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  1. Article ; Online: Homicide numbers, rates, and victims' characteristics in the Tri-City metropolitan area, Poland, between 2010 and 2019.

    Karnecki, Karol / Wrocławski, Adrian / Dalewski, Wojciech / Gos, Tomasz / Kaliszan, Michał

    Archiwum medycyny sadowej i kryminologii

    2024  Volume 73, Issue 4, Page(s) 285–293

    Abstract: Despite a clear global downward trend, homicides still account for a relatively high proportion of all violent deaths, making them a serious problem both in Poland and worldwide. The discrepancy in available data prompted the authors of the study to ... ...

    Title translation Liczby i wskaźniki zabójstw oraz charakterystyka ofiar na terenie aglomeracji Trójmiasta w latach 2010-2019.
    Abstract Despite a clear global downward trend, homicides still account for a relatively high proportion of all violent deaths, making them a serious problem both in Poland and worldwide. The discrepancy in available data prompted the authors of the study to analyse the numbers and rates of homicides and the characteristics of the homicide victims in the Tri-City area of northern Poland. The study was based on data from autopsy reports, supplemented by information from prosecutor's files on all homicides in the Tri-City area between 2010 and 2019. A total of 107 homicides were statistically analysed for age, sex, blood alcohol concentration at the time of death, time and place of death. The annual homicide rate was 1.24 per 100,000 inhabitants, with a clear downward trend over the period analysed. The average age of victims was about 48 years, and the majority of victims were male (70.1%). 92.5% of homicides were committed in the Tri-City, with a clear predominance of Gdansk (49.5%) over other, mostly rural, areas of the analysed agglomeration. The majority of victims (57.8%) whose blood alcohol concentration was measured were intoxicated, with a clear predominance of males in this group (70.9%). Victim characteristics and the homicide rates obtained from the analysed material were similar to other countries in Central and Eastern Europe, which may be related to historical, cultural, and demographic similarities. The study highlights the significant impact of alcohol abuse on the risk of homicide.
    MeSH term(s) Humans ; Homicide/statistics & numerical data ; Poland/epidemiology ; Male ; Female ; Middle Aged ; Adult ; Crime Victims/statistics & numerical data ; Urban Population/statistics & numerical data ; Cause of Death ; Age Distribution ; Sex Distribution ; Aged ; Young Adult
    Language Polish
    Publishing date 2024-04-25
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2780064-7
    ISSN 1689-1716 ; 1689-1716
    ISSN (online) 1689-1716
    ISSN 1689-1716
    DOI 10.4467/16891716AMSIK.23.023.19495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ribosomal DNA transcription is increased in the left nucleus accumbens of heroin-dependent males.

    Gos, Tomasz / Steiner, Johann / Trübner, Kurt / Krzyżanowska, Marta / Kaliszan, Michał

    European archives of psychiatry and clinical neuroscience

    2022  Volume 272, Issue 8, Page(s) 1603–1609

    Abstract: Opioid addiction is a worldwide problem accentuated in the USA and European countries by the COVID-19 pandemic. The nucleus accumbens (NAc) plays an outstanding neurobiological role in opioid addiction as a part of the striatum and key component of brain ...

    Abstract Opioid addiction is a worldwide problem accentuated in the USA and European countries by the COVID-19 pandemic. The nucleus accumbens (NAc) plays an outstanding neurobiological role in opioid addiction as a part of the striatum and key component of brain reward system. The striatal GABAergic medium spiny projection neurons (MSNs) are the main neuronal type in the NAc where addiction-specific synaptic plasticity occurs. The activity of ribosomal DNA (rDNA) transcription is crucial for neural plasticity and molecular studies suggest its increase in the NAc of heroin addicts. Silver-stained argyrophilic nucleolar organizer region (AgNOR) areas visualised in neuronal nuclei in paraffin-embedded brain sections are reliable morphological estimators of rDNA transcription and thus surrogate markers for the activity of brain regions. Our study revealed increased AgNOR areas in MSNs of the left NAc in 11 heroin addicts versus 11 healthy controls from the Magdeburg Brain Bank (U-test P = 0.007). No differences were observed in another investigated part of the striatum, namely the head of caudate nucleus, which is located closely to the NAc. The results were not confounded by significant differences in the age, brain volume and time of formalin fixation existing between compared groups. Our findings suggest an increased NAc activity in heroin addicts, which is consistent with human and animal experimental data.
    MeSH term(s) Male ; Animals ; Humans ; Nucleus Accumbens/physiology ; Heroin ; DNA, Ribosomal ; Pandemics ; COVID-19 ; Heroin Dependence
    Chemical Substances Heroin (70D95007SX) ; DNA, Ribosomal
    Language English
    Publishing date 2022-05-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1045583-8
    ISSN 1433-8491 ; 0175-758X ; 0940-1334
    ISSN (online) 1433-8491
    ISSN 0175-758X ; 0940-1334
    DOI 10.1007/s00406-022-01423-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Epidemiology of suicide in the Tri-City metropolitan area in Poland in 2010-2019.

    Karnecki, Karol / Gos, Tomasz / Steiner, Johann / Mańkowski, Dobrosław / Kaliszan, Michał

    European archives of psychiatry and clinical neuroscience

    2022  Volume 273, Issue 4, Page(s) 911–920

    Abstract: The paper, which is a continuation of our previous epidemiological studies on the phenomenon of suicide in the Tri-City metropolitan area, presents the results of statistical analyses of suicides in the autopsy material of the Department of Forensic ... ...

    Abstract The paper, which is a continuation of our previous epidemiological studies on the phenomenon of suicide in the Tri-City metropolitan area, presents the results of statistical analyses of suicides in the autopsy material of the Department of Forensic Medicine of the Medical University of Gdańsk in the years 2010-2019. The purpose of the study was to analyse in detail demographic data of suicides (age, sex, place of death), as well as to assess suicide methods and the impact of alcohol on suicides in the study area. During the 10-year study period, 8495 autopsies were performed, of which 1261 were suicides (14.8%). Statistical analyses were conducted using the statistical data analysis software system STATISTICA, version 13 (StatSoft, Tulsa, Oklahoma, USA). The results of the study indicate a continuing downward trend in the number of suicides since the beginning of the 21th century, with the number of suicides in rural areas increasing over the same period. In the analysed cohort, suicides were committed in particular by middle-aged men and the number of suicides among older people (65 +) increased at the same time. The increase in suicide occurred in late autumn and early spring. The most common method of suicide was hanging. There was a high percentage of inebriated victims (45%), and a comparison of the present studies with previous ones indicates the increasing impact of alcohol on suicide.
    MeSH term(s) Middle Aged ; Male ; Humans ; Aged ; Suicide ; Poland/epidemiology ; Autopsy ; Forensic Medicine/methods ; Ethanol
    Chemical Substances Ethanol (3K9958V90M)
    Language English
    Publishing date 2022-12-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1045583-8
    ISSN 1433-8491 ; 0175-758X ; 0940-1334
    ISSN (online) 1433-8491
    ISSN 0175-758X ; 0940-1334
    DOI 10.1007/s00406-022-01548-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: AgNOR parameters of dorsal raphe nucleus neurons as a potential diagnostic tool which could aid the differentiation between suicidal and non-suicidal death.

    Krzyżanowska, Marta / Steiner, Johann / Gos, Tomasz

    European archives of psychiatry and clinical neuroscience

    2020  Volume 271, Issue 3, Page(s) 587–589

    MeSH term(s) Adult ; Autopsy ; Dorsal Raphe Nucleus/metabolism ; Female ; Humans ; Male ; Middle Aged ; Nucleolus Organizer Region/genetics ; Nucleolus Organizer Region/metabolism ; Silver Staining/standards ; Suicide, Completed ; Transcription, Genetic
    Language English
    Publishing date 2020-04-07
    Publishing country Germany
    Document type Letter
    ZDB-ID 1045583-8
    ISSN 1433-8491 ; 0175-758X ; 0940-1334
    ISSN (online) 1433-8491
    ISSN 0175-758X ; 0940-1334
    DOI 10.1007/s00406-020-01126-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Homicide mechanisms, weapon types and causes of death in the autopsy material of the Department of Forensic Medicine Medical University of Gdańsk Poland in the years 2010-2019.

    Karnecki, Karol / Wrocławski, Adrian / Pieśniak, Dorota / Dalewski, Wojciech / Gos, Tomasz / Kaliszan, Michał

    Journal of forensic and legal medicine

    2022  Volume 94, Page(s) 102481

    Abstract: The study objective was the analysis of homicides based on reports of 107 medicolegal autopsies of victims, which were carried out in 2010-2019 at the Department of Forensic Medicine of the Medical University of Gdańsk, Poland. The study focused on the ... ...

    Abstract The study objective was the analysis of homicides based on reports of 107 medicolegal autopsies of victims, which were carried out in 2010-2019 at the Department of Forensic Medicine of the Medical University of Gdańsk, Poland. The study focused on the analysis of homicide mechanisms, on the weapon type, injuries characteristics, and both pathomechanisms and causes of death. Alcohol and illicit drugs abuse, which is a predisposing factor, was also assessed. In the analysed cohort, 70.1% were males and 29.9% females. The most frequently used weapon was a blunt instrument (accounting for 47.7% of homicides), while the least common was a firearm (accounting for 4.7% of homicides). There were significant differences in homicide mechanisms related to victims' gender. In males, blunt or sharp instruments predominated, while in females violent suffocation and chop injuries were more frequent. Fatal head injuries and their consequences predominated in the pathomechanisms of death (32.7% of cases). It was shown that the highest blood alcohol concentration (BAC) was found in homicides due to violent strangulation and sharp instrument use, while the lowest BAC was found in gunshot victims. Toxicological tests were performed in 18 cases and in 7 cases showed positive results for illicit drugs. The analysis of various elements involved in homicide may contribute to a conceptual framework for preventive measures aiming at the reduction of homicides number.
    MeSH term(s) Male ; Female ; Humans ; Homicide ; Autopsy ; Blood Alcohol Content ; Poland/epidemiology ; Cause of Death ; Age Distribution ; Sex Distribution ; Forensic Medicine ; Asphyxia ; Causality ; Retrospective Studies
    Chemical Substances Blood Alcohol Content
    Language English
    Publishing date 2022-12-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2268721-X
    ISSN 1878-7487 ; 1752-928X
    ISSN (online) 1878-7487
    ISSN 1752-928X
    DOI 10.1016/j.jflm.2022.102481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The left-lateralisation of citrate synthase activity in the anterior cingulate cortex of male violent suicide victims.

    Karnecki, Karol / Świerczyński, Julian / Steiner, Johann / Krzyżanowska, Marta / Kaliszan, Michał / Gos, Tomasz

    European archives of psychiatry and clinical neuroscience

    2022  Volume 273, Issue 6, Page(s) 1225–1232

    Abstract: The anterior cingulate cortex (AC) as a part of prefrontal cortex plays a crucial role in behavioural regulation, which is profoundly disturbed in suicide. Citrate synthase (CS) is a key enzyme of tricarboxylic acid cycle fundamental for brain energetics ...

    Abstract The anterior cingulate cortex (AC) as a part of prefrontal cortex plays a crucial role in behavioural regulation, which is profoundly disturbed in suicide. Citrate synthase (CS) is a key enzyme of tricarboxylic acid cycle fundamental for brain energetics and neurotransmitter synthesis, which are deteriorated in suicidal behaviour. However, CS activity has not been yet studied in brain structures of suicide victims. CS activity assay was performed bilaterally on frozen samples of the rostral part of the AC of 24 violent suicide completers (21 males and 3 females) with unknown psychiatric diagnosis and 24 non-suicidal controls (20 males and 4 females). Compared to controls, suicide victims revealed decreased CS activity in the right AC, however, insignificant. Further statistical analysis of laterality index revealed the left-lateralisation of CS activity in the AC in male suicides compared to male controls (U-test P = 0.0003, corrected for multiple comparisons). The results were not confounded by postmortem interval, blood alcohol concentration, age, and brain weight. Our findings suggest that disturbed CS activity in the AC plays a role in suicide pathogenesis and correspond with our previous morphological and molecular studies of prefrontal regions in suicide.
    MeSH term(s) Female ; Humans ; Male ; Suicide/psychology ; Gyrus Cinguli/pathology ; Citrate (si)-Synthase ; Blood Alcohol Content ; Brain/pathology ; Prefrontal Cortex/pathology
    Chemical Substances Citrate (si)-Synthase (EC 2.3.3.1) ; Blood Alcohol Content
    Language English
    Publishing date 2022-11-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1045583-8
    ISSN 1433-8491 ; 0175-758X ; 0940-1334
    ISSN (online) 1433-8491
    ISSN 0175-758X ; 0940-1334
    DOI 10.1007/s00406-022-01509-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Inverse pattern of GABAergic system impairment in the external versus internal globus pallidus in male heroin addicts.

