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Article ; Online: Recent Key Efforts to Improve HIV-Related Intersectional Stigma and Discrimination Research.

Goodenow, Maureen M / Rausch, Dianne M

2022 Volume 112, Issue S4, Page(s) S393–S394

MeSH term(s)	HIV Infections ; Humans ; Social Stigma
Language	English
Publishing date	2022-06-28
Publishing country	United States
Document type	Editorial
ZDB-ID	121100-6
ISSN	1541-0048 ; 0090-0036 ; 0002-9572
ISSN (online)	1541-0048
ISSN	0090-0036 ; 0002-9572
DOI	10.2105/AJPH.2022.306712
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Article ; Online: Importance of HIV/AIDS-Related Behavioral and Social Sciences Research at the NIH and Beyond.

Goodenow, Maureen M / Gaist, Paul

Journal of acquired immune deficiency syndromes (1999)

2019 Volume 82 Suppl 2, Page(s) S84–S87

Abstract: Opportunity statement: Key topics discussed in this article were previously presented at the Center for AIDS Research Social and Behavioral Sciences Network's 12th National Scientific Meeting in August 2018. This article highlights the importance of ... ...

Abstract	Opportunity statement: Key topics discussed in this article were previously presented at the Center for AIDS Research Social and Behavioral Sciences Network's 12th National Scientific Meeting in August 2018. This article highlights the importance of behavioral and social sciences research (BSSR) in addressing the HIV/AIDS pandemic. Approach: NIH has made significant investments in HIV/AIDS-related BSSR. These investments support the development of effective, evidence-based sociobehavioral HIV prevention, treatment, and care strategies. Discussion: The implementation and use of evidence-based sociobehavioral approaches in combination with biomedical strategies provide the availability of multiple tools to end the HIV epidemic in the United Sates and the pandemic globally. Future directions: BSSR-related opportunities to mitigate the persistent challenges HIV/AIDS presents include, but are not limited to, further incorporating BSSR into HIV vaccine and cure research; improving interventions that address stigma and the social determinants of health that perpetuate HIV transmission within key populations; and conducting implementation science research that shapes national and international policies impacting HIV prevention, treatment, and care.
MeSH term(s)	Behavioral Sciences/economics ; Behavioral Sciences/trends ; Evidence-Based Medicine ; HIV Infections/prevention & control ; Humans ; National Institutes of Health (U.S.) ; Social Sciences/economics ; Social Sciences/trends ; Social Stigma ; Translational Medical Research ; United States
Language	English
Publishing date	2019-10-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/QAI.0000000000002163
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Article ; Online: Role of NIH in the Ending the HIV Epidemic in the US Initiative: Research Improving Practice.

Glenshaw, Mary T / Gaist, Paul / Wilson, Amber / Cregg, Robert C / Holtz, Timothy H / Goodenow, Maureen M

Journal of acquired immune deficiency syndromes (1999)

2022 Volume 90, Issue S1, Page(s) S9–S16

Abstract: Abstract: In 2019, approximately 1.2 M persons were living with HIV and an estimated 34,800 new HIV infections occurred in the United States (U.S.). Significant disparities in HIV burden exist among persons of color, those with male-to-male sexual ... ...

Abstract	Abstract: In 2019, approximately 1.2 M persons were living with HIV and an estimated 34,800 new HIV infections occurred in the United States (U.S.). Significant disparities in HIV burden exist among persons of color, those with male-to-male sexual contact, young people, and persons experiencing barriers to consistent uptake of HIV interventions and services. These disparities are the root of major gaps in coverage of HIV testing, linkage to prevention and treatment, adherence, and retention in services in the United States. These gaps help fuel the American HIV epidemic. The Ending the HIV Epidemic in the U.S. Initiative (EHE) is built on 4 decades of federal domestic and international responses to HIV/AIDS. As the largest health research agency in the world, the National Institutes for Health (NIH) funds extensive basic, clinical, translational, and implementation HIV research that is crucial to achieving HIV epidemic control. Addressing the gaps and meeting EHE milestones will be accomplished in part through a combination of adaptation, implementation, and scale-up of existing HIV interventions. New discoveries will also be needed to create improved and novel diagnostics, monitor viral loads, and develop new prevention and treatment tools and approaches. HIV implementation research is essential to demonstrate the most effective strategies to facilitate the adaptation, adoption, and integration of evidence-based HIV interventions in real-world settings. This article outlines current NIH research plans to reduce and identify new HIV infections, improve treatment coverage and outcomes among persons with HIV, and effectively respond to HIV transmission outbreaks in the United States.
MeSH term(s)	Adolescent ; Epidemics/prevention & control ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; HIV Testing ; Humans ; Male ; Sexual Behavior ; United States/epidemiology ; Viral Load
Language	English
Publishing date	2022-05-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/QAI.0000000000002960
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Article ; Online: Centring the health of women across the HIV research continuum.

