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  1. Book ; Online: Chapter Mild intervention technologies for increasing shelf life and/or safety of fresh fruits: Opportunity and challenge

    Contigiani, Eunice V. / Cecilia Jaramillo, Gabriela / González, Lucas / Rocio Romero Bernal, Angela / Raffellini, Silvia / Gómez, Paula L. / Maris Alzamora, Stella

    2019  

    Keywords Technology: general issues ; Technology, engineering, agriculture
    Size 1 Online-Ressource
    Publisher InTechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021047398
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Psychiatrists as internists: Some considerations following a COVID-19 redeployment experience.

    Gómez-Arnau, Jorge / González-Lucas, Raúl / Sánchez-Páez, Patricia

    Revista de psiquiatria y salud mental

    2021  Volume 14, Issue 2, Page(s) 121–122

    MeSH term(s) COVID-19 ; Humans ; Physicians ; Psychiatry ; SARS-CoV-2
    Language English
    Publishing date 2021-06-21
    Publishing country Spain
    Document type Letter ; Comment
    ISSN 2173-5050
    ISSN (online) 2173-5050
    DOI 10.1016/j.rpsmen.2020.07.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Psychiatrists as internists: Some considerations following a COVID-19 redeployment experience.

    Gómez-Arnau, Jorge / González-Lucas, Raúl / Sánchez-Páez, Patricia

    Revista de psiquiatria y salud mental

    2020  Volume 14, Issue 2, Page(s) 121–122

    MeSH term(s) COVID-19 ; Humans ; Psychiatry ; SARS-CoV-2
    Keywords covid19
    Language Spanish
    Publishing date 2020-07-23
    Publishing country Spain
    Document type Letter ; Comment
    ISSN 2173-5050
    ISSN (online) 2173-5050
    DOI 10.1016/j.rpsm.2020.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of Lung Cancer on Health-Related Quality of Life, Financial Toxicity, and Household Economics in Patients From the Public and the Private Healthcare Sector in Argentina.

    Augustovski, Federico / Tsou, Florencia / González, Lucas / Martín, Claudio / Vigo, Silvina / Gabay, Carolina / Alcaraz, Andrea / Argento, Fernando

    Value in health regional issues

    2024  Volume 41, Page(s) 94–99

    Abstract: Objectives: Non-small cell lung cancer (NSCLC) is Argentina's first cause of cancer death. Most patients have an advanced stage at diagnosis, with poor expected survival. This study aimed to characterize the health-related quality of life (HRQOL) and ... ...

    Abstract Objectives: Non-small cell lung cancer (NSCLC) is Argentina's first cause of cancer death. Most patients have an advanced stage at diagnosis, with poor expected survival. This study aimed to characterize the health-related quality of life (HRQOL) and economic impact of patients treated in the private healthcare sector and compare it with that of the public sector.
    Methods: We undertook an observational cross-sectional study that extended a previous study to a referral private center in Argentina. Outcomes included the EuroQol EQ-5D-3L (to assess HRQOL), Comprehensive Score for Financial Toxicity (financial toxicity instrument), Work Productivity and Activity Impairment - General Health (to assess productivity loss), and out-of-pocket expenses in adults diagnosed of NSCLC.
    Results: We included 30 consecutive patients from a private healthcare center (July 2021 to March 2022), totaling 131 patients (n = 101 from previous public study). The whole sample had low quality of life and relevant economic impact. Patients in the private healthcare sector showed lower disease severity and higher educational level and household income. In addition, private healthcare system patients showed higher utility (0.77 vs 0.73; P < .05) and lower impairment of daily activities (41% vs 59%; P = .01). Private health system patients also showed lower financial toxicity as measured by the Comprehensive Score for Financial Toxicity score (23.9 vs 20.14; P < .05) but showed no differences when financial toxicity was assessed as a dichotomic variable.
    Conclusions: Although patients with NSCLC treated in a private healthcare center in Argentina showed a relevant HRQOL and economic impact, this impact was smaller than the one observed in publicly funded hospitals.
    MeSH term(s) Humans ; Quality of Life/psychology ; Argentina/epidemiology ; Male ; Female ; Cross-Sectional Studies ; Middle Aged ; Private Sector/statistics & numerical data ; Private Sector/economics ; Lung Neoplasms/economics ; Lung Neoplasms/epidemiology ; Public Sector/economics ; Public Sector/statistics & numerical data ; Aged ; Health Expenditures/statistics & numerical data ; Surveys and Questionnaires ; Cost of Illness ; Carcinoma, Non-Small-Cell Lung/economics ; Carcinoma, Non-Small-Cell Lung/epidemiology ; Adult
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2679127-4
    ISSN 2212-1102 ; 2212-1099
    ISSN (online) 2212-1102
    ISSN 2212-1099
    DOI 10.1016/j.vhri.2023.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6969: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Surgical resection versus stereotactic radiosurgery on local recurrence and survival for patients with a single brain metastasis: a systematic review and meta-analysis.

