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Article ; Online: Relative size of fungiform papillae in patients with neurofibromatosis Type 1.

Speth, U S / Kluwe, L / Gosau, M / Friedrich, R E

Journal of stomatology, oral and maxillofacial surgery

2023 Volume 124, Issue 3, Page(s) 101394

Abstract: Objective: To explore possible manifestations of neurofibromatosis on the tongue, especially, enlarged papillae fungiformes. According to the literature, enlarged fungiform papillae of the tongue are a very common oral finding in patients with ... ...

Abstract	Objective: To explore possible manifestations of neurofibromatosis on the tongue, especially, enlarged papillae fungiformes. According to the literature, enlarged fungiform papillae of the tongue are a very common oral finding in patients with Neurofibromatosis Type 1 (NF1). Materials and methods: Firstly, photos of 18 NF1 patients' tongues, taken at different times were compared to rule of possible fluctuating papillae size. Secondly, 60 photos of 60 patients with NF1 were age/sex matched, blinded and compared to 60 photos of 60 healthy patients. Three independent medical doctors rated the photos in regard of the fungiform papillae as smaller/same/larger at two different times. The inter- and intraindividual results were compared. Thirdly, fungiform papillae of 11 NF1 patients were quantitatively measured using the Denver protocol. Results: The fungiform papillae showed a stable size. The comparison of the healthy individuals to the NF1 patients suggests that the larger papillae are significantly more frequent in NF1 patients than in age- and gender-matched non-NF1 individuals. The agreement between two ratings of each of the 3 raters at different time points was two moderate and one substantial, the agreement among raters was only fair, since the Fleiss' Kappa value of all 6 ratings was 0.38. Conclusion: Although this study confirms that the evaluation of the size of the fungiform papillae by visual inspection only is very subjective, the fungiform papillae in NF1 patients do seem to be enlarged at a statistically significant level. Nonetheless the statistical difference is not distinctive enough to establish this as a diagnostic tool in diagnosing NF1. Clinical relevance: Facilitating the diagnosis of NF1 is an important factor in finding the correct treatment for these patients. A clinical inspection of the tongue is a simple and non-invasive procedure. This paper addresses the question if an inspection of the tongue, especially the fungiform papillae is a reliable indicator for the diagnosis of NF1.
MeSH term(s)	Humans ; Neurofibromatosis 1/complications ; Neurofibromatosis 1/diagnosis ; Neurofibromatosis 1/epidemiology ; Taste Buds ; Tongue
Language	English
Publishing date	2023-01-24
Publishing country	France
Document type	Journal Article
ZDB-ID	2916276-2
ISSN	2468-7855 ; 2468-8509
ISSN (online)	2468-7855
ISSN	2468-8509
DOI	10.1016/j.jormas.2023.101394
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Article ; Online: Multiple central giant cell granuloma of the jaws: diagnostic signposts of Noonan syndrome and RASopathy.

Friedrich, Reinhard E / Rutkowski, Rico / Gosau, Martin

Oral and maxillofacial surgery

2024

Abstract: Noonan syndrome (NS) is a phenotypically variable inherited multi-system disorder. Maxillofacial findings can be diagnostic, especially in the evaluation of discrete facial dysmorphia. Diagnostic landmark findings of therapeutic relevance for the jaws ... ...

Abstract	Noonan syndrome (NS) is a phenotypically variable inherited multi-system disorder. Maxillofacial findings can be diagnostic, especially in the evaluation of discrete facial dysmorphia. Diagnostic landmark findings of therapeutic relevance for the jaws such as central giant cell granuloma (CGCG) are rare in NS. However, recent molecular genetic studies indicate that these rare, benign lesions are neoplasms and more common in specific syndromes grouped under the umbrella term RASopathies. A specialist surgical diagnosis can be helpful in identifying the underlying disease. This report outlines diagnosis and treatment of a case of CGCG for which jaw diagnosis became the key to identifying a syndromic disease.
Language	English
Publishing date	2024-02-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2406731-3
ISSN	1865-1569 ; 1865-1550
ISSN (online)	1865-1569
ISSN	1865-1550
DOI	10.1007/s10006-024-01209-2
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Book ; Thesis: Verlaufsbeschreibung schizophrener Erkrankungen in Abhängigkeit von der Dauer der unbehandelten Psychose und anderer prognostischer Variablen

Gosau, Martin

2004

Author's details	vorgelegt von Martin Gosau
Language	German
Size	70 S., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	München, Univ., Diss., 2004
HBZ-ID	HT014374117
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Assessment of the intrasinusidal volume before and after maxillary sinus augmentation using mri - a pilot study of eight patients.