Barr, Elizabeth / Marshall, Leslie J / Collins, Lauren F / Godfrey, Catherine / St Vil, Noelle / Stockman, Jamila K / Davey, Dvora L Joseph / Dong, Krista / Temkin, Sarah M / Glenshaw, Mary T / Byrd, Corette / Clayton, Janine A / Goodenow, Maureen M

The lancet. HIV

2024 Volume 11, Issue 3, Page(s) e186–e194

Abstract: Despite tremendous advances in HIV research, women and gender diverse people-particularly women from racial and ethnic groups under-represented in research, transgender women, and young women-remain disproportionately affected by HIV. Women and gender ... ...

Abstract	Despite tremendous advances in HIV research, women and gender diverse people-particularly women from racial and ethnic groups under-represented in research, transgender women, and young women-remain disproportionately affected by HIV. Women and gender diverse people face unique challenges and have been under-represented in HIV research. The National Institutes of Health (NIH) is tasked to apply fundamental knowledge about the nature and behaviour of living systems to enhance health, lengthen life, and reduce disability. Rigorous exploration of-and interventions for-the individual, social, biological, structural, and environmental factors that influence HIV prevention, transmission, treatment, and cure is crucial to advance research for women, girls, and gender diverse people across the lifespan. In this Position Paper, we introduce a framework for an intersectional, equity-informed, data-driven approach to research on HIV and women and highlight selected issues for women and gender diverse people, including HIV prevention, HIV cure, ageing with HIV, substance use and misuse, violence, pregnancy, and breastfeeding or chestfeeding. This framework underlines a new HIV and Women Signature Programme from the NIH Office of AIDS Research and Office of Research on Women's Health that advances the NIH vision for women's health, in which all women receive evidence-based HIV prevention, treatment, and care across their lifespan tailored to their unique needs, circumstances, and goals. The time is now to centre the health of women, girls, and gender diverse people across the HIV research continuum.
MeSH term(s)	Humans ; Female ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Acquired Immunodeficiency Syndrome ; Women's Health ; Gender Identity ; Violence
Language	English
Publishing date	2024-02-28
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2352-3018
ISSN (online)	2352-3018
DOI	10.1016/S2352-3018(24)00004-3
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Article ; Online: Editorial: Passive aggressive avoidance of SAMHD1 restriction by HIV-1.

Appelberg, K Sofia / Goodenow, Maureen M

Journal of leukocyte biology

2015 Volume 98, Issue 1, Page(s) 1–3

MeSH term(s)	Gene Expression Profiling ; Humans ; Monomeric GTP-Binding Proteins/metabolism
Chemical Substances	Monomeric GTP-Binding Proteins (EC 3.6.5.2)
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Comment ; Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1189/jlb.4CE0215-044R
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Article ; Online: Unique genotypic features of HIV-1 C gp41 membrane proximal external region variants during pregnancy relate to mother-to-child transmission via breastfeeding.

Yin, Li / Chang, Kai-Fen / Nakamura, Kyle J / Kuhn, Louise / Aldrovandi, Grace M / Goodenow, Maureen M

Journal of clinical pediatrics and neonatology

2020 Volume 1, Issue 1, Page(s) 9–20

Abstract: Mother-to-child transmission (MTCT) through breastfeeding remains a major source of pediatric HIV-1 infection worldwide. To characterize plasma HIV-1 subtype C populations from infected mothers during pregnancy that related to subsequent breast milk ... ...

Abstract	Mother-to-child transmission (MTCT) through breastfeeding remains a major source of pediatric HIV-1 infection worldwide. To characterize plasma HIV-1 subtype C populations from infected mothers during pregnancy that related to subsequent breast milk transmission, an exploratory study was designed to apply next generation sequencing and a custom bioinformatics pipeline for HIV-1 gp41 extending from heptad repeat region 2 (HR2) through the membrane proximal external region (MPER) and the membrane spanning domain (MSD). MPER harbors linear and highly conserved epitopes that repeatedly elicits HIV-1 neutralizing antibodies with exceptional breadth. Viral populations during pregnancy from women who transmitted by breastfeeding, compared to those who did not, displayed greater biodiversity, more frequent amino acid polymorphisms, lower hydropathy index and greater positive charge. Viral characteristics were restricted to MPER, failed to extend into flanking HR2 or MSD regions, and were unrelated to predicted neutralization resistance. Findings provide novel parameters to evaluate an association between maternal MPER variants present during gestation and lactogenesis with subsequent transmission outcomes by breastfeeding. Importance: HIV-1 transmission through breastfeeding accounts for 39% of MTCT and continues as a major route of pediatric infection in developing countries where access to interventions for interrupting transmission is limited. Identifying women who are likely to transmit HIV-1 during breastfeeding would focus therapies, such as broad neutralizing HIV monoclonal antibodies (bn-HIV-Abs), during the breastfeeding period to reduce MTCT. Findings from our pilot study identify novel characteristics of gestational viral MPER quasispecies related to transmission outcomes and raise the possibility for predicting MTCT by breastfeeding based on identifying mothers with high-risk viral populations.
Language	English
Publishing date	2020-04-13
Publishing country	United States
Document type	Journal Article
ISSN	2767-3995
ISSN (online)	2767-3995
DOI	10.46439/pediatrics.1.003
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Article ; Online: Biomarkers detected in cord blood predict vaccine responses in young infants.

