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Article ; Online: Usefulness of plasma procalcitonin as a predictor of bacteremia due to Gram-negative microorganisms.

Salinas-Botrán, Alejandro / Humanes-Navarro, Ana María / González-Romo, Fernando

2024

Title translation	Utilidad de la procalcitonina plasmática como factor predictor de bacteriemias por microorganismos gramnegativos.
Language	Spanish
Publishing date	2024-04-02
Publishing country	Spain
Document type	Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2024.02.008
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Article ; Online: Why Should We Recommend Pneumococcal Vaccine in Patients With Chronic Heart Diseases?

González-Romo, Fernando / Barrios, Vivencio

Revista espanola de cardiologia (English ed.)

2018 Volume 71, Issue 1, Page(s) 57–58

MeSH term(s)	Adolescent ; Adult ; Aged ; Chronic Disease ; Female ; Heart Diseases/complications ; Heart Diseases/mortality ; Humans ; Male ; Middle Aged ; Pneumococcal Infections/complications ; Pneumococcal Infections/mortality ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines/pharmacology ; Risk Factors ; Spain/epidemiology ; Streptococcus pneumoniae/immunology ; Survival Rate/trends ; Vaccination/methods ; Young Adult
Chemical Substances	Pneumococcal Vaccines
Language	Spanish
Publishing date	2018-01
Publishing country	Spain
Document type	Letter
ISSN	1885-5857
ISSN (online)	1885-5857
DOI	10.1016/j.rec.2017.08.020
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Article ; Online: Respiratory Syncytial Virus Vaccination Recommendations for Adults Aged 60 Years and Older: The NeumoExperts Prevention Group Position Paper.

Redondo, Esther / Rivero-Calle, Irene / Mascarós, Enrique / Ocaña, Daniel / Jimeno, Isabel / Gil, Ángel / Linares, Manuel / Onieva-García, María Ángeles / González-Romo, Fernando / Yuste, José / Martinón-Torres, Federico

Archivos de bronconeumologia

2024 Volume 60, Issue 3, Page(s) 161–170

Abstract: Respiratory syncytial virus (RSV) is a major cause of respiratory tract infections in adults, particularly older adults and those with underlying medical conditions. Vaccination has emerged as a potential key strategy to prevent RSV-related morbidity and ...

Abstract	Respiratory syncytial virus (RSV) is a major cause of respiratory tract infections in adults, particularly older adults and those with underlying medical conditions. Vaccination has emerged as a potential key strategy to prevent RSV-related morbidity and mortality. This Neumoexperts Prevention (NEP) Group scientific paper aims to provide an evidence-based positioning and RSV vaccination recommendations for adult patients. We review the current literature on RSV burden and vaccine development and availability, emphasising the importance of vaccination in the adult population. According to our interpretation of the data, RSV vaccines should be part of the adult immunisation programme, and an age-based strategy should be preferred over targeting high-risk groups. The effectiveness and efficiency of this practice will depend on the duration of protection and the need for annual or more spaced doses. Our recommendations should help healthcare professionals formulate guidelines and implement effective vaccination programmes for adult patients at risk of RSV infection now that specific vaccines are available.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Respiratory Syncytial Virus, Human ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Virus Infections/prevention & control ; Respiratory Tract Infections ; Vaccination
Language	Spanish
Publishing date	2024-01-17
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2024.01.004
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Article: Vaccination against Community-Acquired Pneumonia in Spanish Adults: Practical Recommendations by the NeumoExperts Prevention Group.

Redondo, Esther / Rivero-Calle, Irene / Mascarós, Enrique / Ocaña, Daniel / Jimeno, Isabel / Gil, Ángel / Díaz-Maroto, José Luis / Linares, Manuel / Onieva-García, María Ángeles / González-Romo, Fernando / Yuste, José / Martinón-Torres, Federico

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 1

Abstract: In the adult population, community-acquired pneumonia (CAP) is a serious disease that is responsible for high morbidity and mortality rates, being frequently associated with multidrug resistant pathogens. The aim of this review is to update a practical ... ...

