LIVIVO - Search results -

Search results

Result 1 - 10 of total 33

Search options

Article ; Online: Immune Mechanisms in Cardiovascular Diseases Associated With Viral Infection.

Gopal, Radha / Marinelli, Michael A / Alcorn, John F

2020 Volume 11, Page(s) 570681

Abstract: Influenza virus infection causes 3-5 million cases of severe illness and 250,000-500,000 deaths worldwide annually. Although pneumonia is the most common complication associated with influenza, there are several reports demonstrating increased risk for ... ...

Abstract	Influenza virus infection causes 3-5 million cases of severe illness and 250,000-500,000 deaths worldwide annually. Although pneumonia is the most common complication associated with influenza, there are several reports demonstrating increased risk for cardiovascular diseases. Several clinical case reports, as well as both prospective and retrospective studies, have shown that influenza can trigger cardiovascular events including myocardial infarction (MI), myocarditis, ventricular arrhythmia, and heart failure. A recent study has demonstrated that influenza-infected patients are at highest risk of having MI during the first seven days of diagnosis. Influenza virus infection induces a variety of pro-inflammatory cytokines and chemokines and recruitment of immune cells as part of the host immune response. Understanding the cellular and molecular mechanisms involved in influenza-associated cardiovascular diseases will help to improve treatment plans. This review discusses the direct and indirect effects of influenza virus infection on triggering cardiovascular events. Further, we discussed the similarities and differences in epidemiological and pathogenic mechanisms involved in cardiovascular events associated with coronavirus disease 2019 (COVID-19) compared to influenza infection.
MeSH term(s)	Animals ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/virology ; Cardiovascular Diseases/immunology ; Cardiovascular Diseases/virology ; Cytokines/genetics ; Cytokines/immunology ; Humans ; Influenza, Human/genetics ; Influenza, Human/immunology ; Influenza, Human/virology ; Orthomyxoviridae/genetics ; Orthomyxoviridae/physiology ; SARS-CoV-2/genetics ; SARS-CoV-2/physiology
Chemical Substances	Cytokines
Keywords	covid19
Language	English
Publishing date	2020-10-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.570681
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: STAT1 regulates neutrophil gelatinase B-associated lipocalin induction in influenza-induced myocarditis.

Constantinesco, Nicholas J / Srikanth, Sashwath / De Vito, Louis / Moras, Crystal / Ramasubramanian, Vennila / Chinnappan, Baskaran / Hartwick, Sean / Schwab, Kristina E / Wu, Yijen / Gopal, Radha

Scientific reports

2024 Volume 14, Issue 1, Page(s) 11124

Abstract: Influenza is a significant public health and economic threat around the world. Epidemiological studies have demonstrated a close association between influenza pandemics and cardiovascular mortality. Moreover, it has been shown that there is a decrease in ...

Abstract	Influenza is a significant public health and economic threat around the world. Epidemiological studies have demonstrated a close association between influenza pandemics and cardiovascular mortality. Moreover, it has been shown that there is a decrease in cardiovascular mortality in high-risk patients following vaccination with the influenza vaccine. Here, we have investigated the role of anti-viral STAT1 signaling in influenza-induced myocarditis. Wild-type mice (C57BL/6) were infected with either influenza A/PR/8/34 or control, and cellular response and gene expression analysis from the heart samples were assessed 7 days later. The expression of interferon response genes STAT1, STAT2, Mx1, OASL2, ISG15, chemokines CCL2, CCL3, CXCL9 and CXCL10, and the frequency of neutrophils (CD45
MeSH term(s)	Animals ; Myocarditis/virology ; Myocarditis/metabolism ; Myocarditis/etiology ; Lipocalin-2/metabolism ; Lipocalin-2/genetics ; STAT1 Transcription Factor/metabolism ; STAT1 Transcription Factor/genetics ; Mice ; Orthomyxoviridae Infections/complications ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/metabolism ; Mice, Inbred C57BL ; Neutrophils/metabolism ; Neutrophils/immunology ; Male ; Mice, Knockout
Language	English
Publishing date	2024-05-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-61953-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Immune Mechanisms in Cardiovascular Diseases Associated With Viral Infection

