727
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Zs.A 483: Show issues

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Article ; Online: DNMT3A/TET2/ASXL1 Mutations are an Age-independent Thrombotic Risk Factor in Polycythemia Vera Patients: An Observational Study.

Segura-Díaz, Adrián / Stuckey, Ruth / Florido, Yanira / Sobas, Marta / Álvarez-Larrán, Alberto / Ferrer-Marín, Francisca / Pérez-Encinas, Manuel / Carreño-Tarragona, Gonzalo / Fox, María L / Tazón Vega, Barbara / Cuevas, Beatriz / López Rodríguez, Juan F / Farías-Sánchez, Nuria / González-Martín, Jesús M / Gómez-Casares, María T / Bilbao-Sieyro, Cristina

Thrombosis and haemostasis

2024

Abstract: Background: Polycythemia vera (PV) patients are classified as high or low thrombotic risk based on age and prior history of thrombosis. Despite adherence to treatment recommendations, vascular events remain frequent, leading us to question whether ... ...

Abstract	Background: Polycythemia vera (PV) patients are classified as high or low thrombotic risk based on age and prior history of thrombosis. Despite adherence to treatment recommendations, vascular events remain frequent, leading us to question whether thrombotic risk stratification could be improved. We previously reported an association between thrombotic events and mutations in DTA genes ( Methods: PV patients with a minimum follow-up of 3 years were recruited from 8 European centers. Medical history was searched for thrombotic event recorded at any time and next-generation sequencing carried out with a myeloid panel. Multivariable logistic regression evaluated the impact of variables on thrombotic risk. Kaplan-Meier thrombosis-free survival curves were compared by the log rank test. Associations in the total cohort were confirmed in a case-control study to exclude selection bias. Results: Of the 136 patients recruited, 74 (56.1%) had a thrombotic event, with an incidence density of 2.83/100 person-years. In multivariable analysis, DTA mutation was a risk factor for thrombotic event, being predictive for shorter thrombosis-free survival in the whole cohort ( Conclusion: Our results support the use of molecular testing at diagnosis to help predict which PV patients are at higher risk of developing thrombosis.
Language	English
Publishing date	2024-01-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/a-2239-9265
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Uh III Zs.192: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 433: Show issues

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Article ; Online: Analysis of ANRIL Isoforms and Key Genes in Patients with Severe Coronary Artery Disease.

Rodríguez-Esparragón, Francisco / Torres-Mata, Laura B / Cazorla-Rivero, Sara E / Serna Gómez, Jaime A / González Martín, Jesús M / Cánovas-Molina, Ángeles / Medina-Suárez, José A / González-Hernández, Ayose N / Estupiñán-Quintana, Lidia / Bartolomé-Durán, María C / Rodríguez-Pérez, José C / Varas, Bernardino Clavo

International journal of molecular sciences

2023 Volume 24, Issue 22

Abstract: ANRIL (Antisense Noncoding RNA in the INK4 Locus), also named CDKN2B-AS1, is a long non-coding RNA with outstanding functions that regulates genes involved in atherosclerosis development. ANRIL genotypes and the expression of linear and circular isoforms ...

Abstract	ANRIL (Antisense Noncoding RNA in the INK4 Locus), also named CDKN2B-AS1, is a long non-coding RNA with outstanding functions that regulates genes involved in atherosclerosis development. ANRIL genotypes and the expression of linear and circular isoforms have been associated with coronary artery disease (CAD). The CDKN2A and the CDKN2B genes at the CDKN2A/B locus encode the Cyclin-Dependent Kinase inhibitor protein (CDKI) p16INK4a and the p53 regulatory protein p14ARF, which are involved in cell cycle regulation, aging, senescence, and apoptosis. Abnormal ANRIL expression regulates vascular endothelial growth factor (VEGF) gene expression, and upregulated Vascular Endothelial Growth Factor (VEGF) promotes angiogenesis by activating the NF-κB signaling pathway. Here, we explored associations between determinations of the linear, circular, and linear-to-circular ANRIL gene expression ratio, CDKN2A, VEGF and its receptor kinase insert domain-containing receptor (KDR) and cardiovascular risk factors and all-cause mortality in high-risk coronary patients before they undergo coronary artery bypass grafting surgery (CABG). We found that the expression of ANRIL isoforms may help in the prediction of CAD outcomes. Linear isoforms were correlated with a worse cardiovascular risk profile while the expression of circular isoforms of ANRIL correlated with a decrease in oxidative stress. However, the determination of the linear versus circular ratio of ANRIL did not report additional information to that determined by the evaluation of individual isoforms. Although the expressions of the VEFG and KDR genes correlated with a decrease in oxidative stress, in binary logistic regression analysis it was observed that only the expression of linear isoforms of ANRIL and VEGF significantly contributed to the prediction of the number of surgical revascularizations.
MeSH term(s)	Humans ; Coronary Artery Disease/genetics ; Vascular Endothelial Growth Factor A ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; NF-kappa B/genetics ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Protein Isoforms/genetics
Chemical Substances	Vascular Endothelial Growth Factor A ; RNA, Long Noncoding ; NF-kappa B ; Cyclin-Dependent Kinase Inhibitor p16 ; Protein Isoforms
Language	English
Publishing date	2023-11-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242216127
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Article ; Online: Prediction of major bleeding events in 1381 patients with essential thrombocythemia.

