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  1. Book ; Online: Babesia and Human Babesiosis

    Montero, Estrella / Gray, Jeremy / Lobo, Cheryl Ann / González, Luis Miguel / González, Luis Miguel

    2022  

    Keywords Medicine ; Epidemiology & medical statistics ; babesiosis ; Babesia microti ; Babesia duncani ; parasite ; therapy ; atovaquone ; endochin-like quinolones (ELQs) ; human babesiosis ; Nantucket Island ; epidemiology ; ecology ; human risk ; European babesiosis ; Babesia divergens ; Babesia venatorum ; Ixodes ricinus ; parasite identity ; clinical cases ; diagnosis ; treatment ; Babesia ; diversity ; phylogenetic analysis ; blood transfusion ; prevention ; screening ; aspartyl protease ; plasmepsin ; apicomplexa ; piroplasmida ; BmIPA48 ; BMR1_03g00960 ; piroplasmid rhoptry-associated protein-1 (pRAP-1) ; ticks ; Babesia sp ; biological cycle ; experimental transmission ; experimental models ; Ixodes scapularis ; climate ; global warming ; Babesia sp. MO1 ; Babesia capreoli ; rap-1a ; ama-1 ; phylogeny ; sickle-cell anemia ; hemolysis ; haemoglobinopathies ; immunoepidemiology ; case surveillance ; therapeutic drugs ; peptidases ; antibody-based assays ; nucleic acid tests ; multiplex detection ; next generation sequencing ; glycosylphosphatidylinositol ; protein structure ; antigen ; host blood analysis ; fallow deer ; ixodid ticks ; piroplasm ; red deer ; Theileria ; Babesia bovis ; Babesia bigemina ; Colombia ; n/a ; in vitro culture ; erythrocytes ; DMEM-F12 ; virulence
    Language 0|e
    Size 1 electronic resource (294 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021619080
    ISBN 9783036544717 ; 3036544712
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Inés Anitua, directora general de ACICAE y AIC

    González, Luis Miguel

    https://dialnet.unirioja.es/servlet/articulo?codigo=7515676

    "podemos ser competidores y colaboradores al mismo tiempo"

    2020  

    Abstract: Forma parte de la sección: El mosaico vasco ante una etapa de profundo ... ...

    Abstract Forma parte de la sección: El mosaico vasco ante una etapa de profundo cambio
    Keywords Anitua ; Inés Entrevistas Artículos periodísticos ; Industrias automovilísticas Euskadi 2020 Artículos periodísticos ; COVID-19 Artículos periodísticos ; covid19
    Language Spanish
    Publishing country es
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Book ; Online: Un cuaderno de arranque seguro para la factoría de Vitoria = A secure boot notebook for the Vitoria factory ; A secure boot notebook for the Vitoria factory

    González, Luis Miguel

    https://dialnet.unirioja.es/servlet/articulo?codigo=7515672

    2020  

    Abstract: Forma parte de la sección: Mercedes-Benz Vitoria, empleando las mejores ... ...

    Abstract Forma parte de la sección: Mercedes-Benz Vitoria, empleando las mejores prácticas
    Keywords DaimlerChrysler España (Vitoria-Gasteiz) 2020 ; Industrias automovilísticas Vitoria-Gasteiz 2020 Artículos periodísticos ; COVID-19 Artículos periodísticos ; Mercedes-Benz (Vitoria-Gasteiz) 2020 Artículos periodísticos ; covid19
    Language Spanish
    Publishing country es
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Online: Reactividad y colaboración ante una crisis sin precedentes

    González, Luis Miguel

    https://dialnet.unirioja.es/servlet/articulo?codigo=7515677

    la heterogeneidad del sector en el País Vasco ofrece diversas respuestas

    2020  

    Abstract: Forma parte de la sección: El mosaico vasco ante una etapa de profundo ... ...

    Abstract Forma parte de la sección: El mosaico vasco ante una etapa de profundo cambio
    Keywords Industrias automovilísticas Euskadi 2020 Artículos periodísticos ; COVID-19 Artículos periodísticos ; covid19
    Language Spanish
    Publishing country es
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Thesis ; Online: El ingreso mínimo vital. Análisis del Real Decreto Ley 20/2020 de 29 de mayo, antecedentes, marco constitucional y legislación relacionada

    Arroyo González, Luis Miguel

    2020  

    Abstract: ES] El objeto de la presente investigación será el estudio del Real Decreto Ley 20/2020 de 29 de mayo y otros textos legislativos directamente relacionados como el Real Decreto 397/1996, de 1 de marzo, por el que se regula el registro de prestaciones ... ...

    Abstract [ES] El objeto de la presente investigación será el estudio del Real Decreto Ley 20/2020 de 29 de mayo y otros textos legislativos directamente relacionados como el Real Decreto 397/1996, de 1 de marzo, por el que se regula el registro de prestaciones sociales públicas, la Ley 6/2018, de 3 de julio, de Presupuestos Generales del Estado para el año 2018 o el Real Decreto Legislativo 1/2015, de 24 de julio, de garantías y uso racional de los medicamentos y productos sanitarios. Por lo que se refiere al objetivo, se tratará de comprender y analizar la profundidad y complejidad legislativa y la necesidad de la última medida social implementada por el Reino de España ante la coyuntura y debacle social que se plantea tras la crisis del COVID-19 y plantear posibles mejoras a la misma tanto desde un punto de vista social como burocrático y económico. En cuanto a la metodología, se pretende la lectura, análisis y comparación de los textos legales citados y otros que surjan durante la investigación. Búsqueda y análisis de datos y estadísticas sobre la pobreza extrema, pobreza infantil y colectivos y personas en riesgo de exclusión social y alcance de las medidas aprobadas en el Real Decreto Ley 20/2020 de 29 de mayo.

    [EN] The purpose of this investigation will be the study of Royal Decree Law 20/2020 of May 29 and other directly related legislative texts such as Royal Decree 397/1996, of March 1, which regulates the registry of public social benefits , Law 6/2018, of July 3, on General State Budgets for the year 2018 or Royal Legislative Decree 1/2015, of July 24, on guarantees and rational use of medicines and health products. With regard to the objective, it will seek to understand and analyze the legislative depth and complexity and the need for the latest social measure implemented by the Kingdom of Spain in the face of the conjuncture and social debacle that arises after the COVID-19 crisis and raise possible improvements to it both from a social point of view and bureaucratic and economic. Regarding the methodology, the reading, analysis and comparison of the cited legal texts and others that arise during the investigation are intended. Search and analysis of data and statistics on extreme poverty, child poverty and groups and people at risk of social exclusion and scope of the measures approved in Royal Decree Law 20/2020 of May 29.

    Arroyo González, LM. (2020). El ingreso mínimo vital. Análisis del Real Decreto Ley 20/2020 de 29 de mayo, antecedentes, marco constitucional y legislación relacionada. http://hdl.handle.net/10251/152557

    TFGM
    Keywords Inclusión laboral ; Derechos sociales ; Pobreza ; Ingreso mínimo vital ; Pensiones ; Prestaciones ; Estado social de Derecho ; Mínimo vital ; Benefits ; Rule of Law ; Vital minimum ; Pensions ; DERECHO CONSTITUCIONAL ; Grado en Gestión y Administración Pública-Grau en Gestió i Administració Pública ; covid19
    Language Spanish
    Publishing date 2020-10-20
    Publisher Universitat Politècnica de València
    Publishing country es
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Babesia

    Montero, Estrella / Gray, Jeremy / Lobo, Cheryl Ann / González, Luis Miguel

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 4

    Abstract: ... ...

    Abstract Babesia
    Language English
    Publishing date 2022-03-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11040399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dynamics of gliotoxin and bis(methylthio)gliotoxin production during the course of Aspergillus fumigatus infection.

    Gomez-Lopez, Alicia / Rueda, Cristina / Pando Pozo, Rebeca / Sanchez Gonzalez, Luis Miguel

    Medical mycology

    2022  Volume 60, Issue 4

    Abstract: As recently described, fungal secondary metabolism activates during infection in response to a hostile host environment. Gliotoxin and bis(methylthio)gliotoxin are two recognized secondary metabolites produced by Aspergillus fumigatus with differential ... ...

    Abstract As recently described, fungal secondary metabolism activates during infection in response to a hostile host environment. Gliotoxin and bis(methylthio)gliotoxin are two recognized secondary metabolites produced by Aspergillus fumigatus with differential cytotoxicity and involved in virulence. We sought to describe the temporal dynamics of gliotoxin and bis(methylthio)gliotoxin during A. fumigatus progression to further explore their role in the infection. First, we optimized the production of the mycotoxins under different in vitro growth conditions and then specifically measured them using an UHPLC/PDA method. The analytical conditions were selected after testing different parameters such as extraction procedures, column type, and mobile phase composition. We found that gliotoxin and bis(methylthio)gliotoxin are differentially excreted to the extracellular media during the course of A. fumigatus infection regardless of the growth format tested. Dynamic profiles show an early production of gliotoxin, which, after reaching a maximum, decreases coinciding with the increase in the production of the inactive derivative bis(methylthio)gliotoxin. Presence of gliotoxin may indicate an early phase of fungal development, whereas detection of bis(methylthio)gliotoxin may correspond to a more advanced stage of infection. Our chromatographic method successfully characterizes these secondary metabolites. Thus, it may potentially be used to further understand Aspergillus infection.
    Lay summary: Aspergillus fumigatus secondary metabolites may contribute to fungal survival. A new chromatographic method was applied to simultaneously characterize two relevant metabolites. Presence of toxic gliotoxin may indicate an early phase of development, whereas the detection of the inactive derivate may represent an advanced infection stage.
    MeSH term(s) Animals ; Aspergillosis/microbiology ; Aspergillosis/veterinary ; Aspergillus fumigatus ; Gliotoxin/analogs & derivatives ; Gliotoxin/metabolism ; Virulence
    Chemical Substances bis(methylthio)gliotoxin ; Gliotoxin (67-99-2)
    Language English
    Publishing date 2022-04-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1421796-x
    ISSN 1460-2709 ; 1369-3786
    ISSN (online) 1460-2709
    ISSN 1369-3786
    DOI 10.1093/mmy/myac025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Babesia and Theileria Identification in Adult Ixodid Ticks from Tapada Nature Reserve, Portugal

