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Article ; Online: Update and clinical management of anti-DNA auto-antibodies.

González Rodríguez, Concepción / Aparicio Hernández, MªBelén / Alarcón Torres, Inmaculada

Advances in laboratory medicine

2021 Volume 2, Issue 3, Page(s) 313–331

Abstract: Anti-deoxyribonucleic acid (DNA) antibodies in the clinical laboratory are intimately linked to the diagnosis and monitoring of systemic lupus erythematosus (SLE); however, the characteristics of the analytical methods and the properties of the ... ...

Abstract	Anti-deoxyribonucleic acid (DNA) antibodies in the clinical laboratory are intimately linked to the diagnosis and monitoring of systemic lupus erythematosus (SLE); however, the characteristics of the analytical methods and the properties of the antibodies themselves are heterogeneous. To review the definition and properties of anti-double-stranded anti-DNA (anti-dsDNA) antibodies, the adequacy of analytical methods, and the clinical requirements for this biomarker. Through PubMed we searched the existing literature with the terms anti-dsDNA, editorial, review, guideline, meta-analysis and SLE. The last search, anti-dsDNA and SLE restricted to the last two years. Information was expanded through related articles and those published in official state bodies related to anti-dsDNA and SLE. Clinical laboratory methods for anti-dsDNA analysis and their characteristics are analyze. The clinical utility of anti-dsDNA in its diagnostic, clinical association and follow-up aspects of SLE is reviewed. There is wide variability in analytical methods and deficits in standardization persist. They are part of the current SLE classification criteria and are used as markers in the follow-up of the disease. Their diagnostic usefulness improves when they are determined in antinuclear antibody (ANA)-positive patients. In follow-up, quantification is of interest, preferably with the same analytical method (given the deficits in standardization).
Language	Spanish
Publishing date	2021-04-26
Publishing country	Germany
Document type	Journal Article ; Review
ISSN	2628-491X
ISSN (online)	2628-491X
DOI	10.1515/almed-2021-0008
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Article: The HLA-DQA1*05 genotype does not influence the clinical response to ustekinumab and vedolizumab.

Navajas Hernández, Pilar / Del Pino Bellido, Pilar / Lorenzo González, Laura / González Rodríguez, Concepción / Pérez Pérez, Antonio / Argüelles Arias, Federico

Revista espanola de enfermedades digestivas

2023 Volume 115, Issue 11, Page(s) 608–614

Abstract: Background: the success of strategies with earlier anti-TNF drugs for the treatment of inflammatory bowel disease (IBD) have been shadowed by the development of anti-drug antibodies that reduce their effectiveness. The HLA-DQA1*05 allele has been shown ... ...

Abstract	Background: the success of strategies with earlier anti-TNF drugs for the treatment of inflammatory bowel disease (IBD) have been shadowed by the development of anti-drug antibodies that reduce their effectiveness. The HLA-DQA105 allele has been shown to increase the risk of immunogenicity to anti-TNF drugs by approximately two-fold. The negative impact of this allele has not been fully investigated for newer biotherapies. Objective:* whether the presence of the HLA-DQA105 allele is associated with a reduction of response to ustekinumab and vedolizumab was investigated. Material and methods:* the impact of HLA-DQA105 on disease activity in 93 patients with IBD, treated with ustekinumab (n = 39) or vedolizumab (n = 54) was investigated in a retrospective cohort study. Treatment response and remission was assessed at 6 and 12 months for ustekinumab, and up to 18 and 24 months for vedolizumab, using Harvey-Bradshaw index (Crohn's disease) and Mayo score (ulcerative colitis). Results:* the HLA-DQA105 allele was found in 35.9 % and 38.9 % of patients treated with ustekinumab and vedolizumab, respectively. Clinical response was not affected by the presence of the HLA-DQA105 allele for both treatment groups. Conclusions: in contrast to anti-TNF drugs, HLA-DQA1*05 presence does not correlate with the decreased response to ustekinumab or vedolizumab.
MeSH term(s)	Humans ; Ustekinumab/therapeutic use ; Retrospective Studies ; Tumor Necrosis Factor Inhibitors ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/genetics ; Genotype
Chemical Substances	vedolizumab (9RV78Q2002) ; Ustekinumab (FU77B4U5Z0) ; HLA-DQA1 antigen ; Tumor Necrosis Factor Inhibitors
Language	English
Publishing date	2023-06-13
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.17235/reed.2023.9491/2023
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Article ; Online: Study of the diagnostic efficiency of anti-ZnT8 autoantibodies for type 1 diabetes in pediatric patients.