Gopal, Radha / Marinelli, Michael A / Alcorn, John F

Front Immunol

Abstract	Influenza virus infection causes 3-5 million cases of severe illness and 250,000-500,000 deaths worldwide annually. Although pneumonia is the most common complication associated with influenza, there are several reports demonstrating increased risk for cardiovascular diseases. Several clinical case reports, as well as both prospective and retrospective studies, have shown that influenza can trigger cardiovascular events including myocardial infarction (MI), myocarditis, ventricular arrhythmia, and heart failure. A recent study has demonstrated that influenza-infected patients are at highest risk of having MI during the first seven days of diagnosis. Influenza virus infection induces a variety of pro-inflammatory cytokines and chemokines and recruitment of immune cells as part of the host immune response. Understanding the cellular and molecular mechanisms involved in influenza-associated cardiovascular diseases will help to improve treatment plans. This review discusses the direct and indirect effects of influenza virus infection on triggering cardiovascular events. Further, we discussed the similarities and differences in epidemiological and pathogenic mechanisms involved in cardiovascular events associated with coronavirus disease 2019 (COVID-19) compared to influenza infection.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #918135
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Strong Anharmonicity-Induced Low Thermal Conductivity and High n-type Mobility in the Topological Insulator Bi

Pathak, Riddhimoy / Dutta, Prabir / Srivastava, Ashutosh / Rawat, Divya / Gopal, Radha Krishna / Singh, Abhishek K / Soni, Ajay / Biswas, Kanishka

Angewandte Chemie (International ed. in English)

2022 Volume 61, Issue 41, Page(s) e202210783

Abstract: Intrinsically low lattice thermal conductivity ( ... ...

Abstract	Intrinsically low lattice thermal conductivity (κ
Language	English
Publishing date	2022-09-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202210783
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Zinc deficiency enhances sensitivity to influenza A associated bacterial pneumonia in mice.

Gopal, Radha / Tutuncuoglu, Egemen / Bakalov, Veli / Wasserloos, Karla / Li, HuiHua / Lemley, David / DeVito, Louis J / Constantinesco, Nicholas J / Reed, Douglas S / McHugh, Kevin J / Chinnappan, Baskaran / Andreas, Alexis R / Maloy, Abigail / Bain, Daniel / Alcorn, John F / Pitt, Bruce R / Kaynar, Ata Murat

Physiological reports

2024 Volume 12, Issue 1, Page(s) e15902

Abstract: Although zinc deficiency (secondary to malnutrition) has long been considered an important contributor to morbidity and mortality of infectious disease (e.g. diarrhea disorders), epidemiologic data (including randomized controlled trials with ... ...

Abstract	Although zinc deficiency (secondary to malnutrition) has long been considered an important contributor to morbidity and mortality of infectious disease (e.g. diarrhea disorders), epidemiologic data (including randomized controlled trials with supplemental zinc) for such a role in lower respiratory tract infection are somewhat ambiguous. In the current study, we provide the first preclinical evidence demonstrating that although diet-induced acute zinc deficiency (Zn-D: ~50% decrease) did not worsen infection induced by either influenza A (H1N1) or methicillin-resistant staph aureus (MRSA), Zn-D mice were sensitive to the injurious effects of superinfection of H1N1 with MRSA. Although the mechanism underlying the sensitivity of ZnD mice to combined H1N1/MRSA infection is unclear, it was noteworthy that this combination exacerbated lung injury as shown by lung epithelial injury markers (increased BAL protein) and decreased genes related to epithelial integrity in Zn-D mice (surfactant protein C and secretoglobins family 1A member 1). As bacterial pneumonia accounts for 25%-50% of morbidity and mortality from influenza A infection, zinc deficiency may be an important pathology component of respiratory tract infections.
MeSH term(s)	Animals ; Mice ; Influenza A Virus, H1N1 Subtype ; Malnutrition ; Methicillin-Resistant Staphylococcus aureus ; Pneumonia, Bacterial/complications ; Staphylococcus aureus ; Zinc
Chemical Substances	Zinc (J41CSQ7QDS)
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.15902
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Reduced mortality from lower respiratory tract disease in adult diabetic patients treated with metformin.

Mendy, Angelico / Gopal, Radha / Alcorn, John F / Forno, Erick

Respirology (Carlton, Vic.)

2019 Volume 24, Issue 7, Page(s) 646–651

Abstract: Background and objective: Chronic lower respiratory diseases (CLRD) increase the risk of type 2 diabetes, which in turn may worsen lung function. Metformin, a common antidiabetic with anti-inflammatory and antioxidant properties, may improve respiratory ...

