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Article ; Online: Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation: Which Regimen and for How Long?

Goudevenos, John A / Tselepis, Alexandros D

2016 Volume 67, Issue 3, Page(s) 208–211

MeSH term(s)	Coronary Thrombosis/prevention & control ; Drug-Eluting Stents ; Humans ; Percutaneous Coronary Intervention/instrumentation ; Platelet Aggregation Inhibitors/administration & dosage
Chemical Substances	Platelet Aggregation Inhibitors
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	80040-5
ISSN	1940-1574 ; 0003-3197
ISSN (online)	1940-1574
ISSN	0003-3197
DOI	10.1177/0003319715591333
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Article ; Online: Cardioplegic storage solution: Is it the guardian of saphenous vein graft endothelium?

Papakonstantinou, Nikolaos A / Sykaras, Alexandros G / Vourlakou, Christina / Goudevenos, John / Papadopoulos, Georgios / Apostolakis, Efstratios

Journal of cardiac surgery

2020 Volume 35, Issue 5, Page(s) 996–1003

Abstract: Introduction: Despite their suboptimal long-term patency, saphenous vein grafts are the most widely used conduits to achieve complete revascularization during coronary artery bypass grafting (CABG). Although vein storage critically impairs endothelial ... ...

Abstract	Introduction: Despite their suboptimal long-term patency, saphenous vein grafts are the most widely used conduits to achieve complete revascularization during coronary artery bypass grafting (CABG). Although vein storage critically impairs endothelial integrity, contradictory data concerning optimal storage solutions exist. The aim of this study is to explore any in vitro impact of cardioplegic solutions and temperature on vein grafts endothelial integrity during their storage. Materials and methods: A single-center, prospective trial including 40 consecutive patients was conducted. Eligibility criteria included patients submitted to CABG receiving at least one vein graft. An excess segment of the graft was harvested and divided into four different parts. Each one of them was stored under different conditions; either in a conventional heparin-enriched blood solution or in a cardioplegic solution, at room temperature (20°C-22°C) and in the refrigerator (5°C). Endothelial integrity was evaluated via immunohistochemistry using an antibody against CD31. Results: Endothelial integrity (measured in a scale from 1-worst to 5-best) was significantly better after cardioplegic solution storage (2.83 ± 0.15 and 3.10 ± 0.13 in cold and room temperature, respectively) compared with storage in conventional solutions (2.23 ± 0.16 and 2.0 ± 0.15 in cold and room temperature, respectively). A significant effect of cardioplegic storage solution, as well as of cold temperature and cardioplegic solution interaction on endothelial preservation was reported, whereas storage temperature did not prove a significant factor by its own. Conclusions: Cardioplegic storage solutions result in significantly better endothelial preservation compared with conventional heparin-enriched blood solutions. The association with superior clinical outcomes remains to be proved.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Cardioplegic Solutions ; