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  1. Article ; Online: Sleep in disorders of consciousness: diagnostic, prognostic, and therapeutic considerations.

    Gottshall, Jackie L / Rossi Sebastiano, Davide

    Current opinion in neurology

    2020  Volume 33, Issue 6, Page(s) 684–690

    Abstract: Purpose of review: Sleep is important in the evaluation of patients with disorders of consciousness (DOC). However, it remains unclear whether reconstitution of sleep could enable consciousness or vice versa. Here we synthesize recent evidence on ... ...

    Abstract Purpose of review: Sleep is important in the evaluation of patients with disorders of consciousness (DOC). However, it remains unclear whether reconstitution of sleep could enable consciousness or vice versa. Here we synthesize recent evidence on natural recovery of sleep in DOC, and sleep-promoting therapeutic interventions for recovery of consciousness.
    Recent findings: In subacute DOC, physiological sleep--wake cycles and complex sleep patterns are related to better outcomes. Moreover, structured rapid-eye-movement (REM), non-REM (NREM) stages, and presence of sleep spindles correlate with full or partial recovery. In chronic DOC, sleep organization may reflect both integrity of consciousness-supporting brain networks and engagement of those networks during wakefulness. Therapeutic strategies have integrated improvement of sleep and sleep--wake cycles in DOC patients; use of bright light stimulation or drugs enhancing sleep and/or vigilance, treatment of sleep apneas, and neuromodulatory stimulations are promising tools to promote healthy sleep architecture and wakeful recovery.
    Summary: Sleep features and sleep--wake cycles are important prognostic markers in subacute DOC and can provide insight into covert recovery in chronic DOC. Although large-scale studies are needed, preliminary studies in limited patients suggest that therapeutic options restoring sleep and/or sleep--wake cycles may improve cognitive function and outcomes in DOC.
    MeSH term(s) Brain/physiopathology ; Consciousness/physiology ; Consciousness Disorders/diagnosis ; Consciousness Disorders/physiopathology ; Electroencephalography ; Humans ; Prognosis ; Sleep/physiology ; Wakefulness/physiology
    Language English
    Publishing date 2020-11-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000000870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Daytime Central Thalamic Deep Brain Stimulation Modulates Sleep Dynamics in the Severely Injured Brain: Mechanistic Insights and a Novel Framework for Alpha-Delta Sleep Generation.

    Gottshall, Jackie L / Adams, Zoe M / Forgacs, Peter B / Schiff, Nicholas D

    Frontiers in neurology

    2019  Volume 10, Page(s) 20

    Abstract: Loss of organized sleep electrophysiology is a characteristic finding following severe brain injury. The return of structured elements of sleep architecture has been associated with positive prognosis across injury etiologies, suggesting a role for sleep ...

    Abstract Loss of organized sleep electrophysiology is a characteristic finding following severe brain injury. The return of structured elements of sleep architecture has been associated with positive prognosis across injury etiologies, suggesting a role for sleep dynamics as biomarkers of wakeful neuronal circuit function. In a continuing study of one minimally conscious state patient studied over the course of ~8½ years, we sought to investigate whether changes in daytime brain activation induced by central thalamic deep brain stimulation (CT-DBS) influenced sleep electrophysiology. In this patient subject, we previously reported significant improvements in sleep electrophysiology during 5½ years of CT-DBS treatment, including increased sleep spindle frequency and SWS delta power. We now present novel findings that many of these improvements in sleep electrophysiology regress following CT-DBS discontinuation; these regressions in sleep features correlate with a significant decrease in behavioral responsiveness. We also observe the re-emergence of alpha-delta sleep, which had been previously suppressed by daytime CT-DBS in this patient subject. Importantly, CT-DBS was only active during the daytime and has been proposed to mediate recovery of consciousness by driving synaptic activity across frontostriatal systems through the enhancement of thalamocortical output. Accordingly, the improvement of sleep dynamics during daytime CT-DBS and their subsequent regression following CT-DBS discontinuation implicates wakeful synaptic activity as a robust modulator of sleep electrophysiology. We interpret these findings in the context of the "synaptic homeostasis hypothesis," whereby we propose that daytime upregulation of thalamocortical output in the severely injured brain may facilitate organized frontocortical circuit activation and yield net synaptic potentiation during wakefulness, providing a homeostatic drive that reconstitutes sleep dynamics over time. Furthermore, we consider common large-scale network dynamics across several neuropsychiatric disorders in which alpha-delta sleep has been documented, allowing us to formulate a novel mechanistic framework for alpha-delta sleep generation. We conclude that the bi-directional modulation of sleep electrophysiology by daytime thalamocortical activity in the severely injured brain: (1) emphasizes the cyclical carry-over effects of state-dependent circuit activation on large-scale brain dynamics, and (2) further implicates sleep electrophysiology as a sensitive indicator of wakeful brain activation and covert functional recovery in the severely injured brain.
    Language English
    Publishing date 2019-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2019.00020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Poor Sleep Quality is Linked to Elevated Extracellular Vesicle-Associated Inflammatory Cytokines in Warfighters With Chronic Mild Traumatic Brain Injuries.

    Gottshall, Jackie L / Guedes, Vivian A / Pucci, Josephine U / Brooks, Daniel / Watson, Nora / Sheth, Phorum / Gabriel, Ainslee / Mithani, Sara / Leete, Jacqueline J / Lai, Chen / Qu, Bao-Xi / Devoto, Christina / Gill, Jessica M / Kenney, Kimbra / Werner, J Kent

    Frontiers in pharmacology

    2022  Volume 12, Page(s) 762077

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.762077
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  4. Article ; Online: Sleep quality: A common thread linking depression, post-traumatic stress, and post-concussive symptoms to biomarkers of neurodegeneration following traumatic brain injury.

    Gottshall, Jackie L / Agyemang, Amma A / O'Neil, Maya / Wei, Guo / Presson, Angela / Hewins, Bryson / Fisher, Daniel / Mithani, Sara / Shahim, Pashtun / Pugh, Mary Jo / Wilde, Elisabeth A / Devoto, Christina / Yaffe, Kristine / Gill, Jessica / Kenney, Kimbra / Werner, J Kent

    Brain injury

    2022  Volume 36, Issue 5, Page(s) 633–643

    Abstract: Objective: Following mild traumatic brain injury (mTBI), many individuals suffer from persistent post-concussive, depressive, post-traumatic stress, and sleep-related symptoms. Findings from self-report scales link these symptoms to biomarkers of ... ...

    Abstract Objective: Following mild traumatic brain injury (mTBI), many individuals suffer from persistent post-concussive, depressive, post-traumatic stress, and sleep-related symptoms. Findings from self-report scales link these symptoms to biomarkers of neurodegeneration, although the underlying pathophysiology is unclear. Each linked self-report scale includes sleep items, raising the possibility that despite varied symptomology, disordered sleep may underlie these associations. To isolate sleep effects, we examined associations between post-mTBI biomarkers of neurodegeneration and symptom scales according to composite, non-sleep, and sleep components.
    Methods: Plasma biomarkers and self-report scales were obtained from 143 mTBI-positive warfighters. Pearson's correlations and regression models were constructed to estimate associations between total, sleep, and non-sleep scale items with biomarker levels, and with measured sleep quality.
    Results: Symptom severity positively correlated with biomarker levels across scales. Biomarker associations were largely unchanged when sleep items were included, excluded, or considered in isolation. Pittsburgh Sleep Quality Index demonstrated strong correlations with sleep and non-sleep items of all scales.
    Conclusion: The congruency of associations raises the possibility of a common pathophysiological process underlying differing symptomologies. Given its role in neurodegeneration and mood dysregulation, sleep physiology seems a likely candidate. Future longitudinal studies should test this hypothesis, with a focus on identifying novel sleep-related therapeutic targets.
    MeSH term(s) Biomarkers ; Brain Concussion/complications ; Brain Concussion/diagnosis ; Brain Injuries, Traumatic/complications ; Depression/diagnosis ; Depression/etiology ; Humans ; Post-Concussion Syndrome ; Sleep Quality ; Stress Disorders, Post-Traumatic/complications
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-02-19
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 639115-1
    ISSN 1362-301X ; 0269-9052
    ISSN (online) 1362-301X
    ISSN 0269-9052
    DOI 10.1080/02699052.2022.2037711
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2242: Show issues Location:
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  5. Article ; Online: Diminished testing benefits in young adults with attention-deficit hyperactivity disorder.

    Dudukovic, Nicole M / Gottshall, Jackie L / Cavanaugh, Patricia A / Moody, Christine T

    Memory (Hove, England)

    2015  Volume 23, Issue 8, Page(s) 1264–1276

    Abstract: Memory retrieval has been shown to enhance the long-term retention of tested material; however, recent research suggests that limiting attention during retrieval can decrease the benefits of testing memory. The present study examined whether testing ... ...

