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  1. Article: Genetic Deletion of Low Density Lipoprotein Receptor Impairs Sterol-induced Mouse Macrophage ABCA1 Expression: A NEW SREBP1-DEPENDENT MECHANISM

    Zhou, Xiaoye / He, Wei / Huang, Zhiping / Gotto, Antonio M. Jr / Hajjar, David P / Han, Jihong

    Journal of biological chemistry. 2008 Jan. 25, v. 283, no. 4

    2008  

    Abstract: Low density lipoprotein receptor (LDLR) mutations cause familial hypercholesterolemia and early atherosclerosis. ABCA1 facilitates free cholesterol efflux from peripheral tissues. We investigated the effects of LDLR deletion (LDLR⁻/⁻) on ABCA1 expression. ...

    Abstract Low density lipoprotein receptor (LDLR) mutations cause familial hypercholesterolemia and early atherosclerosis. ABCA1 facilitates free cholesterol efflux from peripheral tissues. We investigated the effects of LDLR deletion (LDLR⁻/⁻) on ABCA1 expression. LDLR⁻/⁻ macrophages had reduced basal levels of ABCA1, ABCG1, and cholesterol efflux. A high fat diet increased cholesterol in LDLR⁻/⁻ macrophages but not wild type cells. A liver X receptor (LXR) agonist induced expression of ABCA1, ABCG1, and cholesterol efflux in both LDLR⁻/⁻ and wild type macrophages, whereas expression of LXRα or LXRβ was similar. Interestingly, oxidized LDL induced more ABCA1 in wild type macrophages than LDLR⁻/⁻ cells. LDL induced ABCA1 expression in wild type cells but inhibited it in LDLR⁻/⁻ macrophages in a concentration-dependent manner. However, lipoproteins regulated ABCG1 expression similarly in LDLR⁻/⁻ and wild type macrophages. Cholesterol or oxysterols induced ABCA1 expression in wild type macrophages but had little or inhibitory effects on ABCA1 expression in LDLR⁻/⁻ macrophages. Active sterol regulatory element-binding protein 1a (SREBP1a) inhibited ABCA1 promoter activity in an LXRE-dependent manner and decreased both macrophage ABCA1 expression and cholesterol efflux. Expression of ABCA1 in animal tissues was inversely correlated to active SREBP1. Oxysterols inactivated SREBP1 in wild type macrophages but not in LDLR⁻/⁻ cells. Oxysterol synergized with nonsteroid LXR ligand induced ABCA1 expression in wild type macrophages but blocked induction in LDLR⁻/⁻ cells. Taken together, our studies suggest that LDLR is critical in the regulation of cholesterol efflux and ABCA1 expression in macrophage. Lack of the LDLR impairs sterol-induced macrophage ABCA1 expression by a sterol regulatory element-binding protein 1-dependent mechanism that can result in reduced cholesterol efflux and lipid accumulation in macrophages under hypercholesterolemic conditions.
    Language English
    Dates of publication 2008-0125
    Size p. 2129-2138.
    Publishing place American Society for Biochemistry and Molecular Biology
    Document type Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Diet and heart disease: responses to the findings concluded lrc-cppt

    Gotto, Antonio M., Jr

    Nutrition today. 1984 , v. 19, no. 6

    1984  

    Abstract: In January of this year, the Heart, Lung and Blood Institute of the National Institutes of Health released the results of its study which was designed to measure the effect of the drug, cholestyramine, on the incidence of coronary heart disease and on ... ...

    Abstract In January of this year, the Heart, Lung and Blood Institute of the National Institutes of Health released the results of its study which was designed to measure the effect of the drug, cholestyramine, on the incidence of coronary heart disease and on mortality rates of those suffering that affliction.The drug usedin the 71/2-year study is a synthetic resin which is said to have an affinity for dietary cholesterol. The investigators hoped to exploit this characteristic, hoped that it would reduce serum cholesterol in a group of men selected for their elevated blood cholesterol levels.On January 20, 1984 the final scientific report was published in the Journal of the American Medical Association. The results were reported in mathematical terms, viz, “For each one percent fall in cholesterol level, a 2% reduction, a heart attack risk can be expected.”Nutrition Today published the original transcript of the findings and at the same time editorially expressed our opinion that the claims made to the public were not substantiated by the report.We, therefore, invited 27 health scientists well informed in medicine, dietetics and nutrition biochemistry to comment on the health institute report. In the last issue of the magazine, we published 12 responses and with the following responses, we conclude those who responded to our invitation to comment on the study and report.
    Keywords blood serum ; cholesterol ; cholestyramine ; coronary disease ; diet ; dietetics ; heart ; medicine ; men ; mortality ; myocardial infarction ; nutrition risk assessment
    Language English
    Dates of publication 1984-11
    Size p. 20-25.
    Publishing place Williams & Wilkins
    Document type Article
    Note Affiliations: Dr. Gotto is president of the American Heart Association, a professor, Department of Medicine, Baylor College of Medicine and a professor, Methodist Hospital, Baylor, Texas 77030.
    ZDB-ID 2053548-X
    ISSN 1538-9839 ; 0029-666X
    ISSN (online) 1538-9839
    ISSN 0029-666X
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Is atherosclerosis reversible?

    Gotto, Antonio M. Jr

    Journal - American Dietetic Association. May 1979. v. 74 (5)

    1979  

    Abstract: Abstract: Dietary modifications have been found to reverse atherosclerosis. The lowering of blood lipids in the human diet appears to decrease plaque size. Smoking is associated with the progression of plaque development, while non-smoking seems to ... ...

    Abstract Abstract: Dietary modifications have been found to reverse atherosclerosis. The lowering of blood lipids in the human diet appears to decrease plaque size. Smoking is associated with the progression of plaque development, while non-smoking seems to enhance plaque regression. Blood cholesterol and triglycerides were positively correlated with the rate of atherosclerosis in human beings. Patients who had undergone partial ileal bypass surgery showed no progression of the disease. Peripheral circulation improved in patients treated with diet and clofibrate. The presence of apoproteins and phospholipids can cause a net loss of cholesterol from incubated cells.
    Keywords diet ; atherosclerosis ; cholesterol ; lipids ; triacylglycerols ; diet therapy ; cardiovascular diseases
    Language English
    Dates of publication 1979-05
    Size p. 551-557., ill., charts.
    Document type Article
    Note Literature review.
    ZDB-ID 390806-9
    ISSN 1878-3570 ; 0002-8223
    ISSN (online) 1878-3570
    ISSN 0002-8223
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Effects of a low cholesterol eating plan on plasma lipids: Results of a three-year community study

    Reeves, Rebecca S / Foreyt, John P / Scott, Lynne W / Mitchell, Robert E / Wohlleb, James / Gotto, Antonio M. Jr

    American journal of public health. Aug 1983. v. 73 (8)

    1983  

    Abstract: Extract: In an attempt to demonstrate whether individuals with average plasma lipids would accept a diet low in saturated fat and cholesterol, members of a community organization were taught the HELP Your Heart Eating Plan. Results of 282 individuals ... ...

    Abstract Extract: In an attempt to demonstrate whether individuals with average plasma lipids would accept a diet low in saturated fat and cholesterol, members of a community organization were taught the HELP Your Heart Eating Plan. Results of 282 individuals suggest that reduced dietary cholesterol from selected foods could be sustained for up to 36 months. While both plasma cholesterol and triglycerides fell during a year of instruction, both rose to above initial values by 36 months. Overall, the results suggest that adults may be willing to accept a new style of eating temporarily but are not committed to making permanent dietary changes. (author)
    Keywords cholesterol ; nutrition education ; adults
    Language English
    Dates of publication 1983-08
    Size p. 873-877., ill., charts.
    Document type Article
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  5. Article: A low-cholesterol menu in a steak restaurant

    Scott, Lynne W / Foreyt, John P / Manis, Elizabeth / O'Malley, Mary Pat / Gotto, Antonio M. Jr

    American Dietetic Association Journal Jan 1979. v. 74 (1)

    1979  

    Abstract: Abstract: In an effort to provide a low-cholesterol menu for a steak house chain, the dietary staff at the Baylor College of Medicine submitted a series of recommendations to its owners as part of a 12 month pilot project. Recommendations included use of ...