Baloh, Carolyn H / Venturi, Guglielmo M / Fischer, Bernard M / Sadder, Liane S / Kim-Chang, Julie J / Chan, Cliburn / De Paris, Kristina / Yin, Li / Aldrovandi, Grace M / Goodenow, Maureen M / Sleasman, John W

Frontiers in immunology

2023 Volume 14, Page(s) 1152538

Abstract: Introduction: Factors influencing vaccine immune priming in the first year of life involve both innate and adaptive immunity but there are gaps in understanding how these factors sustain vaccine antibody levels in healthy infants. The hypothesis was ... ...

Abstract	Introduction: Factors influencing vaccine immune priming in the first year of life involve both innate and adaptive immunity but there are gaps in understanding how these factors sustain vaccine antibody levels in healthy infants. The hypothesis was that bioprofiles associated with B cell survival best predict sustained vaccine IgG levels at one year. Methods: Longitudinal study of plasma bioprofiles in 82 term, healthy infants, who received standard recommended immunizations in the United States, with changes in 15 plasma biomarker concentrations and B cell subsets associated with germinal center development monitored at birth, soon after completion of the initial vaccine series at 6 months, and prior to the 12-month vaccinations. Post vaccination antibody IgG levels to Results: Using a least absolute shrinkage and selection operator (lasso) regression model, cord blood (CB) plasma IL-2, IL-17A, IL-31, and soluble CD14 (sCD14) were positively associated with pertussis IgG levels at 12 months, while CB plasma concentrations of APRIL and IL-33 were negatively associated. In contrast, CB concentrations of sCD14 and APRIL were positively associated with sustained tetanus IgG levels. A separate cross-sectional analysis of 18 mother/newborn pairs indicated that CB biomarkers were not due to transplacental transfer, but rather due to immune activation at the fetal/maternal interface. Elevated percentages of cord blood switched memory B cells were positively associated with 12-month Discussion: Sustained B cell immunity is highly influenced by early life immune dynamics beginning prior to birth. The findings provide important insights into how germinal center development shapes vaccine responses in healthy infants and provide a foundation for studies of conditions that impair infant immune development.
MeSH term(s)	Infant, Newborn ; Humans ; Infant ; Whooping Cough ; Longitudinal Studies ; Fetal Blood ; Cross-Sectional Studies ; Lipopolysaccharide Receptors ; Tetanus Toxoid ; Immunoglobulin G
Chemical Substances	Lipopolysaccharide Receptors ; Tetanus Toxoid ; Immunoglobulin G
Language	English
Publishing date	2023-05-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1152538
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Article: Molecular Docking-Based Screening for Novel Inhibitors of the Human Immunodeficiency Virus Type 1 Protease that Effectively Reduce the Viral Replication in Human Cells.

Mavian, Carla / Coman, Roxana M / Zhang, Xinrui / Pomeroy, Steve / Ostrov, David A / Dunn, Ben M / Sleasman, John W / Goodenow, Maureen M

Journal of AIDS & clinical research

2021 Volume 12, Issue 5

Abstract: Therapeutic pressure by protease inhibitors (PIs) contributes to accumulation of mutations in the HIV type 1 (HIV-1) protease (PR) leading to development of drug resistance with subsequent therapy failure. Current PIs target the active site of PR in a ... ...

Abstract	Therapeutic pressure by protease inhibitors (PIs) contributes to accumulation of mutations in the HIV type 1 (HIV-1) protease (PR) leading to development of drug resistance with subsequent therapy failure. Current PIs target the active site of PR in a competitive manner. Identification of molecules that exploit non-active site mechanisms of inhibition is essential to overcome resistance to current PIs. Potential non-active site HIV-1 protease (PR) inhibitors (PI) were identified by in silico screening of almost 140,000 molecules targeting the hinge region of PR. Inhibitory activity of best docking compounds was tested in an
Language	English
Publishing date	2021-05-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2601227-3
ISSN	2155-6113
ISSN	2155-6113
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Article ; Online: Internal pilot design for balanced repeated measures.

