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Article ; Online: Contraceptive dynamics among women with disabilities of reproductive age in Ethiopia: systematic review.

Anshebo, Abebe Alemu / Markos, Yilma / Behera, Sujit / Gopalan, Natarajan

2024 Volume 13, Issue 1, Page(s) 42

Abstract: Background: In low-income countries, women with disabilities have limited access to essential sexual and reproductive health services and are disadvantaged socioeconomically. Even though some studies have been conducted previously, there are scanty ... ...

Abstract	Background: In low-income countries, women with disabilities have limited access to essential sexual and reproductive health services and are disadvantaged socioeconomically. Even though some studies have been conducted previously, there are scanty findings on contraceptive use and associated factors among women with disabilities. Thus, this systematic review aimed to assess contraceptive use and associated factors among women with disabilities of reproductive age in Ethiopia. Methods: The Preferred Reporting Item for Systematic Review and Meta-Analyses [PRISMA] guidance is used to conduct this systematic review. Data were searched from electronic databases: PubMed/Medline, Scopus, Google Scholar, and other relevant sources. Studies screening was done using Rayyan software. The findings were narratively synthesized using a socio-ecological framework for health promotion. Result: Ten cross-sectional studies and 4436 women with disabilities of reproductive age were included in this review. According to this review, women with disabilities are less likely to use contraceptives, with a prevalence of 21.7% in Gondor City and 44.4% in Addis Ababa. The associated factors were identified and themed at individual, interpersonal, community, and institutional levels. Conclusion: Overall, the review findings revealed that women with disabilities continue to encounter challenges ranging from individual level to disability-unfriendly health facility infrastructure or institutional level. Therefore, health professionals and other relevant stakeholders should draw attention to creating awareness towards contraceptive use at individual and interpersonal levels, ensuring accessible contraceptive services and disability-friendly health facilities.
MeSH term(s)	Female ; Humans ; Contraception Behavior ; Contraceptive Agents/administration & dosage ; Cross-Sectional Studies ; Disabled Persons ; Ethiopia ; Family Planning Services ; Health Services Accessibility
Chemical Substances	Contraceptive Agents
Language	English
Publishing date	2024-01-26
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2662257-9
ISSN	2046-4053 ; 2046-4053
ISSN (online)	2046-4053
ISSN	2046-4053
DOI	10.1186/s13643-024-02456-w
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Article ; Online: Isothermal amplification technology (IAT) for rapid diagnosis of Rickettsioses: scope, overview, existing evidence, and the way forward.

Dixit, Rashi / Gopalan, Natarajan / Behera, Sujit Kumar

Diagnostic microbiology and infectious disease

2023 Volume 107, Issue 3, Page(s) 116046

Abstract: Rickettsioses, a category of zoonosis primarily caused by Rickettsia and Orientia, is a huge cause of public health concern worldwide. Diseases like murine typhus, scrub typhus, Mediterranean spotted fever and rocky mountain spotted fever are major ... ...

Abstract	Rickettsioses, a category of zoonosis primarily caused by Rickettsia and Orientia, is a huge cause of public health concern worldwide. Diseases like murine typhus, scrub typhus, Mediterranean spotted fever and rocky mountain spotted fever are major contributors of Rickettsioses globally, with peculiar distributions in south-east Asia, Africa, Arabia and the Americas. With the innovations in molecular diagnostics, Isothermal Amplification Technology is gaining popularity for its fidelity, rapidity and cost-effectiveness. Compared to commercial assays, they are easily adaptable for point-of-care (PoC) settings. Due to nonspecific presentation as an acute undifferentiated febrile illness, diagnosis of Rickettsioses poses a great challenge. Certain isothermal amplification assays have proven to be highly efficient in diagnosing vector borne diseases like dengue, malaria, and chikungunya. The purpose of this review is to provide readers the current advancements, scope, challenges, and future prospects of isothermal amplification technologies in the detection of zoonotic pathogens like Rickettsia and Orientia.
MeSH term(s)	Mice ; Humans ; Rickettsia Infections/diagnosis ; Rickettsia Infections/microbiology ; Rickettsia/genetics ; Scrub Typhus/diagnosis ; Typhus, Endemic Flea-Borne/diagnosis ; Orientia tsutsugamushi ; Animals
Language	English
Publishing date	2023-08-02
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	604920-5
ISSN	1879-0070 ; 0732-8893
ISSN (online)	1879-0070
ISSN	0732-8893
DOI	10.1016/j.diagmicrobio.2023.116046
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Article ; Online: Polymerase Spiral Reaction (PSR) as a point-of-care diagnostic assay: A systematic review.