    Abstract Abstract: In an effort to provide a low-cholesterol menu for a steak house chain, the dietary staff at the Baylor College of Medicine submitted a series of recommendations to its owners as part of a 12 month pilot project. Recommendations included use of margarine in place of butter, vegetable oil, skim milk, and limiting raw meat portions to no more than 8 oz. A "Help Your Heart Menu" was developed using lean meats, margarine and no sour cream. Meats were served without skin and with all visible fat removed. The monthly percentage of sales from the menu ranged from 2.5-5.1.
    Keywords diet ; restaurants ; menu planning
    Language English
    Dates of publication 1979-01
    Size p. 54-56., ill.
    Document type Article
    ZDB-ID 390806-9
    ISSN 1878-3570 ; 0002-8223
    ISSN (online) 1878-3570
    ISSN 0002-8223
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Are low-cholesterol diets expensive?

    Scott, Lynne W / Foreyt, John P / Young, Jackie / Reeves, Rebecca S / O'Malley, Mary Pat / Gotto, Antonio M. Jr

    Journal - American Dietetic Association. May 1979. v. 74 (5)

    1979  

    Abstract: Abstract: A low-cholesterol diet need not be more costly than moderate- or low-cost dietary patterns. Meat is usually the most costly item in a food budget, and it also contributes a large proportion of saturated fat in many individuals' diets. Because a ...

    Abstract Abstract: A low-cholesterol diet need not be more costly than moderate- or low-cost dietary patterns. Meat is usually the most costly item in a food budget, and it also contributes a large proportion of saturated fat in many individuals' diets. Because a low-cholesterol diet limits the intake of meat, food costs can be reduced in this area. High-fat snack foods, which also tend to be relatively costly, are similarly discouraged in low-cholesterol diets. Instead, low-fat crackers, fruits, and skim milk products are suggested as alternative snacks.
    Keywords food purchasing ; costs and returns ; menu planning ; cost effectiveness
    Language English
    Dates of publication 1979-05
    Size p. 558-561.
    Document type Article
    ZDB-ID 390806-9
    ISSN 1878-3570 ; 0002-8223
    ISSN (online) 1878-3570
    ISSN 0002-8223
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Exercise, diet, and high-density-lipoprotein cholesterol

    Zimmerman, Bruce R / Simko, Vlado / Kelley, Robert / Young, Laurens D / Barboriak, J.J / Wetzler, Harry P / Hartung, G. Harley / Foreyt, John P / Mitchell, Robert E / Vlasek, Imogene / Gotto, Antonio M. Jr

    New England journal of medicine July 24, 1980. v. 303 (4)

    1980  

    Abstract: Abstract: In response to an original paper on exercise, diet and high density lipoprotein (HDL) cholesterol, criticisms are that HDL cholesterol measurements will be useful for a change in therapy only in patients with an increase in total cholesterol ... ...

    Title variant Exercise, diet, and high-density-lipoprotein cholesterol. [letters and reply]
    Abstract Abstract: In response to an original paper on exercise, diet and high density lipoprotein (HDL) cholesterol, criticisms are that HDL cholesterol measurements will be useful for a change in therapy only in patients with an increase in total cholesterol related to increased HDL cholesterol; the dietary part of the study was weak because the authors listed significant differences between active and inactive persons (in intake of bacon, sausage and red meat) and then claimed the subgroups had no significant differences in their dietary habits; and the overall behavior patterns of the three groups studied were probably different in ways not readily measureable. Finally, there is a strong hereditary component in the determination of HDL levels, and the notion that running rather than diet elevates HDL is tenuous. The original authors respond that the ratio of HDL to total cholesterol may be an important measurement of cardiovascular risk, but that the other two criticisms have some merit due to the vagaries of self-reported data.
    Keywords exercise ; diet ; lipoproteins ; cholesterol ; patient care ; high density lipoprotein
    Language English
    Dates of publication 1980-0624
    Size p. 223-224., chart.
    Document type Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    Database NAL-Catalogue (AGRICOLA)

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