    Gos, Anna / Steiner, Johann / Trübner, Kurt / Ungewickell, Jonas / Mawrin, Christian / Karnecki, Karol / Kaliszan, Michał / Gos, Tomasz

    European archives of psychiatry and clinical neuroscience

    2023  Volume 274, Issue 2, Page(s) 445–452

    Abstract: Opioid addiction is a global problem that has been exacerbated in the USA and Europe by the COVID-19 pandemic. The globus pallidus (GP) plays a prominent neurobiological role in the regulation of behaviour as an output station of the striato-pallidal ... ...

    Abstract Opioid addiction is a global problem that has been exacerbated in the USA and Europe by the COVID-19 pandemic. The globus pallidus (GP) plays a prominent neurobiological role in the regulation of behaviour as an output station of the striato-pallidal system. GABAergic large projection neurons are the main neuronal type in the external (EGP) and internal (IGP) parts of the GP, where addiction-specific molecular and functional abnormalities occur. In these neurons, glutamate decarboxylase (GAD) with isoforms GAD 65 and 67 is a key enzyme in GABA synthesis, and experimental studies suggest GAD dysregulation in the GP of heroin addicts. Our study, which was performed on paraffin-embedded brains from the Magdeburg Brain Bank, aimed to investigate abnormalities in the GABAergic function of large GP neurons by densitometric evaluation of their GAD 65/67-immunostained thick dendrites. The study revealed a bilaterally decreased fibres density in the EGP paralleled by the increase in the IGP in 11 male heroin addicts versus 11 healthy controls (significant U-test P values). The analysis of confounding variables found no interference of age, brain volume, and duration of formalin fixation with the results. Our findings suggest a dysregulation of GABAergic activity in the GP of heroin addicts, which is consistent with experimental data from animal models and plays potentially a role in the disturbed function of basal ganglia circuit in opioid addiction.
    MeSH term(s) Animals ; Male ; Humans ; Globus Pallidus ; Heroin ; Pandemics ; Basal Ganglia ; Opioid-Related Disorders
    Chemical Substances Heroin (70D95007SX)
    Language English
    Publishing date 2023-07-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1045583-8
    ISSN 1433-8491 ; 0175-758X ; 0940-1334
    ISSN (online) 1433-8491
    ISSN 0175-758X ; 0940-1334
    DOI 10.1007/s00406-023-01656-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Fake gunshot wounds in the skull-post-mortem artifact caused by steel probe during police search for a missing body.

    Kaliszan, Michał / Dalewski, Wojciech / Dawidowska, Joanna / Gos, Tomasz / Jankowski, Zbigniew

    International journal of legal medicine

    2020  Volume 135, Issue 3, Page(s) 879–883

    Abstract: The paper presents a case of a forensic autopsy of a young woman who was murdered and her dismembered body was hidden in soil and water. In the skull of the deceased, in the temporal and occipital regions, the autopsy revealed 3 round, almost identical ... ...

    Abstract The paper presents a case of a forensic autopsy of a young woman who was murdered and her dismembered body was hidden in soil and water. In the skull of the deceased, in the temporal and occipital regions, the autopsy revealed 3 round, almost identical holes, which looked like small caliber gunshot wounds. Doubts about the cause of these injuries were raised by the fact that despite the decomposition of the body, the continuity of the dura at the site of these holes remained undamaged and the absence of any trace of a bullet's wound track in the brain, the absence of a foreign body in the cranial cavity, as well as the absence of wounds on the opposite side of the skull that could be exit wounds. A thorough analysis of the investigation and the activities carried out during the search for the missing body allowed to adopt and finally confirm the hypothesis that the above mentioned skull damage occurred during the search for the cut-off head of the deceased in shallow water by means of special tapered conical steel probes used by the rescue/search teams. Due to the structure of such a spike, i.e., a sharp end and then a wide cone, only a superficial puncture of the steel probe tip three times into the skull had taken place, which caused regular, rounded bone damage without damaging the dura and brain. The presented case indicates that sometimes post-mortem artifacts may suggest a completely different origin of wounds, which emphasizes the need for a comprehensive analysis of all possible causes of their occurrence, particularly data concerning the handling of the corpse before it is delivered to the morgue, so as not to make a diagnostic error during autopsy.
    MeSH term(s) Adult ; Autopsy ; Diagnosis, Differential ; Equipment and Supplies/adverse effects ; Female ; Forensic Pathology ; Humans ; Law Enforcement/methods ; Skull/injuries ; Wounds, Gunshot/diagnosis
    Language English
    Publishing date 2020-09-09
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 1055109-8
    ISSN 1437-1596 ; 0937-9827
    ISSN (online) 1437-1596
    ISSN 0937-9827
    DOI 10.1007/s00414-020-02420-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Fatal haemorrhage from an aortoesophageal fistula secondary to button battery ingestion in a 15-month-old child. Case report and literature review.