Abstract	In the adult population, community-acquired pneumonia (CAP) is a serious disease that is responsible for high morbidity and mortality rates, being frequently associated with multidrug resistant pathogens. The aim of this review is to update a practical immunization prevention guideline for CAP in Spain caused by prevalent respiratory pathogens, based on the available scientific evidence through extensive bibliographic review and expert opinion. The emergence of COVID-19 as an additional etiological cause of CAP, together with the rapid changes in the availability of vaccines and recommendations against SARS-CoV-2, justifies the need for an update. In addition, new conjugate vaccines of broader spectrum against pneumococcus, existing vaccines targeting influenza and pertussis or upcoming vaccines against respiratory syncytial virus (RSV) will be very useful prophylactic tools to diminish the burden of CAP and all of its derived complications. In this manuscript, we provide practical recommendations for adult vaccination against the pathogens mentioned above, including their contribution against antibiotic resistance. This guide is intended for the individual perspective of protection and not for vaccination policies, as we do not pretend to interfere with the official recommendations of any country. The use of vaccines is a realistic approach to fight these infections and ameliorate the impact of antimicrobial resistance. All of the recently available scientific evidence included in this review gives support to the indications established in this practical guide to reinforce the dissemination and implementation of these recommendations in routine clinical practice.
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12010138
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Article ; Online: El desarrollo de nuevas vacunas.

González-Romo, Fernando / Picazo, Juan J

Enfermedades infecciosas y microbiologia clinica

2015 Volume 33, Issue 8, Page(s) 557–568

Abstract: Recent and important advances in the fields of immunology, genomics, functional genomics, immunogenetics, immunogenomics, bioinformatics, microbiology, genetic engineering, systems biology, synthetic biochemistry, proteomics, metabolomics and ... ...

Title translation	Development of new vaccines.
Abstract	Recent and important advances in the fields of immunology, genomics, functional genomics, immunogenetics, immunogenomics, bioinformatics, microbiology, genetic engineering, systems biology, synthetic biochemistry, proteomics, metabolomics and nanotechnology, among others, have led to new approaches in the development of vaccines. The better identification of ideal epitopes, the strengthening of the immune response due to new adjuvants, and the search of new routes of vaccine administration, are good examples of advances that are already a reality and that will favour the development of more vaccines, their use in indicated population groups, or its production at a lower cost. There are currently more than 130 vaccines are under development against the more wished (malaria or HIV), difficult to get (CMV or RSV), severe re-emerging (Dengue or Ebola), increasing importance (Chagas disease or Leishmania), and nosocomial emerging (Clostridium difficile or Staphylococcus aureus) infectious diseases.
MeSH term(s)	Adjuvants, Immunologic ; Communicable Diseases, Emerging/immunology ; Communicable Diseases, Emerging/prevention & control ; Epitopes/immunology ; Humans ; Public Opinion ; Vaccination/psychology ; Vaccination/trends ; Vaccines/adverse effects ; Vaccines/immunology ; Vaccines, Subunit ; Vaccines, Synthetic
Chemical Substances	Adjuvants, Immunologic ; Epitopes ; Vaccines ; Vaccines, Subunit ; Vaccines, Synthetic
Language	Spanish
Publishing date	2015-10
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	1070941-1
ISSN	1578-1852 ; 0213-005X
ISSN (online)	1578-1852
ISSN	0213-005X
DOI	10.1016/j.eimc.2015.06.013
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Article ; Online: Saezia sanguinis

Medina-Pascual, María J / Monzón, Sara / Villalón, Pilar / Cuesta, Isabel / González-Romo, Fernando / Valdezate, Sylvia

International journal of systematic and evolutionary microbiology

2020 Volume 70, Issue 3, Page(s) 2016–2025

Abstract: The taxonomic position of an unknown bacterial strain designated CNM695-12, isolated from the blood of an immunocompromised subject, was investigated via phenotypic, chemotaxonomic, genotypic and genomic analyses. Bacterial cells were determined to be ... ...

