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  1. Article ; Online: Regulation of sodium balance in the distal nephron: urinary exosomes contribute to knowledge.

    Gordon, Richard D

    Journal of hypertension

    2017  Volume 35, Issue 2, Page(s) 246–247

    Language English
    Publishing date 2017-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000001196
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  2. Article ; Online: The importance of not overlooking curable hypertension: primary aldosteronism rarely screened for reflecting poor uptake of Endocrine Society Guidelines.

    Gordon, Richard D

    Journal of hypertension

    2016  Volume 34, Issue 11, Page(s) 2143–2144

    Language English
    Publishing date 2016-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000001093
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  3. Article ; Online: Primary Aldosteronism: Changing Definitions and New Concepts of Physiology and Pathophysiology Both Inside and Outside the Kidney.

    Stowasser, Michael / Gordon, Richard D

    Physiological reviews

    2016  Volume 96, Issue 4, Page(s) 1327–1384

    Abstract: In the 60 years that have passed since the discovery of the mineralocorticoid hormone aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal), regulation (by renin-angiotensin II, potassium, adrenocorticotrophin, and other ...

    Abstract In the 60 years that have passed since the discovery of the mineralocorticoid hormone aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal), regulation (by renin-angiotensin II, potassium, adrenocorticotrophin, and other factors), and effects (on both epithelial and nonepithelial tissues). Once thought to be rare, primary aldosteronism (PA, in which aldosterone secretion by the adrenal is excessive and autonomous of its principal regulator, angiotensin II) is now known to be the most common specifically treatable and potentially curable form of hypertension, with most patients lacking the clinical feature of hypokalemia, the presence of which was previously considered to be necessary to warrant further efforts towards confirming a diagnosis of PA. This, and the appreciation that aldosterone excess leads to adverse cardiovascular, renal, central nervous, and psychological effects, that are at least partly independent of its effects on blood pressure, have had a profound influence on raising clinical and research interest in PA. Such research on patients with PA has, in turn, furthered knowledge regarding aldosterone synthesis, regulation, and effects. This review summarizes current progress in our understanding of the physiology of aldosterone, and towards defining the causes (including genetic bases), epidemiology, outcomes, and clinical approaches to diagnostic workup (including screening, diagnostic confirmation, and subtype differentiation) and treatment of PA.
    MeSH term(s) Aldosterone/physiology ; Animals ; Blood Pressure/physiology ; Humans ; Hyperaldosteronism/physiopathology ; Hypertension, Renal/physiopathology ; Kidney/physiopathology
    Chemical Substances Aldosterone (4964P6T9RB)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 209902-0
    ISSN 1522-1210 ; 0031-9333
    ISSN (online) 1522-1210
    ISSN 0031-9333
    DOI 10.1152/physrev.00026.2015
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  4. Article ; Online: Evaluating the Diversity of Emergency Medicine Foundation (EMF) Grant Recipients in the Last Decade.

    Gordon, Richard D / Kwon, Nancy S / Levy, Phillip D / Madsen, Tracy E / Greenberg, Marna Rayl

    The western journal of emergency medicine

    2020  Volume 21, Issue 3, Page(s) 595–599

    Abstract: Introduction: To study diversity of researchers and barriers to success among Emergency Medicine Foundation (EMF) grant recipients in the last 10 years.: Methods: EMF grant awardees were approached to complete a brief survey, which included ... ...

    Abstract Introduction: To study diversity of researchers and barriers to success among Emergency Medicine Foundation (EMF) grant recipients in the last 10 years.
    Methods: EMF grant awardees were approached to complete a brief survey, which included demographics, queries related to contributions to the literature, success in obtaining grants, and any perceived barriers they encountered.
    Results: Of the 342 researchers contacted by email, a total of 147 completed the survey for a response rate of 43%. The respondents were predominately mid to late career white-male-heterosexual-Christian with an average age of 44 years (range 25-69 years of age). With regards to training and education, the majority of respondents (50%) were either Associate or Professor clinical rank (8% instructor/resident/fellow and 31% Assistant). Sixty-two percent of the respondents reported perceived barriers to career advancement since completion of residency. The largest perceived barrier to success was medical specialty (26%), followed by gender (21%) and age (16%).
    Conclusion: Our survey of EMF grant recipients in the last 10 years shows a considerable lack of diversity. The most commonly perceived barriers to career advancement by this cohort were medical specialty, gender, and age. An opportunity exists for further definition of barriers and development of mechanisms to overcome them, with a goal of increased success for those that are underrepresented.
    MeSH term(s) Adult ; Biomedical Research/economics ; Biomedical Research/organization & administration ; Biomedical Research/trends ; Communication Barriers ; Emergency Medicine ; Emergency Service, Hospital ; Female ; Health Services Research/economics ; Health Services Research/organization & administration ; Health Services Research/trends ; Humans ; Male ; Middle Aged ; Research Personnel/classification ; Research Personnel/statistics & numerical data ; Research Support as Topic/methods ; Research Support as Topic/organization & administration ; Research Support as Topic/statistics & numerical data ; United States
    Language English
    Publishing date 2020-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2375700-0
    ISSN 1936-9018 ; 1936-900X
    ISSN (online) 1936-9018
    ISSN 1936-900X
    DOI 10.5811/westjem.2020.2.46497
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  5. Article ; Online: The Cl

    Wu, Aihua / Wolley, Martin J / Wu, Qi / Gordon, Richard D / Fenton, Robert A / Stowasser, Michael

    Journal of human hypertension

    2020  Volume 35, Issue 10, Page(s) 837–848

    Abstract: In primary aldosteronism (PA), the occurrence of ... ...

    Abstract In primary aldosteronism (PA), the occurrence of K
    MeSH term(s) Aldosterone ; Humans ; Hyperaldosteronism ; Hypertension ; Mineralocorticoids/therapeutic use ; Potassium Chloride/therapeutic use ; Sulfate Transporters/genetics
    Chemical Substances Mineralocorticoids ; SLC26A4 protein, human ; Sulfate Transporters ; Aldosterone (4964P6T9RB) ; Potassium Chloride (660YQ98I10)
    Language English
    Publishing date 2020-11-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639472-3
    ISSN 1476-5527 ; 0950-9240
    ISSN (online) 1476-5527
    ISSN 0950-9240
    DOI 10.1038/s41371-020-00439-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The case for high-dose dexamethasone suppression testing preoperatively in aldosterone-producing adenoma to exclude cosecretion of cortisol.

    Gordon, Richard D

    American journal of hypertension

    2008  Volume 21, Issue 11, Page(s) 1176

    MeSH term(s) Adenoma/metabolism ; Adrenal Gland Neoplasms/metabolism ; Adrenocorticotropic Hormone/metabolism ; Aldosterone/secretion ; Cushing Syndrome/metabolism ; Dexamethasone/pharmacology ; Dose-Response Relationship, Drug ; Glucocorticoids/pharmacology ; Humans ; Hydrocortisone/secretion ; Hyperaldosteronism/metabolism ; Male ; Middle Aged ; Renin-Angiotensin System/physiology
    Chemical Substances Glucocorticoids ; Aldosterone (4964P6T9RB) ; Dexamethasone (7S5I7G3JQL) ; Adrenocorticotropic Hormone (9002-60-2) ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2008-11
    Publishing country United States
    Document type Case Reports ; Comment ; Journal Article
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1038/ajh.2008.283
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  7. Article: Can mutations in ion channel genes cause endocrine dysfunction?

    Gordon, Richard D

    Journal of hypertension

    2006  Volume 24, Issue 3, Page(s) 441–442

    MeSH term(s) Adrenocortical Adenoma/genetics ; Ether-A-Go-Go Potassium Channels/genetics ; Humans ; Mutation
    Chemical Substances Ether-A-Go-Go Potassium Channels
    Language English
    Publishing date 2006-03
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/01.hjh.0000209977.90617.f0
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  8. Article ; Online: Response to Letter to the Editor: "Comparison of Seated With Recumbent Saline Suppression Testing for the Diagnosis of Primary Aldosteronism".

    Stowasser, Michael / Guo, Zeng / Ahmed, Ashraf / Wolley, Martin / Gordon, Richard D

    The Journal of clinical endocrinology and metabolism

    2019  Volume 104, Issue 6, Page(s) 2344–2345

    MeSH term(s) Aldosterone ; Humans ; Hyperaldosteronism ; Saline Solution
    Chemical Substances Saline Solution ; Aldosterone (4964P6T9RB)
    Language English
    Publishing date 2019-02-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/jc.2019-00179
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  9. Article: Primary aldosteronism--actual epidemics or false alarm?

    Gordon, Richard D

    Arquivos brasileiros de endocrinologia e metabologia

    2005  Volume 48, Issue 5, Page(s) 666–673

    Abstract: The prevalence of "primary aldosteronism" (PAL) cannot be precisely determined at this time, given 1) lack of a universally accepted definition, and 2) normotensive as well as normokalemic phases in the evolutionary development of a disease eventually ... ...

    Abstract The prevalence of "primary aldosteronism" (PAL) cannot be precisely determined at this time, given 1) lack of a universally accepted definition, and 2) normotensive as well as normokalemic phases in the evolutionary development of a disease eventually characterized by hypertension and hypokalemia. The exception is fully genetically characterised forms such as glucocorticoid-suppressible hyperaldosteronism, the true prevalence of which could be proven today by universal screening using a single blood sample, but this is neither practical nor appropriate. Controversy has arisen regarding the rareness, or otherwise, of PAL because of 1) rediscovery in the last 12 years of the normokalemic phase described by Conn, 2) application of widely available methods for measurement of aldosterone and renin to "screening", 3) variable quality of these methods, and of their application, and 4) lack of the necessary "diagnostic", in addition to "screening", tests in some studies. PAL is significantly more common than previously thought, and a very important potentially curable form of hypertension. Early diagnosis and specific treatment avoids morbidity. The current focus on increased detection is essential, and will help to resolve the question of prevalence.
    MeSH term(s) Humans ; Hyperaldosteronism/diagnosis ; Hyperaldosteronism/epidemiology
    Language English
    Publishing date 2005-03-07
    Publishing country Brazil
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 603919-4
    ISSN 1677-9487 ; 0004-2730
    ISSN (online) 1677-9487
    ISSN 0004-2730
    DOI 10.1590/s0004-27302004000500012
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  10. Article: The challenge of more robust and reproducible methodology in screening for primary aldosteronism.

    Gordon, Richard D

    Journal of hypertension

    2004  Volume 22, Issue 2, Page(s) 251–255

    MeSH term(s) Aldosterone/blood ; Humans ; Hyperaldosteronism/blood ; Hyperaldosteronism/diagnosis ; Immunologic Techniques ; Mass Screening/methods ; Renin/blood
    Chemical Substances Aldosterone (4964P6T9RB) ; Renin (EC 3.4.23.15)
    Language English
    Publishing date 2004-04-06
    Publishing country England
    Document type Comment ; Editorial ; Review
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/00004872-200402000-00006
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