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  1. Article ; Online: Attitudes toward death and burnout syndrome in geriatrics and gerontology healthcare personnel.

    Cantero-García, María / Llorente, Marta / Gómez-Martínez, Sandra / González-Moreno, Jesús

    Revista espanola de geriatria y gerontologia

    2023  Volume 58, Issue 6, Page(s) 101422

    Abstract: Introduction: Geriatric and gerontology healthcare workers are associated with a series of psychosocial risks such as death, bereavement and illness, and this implies a significant emotional and work overload, which can lead to negative attitudes toward ...

    Abstract Introduction: Geriatric and gerontology healthcare workers are associated with a series of psychosocial risks such as death, bereavement and illness, and this implies a significant emotional and work overload, which can lead to negative attitudes toward death.
    Objective: The aims of this study were to assess attitudes toward death, the level of burnout and the relationship between geriatrics and gerontology professionals.
    Method: A correlational, cross-sectional study was conducted, in which the 42 participants in the sample completed an online questionnaire including the Revised Profile of Attitudes to Death (PAM-R) and the Maslach Burnout Inventory-Human Services Survey (MBI-HSS).
    Results: The results obtained show that the predominant attitude toward death in the sample is that of neutral acceptance, and with regard to burnout syndrome, moderate average levels are found in the dimensions of emotional exhaustion and personal accomplishment, but a low level of depersonalisation.
    Conclusion: Healthcare workers with attitudes of greater fear of death or acceptance of escape tend to experience higher levels of emotional exhaustion and depersonalisation, as do those with an attitude of death avoidance, who also have lower personal fulfillment.
    MeSH term(s) Humans ; Aged ; Cross-Sectional Studies ; Burnout, Psychological ; Health Personnel/psychology ; Burnout, Professional/psychology ; Surveys and Questionnaires ; Geriatrics ; Delivery of Health Care
    Language English
    Publishing date 2023-10-26
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 605609-x
    ISSN 1578-1747 ; 0211-139X
    ISSN (online) 1578-1747
    ISSN 0211-139X
    DOI 10.1016/j.regg.2023.101422
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  2. Article ; Online: Cognitive Stimulation in Moderate Alzheimer's Disease.

    Gonzalez-Moreno, Jesús / Satorres, Encarnacion / Soria-Urios, Gema / Meléndez, Juan C

    Journal of applied gerontology : the official journal of the Southern Gerontological Society

    2022  Volume 41, Issue 8, Page(s) 1934–1941

    Abstract: Cognitive stimulation is one of the non-pharmacological therapies recommended for dementia intervention. The present study evaluated the efficacy of an intervention based on cognitive stimulation in people with moderate Alzheimer's disease. Fifty-nine ... ...

    Abstract Cognitive stimulation is one of the non-pharmacological therapies recommended for dementia intervention. The present study evaluated the efficacy of an intervention based on cognitive stimulation in people with moderate Alzheimer's disease. Fifty-nine subjects with moderate dementia were randomly assigned to the stimulation group (
    MeSH term(s) Alzheimer Disease/therapy ; Cognition/physiology ; Cognitive Behavioral Therapy ; Cognitive Dysfunction ; Dementia/therapy ; Humans ; Neuropsychological Tests
    Language English
    Publishing date 2022-05-27
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 155897-3
    ISSN 1552-4523 ; 0733-4648
    ISSN (online) 1552-4523
    ISSN 0733-4648
    DOI 10.1177/07334648221089283
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  3. Article ; Online: Cognitive Stimulation Program Presented Through New Technologies in a Group of People with Moderate Cognitive Impairment.

    Gonzalez-Moreno, Jesús / Satorres, Encarnacion / Soria-Urios, Gema / Meléndez, Juan C

    Journal of Alzheimer's disease : JAD

    2022  Volume 88, Issue 2, Page(s) 513–519

    Abstract: Background: Cognitive stimulation is one of the non-pharmacological therapies recommended for intervention in dementia, consisting of activities involving different cognitive domains and involving brain activation. New technologies can be very useful in ...