Abstract	The taxonomic position of an unknown bacterial strain designated CNM695-12, isolated from the blood of an immunocompromised subject, was investigated via phenotypic, chemotaxonomic, genotypic and genomic analyses. Bacterial cells were determined to be Gram-stain-negative bacilli, aerobic, non-motile and non-spore-forming. The strain showed catalase activity but no oxidase activity. Optimal growth occurred at 37 °C, pH 7 and with 0-1 % NaCl. C
MeSH term(s)	Aged, 80 and over ; Bacterial Typing Techniques ; Base Composition ; Betaproteobacteria/classification ; Betaproteobacteria/isolation & purification ; Blood/microbiology ; DNA, Bacterial/genetics ; Fatty Acids/chemistry ; Humans ; Male ; Phospholipids/chemistry ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; Spain ; Ubiquinone/chemistry
Chemical Substances	DNA, Bacterial ; Fatty Acids ; Phospholipids ; RNA, Ribosomal, 16S ; Ubiquinone (1339-63-5) ; ubiquinone 8 (CQA993F7P8)
Language	English
Publishing date	2020-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2002336-4
ISSN	1466-5034 ; 1466-5026
ISSN (online)	1466-5034
ISSN	1466-5026
DOI	10.1099/ijsem.0.004010
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Article ; Online: Clinitest rapid COVID-19 antigen test for the diagnosis of SARS-CoV-2 infection: A multicenter evaluation study.

Merino-Amador, Paloma / González-Donapetry, Patricia / Domínguez-Fernández, Mercedes / González-Romo, Fernando / Sánchez-Castellano, Miguel Ángel / Seoane-Estevez, Alejandro / Delgado-Iribarren, Alberto / García, Julio / Bou, Germán / Cuenca-Estrella, Manuel / Oteo-Iglesias, Jesús

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

2021 Volume 143, Page(s) 104961

Abstract: Objectives: RT-PCR assay is the reference method for diagnosis of COVID-19, but it is also a laborious and time-consuming technic, limiting the availability of testing. Rapid antigen-detection tests are faster and less expensive; however, the ... ...

Abstract	Objectives: RT-PCR assay is the reference method for diagnosis of COVID-19, but it is also a laborious and time-consuming technic, limiting the availability of testing. Rapid antigen-detection tests are faster and less expensive; however, the reliability of these tests must be validated before they can be used widely. The objective of this study was to determine the performance of the Clinitest Rapid COVID-19 Antigen Test (ClinitestRT) (SIEMENS) for SARS-CoV-2 in nasopharyngeal swab specimens. Methods: This prospective multicenter study was carried out in three Spanish university hospitals including individuals with clinical symptoms or epidemiological criteria for COVID-19. Only individuals with ≤7 days from the onset of symptoms or from exposure to a confirmed case of COVID-19 were included. Two nasopharyngeal samples were taken to perform the ClinitestRT, as a point-of-care test, and a diagnostic RT-PCR test. Results: Overall sensitivity and specificity for the ClinitestRT among the 450 patients studied were 93.3% (CI 95%: 89.7-96.8) and 99.2% (CI 95%: 97.2-99.8), respectively. Sensitivity in participants with ≤5 days of the clinical course was 93.6% (CI 95%: 89.2-96.3), and in participants who had a C Conclusions: The ClinitestRT provides good clinical performance, with more reliable results for patients with a higher viral load. The results must be interpreted based on the local epidemiological context.
MeSH term(s)	Antigens, Viral ; COVID-19 ; Citric Acid ; Copper Sulfate ; Humans ; Prospective Studies ; Reproducibility of Results ; SARS-CoV-2 ; Sensitivity and Specificity ; Sodium Bicarbonate
Chemical Substances	Antigens, Viral ; Citric Acid (2968PHW8QP) ; Clinitest (63126-89-6) ; Sodium Bicarbonate (8MDF5V39QO) ; Copper Sulfate (LRX7AJ16DT)
Language	English
Publishing date	2021-08-23
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study
ZDB-ID	1446080-4
ISSN	1873-5967 ; 1386-6532
ISSN (online)	1873-5967
ISSN	1386-6532
DOI	10.1016/j.jcv.2021.104961
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Article ; Online: Trends in antifungal resistance in

Díaz-García, Judith / Machado, Marina / Alcalá, Luis / Reigadas, Elena / Pérez-Ayala, Ana / Gómez-García de la Pedrosa, Elia / Gónzalez-Romo, Fernando / Cuétara, María Soledad / García-Esteban, Coral / Quiles-Melero, Inmaculada / Zurita, Nelly Daniela / Muñoz-Algarra, María / Durán-Valle, María Teresa / Sánchez-García, Aida / Muñoz, Patricia / Escribano, Pilar / Guinea, Jesus

Antimicrobial agents and chemotherapy

2023 Volume 67, Issue 11, Page(s) e0098623

Abstract: We previously conducted a multicenter surveillance study ... ...