Fuentes-Cantero, Sandra / González-Rodríguez, Concepción / Rodríguez-Chacón, Carmen / Galvan-Toribio, Raquel / Hermosín-Escudero, Joaquín / Pérez-Pérez, Antonio / León-Justel, Antonio

Laboratory medicine

2023

Abstract: Objective: Zinc transporter 8 autoantibodies (ZNt8A) are 1 of the 4 main autoantibodies used for the diagnosis of type 1 diabetes (T1D), with glutamic acid decarboxylase autoantibodies (GADA), islet antigen-2 autoantibodies (IA-2A), and insulin ... ...

Abstract	Objective: Zinc transporter 8 autoantibodies (ZNt8A) are 1 of the 4 main autoantibodies used for the diagnosis of type 1 diabetes (T1D), with glutamic acid decarboxylase autoantibodies (GADA), islet antigen-2 autoantibodies (IA-2A), and insulin autoantibodies (IAA). The objective of this study is to evaluate the diagnostic efficiency of these autoantibodies for the diagnosis of T1D in pediatric patients. Methods: A retrospective analysis of patients under 16 years of age with suspected T1D was made between June 2020 and January 2021. A total of 80 patients were included in the study, with 1 sample per patient. Subjects were classified according to diagnosis. Results: Of the subjects included in the study, 50 developed T1D. The diagnostic efficacy was IA-2A (cutoff ≥ 28 U/L) sensitivity 0.26 (95% CI: 0.14-0.38) and specificity 0.97 (95% CI: 0.79-1.0); GADA (cutoff ≥ 17 U/mL) sensitivity 0.40 (95% CI: 0.26-0.54) and specificity 0.87 (95% CI: 0.75-0.99); ZnT8A (cut off ≥ 15 U/L) sensitivity 0.62 (95% CI: 0.49-0.75) and specificity 0.97 (95% CI: 0.90-1.0). ZnT8A obtained the most significantly global diagnostic accuracy (0.75), and GADA with ZnT8A showed the highest correlation. Conclusion: The results obtained indicate a higher efficiency of anti-ZnT8 autoantibodies for the diagnosis of T1D in pediatric patients. Clinical efficiency of diabetic autoantibodies is method and assay dependent and influences combined diagnostic strategies.
Language	English
Publishing date	2023-09-02
Publishing country	England
Document type	Journal Article
ZDB-ID	391758-7
ISSN	1943-7730 ; 0007-5027
ISSN (online)	1943-7730
ISSN	0007-5027
DOI	10.1093/labmed/lmad079
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Article ; Online: Comparison of the analytical and clinical performances of two different routine testing protocols for antinuclear antibody screening.

González Rodríguez, Concepción / Fuentes Cantero, Sandra / Pérez Pérez, Antonio / Vázquez Barbero, Francisco Javier / León Justel, Antonio

Journal of clinical laboratory analysis

2021 Volume 35, Issue 9, Page(s) e23914

Abstract: Background: The diagnosis of systemic autoimmune rheumatic diseases (SARD) is based on the detection of serum antinuclear antibodies (ANA) for which indirect immunofluorescence (IIF) is the golden standard. New solid-phase immunoassays have been ... ...