    Abstract Background: Cognitive stimulation is one of the non-pharmacological therapies recommended for intervention in dementia, consisting of activities involving different cognitive domains and involving brain activation. New technologies can be very useful in this field, favoring intervention tasks.
    Objective: The objective of this work is to test the effectiveness of a cognitive stimulation intervention mediated with new technologies on a group of people with moderate dementia.
    Methods: This is a quantitative, quasi-experimental study with a control and treatment group, with three measurement times (pre, post, and follow-up months after the end of the intervention). Ninety-eight subjects with moderate dementia were randomly assigned to the treatment group (N = 50) and the control group (N = 48). The treatment group received 16 intervention sessions including attention, executive function, and memory tasks, which were presented using new technologies and the activity was conducted in a group setting. Control group remained on a waiting list. The evaluators did not know which group each subject belonged to. All participants were assessed with a battery of neuropsychological tests.
    Results: The results show an improvement in post-intervention outcomes in the treatment group compared to the control group on cognitive variables. No differences were found in mood depression. These results fade overtime after a few months without intervention.
    Conclusion: This type of intervention is useful to maintain cognitive functioning using new technologies and in a group setting, which favors the intervention. The improvements of the intervention disappear at follow-up, which would indicate the need to maintain the intervention over time.
    MeSH term(s) Activities of Daily Living ; Cognition/physiology ; Cognitive Behavioral Therapy ; Cognitive Dysfunction/therapy ; Dementia/psychology ; Humans
    Language English
    Publishing date 2022-06-05
    Publishing country Netherlands
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-220245
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  4. Article ; Online: Predictors of Health Satisfaction in Spanish Physically Active Older Adults: A Cross-Sectional Observational Study.

    Agustí, Ana Isabel / Guillem-Saiz, Javier / González-Moreno, Jesús / Cantero-García, María / Cigarroa, Igor / Parra-Rizo, María Antonia

    Geriatrics (Basel, Switzerland)

    2023  Volume 8, Issue 1

    Abstract: Studies that analyze the predictors of satisfaction with the health of the elderly are scarce. That is the reason why the objective of this study is to analyze whether the physical-psychological state, sports practice, and the use of socio-health ... ...

    Abstract Studies that analyze the predictors of satisfaction with the health of the elderly are scarce. That is the reason why the objective of this study is to analyze whether the physical-psychological state, sports practice, and the use of socio-health resources are factors that predict satisfaction with health status in physically active elderly people. The Physical Activity and Quality of Life questionnaires were applied to a sample of 397 elderly people in this cross-sectional observational study. The data have been analyzed using Student's
    Language English
    Publishing date 2023-02-18
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2308-3417
    ISSN (online) 2308-3417
    DOI 10.3390/geriatrics8010027
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  5. Article ; Online: A Systematic Review of Potential Biomarkers for Bacterial Burden and Treatment Efficacy Assessment in Tuberculosis Platform-Based Clinical Trials.

    Espinosa-Pereiro, Juan / Alagna, Riccardo / Saluzzo, Francesca / González-Moreno, Jesús / Heinrich, Norbert / Sánchez-Montalvá, Adrián / Cirillo, Daniela Maria

    The Journal of infectious diseases

    2023  Volume 229, Issue 5, Page(s) 1584–1595

    Abstract: Adaptive platform trials can be more efficient than classic trials for developing new treatments. Moving from culture-based to simpler- or faster-to-measure biomarkers as efficacy surrogates may enhance this advantage. We performed a systematic review of ...