    González, Lucas / Castro, Sebastián / Villa, Eduardo / Zomosa, Gustavo

    British journal of neurosurgery

    2021  Volume 35, Issue 6, Page(s) 703–713

    Abstract: Background: Brain metastases (BM) are the most frequent intracranial tumours in adults. In patients with solitary BM, surgical resection (SR) or stereotactic radiosurgery (SRS) is performed. There is limited evidence comparing one treatment over the ... ...

    Abstract Background: Brain metastases (BM) are the most frequent intracranial tumours in adults. In patients with solitary BM, surgical resection (SR) or stereotactic radiosurgery (SRS) is performed. There is limited evidence comparing one treatment over the other.
    Objective: To compare SR versus SRS on patients with solitary BMs, regarding local recurrence (LR) and overall survival (OS) conducting a systematic review and meta-analysis.
    Methods: Systematic review of literature following PRISMA guidelines, using the databases of Medline, Clinicaltrials.gov, Embase, Web of Science, Sciencedirect, CINAHL, Wiley Online Library, Springerlink and LILACS. Following study selection based on inclusion and exclusion criteria, data extraction and a critical analysis of the literature was performed according to the GRADE scale. For quantitative analysis, a random effects model was used. Data were synthetized and evaluated on a forest plot and funnel plot.
    Results: Two randomized clinical trials, four cohort studies and one case-control studies met our inclusion criteria for the qualitative analysis. None was excluded subsequently. Overall, 614 patients with single metastasis were included. Studies had high heterogeneity. Multiple significant variables affecting the outcome were signalized. Meta-analysis showed no significant differences for survival (HR, 1.10; 95% CI, 0.75-1.45) or LR (HR, 0.81; 95% CI, 0.42-1.20).
    Conclusions: According to current evidence, in patients with a single small metastasis there is no statistically significant difference in OS or LR among the chosen techniques (SR or SRS). Multiple significant co-variables may affect both outcomes. Different outcomes better than OS should be evaluated in further randomized studies.
    MeSH term(s) Adult ; Brain Neoplasms/surgery ; Case-Control Studies ; Cohort Studies ; Humans ; Radiosurgery ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2021-08-25
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2021.1950623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2210: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article: Psychiatrists as internists: Some considerations following a COVID-19 redeployment experience

    Gómez-Arnau, Jorge / González-Lucas, Raúl / Sánchez-Páez, Patricia

    Rev. psiquiatr. salud ment. (Barc., Ed. impr.)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #663752
    Database COVID19

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  7. Article ; Online: Psychiatrists as internists

    Gómez-Arnau, Jorge / González-Lucas, Raúl / Sánchez-Páez, Patricia

    Revista de Psiquiatría y Salud Mental ; ISSN 1888-9891

    Some considerations following a COVID-19 redeployment experience

    2020  

    Keywords Psychiatry and Mental health ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.rpsm.2020.07.001
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Hyperammonemia Alters the Function of AMPA and NMDA Receptors in Hippocampus: Extracellular cGMP Reverses Some of These Alterations.

    Sancho-Alonso, María / Taoro-Gonzalez, Lucas / Cabrera-Pastor, Andrea / Felipo, Vicente / Teruel-Martí, Vicent

    Neurochemical research

    2022  Volume 47, Issue 7, Page(s) 2016–2031

    Abstract: Chronic hyperammonemia alters membrane expression of AMPA and NMDA receptors subunits in hippocampus leading to impaired memory and learning. Increasing extracellular cGMP normalizes these alterations. However, it has not been studied whether ... ...

    Abstract Chronic hyperammonemia alters membrane expression of AMPA and NMDA receptors subunits in hippocampus leading to impaired memory and learning. Increasing extracellular cGMP normalizes these alterations. However, it has not been studied whether hyperammonemia alters the function of AMPA and NMDA receptors. The aims of this work were: (1) assess if hyperammonemia alters AMPA and NMDA receptors function; (2) analyze if extracellular cGMP reverses these alterations. A multielectrode array device was used to stimulate Schäffer collaterals and record postsynaptic currents in the CA1 region in hippocampal slices from control and hyperammonemic rats and analyze different features of the excitatory postsynaptic potentials. Hyperammonemia reduces the amplitude and delays appearance of AMPA EPSPs, whereas increases amplitude, hyperpolarization, depolarization and desensitization area of the NMDA EPSPs. These alterations in AMPA and NMDA function are accentuated as the stimulation intensity increases. Adding extracellular cGMP reverses the alteration in amplitude in both, AMPA and NMDA EPSPs. In control slices extracellular cGMP decreases the AMPA and NMDA EPSPs amplitude and delays the response of neurons and the return to the resting potential at all stimulation intensities. In conclusion, hyperammonemia decreases the AMPA response, whereas increases the NMDA response and extracellular cGMP reverses these alterations.
    MeSH term(s) Animals ; Cyclic GMP/metabolism ; Hippocampus/metabolism ; Hyperammonemia/metabolism ; N-Methylaspartate/metabolism ; N-Methylaspartate/pharmacology ; Rats ; Rats, Wistar ; Receptors, AMPA/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
    Chemical Substances Receptors, AMPA ; Receptors, N-Methyl-D-Aspartate ; N-Methylaspartate (6384-92-5) ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (77521-29-0) ; Cyclic GMP (H2D2X058MU)
    Language English
    Publishing date 2022-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 199335-5
    ISSN 1573-6903 ; 0364-3190
    ISSN (online) 1573-6903
    ISSN 0364-3190
    DOI 10.1007/s11064-022-03588-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Intracellular and extracelluar cyclic GMP in the brain and the hippocampus.

