Article ; Online: Major histocompatibility complex Class II-based therapy for stroke.
2021 Volume 7, Issue 1, Page(s) 37–40
Abstract: This review discusses the potential of major histocompatibility complex (MHC) Class II constructs as stroke therapeutics. We focus on the delivery of MHC Class II construct, DRmQ, as a safe and effective treatment for ischemic stroke. DRmQ was observed ... ...
| Abstract | This review discusses the potential of major histocompatibility complex (MHC) Class II constructs as stroke therapeutics. We focus on the delivery of MHC Class II construct, DRmQ, as a safe and effective treatment for ischemic stroke. DRmQ was observed to attenuate behavioral deficits and decrease microglia activation and proinflammatory cytokines, illustrating its ability to mitigate the secondary cell death following stroke. Similar anti-neuroinflammation treatments, such as transplantation of mesenchymal stem cells and mitochondrial transfers, are briefly discussed to provide further support that sequestration of inflammation stands as a robust therapeutic target for stroke. |
|---|---|
| Language | English |
| Publishing date | 2021-03-30 |
| Publishing country | India |
| Document type | Journal Article ; Review |
| ZDB-ID | 2950273-1 |
| ISSN | 2455-4626 ; 2394-8108 |
| ISSN (online) | 2455-4626 |
| ISSN | 2394-8108 |
| DOI | 10.4103/bc.bc_16_21 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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