    Karnecki, Karol / Pieśniak, Dorota / Jankowski, Zbigniew / Gos, Tomasz / Kaliszan, Michał

    Legal medicine (Tokyo, Japan)

    2020  Volume 45, Page(s) 101707

    Abstract: Small children put various objects into their mouths, which is one of their ways of exploring the surrounding world. Apart from toy parts, e.g. Lego® bricks or magnetic spheres, such objects include coins, small stones, as well as batteries used for ... ...

    Abstract Small children put various objects into their mouths, which is one of their ways of exploring the surrounding world. Apart from toy parts, e.g. Lego® bricks or magnetic spheres, such objects include coins, small stones, as well as batteries used for different electric devices. Such batteries, especially the flat, round button type, may be ingested and become impacted in one of the physiological narrowing sites of the oesophagus, leading to serious complications. The case of a 15-month-old child is presented, who died due to a massive gastrointestinal haemorrhage from an aortoesophageal fistula that developed at the site of a pressure ulcer caused by an impacted button battery. The presented case shows that ingestion of even a small battery may lead to death. The asymptomatic course of the battery ingestion significantly hinders both the assessment of circumstances and the time of the battery ingestion. Sudden death may result from a massive haemorrhage from a pressure-induced injury to a big blood vessel.
    Language English
    Publishing date 2020-04-15
    Publishing country Ireland
    Document type Case Reports
    ZDB-ID 2019555-2
    ISSN 1873-4162 ; 1344-6223
    ISSN (online) 1873-4162
    ISSN 1344-6223
    DOI 10.1016/j.legalmed.2020.101707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Epidemiology of suicide in the Tricity metropolitan area in northern Poland 1980–2009: Evidence of influence by political and socioeconomic changes

    Karnecki, Karol / Steiner, Johann / Guest, Paul C. / Krzyżanowska, Marta / Mańkowski, Dobrosław / Gos, Tomasz / Kaliszan, Michał

    Forensic science international. 2021 July, v. 3

    2021  

    Abstract: The paper presents the results of the statistical analyses of completed suicides in the Tri-City area, Poland from 1980 to 2009. The main objective of this study was to evaluate the trait dynamics of completed suicides in the context of drastic political ...

    Abstract The paper presents the results of the statistical analyses of completed suicides in the Tri-City area, Poland from 1980 to 2009. The main objective of this study was to evaluate the trait dynamics of completed suicides in the context of drastic political and socioeconomic transformations.Statistical analysis of approximately 30,000 autopsy cases, including 3885 suicides, was performed. All data were evaluated using the STATISTICA version 10 software.The analyses revealed an increasing number of suicide completers. Men committed suicide more frequently and were younger than female suicide committers. We observed also an increase in the mean age of suicide completers. More suicides occurred in the spring and summer compared to autumn and winter seasons. The most common method of suicide was hanging.The results of this study suggest temporal changes in trends, methods and social profile of suicide attempters related to political and socioeconomic changes in Poland in the years 1980–2009. These included the activity of the opposition movement “Solidarity”, the introduction of martial law in December 1981, the fall of communism and democratization processes, and the shifting from the system of a centrally planned economy to a neoliberal capitalism.
    Keywords autumn ; capitalism ; centrally planned economy ; epidemiology ; females ; forensic sciences ; metropolitan areas ; necropsy ; politics ; spring ; suicide ; summer ; Poland
    Language English
    Dates of publication 2021-07
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 2665-9107
    DOI 10.1016/j.fsir.2021.100219
    Database NAL-Catalogue (AGRICOLA)

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