Abstract	We previously conducted a multicenter surveillance study on
MeSH term(s)	Humans ; Fluconazole/pharmacology ; Candida ; Antifungal Agents/pharmacology ; Amphotericin B/pharmacology ; Candida parapsilosis/genetics ; Traction ; Echinocandins ; Candida albicans/genetics ; Drug Resistance, Fungal/genetics ; Microbial Sensitivity Tests
Chemical Substances	Fluconazole (8VZV102JFY) ; Antifungal Agents ; ibrexafungerp (A92JFM5XNU) ; Amphotericin B (7XU7A7DROE) ; Echinocandins
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/aac.00986-23
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Article ; Online: Antifungal resistance in Candida spp within the intra-abdominal cavity: study of resistance acquisition in patients with serial isolates.

Díaz-García, Judith / Machado, Marina / Alcalá, Luis / Reigadas, Elena / Sánchez-Carrillo, Carlos / Pérez-Ayala, Ana / Gómez-García de la Pedrosa, Elia / González-Romo, Fernando / Merino, Paloma / Cuétara, María Soledad / García-Esteban, Coral / Quiles-Melero, Inmaculada / Zurita, Nelly Daniela / Muñoz-Algarra, María / Durán-Valle, María Teresa / Martínez-Quintero, Gabriela Andrea / Sánchez-García, Aída / Muñoz, Patricia / Escribano, Pilar /

Guinea, Jesús

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2023 Volume 29, Issue 12, Page(s) 1604.e1–1604.e6

Abstract: Objectives: Antifungal susceptibility testing is mostly conducted on blood-cultured Candida spp isolates. Because the intra-abdominal cavity has been highlighted as a hidden echinocandin-resistant C. glabrata reservoir, we assessed whether testing ... ...

Abstract	Objectives: Antifungal susceptibility testing is mostly conducted on blood-cultured Candida spp isolates. Because the intra-abdominal cavity has been highlighted as a hidden echinocandin-resistant C. glabrata reservoir, we assessed whether testing sequential isolates from a given patient might increase the chances of detecting antifungal resistance. Methods: Intra-abdominal initial and sequential isolates from the same species from patients included in the CANDIdaemia in MADrid study (January 2019 to June 2022) were studied. We assessed antifungal susceptibility to amphotericin B, azoles, anidulafungin, micafungin, and ibrexafungerp using European Committee on Antimicrobial Susceptibility Testing (EUCAST) methodology and molecularly characterized resistant isolates. Results: We collected 308 isolates (C. albicans [n = 179/308; 58.1%], C. glabrata [n = 101/308; 32.8%], C. tropicalis [n = 17/308; 5.5%], and C. parapsilosis [n = 11/308; 3.6%]) from 112 patients distributed as incident (n = 125/308) and sequential (n = 183/308). Per patient resistance rates of fluconazole (13.4% [15/112] vs. 8% [9/112]); 5.4% proportions difference (95% CI, -2.7% to 13.5%, p 0.09) and echinocandins (8.9% [10/112] vs. 1.8% [2/112]); 7.1% proportions difference (95% CI; 1.2-12.9%; p 0.01) were higher when considering all available isolates than only incident isolates. Resistance was detected in 18 of 112 patients and would have been overlooked in 11 of 18 (61.1%) patients if only incident isolates had been studied. Of the patients who harboured fluconazole or echinocandin-resistant isolates, 14 of 15 and 8 of 10 had received or were receiving fluconazole or echinocandins, respectively. Discussion: Testing sequential Candida isolates from intra-abdominal samples is required to detect antifungal resistance, particularly to echinocandins, in patients whose incident isolates turned out to be susceptible. Furthermore, patients with echinocandin-resistant infections had frequently used echinocandins and had common secondary resistance acquisition.
MeSH term(s)	Humans ; Antifungal Agents/pharmacology ; Candida ; Fluconazole ; Echinocandins/pharmacology ; Amphotericin B ; Candida albicans ; Candida parapsilosis ; Candida tropicalis ; Candida glabrata ; Microbial Sensitivity Tests ; Drug Resistance, Fungal
Chemical Substances	Antifungal Agents ; Fluconazole (8VZV102JFY) ; Echinocandins ; Amphotericin B (7XU7A7DROE)
Language	English
Publishing date	2023-08-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2023.08.021
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Article ; Online: Fluconazole-resistant Candida parapsilosis genotypes from hospitals located in five Spanish cities and one in Italy: Description of azole-resistance profiles associated with the Y132F ERG11p substitution.

