Article: Maturation of Borna disease virus glycoprotein
FEBS letters. 2005 Aug. 29, v. 579, no. 21
2005
Abstract: The maturation of Borna disease virus (BDV) glycoprotein GP was studied in regard to intracellular compartmentalization, compartmentalization signal-domains, proteolytic processing, and packaging into virus particles. Our data show that BDV-GP is (i) ... ...
| Abstract | The maturation of Borna disease virus (BDV) glycoprotein GP was studied in regard to intracellular compartmentalization, compartmentalization signal-domains, proteolytic processing, and packaging into virus particles. Our data show that BDV-GP is (i) predominantly located in the endoplasmic reticulum (ER), (ii) partially exists in the ER already as cleaved subunits GP-N and GP-C, (iii) is directed to the ER/cis-Golgi region by its transmembrane and/or cytoplasmic domains in CD8-BDV-GP hybrid constructs and (iv) is incorporated in the virus particles as authentic BDV glycoprotein exclusively in the cleaved form decorated with N-glycans of the complex type. Downregulation of BDV-glycoproteins on the cell surface, their limited proteolytic processing, and protection of antigenic epitopes on the viral glycoproteins by host-identical N-glycans are different strategies for persistent virus infections. |
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| Keywords | Borna disease virus ; viral proteins ; glycoproteins ; virus replication ; endoplasmic reticulum ; cytochemistry ; protein transport ; polysaccharides ; epitopes ; host-pathogen relationships |
| Language | English |
| Dates of publication | 2005-0829 |
| Size | p. 4751-4756. |
| Document type | Article |
| DOI | 10.1016/j.febslet.2005.07.052 |
| Database | NAL-Catalogue (AGRICOLA) |
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