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Article ; Online: Vigencia de la velocidad de sedimentación globular.

Alende-Castro, Vanesa / González-Quintela, Arturo

2023 Volume 161, Issue 3, Page(s) 110–112

Title translation	Current validity of the erythrocyte sedimentation rate.
MeSH term(s)	Humans ; Blood Sedimentation
Language	Spanish
Publishing date	2023-03-24
Publishing country	Spain
Document type	Editorial
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2023.02.005
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Article ; Online: Are corticosteroids safe in adolescent and adult patients with infectious mononucleosis? A retrospective cohort study.

Páez-Guillán, Emilio-Manuel / Campos-Franco, Joaquín / Alende, Rosario / González-Quintela, Arturo

Enfermedades infecciosas y microbiologia clinica (English ed.)

2024

Abstract: Background and aim: The use of systemic corticosteroids during Epstein-Barr virus (EBV)-induced infectious mononucleosis is a controversial but widespread practice. We aimed to investigate the frequency of complications in adolescents and adults with ... ...

Abstract	Background and aim: The use of systemic corticosteroids during Epstein-Barr virus (EBV)-induced infectious mononucleosis is a controversial but widespread practice. We aimed to investigate the frequency of complications in adolescents and adults with infectious mononucleosis in relation to the use of corticosteroids. Methods: We reviewed the clinical records of 396 patients admitted to the hospital with infectious mononucleosis (52.0% male; median age, 19 years; range, 15-87 years), with a focus on both short-term (infectious and non-infectious) and long-term (hematological malignancies) complications in relation to corticosteroid use. Results: A total of 155 (38.6%) patients received corticosteroids at some point during infectious mononucleosis. Corticosteroid use was significantly (P≤0.002) associated with sore throat, lymphadenopathy, leukocytosis, and with antibiotics use (mainly indicated after suspicion of tonsillar bacterial superinfection). Overall, 139/155 (89.7%) patients who were treated with corticosteroids also received antibiotics either before or during hospitalization, compared with 168/241 (69.7%) patients who did not. The frequency of short-term severe complications, either infectious (peritonsillar-parapharyngeal abscess or bacteremia) or non-infectious (splenic rupture, severe thrombocytopenia, myopericarditis, or lymphocytic meningitis) were similar in patients receiving and not receiving corticosteroids. After a median of 15 years of follow-up, only one Hodgkin's lymphoma was diagnosed, in a patient who was not treated with corticosteroids during infectious mononucleosis. Conclusions: The use of systemic corticosteroids during EBV-induced infectious mononucleosis is generally safe, at least with concomitant antibiotic therapy. However, this should not encourage the use of corticosteroids in this context, given that their efficacy has yet to be demonstrated.
Language	English
Publishing date	2024-01-11
Publishing country	Spain
Document type	Journal Article
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2023.10.005
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Article: Hematological Abnormalities Beyond Lymphocytosis During Infectious Mononucleosis: Epstein-Barr Virus-Induced Thrombocytopenia.

Páez-Guillán, Emilio-Manuel / Campos-Franco, Joaquín / Alende, Rosario / Gonzalez-Quintela, Arturo

Mediterranean journal of hematology and infectious diseases

2023 Volume 15, Issue 1, Page(s) e2023023

Abstract: Background: Thrombocytopenia during Epstein-Barr virus mononucleosis is well-known; however, no recent series have investigated its frequency, associated factors, and evolution. The present study aimed to investigate platelet count characteristics in ... ...

Abstract	Background: Thrombocytopenia during Epstein-Barr virus mononucleosis is well-known; however, no recent series have investigated its frequency, associated factors, and evolution. The present study aimed to investigate platelet count characteristics in adult patients with infectious mononucleosis. Methods: We reviewed the clinical records of 400 patients admitted to the hospital with infectious mononucleosis (52.0% male; median age, 19 years [range, 15-87 years]), focusing on blood platelet counts, thrombocytopenia prevalence and outcomes. Results: Thrombocytopenia (platelet count ≤150 ×10 Conclusions: Transient thrombocytopenia is common during infectious mononucleosis in adult patients. Patients with thrombocytopenia have distinct clinical and biological features; it is typically mild during infectious mononucleosis. Cases of severe thrombocytopenia are rare and were not associated with hemorrhagic complications in this series.
Language	English
Publishing date	2023-03-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2674750-9
ISSN	2035-3006
ISSN	2035-3006
DOI	10.4084/MJHID.2023.023
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Article: Association of a Novel Homozygous Variant in

Barbosa-Gouveia, Sofía / Fernández-Crespo, Silvia / Lazaré-Iglesias, Héctor / González-Quintela, Arturo / Vázquez-Agra, Néstor / Hermida-Ameijeiras, Álvaro

Journal of clinical medicine

2023 Volume 12, Issue 7

Abstract: Tangier disease (TD) is a rare autosomal recessive disorder caused by a variant in ... ...