    Abstract Memory retrieval has been shown to enhance the long-term retention of tested material; however, recent research suggests that limiting attention during retrieval can decrease the benefits of testing memory. The present study examined whether testing benefits are reduced in young adults with attention-deficit hyperactivity disorder (ADHD). College students with and without ADHD read three short prose passages, each followed by a free recall test, a restudy period or a distractor task. Two days later participants recalled the passages. Although participants without ADHD did not show a significant benefit of testing over restudying, testing did produce recall benefits relative to not taking a test. These testing benefits were diminished in participants with ADHD, who did not show any advantage of testing over either restudying or no test. The absence of testing benefits in the ADHD group is likely due in part to decreased recall on the initial test. These findings have implications for improving educational practices among individuals with ADHD and also speak to the need to examine individual differences in the effectiveness of testing as a learning strategy.
    MeSH term(s) Attention ; Attention Deficit Disorder with Hyperactivity/physiopathology ; Attention Deficit Disorder with Hyperactivity/psychology ; Educational Measurement ; Female ; Humans ; Individuality ; Learning/physiology ; Male ; Mental Recall ; Neuropsychological Tests ; Practice (Psychology) ; Reading ; Retention (Psychology)/physiology ; Test Taking Skills ; Transfer (Psychology)/physiology ; Young Adult
    Language English
    Publishing date 2015
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1147478-6
    ISSN 1464-0686 ; 0965-8211
    ISSN (online) 1464-0686
    ISSN 0965-8211
    DOI 10.1080/09658211.2014.977921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5983: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Differential timing of granule cell production during cerebellum development underlies generation of the foliation pattern.

    Legué, Emilie / Gottshall, Jackie L / Jaumouillé, Edouard / Roselló-Díez, Alberto / Shi, Wei / Barraza, Luis Humberto / Washington, Senna / Grant, Rachel L / Joyner, Alexandra L

    Neural development

    2016  Volume 11, Issue 1, Page(s) 17

    Abstract: Background: The mouse cerebellum (Cb) has a remarkably complex foliated three-dimensional (3D) structure, but a stereotypical cytoarchitecture and local circuitry. Little is known of the cellular behaviors and genes that function during development to ... ...

    Abstract Background: The mouse cerebellum (Cb) has a remarkably complex foliated three-dimensional (3D) structure, but a stereotypical cytoarchitecture and local circuitry. Little is known of the cellular behaviors and genes that function during development to determine the foliation pattern. In the anteroposterior axis the mammalian cerebellum is divided by lobules with distinct sizes, and the foliation pattern differs along the mediolateral axis defining a medial vermis and two lateral hemispheres. In the vermis, lobules are further grouped into four anteroposterior zones (anterior, central, posterior and nodular zones) based on genetic criteria, and each has distinct lobules. Since each cerebellar afferent group projects to particular lobules and zones, it is critical to understand how the 3D structure of the Cb is acquired. During cerebellar development, the production of granule cells (gcs), the most numerous cell type in the brain, is required for foliation. We hypothesized that the timing of gc accumulation is different in the four vermal zones during development and contributes to the distinct lobule morphologies.
    Methods and results: In order to test this idea, we used genetic inducible fate mapping to quantify accumulation of gcs in each lobule during the first two postnatal weeks in mice. The timing of gc production was found to be particular to each lobule, and delayed in the central zone lobules relative to the other zones. Quantification of gc proliferation and differentiation at three time-points in lobules representing different zones, revealed the delay involves a later onset of maximum differentiation and prolonged proliferation of gc progenitors in the central zone. Similar experiments in Engrailed mutants (En1 (-/+) ;En2 (-/-) ), which have a smaller Cb and altered foliation pattern preferentially outside the central zone, showed that gc production, proliferation and differentiation are altered such that the differences between zones are attenuated compared to wild-type mice.
    Conclusions: Our results reveal that gc production is differentially regulated in each zone of the cerebellar vermis, and our mutant analysis indicates that the dynamics of gc production plays a role in determining the 3D structure of the Cb.
    MeSH term(s) Animals ; Cell Differentiation ; Cell Proliferation ; Cerebellum/growth & development ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Mice ; Mice, Knockout ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Neurons/physiology
    Chemical Substances En1 protein, mouse ; Homeodomain Proteins ; Nerve Tissue Proteins ; engrailed 2 protein
    Language English
    Publishing date 2016-09-08
    Publishing country England
    Document type Journal Article
    ISSN 1749-8104
    ISSN (online) 1749-8104
    DOI 10.1186/s13064-016-0072-z
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