Stuckey, Ruth / Ianotto, Jean-Christophe / Santoro, Marco / Czyż, Anna / Encinas, Manuel M Perez / Gómez-Casares, María Teresa / Pereira, Maria Soledad Noya / de Nałęcz, Anna Kulikowska / Gołos, Aleksandra / Lewandowski, Krzysztof / Szukalski, Łukasz / González-Martín, Jesús M / Sobas, Marta Anna

International journal of hematology

2023 Volume 118, Issue 5, Page(s) 589–595

Abstract: The goal of therapy in essential thrombocythemia (ET) is reducing thrombotic risk. No algorithm to predict hemorrhage risk exists. The impact ofanti-platelet, cytoreductive and anticoagulation therapies on risk of major bleeding (MB) was evaluated. MB ... ...

Abstract	The goal of therapy in essential thrombocythemia (ET) is reducing thrombotic risk. No algorithm to predict hemorrhage risk exists. The impact ofanti-platelet, cytoreductive and anticoagulation therapies on risk of major bleeding (MB) was evaluated. MB events were retrospectively analyzed in 1381 ET from 10 European centers. There were 0.286 MB events/person-year. Neither the International Thrombosis Prognostic Score for thrombosis in essential thrombocythemia (IPSET-t) nor the revised IPSET-t (r-IPSET-t) was predictive for hemorrhage-free survival at 10 years (p = 0.092 vs p = 0.1). Ageand leukocyte count were MB risk factors, while low hemoglobin was protective. For ET with extreme thrombocytosis (ExtT) and leukocytosis cytoreduction was not protective. MB were more frequent in ET with ExtT who received anticoagulation. Antiplatelet therapy was not, while anticoagulation was a risk factor for MB (HR 3.05, p = 0.016, CI 1.23-7.56), in particular vitamin K antagonists (22.6% of those treated had a MB event, HR 2.96, p = 0.004, CI 1.41-6.22). Survival at 10 years was associated with hemorrhage (OR 2.54, p < 0.001) but not thrombosis (HR 0.95, p = 0.829). Hemorrhage has a higher risk of mortality than thrombosis. Improved risk stratification for MB is necessary. The choice of anticoagulation, cytoreduction and antiplatelet therapies is an important area of research in ET.
MeSH term(s)	Humans ; Thrombocythemia, Essential/complications ; Thrombocythemia, Essential/drug therapy ; Retrospective Studies ; Prognosis ; Thrombosis/etiology ; Hemorrhage/etiology ; Risk Factors ; Anticoagulants/adverse effects ; Thrombocytosis/etiology
Chemical Substances	Anticoagulants
Language	English
Publishing date	2023-09-03
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1076875-0
ISSN	1865-3774 ; 0917-1258 ; 0925-5710
ISSN (online)	1865-3774
ISSN	0917-1258 ; 0925-5710
DOI	10.1007/s12185-023-03650-7
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Zs.A 269: Show issues

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Article ; Online: Clinical relevance of circulating angiogenic cells in patients with ischemic stroke.

Rodríguez-Esparragón, Francisco / Torres-Mata, Laura B / López-Fernández, Juan Carlos / Cappiello, Laura / González-Martín, Jesús M / Clavo, Bernardino / Serna-Gómez, Jaime A / Estupiñán-Quintana, Lidia / Torres-Ascensión, Cristina / Villar, Jesús

BMC cardiovascular disorders

2022 Volume 22, Issue 1, Page(s) 118

Abstract: Background: Endothelial progenitor cells (EPCs) are circulating angiogenic cells with endothelial features associated with risk for stroke. We aimed to delve into their functional characteristics. EPCs were isolated and cultured from Ischemic Stroke (IS) ...