    Abstract Adaptive platform trials can be more efficient than classic trials for developing new treatments. Moving from culture-based to simpler- or faster-to-measure biomarkers as efficacy surrogates may enhance this advantage. We performed a systematic review of treatment efficacy biomarkers in adults with tuberculosis. Platform trials can span different development phases. We grouped biomarkers as: α, bacterial load estimates used in phase 2a trials; β, early and end-of treatment end points, phase 2b-c trials; γ, posttreatment or trial-level estimates, phase 2c-3 trials. We considered as analysis unit (biomarker entry) each combination of biomarker, predicted outcome, and their respective measurement times or intervals. Performance metrics included: sensitivity, specificity, area under the receiver-operator curve (AUC), and correlation measures, and classified as poor, promising, or good. Eighty-six studies included 22 864 participants. From 1356 biomarker entries, 318 were reported with the performance metrics of interest, with 103 promising and 41 good predictors. Group results were: α, mycobacterial RNA and lipoarabinomannan (LAM) in sputum, and host metabolites in urine; β, mycobacterial RNA and host transcriptomic or cytokine signatures for early treatment response; and γ, host transcriptomics for recurrence. A combination of biomarkers from different categories could help in designing more efficient platform trials. Efforts to develop efficacy surrogates should be better coordinated.
    MeSH term(s) Humans ; Biomarkers/urine ; Tuberculosis/drug therapy ; Tuberculosis/diagnosis ; Mycobacterium tuberculosis/genetics ; Bacterial Load ; Treatment Outcome ; Antitubercular Agents/therapeutic use ; Clinical Trials as Topic
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad482
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  6. Article ; Online: Community engagement in tuberculosis research: the EU-Patient-cEntric clinicAl tRial pLatforms (EU-PEARL) experience.

    Saluzzo, Francesca / Espinosa-Pereiro, Juan / Dressler, Stephan / Tàvora Dos Santos Filho, Ezio / Seidel, Stephanie / Gonzalez Moreno, Jesus / Heinrich, Norbert / Sanchez-Montalva, Adrian / Cirillo, Daniela Maria

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2023  Volume 130 Suppl 1, Page(s) S20–S24

    Abstract: Objectives: Community representatives are key to ensuring that tuberculosis (TB) research is relevant, culturally sensitive, and appropriate. For all trials (new drugs or treatment regimens, diagnostics, or vaccines) this can result in improvement of ... ...

    Abstract Objectives: Community representatives are key to ensuring that tuberculosis (TB) research is relevant, culturally sensitive, and appropriate. For all trials (new drugs or treatment regimens, diagnostics, or vaccines) this can result in improvement of recruitment, retention, and adherence to the trial schedule. The early engagement of the community will, later in time, support the process of implementation of new policies designed for successful products. We aim at developing a structured protocol for the early engagement of TB community representatives developed in the context of the EU-Patient-cEntric clinicAl tRial pLatforms (EU-PEARL) project.
    Design: The EU-PEARL Innovative Medicine Initiative 2 (IMI2) project TB work package has developed a community engagement (CE) framework to ensure fair and efficient participation of the community in the design and implementation of TB clinical platform trials.
    Results: We showed that early engagement of the EU-PEARL community advisory board highly contributes to the process of development of a community-acceptable Master Protocol Trial and Intervention-Specific Appendixes. We identified capacity building and training as major gaps in advancing CE in the TB field.
    Conclusion: Developing strategies to address these needs can contribute to preventing tokenism and increase the acceptability and appropriateness of TB research.
    MeSH term(s) Humans ; Patient-Centered Care ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/prevention & control ; Community Participation
    Language English
    Publishing date 2023-03-09
    Publishing country Canada
    Document type Clinical Trial ; Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2023.03.008
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  7. Article ; Online: Exeporfinium chloride (XF-73) nasal gel dosed over 24 hours prior to surgery significantly reduced

    Mangino, Julie E / Firstenberg, Michael S / Milewski, Rita K C / Rhys-Williams, William / Lees, James P / Dane, Aaron / Love, William G / Gonzalez Moreno, Jesus

    Infection control and hospital epidemiology

    2023  Volume 44, Issue 7, Page(s) 1171–1173

    Abstract: We studied 83 cardiac-surgery patients with ... ...

    Abstract We studied 83 cardiac-surgery patients with nasal
    MeSH term(s) Humans ; Staphylococcus aureus ; Chlorides/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Nose ; Staphylococcal Infections/drug therapy ; Cardiac Surgical Procedures/adverse effects ; Carrier State/drug therapy
    Chemical Substances Chlorides ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Randomized Controlled Trial ; Clinical Trial, Phase II ; Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2023.17
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