Mesquida, Aina / Alcoceba, Eva / Padilla, Eduardo / Ramírez, Aída / Merino, Paloma / González-Romo, Fernando / De Carolis, Elena / Sanguinetti, Maurizio / Mantecón-Vallejo, María de Los Ángeles / Muñoz-Algarra, María / Durán-Valle, Teresa / Pérez-Ayala, Ana / Gómez-García-de-la-Pedrosa, Elia / Del Carmen Martínez-Jiménez, María / Sánchez-Castellano, Miguel Ángel / Quiles-Melero, Inmaculada / Cuétara, María Soledad / Sánchez-García, Aída / Muñoz, Patricia /

Escribano, Pilar / Guinea, Jesús

Mycoses

2024 Volume 67, Issue 3, Page(s) e13706

Abstract: Background: Fluconazole-resistant Candida parapsilosis is a matter of concern.: Objectives: To describe fluconazole-resistant C. parapsilosis genotypes circulating across hospitals in Spain and Rome and to study their azole-resistance profile ... ...

Abstract	Background: Fluconazole-resistant Candida parapsilosis is a matter of concern. Objectives: To describe fluconazole-resistant C. parapsilosis genotypes circulating across hospitals in Spain and Rome and to study their azole-resistance profile associated with ERG11p substitutions. Patients/methods: We selected fluconazole-resistant C. parapsilosis isolates (n = 528 from 2019 to 2023; MIC ≥8 mg/L according to EUCAST) from patients admitted to 13 hospitals located in five Spanish cities and Rome. Additionally, we tested voriconazole, posaconazole, isavuconazole, amphotericin B, micafungin, anidulafungin and ibrexafungerp susceptibility. Results: Of the 53 genotypes found, 49 harboured the Y132F substitution, five of which were dominating city-specific genotypes involving almost half the isolates. Another genotype involved isolates harbouring the G458S substitution. Finally, we found two genotypes with the wild-type ERG11 gene sequence and one with the R398I substitution. All isolates were fully susceptible/wild-type to amphotericin B, anidulafungin, micafungin and ibrexafungerp. The azole-resistance patterns found were: voriconazole-resistant (74.1%) or voriconazole-intermediate (25.2%), posaconazole-resistant (10%) and isavuconazole non-wild-type (47.5%). Fluconazole-resistant and voriconazole non-wild-type isolates were likely to harbour substitution Y132F if posaconazole was wild type; however, if posaconazole was non-wild type, substitution G458S was indicated if isavuconazole MIC was >0.125 mg/L or substitution Y132F if isavuconazole MIC was ≤0.125 mg/L. Conclusions: We detected a recent clonal spread of fluconazole-resistant C. parapsilosis across some cities in Spain, mostly driven by dominating city-specific genotypes, which involved a large number of isolates harbouring the Y132F ERG11p substitution. Isolates harbouring substitution Y132F can be suspected because they are non-susceptible to voriconazole and rarely posaconazole-resistant.
MeSH term(s)	Humans ; Azoles/pharmacology ; Fluconazole/pharmacology ; Candida parapsilosis/genetics ; Cities ; Voriconazole/pharmacology ; Amphotericin B ; Anidulafungin ; Micafungin ; Italy ; Hospitals ; Genotype ; Triazoles ; Nitriles ; Triterpenes ; Glycosides ; Pyridines
Chemical Substances	Azoles ; Fluconazole (8VZV102JFY) ; isavuconazole (60UTO373KE) ; ibrexafungerp (A92JFM5XNU) ; Voriconazole (JFU09I87TR) ; Amphotericin B (7XU7A7DROE) ; Anidulafungin (9HLM53094I) ; Micafungin (R10H71BSWG) ; Triazoles ; Nitriles ; Triterpenes ; Glycosides ; Pyridines
Language	English
Publishing date	2024-03-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	392487-7
ISSN	1439-0507 ; 0933-7407
ISSN (online)	1439-0507
ISSN	0933-7407
DOI	10.1111/myc.13706
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