Flick, K / Smeets, R / Gosau, M / Meyer, L / Hanning, U / Kyselyova, A A / Scheifele, C / Höhmann, B / Henningsen, A

BMC oral health

2024 Volume 24, Issue 1, Page(s) 142

Abstract: Purpose: The purpose of this study was to evaluate the suitability, accuracy, and reliability of a non-invasive 3-Tesla magnetic resonance imaging technique (3 T-MRI) for the visualization of maxillary sinus grafts in comparison to conventional, X-ray- ... ...

Abstract	Purpose: The purpose of this study was to evaluate the suitability, accuracy, and reliability of a non-invasive 3-Tesla magnetic resonance imaging technique (3 T-MRI) for the visualization of maxillary sinus grafts in comparison to conventional, X-ray-based, established standard imaging techniques. Methods: A total of eight patients with alveolar bone atrophy who required surgical sinus floor augmentation in the course of dental implantation were included in this pilot study. Alongside pre-operative cone-beam computed tomography (CBCT), 3 T-MRI was performed before and 6 months after sinus floor augmentation. Two investigators measured the maxillary sinus volume preoperatively and after bone augmentation. Results: In all cases, MRI demonstrated accurately the volumes of the maxillary sinus grafts. Following surgery, the bony structures suitable for an implant placement increased at an average of 4.89 cm Conclusion: In this preliminary study, we could demonstrate the feasibility of MRI bone volume measurement as a radiation-free alternative with comparable accuracy to CT/CBCT before procedures like sinus floor augmentation. Nevertheless, costs and artifacts, also present in MRI, have to be taken into account. Larger studies will be necessary to justify the practicability of MRI bone volume evaluation.
MeSH term(s)	Humans ; Dental Implantation, Endosseous/methods ; Sinus Floor Augmentation/methods ; Maxillary Sinus/diagnostic imaging ; Maxillary Sinus/surgery ; Pilot Projects ; Reproducibility of Results ; Bone Transplantation/methods ; Cone-Beam Computed Tomography/methods ; Magnetic Resonance Imaging ; Dental Implants ; Maxilla/surgery
Chemical Substances	Dental Implants
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-024-03858-x
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Book ; Thesis: Entwicklung und Anwendung innovativer mechanischer und röntgentechnischer Methoden bei der tierexperimentellen Erprobung beschichteter Schraubenimplantate

Gosau, Martin

1997

Author's details	vorgelegt von Martin Gosau
Language	German
Size	III, 122 S. : Ill., graph. Darst.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Würzburg, Univ., Diss., 1997
HBZ-ID	HT007834919
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Idiopathic Facial Pain Syndromes–An Overview and Clinical Implications.

Ziegeler, Christian / Beikler, Thomas / Gosau, Martin / May, Arne

Deutsches Arzteblatt international

2021 Volume 118, Issue 6, Page(s) 81–87

Abstract: Background: Idiopathic facial pain syndromes are relatively rare. A uniform classification system for facial pain became available only recently, and many physicians and dentists are still unfamiliar with these conditions. As a result, patients ... ...