Dixit, Rashi / Kodali, Naveen Kumar / Biswal, Manisha / Prakash, John Antony Jude / Gopalan, Natarajan / Das, Padma / Behera, Sujit Kumar

Expert review of molecular diagnostics

2024 Volume 24, Issue 1-2, Page(s) 79–88

Abstract: Introduction: The current systematic review aimed to collect and analyze the comprehensive evidence regarding Polymerase Spiral Reaction (PSR) and to estimate its diagnostic performance and usefulness as a point-of-care (PoC) assay.: Methods: ... ...

Abstract	Introduction: The current systematic review aimed to collect and analyze the comprehensive evidence regarding Polymerase Spiral Reaction (PSR) and to estimate its diagnostic performance and usefulness as a point-of-care (PoC) assay. Methods: Literature was retrieved systematically from 2015 to 2023 from PubMed and Scopus. Studies were screened and selected against pre-determined inclusion and exclusion criteria. Quality assessment and risk of bias were critiqued using QUADAS-2. A systematic, qualitative narrative synthesis was employed to synthesize the data. Results: 11 studies were selected for the systematic review, testing diseases in humans utilizing PSR. Only 2 studies clinically validated the test with a sample size > 150. 5 studies were of poor quality; 3 studies were of moderate quality and 3 studies were deemed to be of high quality. 3 studies quantified the diagnostic throughput and reported clinical sensitivity and specificity of PSR approaching to be > 92% and ~ 100%, respectively. Conclusion: Polymerase spiral reaction promises to be an optimistic isothermal assay; however, a huge research gap can be attributed to the lack of statistical and clinical evidence to validate the assay. Adequate research, focused on optimization, coupled with statistical and clinical validation, can help in estimating its true diagnostic potential and applicability. Registration and protocol: A detailed protocol of this review is registered and available in Prospero (registration number CRD42023406265).
MeSH term(s)	Humans ; Point-of-Care Systems ; Sensitivity and Specificity ; Point-of-Care Testing
Language	English
Publishing date	2024-02-09
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2112530-2
ISSN	1744-8352 ; 1473-7159
ISSN (online)	1744-8352
ISSN	1473-7159
DOI	10.1080/14737159.2024.2315286
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Article ; Online: Socio-economic and household determinants of malaria in adults aged 45 and above

Indumathi Mohan / Naveen Kumar Kodali / Savitha Chellappan / Balasubramani Karuppusamy / Sujit Kumar Behera / Gopalan Natarajan / Praveen Balabaskaran Nina

Malaria Journal, Vol 20, Iss 1, Pp 1-

analysis of longitudinal ageing survey in India, 2017–2018

2021 Volume 9

Abstract: Abstract Background Even though malaria cases have drastically come down in the last decade, malaria remains a serious public health concern in many parts of India. National Framework for Malaria Elimination in India (2016–2030) has been launched with ... ...

Abstract	Abstract Background Even though malaria cases have drastically come down in the last decade, malaria remains a serious public health concern in many parts of India. National Framework for Malaria Elimination in India (2016–2030) has been launched with the goal to eliminate malaria by 2030. Understanding the socio-economic and household determinants of malaria at the national level will greatly aid India’s malaria elimination efforts. Methods The data from Longitudinal Ageing Survey of India (LASI) Wave 1 (2017–2018) survey comprising 70,671 respondents ≥ 45 years across all the States and Union Territories were used for the analysis. Simple and multiple logistic regressions were used to obtain the unadjusted and adjusted odds ratio respectively of the socio-economic and household variables. Results The major socio-economic variables that increase the likelihood of malaria are caste (‘scheduled tribes’), low education levels and rural residence. The scheduled tribes have 1.8 times higher odds of malaria than the scheduled castes (AOR: 1.8; 95% CI: 1.5–2.1). Respondents with high school education (6–12 grade) (AOR: 0.7; 95% CI: 0.6–0.8) and college education (AOR: 0.5; 95% CI: 0.4–0.6) had a very low risk of malaria than those with no school years. Rural residence and occupation (agriculture and allied jobs) also increases the odds of malaria. The major housing determinants are household size (≥ 6), housing type (kutcha), use of unclean fuel, outside water source, improper sanitation (toilet facilities) and damp wall/ceiling. Conclusions The study has identified the major socio-economic and housing factors associated with malaria in adults aged 45 and above. In addition to vector and parasite control strategies in the tribal dominated regions of India, improving literacy and housing conditions may help India’s malaria elimination efforts.
Keywords	LASI ; Socio-economic determinants of malaria ; Household determinants of malaria ; Schedule tribe and malaria ; Unclean cooking fuel and malaria ; Arctic medicine. Tropical medicine ; RC955-962 ; Infectious and parasitic diseases ; RC109-216
Subject code	950
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Awareness, Acceptance, and Associated Factors of Human Papillomavirus Vaccine among Parents of Daughters in Hadiya Zone, Southern Ethiopia: A Cross-Sectional Study.