Abstract	Background: The diagnosis of systemic autoimmune rheumatic diseases (SARD) is based on the detection of serum antinuclear antibodies (ANA) for which indirect immunofluorescence (IIF) is the golden standard. New solid-phase immunoassays have been developed to be used alone or in combination with the detection of extractable antinuclear antibodies (ENA) to improve SARD diagnosis. The purpose of this study was to compare the clinical performances of different ANA screening methods alone or in combination with ENA screening methods for SARD diagnosis. Methods: A total of 323 patients were screened for ANA by IIF, EliA™ CTD Screen, and ELISA methods. Agreements were calculated between the methods. Then, EliA™ CTD Screen positive samples were screened for ENA by line immunoassay (LIA) and fluorescence enzyme immunoassay (FEIA). Results: The diagnostic accuracy of EliA™ CTD Screen (79% sensitivity and 91% specificity) was better than that of ELISA or IIF. The combination of EliA™ CTD plus IIF had the highest sensitivity (93%). ENA determination revealed that Ro52 and Ro60 were the most prevalent specificities. The use of IIF alone was not able of detecting up to 36% of samples positive for Ro52, and 41% for Ro60. Conclusions: EliA™ CTD Screen has a better diagnostic performance when compared to IIF and ELISA. The combined use of EliA™ CTD Screen and IIF clearly improves the rate and accuracy of SARD diagnosis. The use of EliA™ CTD Screen as first-line screening technique allows the detection of antibodies, which could not be detected by IIF alone.
MeSH term(s)	Antibodies, Antinuclear/blood ; Antibodies, Antinuclear/immunology ; Autoimmune Diseases/blood ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/immunology ; Blood Coagulation Tests/methods ; Enzyme-Linked Immunosorbent Assay/methods ; Female ; Fluorescent Antibody Technique, Indirect/methods ; Humans ; Immunoassay/methods ; Immunoenzyme Techniques/methods ; Male ; Mass Screening/methods ; Middle Aged ; Rheumatic Diseases/blood ; Rheumatic Diseases/diagnosis ; Rheumatic Diseases/immunology
Chemical Substances	Antibodies, Antinuclear
Language	English
Publishing date	2021-08-04
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	645095-7
ISSN	1098-2825 ; 0887-8013
ISSN (online)	1098-2825
ISSN	0887-8013
DOI	10.1002/jcla.23914
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Article ; Online: Screening for Gestational Diabetes Mellitus by Measuring Glycated Hemoglobin Can Reduce the Use of the Glucose Challenge Test.

Maesa, Jose Maria / Fernandez-Riejos, Patricia / Gonzalez-Rodriguez, Concepcion / Sanchez-Margalet, Victor

Annals of laboratory medicine

2019 Volume 39, Issue 6, Page(s) 524–529

Abstract: Background: Physiological changes during pregnancy, such as dilutional anemia and a reduced half-life of red blood cells, have prevented the use of glycated Hb (HbA: Methods: This case-control study involved 607 pregnant women between the 24th and ... ...

Abstract	Background: Physiological changes during pregnancy, such as dilutional anemia and a reduced half-life of red blood cells, have prevented the use of glycated Hb (HbA Methods: This case-control study involved 607 pregnant women between the 24th and 28th week of gestation. HbA Results: The AUC for HbA Conclusions: HbA
MeSH term(s)	Adult ; Area Under Curve ; Biomarkers/blood ; Case-Control Studies ; Diabetes, Gestational/diagnosis ; Female ; Gestational Age ; Glucose Tolerance Test ; Glycated Hemoglobin A/analysis ; Humans ; Pregnancy ; ROC Curve ; Sensitivity and Specificity
Chemical Substances	Biomarkers ; Glycated Hemoglobin A
Language	English
Publishing date	2019-06-25
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2677441-0
ISSN	2234-3814 ; 2234-3806
ISSN (online)	2234-3814
ISSN	2234-3806
DOI	10.3343/alm.2019.39.6.524
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Article ; Online: Effects of the COVID-19 pandemic on the activity of clinical laboratories in Spain, evolution in the 2019-2021 period.