Abstract	Background and objective: Chronic lower respiratory diseases (CLRD) increase the risk of type 2 diabetes, which in turn may worsen lung function. Metformin, a common antidiabetic with anti-inflammatory and antioxidant properties, may improve respiratory outcomes. Therefore, we examined the association of metformin use with the risk of mortality from CLRD. Methods: We analysed data from the National Health and Nutrition Examination Survey during 1988-1994 and 1999-2010 for participants aged 40 years or older who had diabetes and were followed up for mortality through 2011. Information on prescription medicine was collected at baseline and CLRD-related mortality during follow-up was defined using the 10th Revision of the International Classification of Diseases (ICD-10). Cox proportional hazards modelling was used to determine the mortality hazard ratio (HR) associated with metformin use, adjusting for relevant covariates. Results: A total of 5266 participants with a median follow-up of 6.1 years were included. The prevalence of metformin use was 31.9% and 1869 participants died during follow-up, including 72 of CLRD. In the adjusted Cox proportional regression analysis, metformin was associated with a decreased risk of CLRD mortality in the overall population (HR: 0.39, 95% CI: 0.15-0.99) and among participants with baseline CLRD (HR: 0.30, 95% CI: 0.10-0.93), after adjusting for age, gender, race/ethnicity, cigarette smoking, body mass index, current asthma and chronic obstructive pulmonary disease (COPD), insulin and other diabetic medications, and glycohaemoglobin level. We found no association between other antidiabetic medications and CLRD mortality. Conclusion: In this sample representative of the U.S. population, metformin was associated with lower CLRD mortality in adults with diabetes.
MeSH term(s)	Adult ; Aged ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/etiology ; Female ; Follow-Up Studies ; Humans ; Hypoglycemic Agents/therapeutic use ; Male ; Metformin/therapeutic use ; Middle Aged ; Nutrition Surveys ; Respiratory Tract Diseases/complications ; Respiratory Tract Diseases/mortality ; Survival Rate/trends ; Time Factors ; United States/epidemiology
Chemical Substances	Hypoglycemic Agents ; Metformin (9100L32L2N)
Language	English
Publishing date	2019-02-13
Publishing country	Australia
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
ZDB-ID	1435849-9
ISSN	1440-1843 ; 1323-7799
ISSN (online)	1440-1843
ISSN	1323-7799
DOI	10.1111/resp.13486
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4957: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Sodium-Glucose Cotransporter-2 Inhibitor, Empagliflozin, Suppresses the Inflammatory Immune Response to Influenza Infection.

Constantinesco, Nicholas J / Chinnappan, Baskaran / DeVito, Louis J / Moras, Crystal / Srikanth, Sashwath / Garcia-Hernandez, Maria de la Luz / Rangel-Moreno, Javier / Gopal, Radha

ImmunoHorizons

2023 Volume 7, Issue 12, Page(s) 861–871

Abstract: Influenza is a highly contagious, acute respiratory disease that causes significant public health and economic threats. Influenza infection induces various inflammatory mediators, IFNs, and recruitment of inflammatory cells in the host. This inflammatory ...

Abstract	Influenza is a highly contagious, acute respiratory disease that causes significant public health and economic threats. Influenza infection induces various inflammatory mediators, IFNs, and recruitment of inflammatory cells in the host. This inflammatory "cytokine storm" is thought to play a role in influenza-induced lung pathogenesis. Empagliflozin is a drug primarily used to lower blood glucose in type II diabetes patients by inhibiting the sodium-glucose cotransporter-2 (SGLT-2) found in the proximal tubules in the kidneys. In this study, we have investigated the effects of empagliflozin on the pulmonary immune response to influenza infection. C57BL/6 mice (wild type) were infected with influenza A/PR/8/34 and treated with empagliflozin, and the disease outcomes were analyzed. Empagliflozin treatment decreased the expression of the inflammatory cytokines IL-1β, IL-6, and CCL2; the percentage of inflammatory monocytes and inducible NO synthase-positive macrophages; and IFN response genes Stat1 and CXCL9 during influenza infection. Further, empagliflozin treatment decreases the expression of IL-6, CCL2, and CCL5 in RAW264.7 macrophages and bone marrow-derived macrophages. However, empagliflozin treatment increased influenza viral titer during infection. Despite fostering an increased viral burden, treatment with empagliflozin decreases the mortality in wild type and high fat diet-induced atherosclerotic LDLR-/- mice. Based on our findings, empagliflozin may have therapeutic implications for use in patients to prevent lung damage and acute respiratory illness.
MeSH term(s)	Humans ; Mice ; Animals ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Diabetes Mellitus, Type 2 ; Influenza, Human/drug therapy ; Interleukin-6 ; Mice, Inbred C57BL ; Blood Glucose ; Immunity ; Sodium/therapeutic use
Chemical Substances	empagliflozin (HDC1R2M35U) ; Sodium-Glucose Transporter 2 Inhibitors ; Interleukin-6 ; Blood Glucose ; Sodium (9NEZ333N27)
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Journal Article
ISSN	2573-7732
ISSN (online)	2573-7732
DOI	10.4049/immunohorizons.2300077
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Immune reconstitution inflammatory syndrome associated with pulmonary pathogens.

Gopal, Radha / Rapaka, Rekha R / Kolls, Jay K

European respiratory review : an official journal of the European Respiratory Society

2017 Volume 26, Issue 143

Abstract: Immune reconstitution inflammatory syndrome (IRIS) is an exaggerated immune response to a variety of pathogens in response to antiretroviral therapy-mediated recovery of the immune system in HIV-infected patients. Although IRIS can occur in many organs, ... ...