Larebo, Yilma Markos / Elilo, Legesse Tesfaye / Abame, Desta Erkalo / Akiso, Denebo Ersulo / Bawore, Solomon Gebre / Anshebo, Abebe Alemu / Gopalan, Natarajan

Vaccines

2022 Volume 10, Issue 12

Abstract: Introduction: Human papillomavirus infections are the most prevalent sexually transmitted disease among women worldwide. Cervical cancer is the second-most frequent disease worldwide in terms of incidence and mortality, and it is primarily responsible ... ...

Abstract	Introduction: Human papillomavirus infections are the most prevalent sexually transmitted disease among women worldwide. Cervical cancer is the second-most frequent disease worldwide in terms of incidence and mortality, and it is primarily responsible for fatalities in low- to middle-income nations, including Ethiopia. Objective: To assess awareness, acceptance, and associated factors of the human papillomavirus vaccine among parents of daughters in the Hadiya zone, southern Ethiopia. Methods: From November to December 2021, a community-based cross-sectional study was conducted in the Hadiya zone among parents with daughters in the zone. The study respondents were chosen using a two-stage sampling technique from parents with a 9-14-year-old daughter. An interviewer-administered questionnaire was used to collect data. For analysis, the data were entered into Epidata version 3.1 and exported to SPSS version 25. Variables with a Results: The study showed that the overall acceptance of parents to vaccinate their daughters with HPV vaccination was 450 (84.9%). Parents of daughters of male sex (AOR: 0.407; 95%CI: 0.221, 0.748), who had only one daughter (AOR: 2.122; 95%CI: 1.221, 3.685), whose daughter(s) attended a government school (AOR: 0.476; 95%CI: 0.263, 0.861), who had poor knowledge (AOR: 0.532; 95%CI: 0.293, 0.969) and who had a negative attitude (AOR: 0.540; 95%CI: 0.299, 0.977) were discovered to have a strong correlation. Conclusion: This study found that there was a high level of parental acceptance; attitudes and knowledge about the HPV vaccine are significant in determining their intentions to vaccinate their daughter. Authorities in high-risk areas for cervical cancer incidence should plan and implement strategies by providing health information regarding human papillomavirus vaccination with an emphasis on raising community awareness.
Language	English
Publishing date	2022-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10121988
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Article ; Online: Spatio-temporal epidemiology and associated indicators of COVID-19 (wave-I and II) in India.

Balasubramani, Karuppusamy / Ravichandran, Venkatesh / Prasad, Kumar Arun / Ramkumar, Mu / Shekhar, Sulochana / James, Meenu Mariya / Kodali, Naveen Kumar / Behera, Sujit Kumar / Gopalan, Natarajan / Sharma, Rakesh Kumar / Sarma, Devojit Kumar / Santosh, M / Dash, Aditya Prasad / Balabaskaran Nina, Praveen

Scientific reports

2024 Volume 14, Issue 1, Page(s) 220

Abstract: The spatio-temporal distribution of COVID-19 across India's states and union territories is not uniform, and the reasons for the heterogeneous spread are unclear. Identifying the space-time trends and underlying indicators influencing COVID-19 ... ...