Lasierra Monclús, Ana Belén / González, Álvaro / Bernabéu Andreu, Francisco A / Caballé Martín, Imma / Buño Soto, Antonio / Ibarz, Mercè / González Rodríguez, Concepción / Puzo Foncillas, José

Advances in laboratory medicine

2022 Volume 3, Issue 4, Page(s) 361–382

Abstract: Objectives: To assess the impact of the COVID-19 pandemic on the activity of clinical laboratories in Spain.: Methods: A descriptive, observational, retrospective, multicenter study.: Results: Between March and December 2020, there was a ... ...

Abstract	Objectives: To assess the impact of the COVID-19 pandemic on the activity of clinical laboratories in Spain. Methods: A descriptive, observational, retrospective, multicenter study. Results: Between March and December 2020, there was a statistically significant decrease in the number of test requests (-17.7%, p=<0.001) and total tests performed (-18.3%, p<0.001) with respect to the same period in 2019. A decrease was observed in the number of requests from primary care (-37.4%) (p<0.001) and in the number of foecal occult blood (-45.8%); qualitative urine (-30.1%); PSA (-28.5%); TSH (-27.8%); total cholesterol (-27.2%) and HbA Conclusions: There were changes in the origin and number of test requested to clinical laboratories in Spain. The number of requests for the evaluation and monitoring of COVID-19 patients increased, whereas requests for the control of non-COVID patients and for population screening decreased. Long-term analysis reveals that the volume of tests performed for the control of chronic diseases returned to normal over time, whereas the increase observed in the volume of tests performed for the management of COVID-19 patients is maintained.
Language	Spanish
Publishing date	2022-12-06
Publishing country	Germany
Document type	Journal Article
ISSN	2628-491X
ISSN (online)	2628-491X
DOI	10.1515/almed-2022-0107
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Article: Fasting Glycemia as Screening Tool to Rule-Out Gestational Diabetes in Low-Risk Population.

Maesa, Jose-Maria / Fernandez-Riejos, Patricia / Sanchez-Margalet, Victor / Gonzalez-Rodriguez, Concepcion

Clinical laboratory

2018 Volume 64, Issue 4, Page(s) 461–465

Abstract: Background: The use of a glucose challenge test as the universal screening for gestational diabetes is common in many countries. This test represents significant costs for laboratories and inconveniences for the patients, who have to wait for one hour ... ...

Abstract	Background: The use of a glucose challenge test as the universal screening for gestational diabetes is common in many countries. This test represents significant costs for laboratories and inconveniences for the patients, who have to wait for one hour and, very often, feel discomfort and nausea. In this work we propose the use of fasting glycemia, in a population with low prevalence of gestational diabetes as a pre-screening test that would avoid the oral glucose overload in those pregnant women with low risk of gestational diabetes. Methods: The study was done with the fasting glucose levels of 6,573 pregnant women who underwent a two steps strategy to screen for gestational diabetes, a first step consisting of a 50 g glucose challenge test, followed when glycemia ≥ 140 mg/dL by a 100 g Oral Glucose Tolerance Test, based on recommendations made by National Diabetes Data Group. Results: The ROC curve for fasting glucose was calculated, and we obtained an AUC = 0.633 (0.569 - 0.696). The sensitivity, specificity, and predictive values were established for different thresholds. Conclusions: We proposed that women with fasting glycemia ≤ 62 mg/dL, (S = 91.3%, NPV = 98.79% and LR- = 0.87) are in low risk of suffering gestational diabetes, which means that 10% of our population would not undergo the glucose challenge test.
MeSH term(s)	Adult ; Blood Glucose/metabolism ; Diabetes, Gestational/blood ; Diabetes, Gestational/diagnosis ; Fasting/blood ; Female ; Glucose Tolerance Test ; Humans ; Mass Screening/methods ; Pregnancy ; ROC Curve ; Retrospective Studies
Chemical Substances	Blood Glucose
Language	English
Publishing date	2018-05-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2017.170920
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Article ; Online: Evaluation of health outcomes after the implementation of rotational thromboelastometry in patients undergoing cardiac surgery.

