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  1. Article ; Online: Talking with teens about traffic safety: Initial feasibility, acceptability, and efficacy of a parent-targeted intervention for primary care settings.

    Mirman, Jessica H / Goodman, Emma S / Friedrich, Elizabeth / Ford, Carol A

    Journal of safety research

    2018  Volume 66, Page(s) 113–120

    Abstract: Introduction: The aims of the current pilot study were to evaluate the feasibility, acceptability, and preliminary efficacy of the Talking with Teens about Traffic Safety Program. The program consists of a clinic-based health coaching session with ... ...

    Abstract Introduction: The aims of the current pilot study were to evaluate the feasibility, acceptability, and preliminary efficacy of the Talking with Teens about Traffic Safety Program. The program consists of a clinic-based health coaching session with parents of adolescents at their annual well-child visit to promote parent-teen communication about teen driver safety including: a Parent Handbook that is designed to serve as a primer on teen driver safety and facilitate parent-teen communication on a variety of teen driver topics; an interactive practice driving toolset; and an endorsement of the materials by the primary care provider.
    Method: Fifty-four parent-teen dyads (n = 108 total) were recruited from a primary care practice. Dyads were randomized (1:1) into a treatment group or a usual care group. Implementation fidelity was assessed using checklists completed by health coaches and parent interviews. After 6 months, parents reported how often they talked with their teen about 12 safe driving topics (e.g., state graduated driver licensing laws).
    Results: Parents in the treatment group reported more frequent discussions than parents in the control group on 7 out of the 12 topics. Fidelity data indicate that 100% of sessions were implemented as designed and were acceptable to parents.
    Conclusions: The program was feasible to administer and there was evidence for preliminary efficacy. Generally, effects were larger for more infrequently discussed topics, which is to be expected due to the potential for ceiling effects on more commonly discussed topics (e.g., distracted driving). A larger multi-site study is warranted.
    Practical applications: The results from this pilot study provide support for implementation fidelity and establish a proof-of-concept for the Talking with Teens about Traffic Safety Program. The results provide guidance for developing partnerships with pediatricians and parents to develop parent-teen communication interventions on injury prevention topics.
    MeSH term(s) Accidents, Traffic/prevention & control ; Accidents, Traffic/psychology ; Adolescent ; Adolescent Behavior/psychology ; Automobile Driving/psychology ; Feasibility Studies ; Female ; Humans ; Information Dissemination/methods ; Male ; Parent-Child Relations ; Pilot Projects ; Primary Health Care ; Safety ; United States
    Language English
    Publishing date 2018-06-23
    Publishing country United States
    Document type Evaluation Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2015321-1
    ISSN 1879-1247 ; 0022-4375
    ISSN (online) 1879-1247
    ISSN 0022-4375
    DOI 10.1016/j.jsr.2018.06.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: FS222, a CD137/PD-L1 Tetravalent Bispecific Antibody, Exhibits Low Toxicity and Antitumor Activity in Colorectal Cancer Models.

    Lakins, Matthew A / Koers, Alexander / Giambalvo, Raffaella / Munoz-Olaya, Jose / Hughes, Robert / Goodman, Emma / Marshall, Sylwia / Wollerton, Francisca / Batey, Sarah / Gliddon, Daniel / Tuna, Mihriban / Brewis, Neil

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2020  Volume 26, Issue 15, Page(s) 4154–4167

    Abstract: Purpose: With the increased prevalence in checkpoint therapy resistance, there remains a significant unmet need for additional therapies for patients with relapsing or refractory cancer. We have developed FS222, a bispecific tetravalent antibody ... ...

    Abstract Purpose: With the increased prevalence in checkpoint therapy resistance, there remains a significant unmet need for additional therapies for patients with relapsing or refractory cancer. We have developed FS222, a bispecific tetravalent antibody targeting CD137 and PD-L1, to induce T-cell activation to eradicate tumors without the current toxicity and efficacy limitations seen in the clinic.
    Experimental design: A bispecific antibody (FS222) was developed by engineering CD137 antigen-binding sites into the Fc region of a PD-L1 IgG1 mAb. T-cell activation by FS222 was investigated using multiple
    Results: We demonstrated simultaneous binding of CD137 and PD-L1 and showed potent T-cell activation across CD8
    Conclusions: By targeting CD137 agonism to areas of PD-L1 expression, predominantly found in the tumor microenvironment, FS222 has the potential to leverage a focused, potent, and safe immune response augmenting the PD-(L)1 axis blockade.
    MeSH term(s) Animals ; Antibodies, Bispecific/physiology ; Antibodies, Bispecific/therapeutic use ; Antineoplastic Agents, Immunological/pharmacology ; Antineoplastic Agents, Immunological/therapeutic use ; B7-H1 Antigen/antagonists & inhibitors ; Cell Line, Tumor/transplantation ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/pathology ; Disease Models, Animal ; Drug Screening Assays, Antitumor ; Female ; HEK293 Cells ; Humans ; Leukocytes, Mononuclear ; Macaca fascicularis ; Mice ; Primary Cell Culture ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology ; Tumor Necrosis Factor Receptor Superfamily, Member 9/antagonists & inhibitors
    Chemical Substances Antibodies, Bispecific ; Antineoplastic Agents, Immunological ; B7-H1 Antigen ; CD274 protein, human ; TNFRSF9 protein, human ; Tumor Necrosis Factor Receptor Superfamily, Member 9
    Language English
    Publishing date 2020-04-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-19-2958
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Atypical frontoamygdala functional connectivity in youth with autism.