Abstract	The spatio-temporal distribution of COVID-19 across India's states and union territories is not uniform, and the reasons for the heterogeneous spread are unclear. Identifying the space-time trends and underlying indicators influencing COVID-19 epidemiology at micro-administrative units (districts) will help guide public health strategies. The district-wise daily COVID-19 data of cases and deaths from February 2020 to August 2021 (COVID-19 waves-I and II) for the entire country were downloaded and curated from public databases. The COVID-19 data normalized with the projected population (2020) and used for space-time trend analysis shows the states/districts in southern India are the worst hit. Coastal districts and districts adjoining large urban regions of Mumbai, Chennai, Bengaluru, Goa, and New Delhi experienced > 50,001 cases per million population. Negative binomial regression analysis with 21 independent variables (identified through multicollinearity analysis, with VIF < 10) covering demography, socio-economic status, environment, and health was carried out for wave-I, wave-II, and total (wave-I and wave-II) cases and deaths. It shows wealth index, derived from household amenities datasets, has a high positive risk ratio (RR) with COVID-19 cases (RR: 3.577; 95% CI: 2.062-6.205) and deaths (RR: 2.477; 95% CI: 1.361-4.506) across the districts. Furthermore, socio-economic factors such as literacy rate, health services, other workers' rate, alcohol use in men, tobacco use in women, overweight/obese women, and rainfall have a positive RR and are significantly associated with COVID-19 cases/deaths at the district level. These positively associated variables are highly interconnected in COVID-19 hotspot districts. Among these, the wealth index, literacy rate, and health services, the key indices of socio-economic development within a state, are some of the significant indicators associated with COVID-19 epidemiology in India. The identification of district-level space-time trends and indicators associated with COVID-19 would help policymakers devise strategies and guidelines during public health emergencies.
MeSH term(s)	Male ; Humans ; Female ; COVID-19/epidemiology ; India/epidemiology ; Family Characteristics
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-50363-2
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Article: Emergence of SARS-CoV-2 Omicron Variant JN.1 in Tamil Nadu, India - Clinical Characteristics and Novel Mutations.

Selvavinayagam, Sivaprakasam T / Sankar, Sathish / Yong, Yean K / Murugesan, Amudhan / Suvaithenamudhan, Suvaiyarasan / Hemashree, Kannan / Rajeshkumar, Manivannan / Kumaresan, Anandhazhvar / Pandey, Ramendra P / Shanmugam, Saravanan / Arthydevi, Parthiban / Kumar, Masilamani S / Gopalan, Natarajan / Kannan, Meganathan / Cheedarla, Narayanaiah / Tan, Hong Y / Zhang, Ying / Larsson, Marie / Balakrishnan, Pachamuthu /

Velu, Vijayakumar / Byrareddy, Siddappa N / Shankar, Esaki M / Raju, Sivadoss

medRxiv : the preprint server for health sciences

2024

Abstract: In December 2023, we observed a notable shift in the COVID-19 landscape, when the JN.1 emerged as a predominant SARS-CoV-2 variant with a 95% incidence. We characterized the clinical profile, and genetic changes in JN.1, an emerging SARS-CoV-2 variant of ...

Abstract	In December 2023, we observed a notable shift in the COVID-19 landscape, when the JN.1 emerged as a predominant SARS-CoV-2 variant with a 95% incidence. We characterized the clinical profile, and genetic changes in JN.1, an emerging SARS-CoV-2 variant of interest. Whole genome sequencing was performed on SARS-CoV-2 positive samples, followed by sequence analysis. Mutations within the spike protein sequences were analyzed and compared with the previous lineages and sublineages of SARS-CoV-2, to identify the potential impact of these unique mutations on protein structure and possible functionality. Several unique and dynamic mutations were identified herein. Our data provides key insights into the emergence of newer variants of SARS-CoV-2 in our region and highlights the need for robust and sustained genomic surveillance of SARS-CoV-2.
Language	English
Publishing date	2024-04-19
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.04.16.24305882
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Article: Plasma CXCL8 and MCP-1 as biomarkers of latent tuberculosis infection.

Selvavinayagam, Sivaprakasam T / Aswathy, Bijulal / Yong, Yean K / Frederick, Asha / Murali, Lakshmi / Kalaivani, Vasudevan / Jith, Karishma S / Rajeshkumar, Manivannan / Anusree, Adukkadukkam / Kannan, Meganathan / Gopalan, Natarajan / Vignesh, Ramachandran / Murugesan, Amudhan / Tan, Hong Yien / Zhang, Ying / Chandramathi, Samudi / Sivasankaran, Munusamy Ponnan / Govindaraj, Sakthivel / Byrareddy, Siddappa N /

Velu, Vijayakumar / Larsson, Marie / Shankar, Esaki M / Raju, Sivadoss

medRxiv : the preprint server for health sciences

2023

Abstract: Background: Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision of : Methods: We investigated whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts (HHCs) ...

Abstract	Background: Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision of Methods: We investigated whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts (HHCs) positive for IGRA, HHCs negative for IGRA, and healthy controls. We also measured the plasma cytokines using a commercial Results: Increased plasma CXCL8 and decreased MCP-1, TNF-α, and IFN-γ were associated with LTBI. Regression analysis showed that a combination of CXCL8 and MCP-1 increased the risk of LTBI among HHCs to 14-fold. Conclusions: We postulated that CXCL8 and MCP-1 could be the surrogate biomarkers of LTBI, especially in resource-limited settings.
Language	English
Publishing date	2023-08-09
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.08.07.23293767
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Article ; Online: Plasma CXCL8 and MCP-1 as surrogate plasma biomarkers of latent tuberculosis infection among household contacts-A cross-sectional study.