Abstract	Immune reconstitution inflammatory syndrome (IRIS) is an exaggerated immune response to a variety of pathogens in response to antiretroviral therapy-mediated recovery of the immune system in HIV-infected patients. Although IRIS can occur in many organs, pulmonary IRIS, associated with opportunistic infections such as Mycobacterium tuberculosis and Pneumocystis jirovecii, is particularly associated with high morbidity and mortality. The pathology of IRIS is associated with a variety of innate and adaptive immune factors, including CD4
MeSH term(s)	Adaptive Immunity ; Animals ; Cytokines/immunology ; Cytokines/metabolism ; Disease Models, Animal ; Host-Pathogen Interactions/immunology ; Humans ; Immune Reconstitution Inflammatory Syndrome/diagnosis ; Immune Reconstitution Inflammatory Syndrome/genetics ; Immune Reconstitution Inflammatory Syndrome/immunology ; Immune Reconstitution Inflammatory Syndrome/metabolism ; Immunity, Innate ; Inflammation Mediators/immunology ; Inflammation Mediators/metabolism ; Lymphocyte Subsets/immunology ; Lymphocyte Subsets/metabolism ; Mice, Knockout ; Primates ; Prognosis ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/genetics ; Respiratory Tract Infections/immunology ; Respiratory Tract Infections/metabolism ; Signal Transduction ; Toll-Like Receptors/immunology ; Toll-Like Receptors/metabolism
Chemical Substances	Cytokines ; Inflammation Mediators ; Toll-Like Receptors
Language	English
Publishing date	2017-01-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1077620-5
ISSN	1600-0617 ; 0905-9180
ISSN (online)	1600-0617
ISSN	0905-9180
DOI	10.1183/16000617.0042-2016
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3265: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Vaccines against tuberculosis: moving forward with new concepts.

Gopal, Radha / Khader, Shabaana A

Expert review of vaccines

2013 Volume 12, Issue 8, Page(s) 829–831

MeSH term(s)	Clinical Trials as Topic ; Drug Discovery/trends ; Drug Evaluation, Preclinical/methods ; Humans ; Interleukin-17/metabolism ; Tuberculosis/immunology ; Tuberculosis/prevention & control ; Tuberculosis Vaccines/immunology ; Tuberculosis Vaccines/isolation & purification
Chemical Substances	Interleukin-17 ; Tuberculosis Vaccines
Language	English
Publishing date	2013-08-14
Publishing country	England
Document type	Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2181284-6
ISSN	1744-8395 ; 1476-0584
ISSN (online)	1744-8395
ISSN	1476-0584
DOI	10.1586/14760584.2013.814836
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6077: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: IL-17 in protective immunity to intracellular pathogens.

Khader, Shabaana A / Gopal, Radha

Virulence

2011 Volume 1, Issue 5, Page(s) 423–427

Abstract: The identification of a new T cell subset referred to as T helper 17 (Th17) cells and its role in protective immunity against extracellular bacterial infections is well established. In contrast, initial studies suggested that the IL-23-IL-17 pathway was ... ...

Abstract	The identification of a new T cell subset referred to as T helper 17 (Th17) cells and its role in protective immunity against extracellular bacterial infections is well established. In contrast, initial studies suggested that the IL-23-IL-17 pathway was not required for protection against intracellular pathogens such as mycobacterial infections. However, recent studies demonstrate that Th17-IL-23 pathway may play a crucial role in protective immunity against other intracellular pathogens by regulating the innate and adaptive immune responses. The current outlook on the role of IL-23-IL-17 pathway in protective immunity to intracellular pathogens is discussed here.
MeSH term(s)	Animals ; Bacterial Infections/immunology ; Chlamydia muridarum/immunology ; Chlamydia muridarum/pathogenicity ; Francisella tularensis/immunology ; Francisella tularensis/pathogenicity ; Humans ; Interleukin-17/immunology ; Interleukin-23/immunology ; Models, Biological ; Mycobacterium bovis/immunology ; Mycobacterium bovis/pathogenicity ; Mycobacterium tuberculosis/immunology ; Mycobacterium tuberculosis/pathogenicity ; Salmonella typhimurium/immunology ; Salmonella typhimurium/pathogenicity ; Th17 Cells/immunology
Chemical Substances	Interleukin-17 ; Interleukin-23
Language	English
Publishing date	2011-02-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2657572-3
ISSN	2150-5608 ; 2150-5594
ISSN (online)	2150-5608
ISSN	2150-5594
DOI	10.4161/viru.1.5.12862
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito