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  1. Article ; Online: Correspondence on "Oncologic outcomes of surgical para-aortic lymph node staging in patients with advanced cervical carcinoma undergoing chemoradiation" by Nasioudis et al.

    Gorostidi, Mikel

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2022  

    Language English
    Publishing date 2022-08-04
    Publishing country England
    Document type Letter
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2022-003848
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    Zs.A 3198: Show issues Location:
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  2. Article ; Online: ASO Author Reflections: Low Case-Load and Lack of Centralization have Negative Impact on Uterine Sarcoma Outcomes.

    Gorostidi, Mikel / Zapardiel, Ignacio

    Annals of surgical oncology

    2023  Volume 30, Issue 12, Page(s) 7663–7664

    MeSH term(s) Humans ; Pelvic Neoplasms ; Sarcoma/therapy ; Soft Tissue Neoplasms
    Language English
    Publishing date 2023-07-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13871-z
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    Zs.A 4042: Show issues Location:
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  3. Article ; Online: Endometrial carcinoma originating in an isthmocele.

    Gorostidi, Mikel / Rodriguez, Daniel

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2021  Volume 31, Issue 5, Page(s) 799–800

    Language English
    Publishing date 2021-03-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2020-002016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3198: Show issues Location:
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  4. Article ; Online: Role of fluorescence imaging for intraoperative intestinal assessment in gynecological surgery: a systematic review.

    Spagnolo, Emanuela / Zapardiel, Ignacio / Gorostidi, Mikel

    Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy

    2022  Volume 31, Issue 7, Page(s) 992–999

    Abstract: Background: Our aim was to review the current knowledge of the role of fluorescence imaging for intraoperative intestinal assessment in gynecological surgery.: Material and methods: A computer-based systematic review was performed from 2000 to 2020. ... ...

    Abstract Background: Our aim was to review the current knowledge of the role of fluorescence imaging for intraoperative intestinal assessment in gynecological surgery.
    Material and methods: A computer-based systematic review was performed from 2000 to 2020. All articles describing the use of indocyanine green (ICG) applied to bowel assessments in gynecology or endometriosis surgery were considered for review.
    Results: ICG is an effective tool for assessing bowel vascularization, potentially preventing anastomotic leakage and recto-vaginal fistula and can therefore be useful for endometriosis surgery or bowel assessment in gynecological oncology procedures. Real-time characterization of the hypovascular pattern of endometriotic nodules has been associated with a larger nodule size and lower microvessel density, helping surgeons choose the best transecting line and the most appropriate technique. ICG angiography allows for a laparoscopic and intrarectal bowel assessment, which can act as a double check of bowel perfusion, enabling the assessment of mucosa vascularization. ICG fluorescence can guide intraoperative decision-making after intestinal anastomosis, discoid resection, and rectal shaving, preventing anastomotic leakage and postoperative recto-vaginal fistula in low anterior resections.
    Conclusions: ICG angiography provides a better intestinal assessment. Larger, prospective, randomized controlled studies are needed to validate the technique and confirm these encouraging results.
    MeSH term(s) Anastomosis, Surgical/methods ; Anastomotic Leak/prevention & control ; Anastomotic Leak/surgery ; Endometriosis/surgery ; Female ; Gynecologic Surgical Procedures ; Humans ; Indocyanine Green ; Laparoscopy/methods ; Optical Imaging/methods ; Prospective Studies ; Vaginal Fistula/surgery
    Chemical Substances Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2022-04-20
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 1317160-4
    ISSN 1365-2931 ; 1364-5706
    ISSN (online) 1365-2931
    ISSN 1364-5706
    DOI 10.1080/13645706.2022.2064715
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    Zs.A 3467: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: ASO Author Reflections: Fluorescence-Guided Surgery in Gynecology Becomes a Standard.

    Gorostidi, Mikel / Zapardiel, Ignacio

    Annals of surgical oncology

    2020  Volume 28, Issue 6, Page(s) 3279–3280

    MeSH term(s) Fluorescence ; Gynecology ; Humans
    Language English
    Publishing date 2020-10-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-020-09231-w
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    Zs.A 4042: Show issues Location:
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  6. Article ; Online: Is minimal invasive surgery for primary and secondary debulking of ovarian/peritoneal/fallopian tube cancer going too far?

    Gorostidi, Mikel

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2014  Volume 24, Issue 7, Page(s) 1138–1139

    MeSH term(s) Disease-Free Survival ; Ethics, Medical ; Fallopian Tube Neoplasms/diagnosis ; Fallopian Tube Neoplasms/pathology ; Fallopian Tube Neoplasms/surgery ; Female ; Gynecologic Surgical Procedures/ethics ; Gynecologic Surgical Procedures/standards ; Gynecologic Surgical Procedures/trends ; Humans ; Laparotomy/utilization ; Minimally Invasive Surgical Procedures/ethics ; Minimally Invasive Surgical Procedures/standards ; Minimally Invasive Surgical Procedures/trends ; Neoplasm, Residual ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/surgery ; Peritoneal Neoplasms/diagnosis ; Peritoneal Neoplasms/pathology ; Peritoneal Neoplasms/surgery ; Prognosis ; Reoperation ; Treatment Outcome
    Language English
    Publishing date 2014-06-10
    Publishing country England
    Document type Letter
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1097/IGC.0000000000000210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Vaginal carcinoma after cervical dysplasia.

    Gorostidi, Mikel / Lekuona, Arantza / Juaristi, Arantxa / Baiocchi, Glauco

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2020  Volume 30, Issue 2, Page(s) 265–273

    MeSH term(s) Cervical Intraepithelial Neoplasia/pathology ; Conization ; Female ; Humans ; Middle Aged ; Uterine Cervical Dysplasia/pathology ; Uterine Cervical Neoplasms/pathology ; Vaginal Neoplasms/pathology
    Language English
    Publishing date 2020-01-06
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2019-001062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3198: Show issues Location:
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  8. Article ; Online: Maximizing sentinel node detection in endometrial cancer with dual cervical and transcervical fundal indocyanine green injection: 5-year single-center prospective study.

    Ruiz, Ruben / Gorostidi, Mikel / Jaunarena, Ibon / Cobas, Paloma / Lekuona, Arantxa

    European journal of obstetrics, gynecology, and reproductive biology

    2021  Volume 261, Page(s) 59–64

    Abstract: Objective: The aim of this study was to describe our latest results using dual cervical and fundal indocyanine green injection for detection of sentinel lymph node (SLN) in endometrial cancer.: Methods: A prospective observational study was conducted ...

    Abstract Objective: The aim of this study was to describe our latest results using dual cervical and fundal indocyanine green injection for detection of sentinel lymph node (SLN) in endometrial cancer.
    Methods: A prospective observational study was conducted between 26 June 2014 and 31 December 2019 with 278 patients that underwent laparoscopic surgery for endometrial cancer at our institution. In all cases, we performed SLN biopsy with dual cervical and fundal indocyanine green injection. All SLNs were processed with an ultrastaging technique. A total of 128 patients also underwent total pelvic and paraaortic lymphadenectomy.
    Results: The detection rates were as follows: 93.5 % (260/278) overall for SLNs; 90.7 % (252/278) overall for pelvic SLNs; 68.0 % (189/278) for bilateral SLNs; 66.9 % (186/278) for paraaortic SLNs, and 2.9 % (8/278) for isolated paraaortic SLNs. We found macroscopic lymph node metastasis in 26 patients (10.0 %) and microdisease in lymph nodes in another 48 patients, raising the overall rate of lymph node involvement to 16.2 %. There was one false negative (negative SLN biopsy but positive lymphadenectomy). Applying the SLN algorithm, the sensitivity of detection was 97.9 % (95 % CI 89.1-99.6), specificity 100 % (95 % CI 98.2-100), negative predictive value 99.5 % (95 % CI 97.4-99.9), and positive predictive value 100 % (95 % CI 92.4-100).
    Conclusions: Dual sentinel node injection is a feasible technique that achieves adequate detection rates. Additionally, this technique allows a high rate of aortic detection, identifying a non-negligible percentage of isolated aortic metastases. Aortic metastases in endometrial cancer are possible and we should not give up actively looking for them.
    MeSH term(s) Endometrial Neoplasms/pathology ; Female ; Humans ; Indocyanine Green ; Lymph Node Excision ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology ; Neoplasm Staging ; Prospective Studies ; Sentinel Lymph Node/diagnostic imaging ; Sentinel Lymph Node/pathology ; Sentinel Lymph Node Biopsy
    Chemical Substances Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2021-04-15
    Publishing country Ireland
    Document type Journal Article ; Observational Study
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2021.04.015
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    Zs.A 837: Show issues Location:
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  9. Article ; Online: Aortic sentinel node detection in endometrial cancer: 6 year prospective study.

    Gorostidi, Mikel / Ruiz, Ruben / Cespedes, Juan / Jaunarena, Ibon / Cobas, Paloma / Lekuona, Arantxa / Diez-Itza, Irene

    Journal of gynecology obstetrics and human reproduction

    2023  Volume 52, Issue 5, Page(s) 102584

    Abstract: Objective: The aim of this study was to describe our final results using dual cervical and fundal indocyanine green injection for the detection of sentinel lymph nodes (SLNs) in endometrial cancer along parametrial and infundibular drainage pathways.: ...

    Abstract Objective: The aim of this study was to describe our final results using dual cervical and fundal indocyanine green injection for the detection of sentinel lymph nodes (SLNs) in endometrial cancer along parametrial and infundibular drainage pathways.
    Methods: We conducted a prospective observational study between 26 June 2014 and 31 December 2020 enrolling 332 patients that underwent laparoscopic surgery for endometrial cancer at our hospital. In all cases, we performed SLN biopsy with dual cervical and fundal indocyanine green injection identifying pelvic and aortic SLNs. All SLNs were processed with an ultrastaging technique. A total of 172 patients also underwent total pelvic and para-aortic lymphadenectomy.
    Results: The detection rates were as follows: 94.0% overall for SLNs; 91.3% overall for pelvic SLNs; 70.5% for bilateral SLNs; 68.1% for para-aortic SLNs, and 3.0% for isolated paraaortic SLNs. We found lymph node involvement in 56 (16.9%) cases, macrometastasis in 22, micrometastasis in 12 and isolated tumor cells in 22. Fourteen patients had isolated aortic nodal involvement, representing 25% of the positive cases. There was one false negative (SLN biopsy negative but lymphadenectomy positive). Applying the SLN algorithm, the sensitivity of the dual injection technique for SLN detection was 98.3% (95% CI 91-99.7), specificity 100% (95% CI 98.5-100), negative predictive value 99.6% (95% CI 97.8-99.9), and positive predictive value 100% (95% CI 93.8-100). Overall survival at 60 months was 91.35%, with no differences between patients with negative nodes, isolated tumor cells and treated nodal micrometastasis.
    Conclusions: Dual sentinel node injection is a feasible technique that achieves adequate detection rates. Additionally, this technique allows a high rate of aortic detection, identifying a non-negligible percentage of isolated aortic metastases. Aortic metastases in endometrial cancer account for as many as a quarter of the positive cases and should be considered, especially in high-risk patients.
    MeSH term(s) Female ; Humans ; Sentinel Lymph Node/pathology ; Sentinel Lymph Node Biopsy ; Indocyanine Green ; Prospective Studies ; Neoplasm Micrometastasis/pathology ; Endometrial Neoplasms/surgery ; Endometrial Neoplasms/pathology
    Chemical Substances Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2023-04-07
    Publishing country France
    Document type Observational Study ; Journal Article
    ISSN 2468-7847
    ISSN (online) 2468-7847
    DOI 10.1016/j.jogoh.2023.102584
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  10. Article: Role of Adjuvant Radiotherapy in Patients with Cervical Cancer Undergoing Radical Hysterectomy.

    Alonso-Espías, María / Gorostidi, Mikel / Gracia, Myriam / García-Pineda, Virginia / Diestro, María Dolores / Siegrist, Jaime / Hernández, Alicia / Zapardiel, Ignacio

    Journal of personalized medicine

    2023  Volume 13, Issue 10

    Abstract: The benefit of adjuvant radiotherapy (RT) after radical hysterectomy in patients with cervical cancer remains controversial. The aim of this study was to determine adjuvant RT's impact on survival in accordance with Sedlis criteria. Patients with early- ... ...

    Abstract The benefit of adjuvant radiotherapy (RT) after radical hysterectomy in patients with cervical cancer remains controversial. The aim of this study was to determine adjuvant RT's impact on survival in accordance with Sedlis criteria. Patients with early-stage cervical cancer undergoing radical hysterectomy between 2005 and 2022 at a single tertiary care institution were included. A multivariate analysis was performed to determinate if RT was an independent prognostic factor for recurrence or death. We also analysed whether there was a statistically significant difference in overall survival (OS) between patients who met only one or two Sedlis criteria, depending on whether they received adjuvant RT or not. 121 patients were included in this retrospective study, of whom 48 (39.7%) received adjuvant RT due to the presence of unfavourable pathological findings. In multivariate analysis, RT was not found to be a statistically significant prognostic factor for OS (
    Language English
    Publishing date 2023-10-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13101486
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