Selvavinayagam, Sivaprakasam T / Aswathy, Bijulal / Yong, Yean K / Frederick, Asha / Murali, Lakshmi / Kalaivani, Vasudevan / Karishma, Sree J / Rajeshkumar, Manivannan / Anusree, Adukkadukkam / Kannan, Meganathan / Gopalan, Natarajan / Vignesh, Ramachandran / Murugesan, Amudhan / Tan, Hong Yien / Zhang, Ying / Chandramathi, Samudi / Sivasankaran, Munusamy Ponnan / Balakrishnan, Pachamuthu / Govindaraj, Sakthivel /

Byrareddy, Siddappa N / Velu, Vijayakumar / Larsson, Marie / Shankar, Esaki M / Raju, Sivadoss

PLOS global public health

2023 Volume 3, Issue 11, Page(s) e0002327

Abstract: Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision of End Tuberculosis Strategy. The study investigates whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts ...

Abstract	Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision of End Tuberculosis Strategy. The study investigates whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts (HHCs) positive for IGRA, HHCs negative for IGRA, and healthy controls. The plasma cytokines were measured using a commercial Bio-Plex Pro Human Cytokine 17-plex assay. Increased plasma CXCL8 and decreased MCP-1, TNF-α, and IFN-γ were associated with LTBI. Regression analysis showed that a combination of CXCL8 and MCP-1 increased the risk of LTBI among HHCs to 14-fold. Our study suggests that CXCL-8 and MCP-1 could serve as the surrogate biomarkers of LTBI, particularly in resource-limited settings. Further laboratory investigations are warranted before extrapolating CXCL8 and MCP-1 for their usefulness as surrogate biomarkers of LTBI in resource-limited settings.
Language	English
Publishing date	2023-11-22
Publishing country	United States
Document type	Journal Article
ISSN	2767-3375
ISSN (online)	2767-3375
DOI	10.1371/journal.pgph.0002327
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Article ; Online: Genomic surveillance of omicron B.1.1.529 SARS-CoV-2 and its variants between December 2021 and March 2023 in Tamil Nadu, India-A state-wide prospective longitudinal study.

Selvavinayagam, Sivaprakasam T / Suvaithenamudhan, Suvaiyarasan / Yong, Yean K / Hemashree, Kannan / Rajeshkumar, Manivannan / Kumaresan, Anandhazhvar / Arthydevi, Parthiban / Kannan, Meganathan / Gopalan, Natarajan / Vignesh, Ramachandran / Murugesan, Amudhan / Sivasankaran, Munusamy P / Sankar, Sathish / Cheedarla, Narayanaiah / Anshad, Abdul R / Govindaraj, Sakthivel / Zhang, Ying / Tan, Hong Y / Larsson, Marie /

Saravanan, Shanmugam / Balakrishnan, Pachamuthu / Kulanthaivel, Langeswaran / Singh, Kamalendra / Joseph, Narcisse / Velu, Vijayakumar / Byrareddy, Siddappa N / Shankar, Esaki M / Raju, Sivadoss

Journal of medical virology

2024 Volume 96, Issue 2, Page(s) e29456

Abstract: A state-wide prospective longitudinal investigation of the genomic surveillance of the omicron B.1.1.529 SARS-CoV-2 variant and its sublineages in Tamil Nadu, India, was conducted between December 2021 and March 2023. The study aimed to elucidate their ... ...

Abstract	A state-wide prospective longitudinal investigation of the genomic surveillance of the omicron B.1.1.529 SARS-CoV-2 variant and its sublineages in Tamil Nadu, India, was conducted between December 2021 and March 2023. The study aimed to elucidate their mutational patterns and their genetic interrelationship in the Indian population. The study identified several unique mutations at different time-points, which likely could attribute to the changing disease characteristics, transmission, and pathogenicity attributes of omicron variants. The study found that the omicron variant is highly competent in its mutating potentials, and that it continues to evolve in the general population, likely escaping from natural as well as vaccine-induced immune responses. Our findings suggest that continuous surveillance of viral variants at the global scenario is warranted to undertake intervention measures against potentially precarious SARS-CoV-2 variants and their evolution.
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; India/epidemiology ; Longitudinal Studies ; Prospective Studies ; COVID-19/epidemiology ; Genomics
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29456
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