Rodríguez-Martín, Isabel / Sánchez-Mora, Catalina / Fernández-López, Antonio R / González-Fernández, Francisco J / Téllez-Cantero, Juan Carlos / Blanco-Marquez, Verónica / García de la Borbolla, Mariano / Santos-Jiménez, Juan C / González-Rodríguez, Concepción / Garnacho-Montero, José / Sánchez-Margalet, Víctor

Scandinavian journal of clinical and laboratory investigation

2022 Volume 82, Issue 2, Page(s) 143–149

Abstract: Background: Viscoelastic tests (rotational thromboelastometry, ROTEM: Methods: Retrospective cohort study including 675 patients who underwent cardiac surgery with cardiopulmonary bypass. The incidence of allogeneic blood transfusions and clinical ... ...

Abstract	Background: Viscoelastic tests (rotational thromboelastometry, ROTEM Methods: Retrospective cohort study including 675 patients who underwent cardiac surgery with cardiopulmonary bypass. The incidence of allogeneic blood transfusions and clinical postoperative complications were analyzed before and after ROTEM Results: Following viscoelastic testing and the implementation of a specific algorithm for coagulation management, the incidence of any allogeneic blood transfusion decreased (41.4% vs 31.9%, Conclusions: The monitoring of hemostasis by ROTEM
MeSH term(s)	Cardiac Surgical Procedures/adverse effects ; Humans ; Outcome Assessment, Health Care ; Postoperative Hemorrhage/prevention & control ; Retrospective Studies ; Thrombelastography/methods
Language	English
Publishing date	2022-02-03
Publishing country	England
Document type	Journal Article
ZDB-ID	3150-1
ISSN	1502-7686 ; 0036-5513
ISSN (online)	1502-7686
ISSN	0036-5513
DOI	10.1080/00365513.2022.2034038
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Article ; Online: Association of the Shared Epitope, Smoking and the Interaction Between the Two With the Presence of Autoantibodies (Anti-CCP and RF) in Patients With Rheumatoid Arthritis in a Hospital in Seville, Spain.

García de Veas Silva, José Luis / González Rodríguez, Concepción / Hernández Cruz, Blanca

Reumatologia clinica

2017 Volume 15, Issue 5, Page(s) 289–295

Abstract: Objectives: To evaluate the association of shared epitope, smoking and their interaction on the presence of autoantibodies (anti-cyclic citrullinated peptide [CCP] antibodies and rheumatoid factor) in patients with rheumatoid arthritis in our ... ...

