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  1. AU="Gonzalez, Azuah L"
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  1. Article ; Online: Getting under the skin: resident memory CD8

    Neuwirth, Teresa / Gonzalez, Azuah L / Fisher-Gupta, Emilie / Stary, Georg

    Genes and immunity

    2024  Volume 25, Issue 2, Page(s) 105–107

    MeSH term(s) CD8-Positive T-Lymphocytes ; Immunologic Memory ; Lymph Nodes/immunology ; Skin/immunology ; Humans ; Mice
    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Journal Article ; News
    ZDB-ID 2060566-3
    ISSN 1476-5470 ; 1466-4879
    ISSN (online) 1476-5470
    ISSN 1466-4879
    DOI 10.1038/s41435-024-00266-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Inflammation Resolution in the Cardiovascular System: Arterial Hypertension, Atherosclerosis, and Ischemic Heart Disease.

    Gonzalez, Azuah L / Dungan, Matthew M / Smart, C Duncan / Madhur, Meena S / Doran, Amanda C

    Antioxidants & redox signaling

    2023  Volume 40, Issue 4-6, Page(s) 292–316

    Abstract: Significance: ...

    Abstract Significance:
    MeSH term(s) Humans ; Atherosclerosis/metabolism ; Inflammation/metabolism ; Myocardial Infarction/drug therapy ; Cardiovascular System/metabolism ; Hypertension/drug therapy ; Inflammation Mediators/metabolism
    Chemical Substances Inflammation Mediators
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2023.0284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Iron availability and oxygen tension regulate the Yersinia Ysc type III secretion system to enable disseminated infection.

    Hooker-Romero, Diana / Mettert, Erin / Schwiesow, Leah / Balderas, David / Alvarez, Pablo A / Kicin, Anadin / Gonzalez, Azuah L / Plano, Gregory V / Kiley, Patricia J / Auerbuch, Victoria

    PLoS pathogens

    2019  Volume 15, Issue 12, Page(s) e1008001

    Abstract: The enteropathogen Yersinia pseudotuberculosis and the related plague agent Y. pestis require the Ysc type III secretion system (T3SS) to subvert phagocyte defense mechanisms and cause disease. Yet type III secretion (T3S) in Yersinia induces growth ... ...

    Abstract The enteropathogen Yersinia pseudotuberculosis and the related plague agent Y. pestis require the Ysc type III secretion system (T3SS) to subvert phagocyte defense mechanisms and cause disease. Yet type III secretion (T3S) in Yersinia induces growth arrest and innate immune recognition, necessitating tight regulation of the T3SS. Here we show that Y. pseudotuberculosis T3SS expression is kept low under anaerobic, iron-rich conditions, such as those found in the intestinal lumen where the Yersinia T3SS is not required for growth. In contrast, the Yersinia T3SS is expressed under aerobic or anaerobic, iron-poor conditions, such as those encountered by Yersinia once they cross the epithelial barrier and encounter phagocytic cells. We further show that the [2Fe-2S] containing transcription factor, IscR, mediates this oxygen and iron regulation of the T3SS by controlling transcription of the T3SS master regulator LcrF. IscR binds directly to the lcrF promoter and, importantly, a mutation that prevents this binding leads to decreased disseminated infection of Y. pseudotuberculosis but does not perturb intestinal colonization. Similar to E. coli, Y. pseudotuberculosis uses the Fe-S cluster occupancy of IscR as a readout of oxygen and iron conditions that impact cellular Fe-S cluster homeostasis. We propose that Y. pseudotuberculosis has coopted this system to sense entry into deeper tissues and induce T3S where it is required for virulence. The IscR binding site in the lcrF promoter is completely conserved between Y. pseudotuberculosis and Y. pestis. Deletion of iscR in Y. pestis leads to drastic disruption of T3S, suggesting that IscR control of the T3SS evolved before Y. pestis split from Y. pseudotuberculosis.
    MeSH term(s) Animals ; Bacterial Proteins/metabolism ; Bacterial Secretion Systems/genetics ; Escherichia coli/metabolism ; Escherichia coli Proteins/metabolism ; Gene Expression Regulation, Bacterial/genetics ; Iron/metabolism ; Oxygen/metabolism ; Promoter Regions, Genetic/genetics ; Transcription, Genetic ; Type III Secretion Systems/metabolism ; Yersinia/metabolism ; Yersinia pseudotuberculosis/pathogenicity ; Yersinia pseudotuberculosis Infections/immunology ; Yersinia pseudotuberculosis Infections/metabolism
    Chemical Substances Bacterial Proteins ; Bacterial Secretion Systems ; Escherichia coli Proteins ; Type III Secretion Systems ; Iron (E1UOL152H7) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2019-12-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1008001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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