Abstract	Tangier disease (TD) is a rare autosomal recessive disorder caused by a variant in the
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12072596
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Article ; Online: Reproducibility of continuous glucose monitoring results under real-life conditions in an adult population: a functional data analysis.

Matabuena, Marcos / Pazos-Couselo, Marcos / Alonso-Sampedro, Manuela / Fernández-Merino, Carmen / González-Quintela, Arturo / Gude, Francisco

Scientific reports

2023 Volume 13, Issue 1, Page(s) 13987

Abstract: Continuous glucose monitoring systems (CGM) are a very useful tool to understand the behaviour of glucose in different situations and populations. Despite the widespread use of CGM systems in both clinical practice and research, our understanding of the ... ...

Abstract	Continuous glucose monitoring systems (CGM) are a very useful tool to understand the behaviour of glucose in different situations and populations. Despite the widespread use of CGM systems in both clinical practice and research, our understanding of the reproducibility of CGM data remains limited. The present work examines the reproducibility of the results provided by a CGM system in a random sample of a free-living adult population, from a functional data analysis approach. Functional intraclass correlation coefficients (ICCs) and their 95% confidence intervals (CI) were calculated to assess the reproducibility of CGM results in 581 individuals. 62% were females 581 participants (62% women) mean age 48 years (range 18-87) were included, 12% had previously been diagnosed with diabetes. The inter-day reproducibility of the CGM results was greater for subjects with diabetes (ICC 0.46 [CI 0.39-0.55]) than for normoglycaemic subjects (ICC 0.30 [CI 0.27-0.33]); the value for prediabetic subjects was intermediate (ICC 0.37 [CI 0.31-0.42]). For normoglycaemic subjects, inter-day reproducibility was poorer among the younger (ICC 0.26 [CI 0.21-0.30]) than the older subjects (ICC 0.39 [CI 0.32-0.45]). Inter-day reproducibility was poorest among normoglycaemic subjects, especially younger normoglycaemic subjects, suggesting the need to monitor some patient groups more often than others.
MeSH term(s)	Humans ; Adult ; Female ; Adolescent ; Young Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Male ; Blood Glucose ; Blood Glucose Self-Monitoring ; Reproducibility of Results ; Data Analysis ; Glucose
Chemical Substances	Blood Glucose ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-08-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-40949-1
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Article ; Online: The Unsolved Relationship of Alcohol and Asthma.

Linneberg, Allan / Gonzalez-Quintela, Arturo

International archives of allergy and immunology

2016 Volume 171, Issue 3-4, Page(s) 155–157

MeSH term(s)	Alcohol Drinking/adverse effects ; Alcohols/adverse effects ; Animals ; Asthma/etiology ; Disease Models, Animal ; Humans ; Mice
Chemical Substances	Alcohols
Language	English
Publishing date	2016
Publishing country	Switzerland
Document type	Editorial ; Letter
ZDB-ID	1108932-5
ISSN	1423-0097 ; 1018-2438
ISSN (online)	1423-0097
ISSN	1018-2438
DOI	10.1159/000454809
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Article ; Online: Transient hypertriglyceridemia: a common finding during Epstein-Barr virus-induced infectious mononucleosis.

Páez-Guillán, Emilio-Manuel / Campos-Franco, Joaquín / Alende, Rosario / Garitaonaindía, Yago / González-Quintela, Arturo

Lipids in health and disease

2021 Volume 20, Issue 1, Page(s) 177

Abstract: Background: Hypertriglyceridemia can occur in lymphoproliferative disorders. Infectious mononucleosis is a self-limiting, benign lymphoproliferative disorder. This study aimed to investigate the serum triglyceride concentrations and their change over ... ...