Title translation	Asociación del epítopo compartido, el tabaquismo y la interacción entre ambos con la presencia de autoanticuerpos (anti-PCC y FR) en pacientes con artritis reumatoide en un hospital de Sevilla, España.
Abstract	Objectives: To evaluate the association of shared epitope, smoking and their interaction on the presence of autoantibodies (anti-cyclic citrullinated peptide [CCP] antibodies and rheumatoid factor) in patients with rheumatoid arthritis in our geographical area. Methods: A descriptive and cross-sectional study was carried out in a cohort of 106 patients diagnosed with RA. Odds ratios (OR) for antibody development were calculated for shared epitope, tobacco exposure and smoking dose. Statistical analysis was performed with univariate and multivariate statistics using ordinal logistic regression. Odds ratios were calculated with 95% confidence interval (95% CI) and a value of P<.05 was considered significant. Results: In univariate analysis, shared epitope (OR=2.68; 95% CI: 1.11-6.46), tobacco exposure (OR=2.79; 95% CI: 1.12-6.97) and heavy smoker (>20 packs/year) (OR=8.93; 95% CI: 1.95-40.82) were associated with the presence of anti-CCP antibodies. For rheumatoid factor, the association was only significant for tobacco exposure (OR=3.89; 95% CI: 1.06-14.28) and smoking dose (OR=8.33; 95% CI: 1.05-66.22). By ordinal logistic regression analysis, an association with high titers of anti-CCP (>200U/mL) was identified with South American mestizos, patients with homozygous shared epitope, positive FR and heavy smokers. Conclusions: Being a South American mestizo, having a shared epitope, rheumatoid factor positivity and a smoking dose>20 packs/year are independent risk factors for the development of rheumatoid arthritis with a high titer of anti-CCP (>200U/mL). In shared epitope-positive rheumatoid arthritis patients, the intensity of smoking is more strongly associated than tobacco exposure with an increased risk of positive anti-CCP.
MeSH term(s)	Adult ; Alleles ; Anti-Citrullinated Protein Antibodies ; Arthritis, Rheumatoid/ethnology ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/immunology ; Confidence Intervals ; Cross-Sectional Studies ; Epitopes/genetics ; Epitopes/immunology ; Ex-Smokers/statistics & numerical data ; Female ; HLA-DRB1 Chains ; Humans ; Logistic Models ; Male ; Middle Aged ; Odds Ratio ; Rheumatoid Factor ; Smokers/statistics & numerical data ; Smoking/adverse effects ; Smoking/immunology ; Spain
Chemical Substances	Anti-Citrullinated Protein Antibodies ; Epitopes ; HLA-DRB1 Chains ; Rheumatoid Factor (9009-79-4)
Language	Spanish
Publishing date	2017-11-02
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5743
ISSN (online)	2173-5743
DOI	10.1016/j.reuma.2017.08.013
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Article ; Online: Coexistence of anti-Jo1 and anti-signal recognition particle antibodies in a polymyositis patient.

Melguizo Madrid, Enrique / Fernández Riejos, Patricia / Toyos Sáenz de Miera, Francisco Javier / Fernández Pérez, Berta / González Rodríguez, Concepción

Reumatologia clinica

2018 Volume 15, Issue 6, Page(s) e111–e113

Abstract: Idiopathic inflammatory myopathies are a heterogeneous group of potentially treatable myopathies. They are classified, on the basis of clinical and histopathological features, into four subtypes: dermatomyositis, polymyositis, necrotizing autoimmune ... ...

Title translation	Coexistencia de anticuerpos anti-histidil-tRNA-sintetasa y anti-partícula de reconocimiento de la señal en un paciente con polimiositis.
Abstract	Idiopathic inflammatory myopathies are a heterogeneous group of potentially treatable myopathies. They are classified, on the basis of clinical and histopathological features, into four subtypes: dermatomyositis, polymyositis, necrotizing autoimmune myositis and inclusion-body myositis. Myositis-associated antibodies and myositis-specific autoantibodies are frequently found in patients with idiopathic inflammatory myopathies, and are useful in the diagnosis and classification. Anti-histidyl transfer RNA synthetase antibody is the most widely prevalent and is highly specific for polymyositis. Signal recognition particle antibody is also a specific autoantibody for polymyositis, but it is infrequent and rarely found in patients having other myositis-specific autoantibodies. We present a man with polymyositis who had both antibodies in serum, which is considered an extremely rare clinical situation. Here we analyze the clinical course and findings, and examine the effect of the coexistence and possible interaction on prognosis.
MeSH term(s)	Autoantibodies/blood ; Histidine-tRNA Ligase/immunology ; Humans ; Male ; Middle Aged ; Polymyositis/blood ; Signal Recognition Particle/immunology
Chemical Substances	Autoantibodies ; Signal Recognition Particle ; Histidine-tRNA Ligase (EC 6.1.1.21)
Language	Spanish
Publishing date	2018-03-28
Publishing country	Spain
Document type	Case Reports ; Journal Article
ISSN	2173-5743
ISSN (online)	2173-5743
DOI	10.1016/j.reuma.2017.12.003
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