    Odriozola, Paola / Dajani, Dina R / Burrows, Catherine A / Gabard-Durnam, Laurel J / Goodman, Emma / Baez, Adriana C / Tottenham, Nim / Uddin, Lucina Q / Gee, Dylan G

    Developmental cognitive neuroscience

    2018  Volume 37, Page(s) 100603

    Abstract: Functional connectivity (FC) between the amygdala and the ventromedial prefrontal cortex underlies socioemotional functioning, a core domain of impairment in autism spectrum disorder (ASD). Although frontoamygdala circuitry undergoes dynamic changes ... ...

    Abstract Functional connectivity (FC) between the amygdala and the ventromedial prefrontal cortex underlies socioemotional functioning, a core domain of impairment in autism spectrum disorder (ASD). Although frontoamygdala circuitry undergoes dynamic changes throughout development, little is known about age-related changes in frontoamygdala networks in ASD. Here we characterize frontoamygdala resting-state FC in a cross-sectional sample (ages 7-25) of 58 typically developing (TD) individuals and 53 individuals with ASD. Contrary to hypotheses, individuals with ASD did not show different age-related patterns of frontoamygdala FC compared with TD individuals. However, overall group differences in frontoamygdala FC were observed. Specifically, relative to TD individuals, individuals with ASD showed weaker frontoamygdala FC between the right basolateral (BL) amygdala and the rostral anterior cingulate cortex (rACC). These findings extend prior work to a broader developmental range in ASD, and indicate ASD-related differences in frontoamygdala FC that may underlie core socioemotional impairments in children and adolescents with ASD.
    MeSH term(s) Amygdala/physiopathology ; Autism Spectrum Disorder/physiopathology ; Child ; Cross-Sectional Studies ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Prefrontal Cortex/physiopathology
    Language English
    Publishing date 2018-12-07
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1878-9307
    ISSN (online) 1878-9307
    DOI 10.1016/j.dcn.2018.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2.

    Peña, Catherine J / Kronman, Hope G / Walker, Deena M / Cates, Hannah M / Bagot, Rosemary C / Purushothaman, Immanuel / Issler, Orna / Loh, Yong-Hwee Eddie / Leong, Tin / Kiraly, Drew D / Goodman, Emma / Neve, Rachael L / Shen, Li / Nestler, Eric J

    Science (New York, N.Y.)

    2017  Volume 356, Issue 6343, Page(s) 1185–1188

    Abstract: Early life stress increases risk for depression. Here we establish a "two-hit" stress model in mice wherein stress at a specific postnatal period increases susceptibility to adult social defeat stress and causes long-lasting transcriptional alterations ... ...

    Abstract Early life stress increases risk for depression. Here we establish a "two-hit" stress model in mice wherein stress at a specific postnatal period increases susceptibility to adult social defeat stress and causes long-lasting transcriptional alterations that prime the ventral tegmental area (VTA)-a brain reward region-to be in a depression-like state. We identify a role for the developmental transcription factor orthodenticle homeobox 2 (
    MeSH term(s) Age Factors ; Animals ; Depression/genetics ; Depression/physiopathology ; Female ; Gene Expression Regulation ; Gene Knockdown Techniques ; Male ; Mice ; Mice, Inbred C57BL ; Otx Transcription Factors/genetics ; Protein Binding ; Stress, Physiological/genetics ; Ventral Tegmental Area/physiopathology
    Chemical Substances Otx Transcription Factors ; Otx2 protein, mouse
    Language English
    Publishing date 2017--16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aan4491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Families with children conceived by donor insemination: a follow-up at age twelve.

    Golombok, Susan / MacCallum, Fiona / Goodman, Emma / Rutter, Michael

    Child development

    2002  Volume 73, Issue 3, Page(s) 952–968

    Abstract: Growing public awareness of the use of donor insemination (DI) to enable infertile couples to become parents has been accompanied by increasing concern regarding the potentially negative consequences for family relationships and child development. ... ...

    Abstract Growing public awareness of the use of donor insemination (DI) to enable infertile couples to become parents has been accompanied by increasing concern regarding the potentially negative consequences for family relationships and child development. Findings are presented from a prospective study of the quality of parenting and psychological adjustment of DI children at age 12. Thirty-seven DI families, 49 adoptive families, and 91 families with a naturally conceived child were compared on standardized interview and questionnaire measures administered to mothers, fathers, children, and teachers. The differences between DI families and the other family types reflected greater expressive warmth of DI mothers toward their children and less involvement in the discipline of their children by DI fathers. The DI children were well adjusted in terms of their social and emotional development. The findings are discussed with respect to the secrecy surrounding DI and the imbalance in genetic relatedness between the parents and the child.
    MeSH term(s) Adaptation, Psychological ; Child ; Female ; Follow-Up Studies ; Humans ; Insemination, Artificial ; Male ; Parent-Child Relations ; Prospective Studies ; Self Concept ; Surveys and Questionnaires ; Tissue Donors
    Language English
    Publishing date 2002-01-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 215602-7
    ISSN 1467-8624 ; 0009-3920
    ISSN (online) 1467-8624
    ISSN 0009-3920
    DOI 10.1111/1467-8624.00449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Follow-up studies on the psychological consequences of successful IVF treatment.

    Goodman, Emma / MacCallum, Fiona / Golombok, Susan

    Biomedical ethics (Tubingen, Germany)

    1998  Volume 3, Issue 2, Page(s) 40–43

    MeSH term(s) Child ; Empirical Research ; Family Relations ; Fertilization in Vitro ; Humans ; Infertility ; Marriage ; Psychology ; Reproductive Techniques, Assisted ; Research ; Stress, Psychological
    Language English
    Publishing date 1998
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1363429-x
    ISSN 1430-9858
    ISSN 1430-9858
    Database MEDical Literature Analysis and Retrieval System OnLINE

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