Abstract	Background: Hypertriglyceridemia can occur in lymphoproliferative disorders. Infectious mononucleosis is a self-limiting, benign lymphoproliferative disorder. This study aimed to investigate the serum triglyceride concentrations and their change over time in patients with infectious mononucleosis. Methods: We evaluated an adult patient with severe hypertriglyceridemia (>1000 mg/dL) during infectious mononucleosis and reviewed the records of 360 patients admitted to our hospital because of infectious mononucleosis (median age, 19 years; range, 15-87 years; 51.4% male). We compared the serum triglyceride concentrations with those of a control sample from the general population (n=75). A second triglyceride measurement, obtained during convalescence (median of 30 days after the initial determination), was available for 160 patients. Results: The triglyceride concentrations in the acute phase (median: 156 mg/dL) were significantly higher than those of the controls (median, 76 mg/dL; P<0.001). A total of 194 (53.9%) patients presented with hypertriglyceridemia (>150 mg/dL), which was more common in the patients older than 30 years than in the younger patients (78.6% vs. 50.6%; P<0.001). A significant correlation (P<0.005) was observed between the triglyceride levels and white blood cell counts, total cholesterol levels, and liver damage markers. The triglyceride concentrations decreased during convalescence (P<0.001) and were lower than the initial measurement in 83.7% of the cases. Conversely, the total cholesterol concentrations during the acute phase were lower than those of the controls and increased during convalescence (P<0.001). Conclusions: Patients with severe infectious mononucleosis frequently show mild, transient hypertriglyceridemia. Further studies are needed to elucidate the mechanisms underlying this finding.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Cholesterol/blood ; Female ; Herpesvirus 4, Human ; Humans ; Hypertriglyceridemia/etiology ; Hypertriglyceridemia/virology ; Infectious Mononucleosis/blood ; Infectious Mononucleosis/complications ; Infectious Mononucleosis/metabolism ; Male ; Middle Aged ; Time Factors ; Triglycerides/blood ; Young Adult
Chemical Substances	Triglycerides ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2021-12-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2091381-3
ISSN	1476-511X ; 1476-511X
ISSN (online)	1476-511X
ISSN	1476-511X
DOI	10.1186/s12944-021-01603-9
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Article ; Online: Temporal trends in the incidence and prevalence of Multiple Sclerosis in the Northwest of Spain.

Costa-Arpín, Eva / Ares, Begoña / González-Quintela, Arturo / Prieto-González, José

Multiple sclerosis and related disorders

2021 Volume 52, Page(s) 102979

Abstract: Background: During the last decades, the frequency of multiple sclerosis (MS) is increasing worldwide. Nevertheless, the higher sensibility of the new diagnostic criteria obscures the comparison between studies performed in different decades.: Methods! ...

Abstract	Background: During the last decades, the frequency of multiple sclerosis (MS) is increasing worldwide. Nevertheless, the higher sensibility of the new diagnostic criteria obscures the comparison between studies performed in different decades. Methods: The evolution of the frequency of MS in Santiago de Compostela (North-West of Spain) between 2003 and 2015 was analyzed using Poisson regression. The diagnosis was confirmed according to Poser criteria. Several sources were consulted for case ascertainment: databases from the MS Unit, the Infusion Center, and the Departments of Neurology, Pharmacy, Pediatric Neurology and Codification of the public Hospital of Santiago, private hospitals, neurologists with private activity, general practitioners, and associations of patients. Results: In 12 years, the prevalence increased from 68 to 143 cases/100,000 inhabitants, from 83 to 176 in females; and from 49 to 106 in males (p <0.0001, 0.0001, and 0.0002 respectively). The incidence rise was not significant (from 5 to 8 cases/ 100,000 inhabitants/ year (p=0.4243). The mean age of the population growth 5.7 years (p=0.008). The changes in female: male ratio (12.9%), in the age at the first symptom (2.2 years), and the diagnosis delay (0.12 years) did not achieve significance (p=0.7750, 0.1606, 0.8581). Conclusion: The prevalence of MS doubled in 12 years whilst the difference in incidence was lower and not significant. The disproportion in the growth of both parameters, as well as the higher mean age in the last study, suggest a longer survival of patients with MS.
MeSH term(s)	Child ; Child, Preschool ; Databases, Factual ; Female ; Humans ; Incidence ; Male ; Multiple Sclerosis ; Prevalence ; Spain
Language	English
Publishing date	2021-04-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2645330-7
ISSN	2211-0356 ; 2211-0348
ISSN (online)	2211-0356
ISSN	2211-0348
DOI	10.1016/j.msard.2021.102979
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Article ; Online: Jaundice in relation to immune activation during Epstein-Barr virus-induced infectious mononucleosis.

Páez-Guillán, Emilio-Manuel / Campos-Franco, Joaquín / Alende, Rosario / Lázare, Héctor / Beceiro, Carmen / Gonzalez-Quintela, Arturo

The American journal of the medical sciences

2022 Volume 365, Issue 3, Page(s) 270–278

Abstract: Background: Liver involvement during infectious mononucleosis is common, but jaundice is considered rare. This study aimed to investigate serum bilirubin concentrations in patients with infectious mononucleosis and immune abnormalities associated with ... ...

