Article: Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas
Cell. 2017 Nov. 02, v. 171, no. 4
2017
Abstract: Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue sarcomas representing 6 major types. Along with novel insights into the ... ...
| Institution | The Cancer Genome Atlas Research Network | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Abstract | Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue sarcomas representing 6 major types. Along with novel insights into the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-number changes, with low mutational loads and only a few genes (TP53, ATRX, RB1) highly recurrently mutated across sarcoma types; (2) within sarcoma types, genomic and regulomic diversity of driver pathways defines molecular subtypes associated with patient outcome; and (3) the immune microenvironment, inferred from DNA methylation and mRNA profiles, associates with outcome and may inform clinical trials of immune checkpoint inhibitors. Overall, this large-scale analysis reveals previously unappreciated sarcoma-type-specific changes in copy number, methylation, RNA, and protein, providing insights into refining sarcoma therapy and relationships to other cancer types. |
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| Keywords | DNA methylation ; adults ; clinical trials ; epithelium ; genes ; genomics ; histology ; messenger RNA ; patients ; sarcoma ; therapeutics | ||||||||||
| Language | English | ||||||||||
| Dates of publication | 2017-1102 | ||||||||||
| Size | p. 950-965.e28. | ||||||||||
| Publishing place | Elsevier Inc. | ||||||||||
| Document type | Article | ||||||||||
| ZDB-ID | 187009-9 | ||||||||||
| ISSN | 1097-4172 ; 0092-8674 | ||||||||||
| ISSN (online) | 1097-4172 | ||||||||||
| ISSN | 0092-8674 | ||||||||||
| DOI | 10.1016/j.cell.2017.10.014 | ||||||||||
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| Database | NAL-Catalogue (AGRICOLA) |
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