    Fernández, Nélida / Revuelta, Belen / Aguilar, Irene / Soares, Jorge Francisco / Zintl, Annetta / Gray, Jeremy / Montero, Estrella / Gonzalez, Luis Miguel

    Pathogens. 2022 Feb. 08, v. 11, no. 2

    2022  

    Abstract: This study, conducted in a nature reserve in southern Portugal, investigated the frequency and diversity of tick-borne piroplasms in six species of adult ixodid ticks removed from 71 fallow deer (Dama dama) and 12 red deer (Cervus elaphus), collected ... ...

    Abstract This study, conducted in a nature reserve in southern Portugal, investigated the frequency and diversity of tick-borne piroplasms in six species of adult ixodid ticks removed from 71 fallow deer (Dama dama) and 12 red deer (Cervus elaphus), collected over the period 2012–2019. The majority of 520 ticks were Ixodes ricinus (78.5%), followed by Rhipicephalus sanguineus sensu lato, Hyalomma lusitanicum, Haemaphysalis punctata, Dermacentor marginatus, and Ixodes hexagonus. The R. sanguineus ticks collected from the deer were clearly exophilic, in contrast to the endophilic species usually associated with dogs. Four tick-borne piroplasms, including Theileria spp., and the zoonotic species, Babesia divergens and Babesia microti, were detected. B. divergens 18S rDNA, identical to that of the bovine reference strain U16370 and to certain strains from red deer, was detected in I. ricinus ticks removed from fallow deer. The sporadic detection of infections in ticks removed from the same individual hosts suggests that the piroplasms were present in the ticks rather than the hosts. Theileria sp. OT3 was found in I. ricinus and, along with T. capreoli, was also detected in some of the other tick species. The natural vector and pathogenic significance of this piroplasm are unknown.
    Keywords Babesia divergens ; Babesia microti ; Cervus dama ; Cervus elaphus ; Dermacentor marginatus ; Haemaphysalis punctata ; Hyalomma ; Ixodes hexagonus ; Ixodes ricinus ; Rhipicephalus sanguineus ; Theileria ; adults ; cattle ; conservation areas ; deer ; ticks ; Portugal
    Language English
    Dates of publication 2022-0208
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11020222
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Integration of Genomic and Transcriptomic Data to Elucidate Molecular Processes in Babesia divergens.

    Gonzalez, Luis Miguel / Sevilla, Elena / Fernández-García, Miguel / Sanchez-Flores, Alejandro / Montero, Estrella

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2369, Page(s) 199–215

    Abstract: Emerging pathogens have developed ingenious life cycles to facilitate their growth and survival in the host organism. Detailed knowledge of the life cycle of these pathogens is increasingly necessary if we are to design new strategies to prevent ... ...

    Abstract Emerging pathogens have developed ingenious life cycles to facilitate their growth and survival in the host organism. Detailed knowledge of the life cycle of these pathogens is increasingly necessary if we are to design new strategies to prevent infection and transmission. Multi-omics platforms provide useful data at different biological levels, and integration of these data into current approaches can facilitate holistic assessment of emerging pathogens. In this chapter, we bring together various methods and apply an integrative approach for analysis of genomic and transcriptomic data in Babesia divergens, an Apicomplexa emerging parasite that invades red blood cells and causes redwater fever in cattle and the most severe form of babesiosis in humans in Europe. The integrative methodology described herein can be helpful to identify genes active at specific points during life cycle of Apicomplexa parasites.
    MeSH term(s) Animals ; Babesia/genetics ; Babesiosis ; Cattle ; Cattle Diseases ; Genomics ; Life Cycle Stages/genetics ; Transcriptome
    Language English
    Publishing date 2021-07-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1681-9_12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Correction to: Seminal Plasma and Serum Afamin Levels Are Associated with Infertility in Men with Oligoasthenoteratozoospermia.

    Nuñez-Calonge, Rocio / Cortes, Susana / Peregrín, Pedro Caballero / Gonzalez, Luis Miguel Gutierrez / Kireev, Roman

    Reproductive sciences (Thousand Oaks, Calif.)

    2021  Volume 28, Issue 5, Page(s) 1507

    Language English
    Publishing date 2021-02-22
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2276411-2
    ISSN 1933-7205 ; 1933-7191
    ISSN (online) 1933-7205
    ISSN 1933-7191
    DOI 10.1007/s43032-021-00489-3
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    Zs.A 4113: Show issues Location:
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