Abstract	Background: Endothelial progenitor cells (EPCs) are circulating angiogenic cells with endothelial features associated with risk for stroke. We aimed to delve into their functional characteristics. EPCs were isolated and cultured from Ischemic Stroke (IS) patients and predictors of their variance evaluated. Methods: This is a single-center observational study evaluating 187 consecutively hospitalized patients with IS. EPCs were isolated from blood samples. The number of circulating angiogenic cells (CACs), colony-forming units (CFU-ECs) and the emergence of late outgrowths endothelial cells (LOECs) were counted. We collected clinical variables and measured the stromal cell-derived factor 1 alpha (SDF1α) serum levels. We also examined the relative telomere length and the expression of osteogenic gene markers in CACs. Results: CACs counts and CFU-ECs colony numbers were positively correlated (rho = 0.41, p < 0.001, n = 187). We found significant differences according to whether thrombolytic treatment was performed in the distribution of CFU-ECs (odds ratio (OR) = 2.5; 95% confidence interval (CI) 1.01-6.35; p = 0.042) and CACs (OR = 4.45; 95% IC 1.2-15.5; p = 0.012). The main determinants of CACs variation were the number of risks factors, thrombolysis treatment, arterial hypertension, LOECs occurrence, and the vascular endothelial growth factor expression, whereas CFU-ECs variations depended on hemoglobin content and the relative reduction in the National Institutes of Health Stroke Scale (NIHSS) criteria. The main predictors of LOECs appearance were thrombolysis and length of hospital stay. Conclusions: Our study supports the relevance of patient risk factors and treatments in the analysis of the functional properties of EPCs.
MeSH term(s)	Endothelial Progenitor Cells ; Humans ; Ischemic Stroke ; Stem Cells/metabolism ; Stroke/diagnosis ; Stroke/therapy ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Vascular Endothelial Growth Factor A
Language	English
Publishing date	2022-03-21
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2059859-2
ISSN	1471-2261 ; 1471-2261
ISSN (online)	1471-2261
ISSN	1471-2261
DOI	10.1186/s12872-021-02421-8
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Article ; Online: Ultrasonographic Size of the Thenar Muscles of the Nondominant Hand Correlates with Total Body Lean Mass in Healthy Subjects.

Pedrianes-Martin, Pablo B / Hernanz-Rodriguez, Gema M / Gonzalez-Martin, Jesus M / Perez-Valera, Mario / De Pablos-Velasco, Pedro L

Academic radiology

2020 Volume 28, Issue 4, Page(s) 517–523

Abstract: Rationale and objectives: Sarcopenia is associated with adverse outcomes in clinical situations such as elderly population, in-hospital setting and oncologic patients. However, no direct measurement of muscular mass is routinely available for clinicians. ...

Abstract	Rationale and objectives: Sarcopenia is associated with adverse outcomes in clinical situations such as elderly population, in-hospital setting and oncologic patients. However, no direct measurement of muscular mass is routinely available for clinicians. The aim of this study was to assess the correlation between thenar musculature of the nondominant hand evaluated by ultrasound and body fat-free mass. Materials and methods: In this one-center, cross-sectional, observational study, the width and depth of thenar muscles of both hands was assessed by ultrasonography. Nondominant hand musculature was taken as reference as a better estimator of total body muscular mass. These data were compared to body composition by bioimpedance analysis and dual-energy X-ray absorptiometry (DXA), hand grip strength, arm muscular area and physical activity (with International Physical Activity Questionnaire ). Statistical correlation was determined for each parameter. Results: We obtained ultrasonographic measurements, International Physical Activity Questionnaire and hand grip strength from 83 subjects, whereas bioimpedance was performed in 64 subjects and DXA in 29 subjects. The strongest correlations were found between longitudinal thenar depth vs fat-free mass index (fat-free mass in DXA [kg]/height Conclusion: Ultrasonographic examination of the nondominant thenar musculature is a fast and simple way of assessing total body fat-free mass, showing a good correlation with body composition measured by bioimpedance analysis and DXA, hand grip strength and arm muscular area.
MeSH term(s)	Absorptiometry, Photon ; Aged ; Body Composition ; Body Mass Index ; Cross-Sectional Studies ; Hand Strength ; Healthy Volunteers ; Humans
Language	English
Publishing date	2020-07-30
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	1355509-1
ISSN	1878-4046 ; 1076-6332
ISSN (online)	1878-4046
ISSN	1076-6332
DOI	10.1016/j.acra.2020.02.029
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Article ; Online: Validation of thrombotic risk factors in 1381 patients with essential thrombocythaemia: A multicentre retrospective real-life study.