Abstract	Background: Idiopathic facial pain syndromes are relatively rare. A uniform classification system for facial pain became available only recently, and many physicians and dentists are still unfamiliar with these conditions. As a result, patients frequently do not receive appropriate treatment. Methods: This article is based on pertinent publications retrieved by a selective search in PubMed, focusing on current international guidelines and the International Classification of Orofacial Pain (ICOP). Results: The ICOP subdivides orofacial pain syndromes into six major groups, the first three of which consist of diseases of the teeth, the periodontium, and the temporomandibular joint. The remaining three groups (non-dental facial pain) are discussed in the present review. Attack-like facial pain syndromes most closely resemble the well-known primary headache syndromes, such as migraine, but with pain located below the orbitomeatal line. These syndromes are treated in accordance with the guidelines for the corresponding types of headache. Persistent idiopathic facial pain (PIFP) is a chronic pain disorder with persistent, undulating pain in the face and/or teeth, without any structural correlate. Since this type of pain tends to become chronified after invasive procedures, no dental procedures should be performed to treat it if the teeth are healthy; rather, the treatmentis similar to that of neuropathic pain, e.g., with antidepressant and anticonvulsive drugs. Neuropathic facial pain is also undulating and persistent. It is often described as a burning sensation, and neuralgiform attacks may additionally be present. Trigeminal neuralgia is a distinct condition involving short-lasting, lancinating pain of high intensity with a maximum duration of two minutes. The first line of treatment is with medications; invasive treatment options should be considered only if pharmacotherapy is ineffective or poorly tolerated. Conclusion: With the aid of this pragmatic classification system, the clinician can distinguish persistent and attack-like primary facial pain syndromes rather easily and treat each syndrome appropriately.
MeSH term(s)	Facial Neuralgia/diagnosis ; Facial Neuralgia/therapy ; Facial Pain/diagnosis ; Facial Pain/therapy ; Headache ; Humans ; Neuralgia ; Trigeminal Neuralgia
Language	English
Publishing date	2021-04-08
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2406159-1
ISSN	1866-0452 ; 1866-0452
ISSN (online)	1866-0452
ISSN	1866-0452
DOI	10.3238/arztebl.m2021.0006
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Article: Case Report: Early detection of lung carcinoid in an asymptomatic individual by blood-test initiated PET-CT imaging.

Burg, Simon / Smeets, Ralf / Gosau, Martin / Failing, Katja / Grust, Audrey Laure Céline

Frontiers in oncology

2023 Volume 13, Page(s) 1177237

Abstract: We present the case of a 53-year-old woman who was diagnosed with early-stage lung cancer by targeted cancer screening consisting of an immunological biopsy-based blood test followed by radiological imaging. The PanTum Detect blood test detects the ... ...

Abstract	We present the case of a 53-year-old woman who was diagnosed with early-stage lung cancer by targeted cancer screening consisting of an immunological biopsy-based blood test followed by radiological imaging. The PanTum Detect blood test detects the biomarkers Apo10/DNaseX and Transketolase-like 1 (TKTL1) in circulating macrophage-like cells from peripheral blood samples to identify asymptomatic individuals with a high risk for malignancy. The elevated blood test values initiated an
Language	English
Publishing date	2023-06-06
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1177237
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Article ; Online: Intraoperative ICG-based fluorescence-angiography in head and neck reconstruction: Predictive value for impaired perfusion of free flaps.

Schöpper, Steffen / Smeets, Ralf / Gosau, Martin / Hanken, Henning

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

2021 Volume 50, Issue 4, Page(s) 371–379

Abstract: The aim of this study was to prove the hypothesis that intraoperative fluorescence-angiography using indocyanine-green (ICGFA) can be used to predict the occurrence of perfusion-associated complications following microvascular reconstruction. ... ...

Abstract	The aim of this study was to prove the hypothesis that intraoperative fluorescence-angiography using indocyanine-green (ICGFA) can be used to predict the occurrence of perfusion-associated complications following microvascular reconstruction. Consecutively perioperative data of patients who received microvascular reconstruction of the head and neck region and underwent ICGFA immediately after anastomosis was established were analyzed. The flow parameters analyzed in the investigation were (1) the baseline (Int
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Fluorescein Angiography/methods ; Free Tissue Flaps/blood supply ; Humans ; Indocyanine Green ; Male ; Microcirculation ; Middle Aged ; Perfusion ; Postoperative Complications ; Reconstructive Surgical Procedures/methods
Chemical Substances	Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2021-10-01
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	91267-0
ISSN	1878-4119 ; 1010-5182 ; 0301-0503
ISSN (online)	1878-4119
ISSN	1010-5182 ; 0301-0503
DOI	10.1016/j.jcms.2021.09.020
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Zs.A 882: Show issues

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Article ; Online: Outcomes and influencing factors of dental implants in fibula, iliac crest, and scapula free flaps: a retrospective case-control study.

