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  1. Article ; Online: Synthesis of 2,3-Disubstituted 4-Ethoxycarbonyl-β-carbolin-1-ones: Application to the Synthesis of SL651498 and Its Analogue.

    Miura, Ryoya / Goto, Shinsuke / Hashimoto, Takahide / Hachiya, Iwao

    ACS omega

    2020  Volume 5, Issue 25, Page(s) 15631–15656

    Abstract: Synthesis of 2,3-disubstituted 4-ethoxycarbonyl-β-carbolin-1-ones is developed using palladium-catalyzed intramolecular amination of 3-amino-4-(2-bromophenyl)-2-pyridones prepared by the conjugate addition reaction of diethyl 2-aminomalonate to alkynyl ... ...

    Abstract Synthesis of 2,3-disubstituted 4-ethoxycarbonyl-β-carbolin-1-ones is developed using palladium-catalyzed intramolecular amination of 3-amino-4-(2-bromophenyl)-2-pyridones prepared by the conjugate addition reaction of diethyl 2-aminomalonate to alkynyl imines. The method was applied to the total syntheses of SL651498 exhibiting anxiolytic activity and its analogue.
    Language English
    Publishing date 2020-06-16
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.0c01854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Association of clinical symptoms and metabolic syndrome-related factors in patients undergoing high tibial osteotomy.

    Azuma, Toshiki / Ueno, Katsuya / Goto, Shinsuke / Sugiki, Syunsuke / Izumoji, Tomo / Kamiji, Mototaka / Kuroda, Kazunari / Takahashi, Masaki / Asa, Ryousuke / Katsuki, Tatsuo / Haba, Toshihiro

    Journal of physical therapy science

    2023  Volume 35, Issue 5, Page(s) 373–378

    Abstract: Purpose] This study aimed to investigate the relationship between clinical outcomes after high tibial osteotomy and metabolic syndrome-related factors, such as hypertension, dyslipidemia, diabetes mellitus, and obesity. [Participants and Methods] A ... ...

    Abstract [Purpose] This study aimed to investigate the relationship between clinical outcomes after high tibial osteotomy and metabolic syndrome-related factors, such as hypertension, dyslipidemia, diabetes mellitus, and obesity. [Participants and Methods] A total of 73 patients (73 knees) who underwent high tibial osteotomy for knee osteoarthritis between 2018 and 2020 were included. We investigated the correlation between metabolic syndrome-related factors and clinical symptom assessment (Japanese Orthopedic Association Score) and examined knee function and lower alignment. [Results] At three months postoperatively, the Japanese Orthopedic Association score showed no main and synergistic effects on metabolic syndrome-related factors, and the preoperative Japanese Orthopedic Association score only showed a main effect on metabolic syndrome-related factors. At 12 months postoperatively, the Japanese Orthopedic Association score showed main and synergistic effects on diabetes mellitus, obesity, hypertension and dislipidemia. [Conclusion] Metabolic syndrome-related factors are associated with poorer clinical outcomes after high tibial osteotomy.
    Language English
    Publishing date 2023-05-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2038898-6
    ISSN 0915-5287
    ISSN 0915-5287
    DOI 10.1589/jpts.35.373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Association between clinical symptoms and lateral thrust 12 months after high tibial osteotomy.

    Azuma, Toshiki / Sasaki, Kentaro / Yokota, Ayako / Watanabe, Yousuke / Kuroda, Kazunari / Takahashi, Masaki / Asa, Ryousuke / Sakamoto, Kyouichi / Ohta, Yusuke / Haba, Toshihiro / Goto, Shinsuke

    Journal of physical therapy science

    2023  Volume 35, Issue 6, Page(s) 465–470

    Abstract: Purpose] This study aimed to assess the correlation between lateral thrust and clinical symptoms after high tibial osteotomy and determine lower limb alignments that may decrease lateral thrust. [Participants and Methods] We included 54 patients (73 ... ...

    Abstract [Purpose] This study aimed to assess the correlation between lateral thrust and clinical symptoms after high tibial osteotomy and determine lower limb alignments that may decrease lateral thrust. [Participants and Methods] We included 54 patients (73 knees) who underwent high tibial osteotomy. Clinical symptoms, including the Japanese Orthopaedic Association score and the hip-knee-ankle angle measured via radiography, were assessed 12 months postoperatively. Lateral thrust was measured using three-dimensional motion analyses. Logistic regression was used to calculate the cut-off values with good Japanese Orthopaedic Association score and lateral thrust as dependent variables and both lateral thrust and hip-knee-ankle angle as independent variables. [Results] The lateral thrust cut-off was 3.1° (sensitivity: 0.83; specificity: 0.74; area under the curve: 0.76), while that of the hip-knee-ankle angle was 1.9° of valgus (sensitivity: 0.71; specificity: 0.81; area under the curve: 0.72). [Conclusion] Good clinical outcomes after high tibial osteotomy can be expected with a lateral thrust of ≤3.0°, indicating that the target hip-knee-ankle angle should be 2.0° valgus. In cases where valgus alignment is insufficient, lateral thrust may develop, which should be assessed using gait analysis.
    Language English
    Publishing date 2023-06-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2038898-6
    ISSN 0915-5287
    ISSN 0915-5287
    DOI 10.1589/jpts.35.465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: In-hospital grouping rehabilitation of hybrid closed-wedge high tibial osteotomy results in shorter hospital stays and better clinical outcomes.

    Azuma, Toshiki / Ueno, Katsuya / Sugiki, Syunsuke / Kurokawa, Ryota / Izumoji, Tomo / Yamada, Natsumi / Sakanaka, Ryouko / Watanabe, Yousuke / Kamiji, Mototaka / Kuroda, Kazunari / Takahashi, Masaki / Asa, Ryousuke / Haba, Toshihiro / Goto, Shinsuke

    Journal of physical therapy science

    2023  Volume 35, Issue 8, Page(s) 575–580

    Abstract: Purpose] This study aimed to examine the impact of physiotherapy on various patients who underwent hybrid closed-wedge high tibial osteotomy. [Participants and Methods] Eighty-four patients were divided into three groups: non-weight-bearing, enhanced ... ...

    Abstract [Purpose] This study aimed to examine the impact of physiotherapy on various patients who underwent hybrid closed-wedge high tibial osteotomy. [Participants and Methods] Eighty-four patients were divided into three groups: non-weight-bearing, enhanced recovery after surgery, and grouping exercise. The number of hospital days, distinctions in the duration of cane-walking independence, and postoperative complications were compared among the three groups. Furthermore, the Japanese Orthopaedic Association score and physical function were assessed preoperatively and at 3 and 12 months postoperatively. [Results] There were no considerable differences in postoperative complications among the three groups, and the mean hospital stay was the shortest for the grouping exercise group. At 3 months postoperatively, the grouping exercise group reported less walking pain than the enhanced recovery after surgery group. At 3 and 12 months postoperatively, the grouping exercise group showed greater mean knee extensor strength and a higher mean Japanese Orthopaedic Association score than the non-weight-bearing group. [Conclusion] Grouping exercise therapy, in addition to enhanced recovery after surgery protocol, results in shorter hospital stays, no difference in postoperative complications, and good clinical outcomes.
    Language English
    Publishing date 2023-08-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2038898-6
    ISSN 0915-5287
    ISSN 0915-5287
    DOI 10.1589/jpts.35.575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effects of the Drop-set and Reverse Drop-set Methods on the Muscle Activity and Intramuscular Oxygenation of the Triceps Brachii among Trained and Untrained Individuals

    Masahiro Goto, Shinsuke Nirengi, Yuko Kurosawa, Akinori Nagano, Takafumi Hamaoka

    Journal of Sports Science and Medicine, Vol 15, Iss 4, Pp 562-

    2016  Volume 568

    Abstract: Influence of different load exercise to muscle activity during subsequent exercise with 75% of one repetition maximum (RM) load among trained and untrained individuals was verified. Resistance-trained men who were involved in resistance training (n = 16) ...

    Abstract Influence of different load exercise to muscle activity during subsequent exercise with 75% of one repetition maximum (RM) load among trained and untrained individuals was verified. Resistance-trained men who were involved in resistance training (n = 16) and healthy young men who did not exercise regularly (n = 16) were recruited for this study. Each subject performed bench pressing with a narrow grip exercise using two different training set methods, the drop-set (DS) (3 sets × 2-10 repetitions with 95-75% of 1RM) and the reverse drop-set (RDS) (3 sets × 3-10 repetitions with 55-75% of 1RM). The mean concentric contraction power, root mean square (RMS) of electromyography (EMG), area under the oxygenated hemoglobin (Oxy-Hb) curve, and time constant for muscle oxygen consumption (TcVO2mus) values of the triceps brachii were measured during and after the DS and RDS. The trained group demonstrated significantly higher mean muscle power (242.9 ± 39.6 W vs. 215.8 ± 31.7 W), RMS of EMG (86.4 ± 10.4 % vs. 68.3 ± 9.6 %), and area under the Oxy-Hb curve (38.6 ± 7.4 %• sec vs. 29.3 ± 5.8 %• sec) values during the DS than during the RDS (p < 0.05). However, in the untrained group none of the parameters differed significantly for both the DS and RDS. Furthermore, a negative correlation was detected between the area under the Oxy-Hb curve and muscle thickness (r = -0.51, p < 0.01). Long-term effects of DS on muscle strengthening and hypertrophy will be explored in further research.
    Keywords Drop-set ; resistance exercise ; hypertrophy ; hypoxia ; NIRS ; Sports ; GV557-1198.995 ; Sports medicine ; RC1200-1245
    Subject code 796
    Language English
    Publishing date 2016-12-01T00:00:00Z
    Publisher University of Uludag
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Association between the severity of symptomatic knee osteoarthritis and cumulative metabolic factors.

    Yasuda, Emi / Nakamura, Ryuichi / Matsugi, Ryo / Goto, Shinsuke / Ikenaga, Yasunori / Kuroda, Kazunari / Nakamura, Syunsuke / Katsuki, Yasuo / Katsuki, Tatsuo

    Aging clinical and experimental research

    2017  Volume 30, Issue 5, Page(s) 481–488

    Abstract: Background: The association between cumulative metabolic syndrome (MS) factors and knee osteoarthritis (KOA) has been highlighted over the past two decades.: Aims: To clarify the relationship between cumulative MS factors and symptomatic KOA.: ... ...

    Abstract Background: The association between cumulative metabolic syndrome (MS) factors and knee osteoarthritis (KOA) has been highlighted over the past two decades.
    Aims: To clarify the relationship between cumulative MS factors and symptomatic KOA.
    Methods: A cross-sectional survey involving 119 women aged 45-88 years who were scheduled to undergo knee surgery was conducted. They were stratified into tertiles of symptoms as assessed by the Japanese Orthopedic Association score for KOA. Multinomial logistic regressions were performed using the severity of symptomatic KOA as the dependent variable and each MS factor or the cumulative MS factors as the independent variables.
    Results: Logistic regression analyses were performed with the upper tertile of stratified symptoms of subjects used as the reference group. After adjustment for confounders, KOA patients who had two (p = 0.004) or three or more (p < 0.0001) MS factors were significantly more likely to have severe symptoms compared to those who had no MS factors. MS factors excluding obesity were similarly analyzed. Even after additional adjustment for body mass index (BMI), KOA patients who had two or more (p = 0.005) MS factors were significantly more likely to have severe symptoms.
    Conclusion: Among KOA female patients diagnosed using radiographic definition, the severity of symptomatic KOA was significantly associated with hypertension, dyslipidemia, and the number of MS factors after adjustment for age, BMI, strength of the knee extensor, and Kellgren-Lawrence grade. The severity of radiographic KOA was not associated with any MS factor or cumulative MS factors.
    MeSH term(s) Aged ; Aged, 80 and over ; Blood Glucose/analysis ; Body Mass Index ; Cross-Sectional Studies ; Dyslipidemias/classification ; Female ; Humans ; Hypertension/classification ; Hypertension/etiology ; Knee Joint/diagnostic imaging ; Logistic Models ; Metabolic Syndrome/classification ; Metabolic Syndrome/etiology ; Metabolic Syndrome/physiopathology ; Middle Aged ; Obesity/classification ; Obesity/epidemiology ; Osteoarthritis, Knee/classification ; Osteoarthritis, Knee/complications ; Osteoarthritis, Knee/diagnostic imaging ; Radiography ; Retrospective Studies ; Severity of Illness Index
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2017-07-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-017-0808-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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