    Taoro-González, Lucas / Cabrera-Pastor, Andrea / Sancho-Alonso, María / Felipo, Vicente

    Vitamins and hormones

    2022  Volume 118, Page(s) 247–288

    Abstract: Cyclic Guanosine-Monophosphate (cGMP) is implicated as second messenger in a plethora of pathways and its effects are executed mainly by cGMP-dependent protein kinases (PKG). It is involved in both peripheral (cardiovascular regulation, intestinal ... ...

    Abstract Cyclic Guanosine-Monophosphate (cGMP) is implicated as second messenger in a plethora of pathways and its effects are executed mainly by cGMP-dependent protein kinases (PKG). It is involved in both peripheral (cardiovascular regulation, intestinal secretion, phototransduction, etc.) and brain (hippocampal synaptic plasticity, neuroinflammation, cognitive function, etc.) processes. Stimulation of hippocampal cGMP signaling have been proved to be beneficial in animal models of aging, Alzheimer's disease or hepatic encephalopathy, restoring different cognitive functions such as passive avoidance, object recognition or spatial memory. However, even when some inhibitors of cGMP-degrading enzymes (PDEs) are already used against peripheral pathologies, their utility as neurological treatments is still under clinical investigation. Additionally, it has been demonstrated a list of cGMP roles as not second but first messenger. The role of extracellular cGMP has been specially studied in hippocampal function and cognitive impairment in animal models and it has emerged as an important modulator of neuroinflammation-mediated cognitive alterations and hippocampal synaptic plasticity malfunction. Specifically, it has been demonstrated that extracellular cGMP decreases hippocampal IL-1β levels restoring membrane expression of glutamate receptors in the hippocampus and cognitive function in hyperammonemic rats. The mechanisms implicated are still unclear and might involve complex interactions between hippocampal neurons, astrocytes and microglia. Membrane targets for extracellular cGMP are still poorly understood and must be addressed in future studies.
    MeSH term(s) Animals ; Cyclic GMP/metabolism ; Cyclic GMP/pharmacology ; Hippocampus/metabolism ; Hyperammonemia/metabolism ; Microglia/metabolism ; Rats ; Signal Transduction/physiology
    Chemical Substances Cyclic GMP (H2D2X058MU)
    Language English
    Publishing date 2022-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 201161-x
    ISSN 2162-2620 ; 0083-6729
    ISSN (online) 2162-2620
    ISSN 0083-6729
    DOI 10.1016/bs.vh.2021.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.238: Show issues Location:
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  10. Article: Ether lipids and a peroxisomal riddle in sperm.

    Horta Remedios, Mayrene / Liang, Weisheng / González, Lucas N / Li, Victoria / Da Ros, Vanina G / Cohen, Débora J / Zaremberg, Vanina

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1166232

    Abstract: Sperm are terminally differentiated cells that lack most of the membranous organelles, resulting in a high abundance of ether glycerolipids found across different species. Ether lipids include plasmalogens, platelet activating factor, GPI-anchors and ... ...

    Abstract Sperm are terminally differentiated cells that lack most of the membranous organelles, resulting in a high abundance of ether glycerolipids found across different species. Ether lipids include plasmalogens, platelet activating factor, GPI-anchors and seminolipid. These lipids play important roles in sperm function and performance, and thus are of special interest as potential fertility markers and therapeutic targets. In the present article, we first review the existing knowledge on the relevance of the different types of ether lipids for sperm production, maturation and function. To further understand ether-lipid metabolism in sperm, we then query available proteomic data from highly purified sperm, and produce a map of metabolic steps retained in these cells. Our analysis pinpoints the presence of a truncated ether lipid biosynthetic pathway that would be competent for the production of precursors through the initial peroxisomal core steps, but devoid of subsequent microsomal enzymes responsible for the final synthesis of all complex ether-lipids. Despite the widely accepted notion that sperm lack peroxisomes, the thorough analysis of published data conducted herein identifies nearly 70% of all known peroxisomal resident proteins as part of the sperm proteome. In view of this, we highlight open questions related to lipid metabolism and possible peroxisomal functions in sperm. We propose a repurposed role for the truncated peroxisomal ether-lipid pathway in detoxification of products from oxidative stress, which is known to critically influence sperm function. The likely presence of a peroxisomal-derived remnant compartment that could act as a sink for toxic fatty alcohols and fatty aldehydes generated by mitochondrial activity is discussed. With this perspective, our review provides a comprehensive metabolic map associated with ether-lipids and peroxisomal-related functions in sperm and offers new insights into potentially relevant antioxidant mechanisms that warrant further research.
    Language English
    Publishing date 2023-05-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1166232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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