Kaiser, Marina / Burg, Simon / Speth, Ulrike / Cotter, Marie-Luise / Smeets, Ralf / Gosau, Martin / König, Daniela

International journal of implant dentistry

2024 Volume 10, Issue 1, Page(s) 8

Abstract: Purpose: Reconstruction with vascularized bone grafts after ablative surgery and subsequent dental rehabilitation with implants is often challenging; however, it helps improve the patient's quality of life. This retrospective case-control study aimed to ...

Abstract	Purpose: Reconstruction with vascularized bone grafts after ablative surgery and subsequent dental rehabilitation with implants is often challenging; however, it helps improve the patient's quality of life. This retrospective case-control study aimed to determine the implant survival/success rates in different vascularized bone grafts and potential risk factors. Methods: Only patients who received implants in free vascularized bone grafts between 2012 and 2020 were included. The free flap donor sites were the fibula, iliac crest, and scapula. The prosthetic restoration had to be completed, and the observation period had to be over one year after implantation. Implant success was defined according to the Health Scale for Dental Implants criteria. Results: Sixty-two patients with 227 implants were included. The implant survival rate was 86.3% after an average of 48.7 months. The causes of implant loss were peri-implantitis (n = 24), insufficient osseointegration (n = 1), removal due to tumor recurrence (n = 1), and osteoradionecrosis (n = 5). Of all implants, 52.4% were classified as successful, 19.8% as compromised, and 27.8% as failed. Removal of osteosynthesis material prior to or concurrent with implant placement resulted in significantly better implant success than material not removed (p = 0.035). Localization of the graft in the mandibular region was associated with a significantly better implant survival (p = 0.034) and success (p = 0.002), also a higher Karnofsky Performance Status Scale score with better implant survival (p = 0.014). Conclusion: Implants placed in vascularized grafts showed acceptable survival rates despite the potential risk factors often present in these patient groups. However, peri-implantitis remains a challenge.
MeSH term(s)	Humans ; Free Tissue Flaps/transplantation ; Retrospective Studies ; Dental Implants/adverse effects ; Case-Control Studies ; Peri-Implantitis ; Fibula/transplantation ; Ilium/surgery ; Quality of Life ; Scapula/surgery
Chemical Substances	Dental Implants
Language	English
Publishing date	2024-02-09
Publishing country	Germany
Document type	Journal Article
ISSN	2198-4034
ISSN (online)	2198-4034
DOI	10.1186/s40729-024-00522-5
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Article ; Online: Der erste Modellstudiengang Zahnmedizin in Deutschland – iMED DENT.

Guse, Andreas H / Beikler, Thomas / Heydecke, Guido / Gosau, Martin / Kahl-Nieke, Bärbel

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz

2023 Volume 66, Issue 12, Page(s) 1345–1352

Abstract: October 2019 saw the launch of iMED DENT, the first model study program in dentistry in Germany. The launch was preceded by a development process lasting several years in which European locations, among others, with innovative dental study programs were ... ...

Title translation	iMED DENT-First in place model curriculum in dentistry in Germany.
Abstract	October 2019 saw the launch of iMED DENT, the first model study program in dentistry in Germany. The launch was preceded by a development process lasting several years in which European locations, among others, with innovative dental study programs were initially visited. The central reform objective of the model study program was then defined: the development, implementation, and ongoing optimization of an interdisciplinary curriculum with a scientific focus that integrates theoretical and practical dental content. Further steps were the development of the study program objectives and the modular study structure. The latter consists of the three parts: "Normal Function," "From Symptom to Disease," and "Therapy." In the curriculum, the central area of dentistry is flanked by basic and clinical medical subjects. This article reports on the important development steps of the model study program, its structure, and quality assurance measures. First evaluations of the achievement of study program objectives and the need for optimization in the current curriculum are presented.
MeSH term(s)	Humans ; Germany ; Curriculum ; Longitudinal Studies ; Dentistry
Language	German
Publishing date	2023-11-03
Publishing country	Germany
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1461973-8
ISSN	1437-1588 ; 1436-9990
ISSN (online)	1437-1588
ISSN	1436-9990
DOI	10.1007/s00103-023-03801-5
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