Zhang, Xinrui / Muller, Keith E / Goodenow, Maureen M / Chi, Yueh-Yun

Statistics in medicine

2017 Volume 37, Issue 3, Page(s) 375–389

Abstract: Repeated measures are common in clinical trials and epidemiological studies. Designing studies with repeated measures requires reasonably accurate specifications of the variances and correlations to select an appropriate sample size. Underspecifying the ... ...

Abstract	Repeated measures are common in clinical trials and epidemiological studies. Designing studies with repeated measures requires reasonably accurate specifications of the variances and correlations to select an appropriate sample size. Underspecifying the variances leads to a sample size that is inadequate to detect a meaningful scientific difference, while overspecifying the variances results in an unnecessarily large sample size. Both lead to wasting resources and placing study participants in unwarranted risk. An internal pilot design allows sample size recalculation based on estimates of the nuisance parameters in the covariance matrix. We provide the theoretical results that account for the stochastic nature of the final sample size in a common class of linear mixed models. The results are useful for designing studies with repeated measures and balanced design. Simulations examine the impact of misspecification of the covariance matrix and demonstrate the accuracy of the approximations in controlling the type I error rate and achieving the target power. The proposed methods are applied to a longitudinal study assessing early antiretroviral therapy for youth living with HIV.
MeSH term(s)	Clinical Trials as Topic ; Computer Simulation ; Humans ; Linear Models ; Longitudinal Studies ; Multivariate Analysis ; Pilot Projects ; Research Design ; Sample Size ; Stochastic Processes
Language	English
Publishing date	2017-11-21
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	843037-8
ISSN	1097-0258 ; 0277-6715
ISSN (online)	1097-0258
ISSN	0277-6715
DOI	10.1002/sim.7524
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Zs.A 1756: Show issues

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Article ; Online: Anti-inflammatory effects of recreational marijuana in virally suppressed youth with HIV-1 are reversed by use of tobacco products in combination with marijuana.

Yin, Li / Dinasarapu, Ashok R / Borkar, Samiksha A / Chang, Kai-Fen / De Paris, Kristina / Kim-Chang, Julie J / Sleasman, John W / Goodenow, Maureen M

Retrovirology

2022 Volume 19, Issue 1, Page(s) 10

Abstract: Background: Marijuana's putative anti-inflammatory properties may benefit HIV-associated comorbidities. How recreational marijuana use affects gene expression in peripheral blood cells (PBC) among youth with HIV-1 (YWH) is unknown.: Approach: YWH ... ...

Abstract	Background: Marijuana's putative anti-inflammatory properties may benefit HIV-associated comorbidities. How recreational marijuana use affects gene expression in peripheral blood cells (PBC) among youth with HIV-1 (YWH) is unknown. Approach: YWH with defined substance use (n = 54) receiving similar antiretroviral therapy (ART) were assigned to one of four analysis groups: YWH with detectable plasma HIV-1 (> 50 RNA copies/ml) who did not use substances (H+V+S-), and YWH with undetectable plasma HIV-1 who did not use substances (H+V-S-), or used marijuana alone (H+V-S+[M]), or marijuana in combination with tobacco (H+V-S+[M/T]). Non-substance using youth without HIV infection (H-S-, n = 25) provided a reference group. PBC mRNA was profiled by Affymetrix GeneChip Human Genome U133 Plus 2.0 Array. Differentially expressed genes (DEG) within outcome groups were identified by Significance Analysis of Microarrays and used for Hierarchical Clustering, Principal Component Analysis, and Ingenuity Pathways Analysis. Results: HIV-1 replication resulted in > 3000 DEG involving 27 perturbed pathways. Viral suppression reduced DEG to 313, normalized all 27 pathways, and down-regulated two additional pathways, while marijuana use among virally suppressed YWH resulted in 434 DEG and no perturbed pathways. Relative to H+V-S-, multiple DEG normalized in H+V-S+[M]. In contrast, H+V-S+[M/T] had 1140 DEG and 10 dysregulated pathways, including multiple proinflammatory genes and six pathways shared by H+V+S-. Conclusions: YWH receiving ART display unique transcriptome bioprofiles based on viral replication and substance use. In the context of HIV suppression, marijuana use, alone or combined with tobacco, has opposing effects on inflammatory gene expression.
MeSH term(s)	Adolescent ; Cannabis ; HIV Infections/drug therapy ; HIV-1/genetics ; Humans ; Substance-Related Disorders ; Tobacco Products
Language	English
Publishing date	2022-05-31
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Intramural
ZDB-ID	2142602-8
ISSN	1742-4690 ; 1742-4690
ISSN (online)	1742-4690
ISSN	1742-4690
DOI	10.1186/s12977-022-00594-4
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