Abstract	Background: Liver involvement during infectious mononucleosis is common, but jaundice is considered rare. This study aimed to investigate serum bilirubin concentrations in patients with infectious mononucleosis and immune abnormalities associated with jaundice. Methods: We report on an adult patient with monoclonal B lymphocytosis and IgM-lambda gammopathy who developed a severe icteric hepatitis during infectious mononucleosis. We then reviewed the clinical records of 389 patients admitted to the hospital with infectious mononucleosis between 1995 and 2018 (51.7% male patients; median age, 19 years; range, 15-87 years) with focus on liver abnormalities and associated factors. Results: Fifty-nine patients (15.1%) had serum bilirubin concentrations between 1.5 and 3 mg/dL, and 47 patients (12.0%) had serum bilirubin >3 mg/dL. Patients with increased bilirubin concentrations had a distinct clinical presentation, with more frequent abdominal pain, nausea and vomiting, and less frequent sore throat than patients with normal bilirubin. Age and sex were not significantly different for the patients with increased and normal serum bilirubin concentrations. The patients with increased serum bilirubin concentrations showed higher levels of immune activation markers than the patients with normal bilirubin, including blood lymphocyte counts, serum IgM, and β Conclusions: Transient hyperbilirubinemia is common during severe (in-hospital) infectious mononucleosis in adult patients. Patients with hyperbilirubinemia have less frequent pharyngitis symptoms and more frequent abdominal symptoms. Hyperbilirubinemia during infectious mononucleosis is associated with immune activation markers.
MeSH term(s)	Adult ; Humans ; Male ; Young Adult ; Female ; Infectious Mononucleosis/complications ; Herpesvirus 4, Human ; Epstein-Barr Virus Infections/complications ; Jaundice/complications ; Jaundice/diagnosis ; Hyperbilirubinemia/complications ; Bilirubin ; Immunoglobulin M
Chemical Substances	Bilirubin (RFM9X3LJ49) ; Immunoglobulin M
Language	English
Publishing date	2022-12-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	82078-7
ISSN	1538-2990 ; 0002-9629
ISSN (online)	1538-2990
ISSN	0002-9629
DOI	10.1016/j.amjms.2022.12.004
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Article: Implications of Inflammatory and Oxidative Stress Markers in the Attenuation of Nocturnal Blood Pressure Dipping.

Hermida-Ameijeiras, Alvaro / Vazquez-Agra, Nestor / Cruces-Sande, Anton / Mendez-Alvarez, Estefania / Soto-Otero, Ramon / Lopez-Paz, Jose-Enrique / Pose-Reino, Antonio / Gonzalez-Quintela, Arturo

Journal of clinical medicine

2023 Volume 12, Issue 4

Abstract: To date, no model has jointly encompassed clinical, inflammatory, and redox markers with the risk of a non-dipper blood pressure (BP) profile. We aimed to evaluate the correlation between these features and the main twenty-four-hour ambulatory blood ... ...

Abstract	To date, no model has jointly encompassed clinical, inflammatory, and redox markers with the risk of a non-dipper blood pressure (BP) profile. We aimed to evaluate the correlation between these features and the main twenty-four-hour ambulatory blood pressure monitoring (24-h ABPM) indices, as well as to establish a multivariate model including inflammatory, redox, and clinical markers for the prediction of a non-dipper BP profile. This was an observational study that included hypertensive patients older than 18 years. We enrolled 247 hypertensive patients (56% women) with a median age of 56 years. The results showed that higher levels of fibrinogen, tissue polypeptide-specific antigen, beta-2-microglobulin, thiobarbituric acid reactive substances, and copper/zinc ratio were associated with a higher risk of a non-dipper BP profile. Nocturnal systolic BP dipping showed a negative correlation with beta-globulin, beta-2-microglobulin, and gamma-globulin levels, whereas nocturnal diastolic BP dipping was positively correlated with alpha-2-globulin levels, and negatively correlated with gamma-globulin and copper levels. We found a correlation between nocturnal pulse pressure and beta-2-microglobulin and vitamin E levels, whereas the day-to-night pulse pressure gradient was correlated with zinc levels. Twenty-four-hour ABPM indices could exhibit singular inflammatory and redox patterns with implications that are still poorly understood. Some inflammatory and redox markers could be associated with the risk of a non-dipper BP profile.
Language	English
Publishing date	2023-02-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12041643
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