Article ; Online: Therapeutic Approaches for Intravascular Microthrombi-induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19 Infection.
Current pharmaceutical biotechnology
2022 Volume 24, Issue 8, Page(s) 970–987
Abstract: The COVID-19 pandemic has overwhelmed our health care capacity in an unprecedented way due to the sheer number of critically infected patients admitted to hospitals during the last two years. Endothelial injury is seen as one of the central hallmarks of ... ...
Abstract | The COVID-19 pandemic has overwhelmed our health care capacity in an unprecedented way due to the sheer number of critically infected patients admitted to hospitals during the last two years. Endothelial injury is seen as one of the central hallmarks of COVID-19 infection that is the starting point in the generation of microthrombi and sepsis eventually leading to acute respiratory distress syndrome (ARDs) and multi-organ failure. The dramatic fall in lung function during ARDs is attributed to the microthrombi-induced coagulopathy primed by a hyperactive immune system. Due to the lack of effective antiviral agents, the line of treatment is limited to the management of two key risk factors i.e., immune activation and coagulopathy. In the present review, we describe the mechanistic role, therapeutic targets, and opportunities to control immune activation and coagulopathy during the pathogenesis of COVID-19-induced ARDs. |
|||||
---|---|---|---|---|---|---|
MeSH term(s) | Humans ; COVID-19/complications ; SARS-CoV-2 ; Pandemics ; Respiratory Distress Syndrome/etiology ; Multiple Organ Failure | |||||
Language | English | |||||
Publishing date | 2022-07-15 | |||||
Publishing country | Netherlands | |||||
Document type | Review ; Journal Article | |||||
ZDB-ID | 2132197-8 | |||||
ISSN | 1873-4316 ; 1389-2010 | |||||
ISSN (online) | 1873-4316 | |||||
ISSN | 1389-2010 | |||||
DOI | 10.2174/1389201023666220713113713 | |||||
Shelf mark |
|
|||||
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Zs.A 6212: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.