Stuckey, Ruth / Ianotto, Jean-Christophe / Santoro, Marco / Czyż, Anna / Perez Encinas, Manuel M / Gómez-Casares, María Teresa / Noya Pereira, Maria Soledad / de Nałęcz, Anna Kulikowska / Gołos, Aleksandra / Lewandowski, Krzysztof / Szukalski, Łukasz / González-Martín, Jesús M / Wróbel, Tomasz / Sobas, Marta Anna

British journal of haematology

2022 Volume 199, Issue 1, Page(s) 86–94

Abstract: Thrombosis and haemorrhage are frequent in patients with essential thrombocythaemia (ET). The 2016 revised International Prognostic Score for Thrombosis in Essential Thrombocythaemia-thrombosis (r-IPSET-t) score stratifies patients into very-low- (VLR), ... ...

Abstract	Thrombosis and haemorrhage are frequent in patients with essential thrombocythaemia (ET). The 2016 revised International Prognostic Score for Thrombosis in Essential Thrombocythaemia-thrombosis (r-IPSET-t) score stratifies patients into very-low- (VLR), low- (LR), intermediate- (IR) and high-risk (HR) groups. We validated the r-IPSET-t in the biggest population of patients with ET (n = 1381) to date and found it to be a better fit than the earlier IPSET-t score. With an average follow-up of 87.7 months, there were 0.578 thrombotic events/person-year and 0.286 bleeding events/person-year after diagnosis. The 10-year thrombosis-free survival was 88% and 99% for the r-IPSET-t LR and VLR groups (p < 0.001). Cytoreduction was a thrombotic risk factor in younger patients (aged <60 years, hazard ratio 9.49, p = 0.026; aged ≥60 years, hazard ratio 1.04, p = 0.93). In multivariable Cox regression analysis, anti-aggregation after diagnosis was protective for thrombosis (hazard ratio 0.31, p = 0.005) but a risk factor for major bleeding (hazard ratio 10.56, p = 0.021). Of the IPSET-t HR and LR groups, 132/780 and 249/301 were re-classified as LR and VLR respectively (p < 0.001). The European LeukemiaNET (ELN) does not recommend aspirin for VLR patients but in this real-life analysis 83.1% of VLR patients received it. Our results validate the r-IPSET-t score as more predictive for thrombosis than the ELN-recommended IPSET-t and raise concerns about unnecessary cytoreductive and anti-aggregative therapy.
MeSH term(s)	Aspirin/therapeutic use ; Humans ; Prognosis ; Retrospective Studies ; Risk Factors ; Thrombocythemia, Essential/diagnosis ; Thrombosis/diagnosis ; Thrombosis/epidemiology ; Thrombosis/etiology
Chemical Substances	Aspirin (R16CO5Y76E)
Language	English
Publishing date	2022-07-29
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.18387
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Article ; Online: Ozone Eliminates SARS-CoV-2 from Difficult-to-Clean Office Supplies and Clinical Equipment.

Torres-Mata, Laura B / García-Pérez, Omar / Rodríguez-Esparragón, Francisco / Blanco, Angeles / Villar, Jesús / Ruiz-Apodaca, Fernando / Martín-Barrasa, José L / González-Martín, Jesús M / Serrano-Aguilar, Pedro / Piñero, José E / Córdoba-Lanús, Elizabeth / Lorenzo-Morales, Jacob / Clavo, Bernardino

International journal of environmental research and public health

2022 Volume 19, Issue 14

Abstract: 1) Background: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) continues to cause profound health, economic, and social problems worldwide. The management and disinfection of materials used daily in health centers and common working ... ...

Abstract	(1) Background: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) continues to cause profound health, economic, and social problems worldwide. The management and disinfection of materials used daily in health centers and common working environments have prompted concerns about the control of coronavirus disease 2019 (COVID-19) infection risk. Ozone is a powerful oxidizing agent that has been widely used in disinfection processes for decades. The aim of this study was to assess the optimal conditions of ozone treatment for the elimination of heat-inactivated SARS-CoV-2 from office supplies (personal computer monitors, keyboards, and computer mice) and clinical equipment (continuous positive airway pressure tubes and personal protective equipment) that are difficult to clean. (2) Methods: The office supplies and clinical equipment were contaminated in an area of 1 cm
MeSH term(s)	COVID-19/prevention & control ; Humans ; Ozone ; Pandemics/prevention & control ; RNA, Viral ; SARS-CoV-2
Chemical Substances	RNA, Viral ; Ozone (66H7ZZK23N)
Language	English
Publishing date	2022-07-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19148672
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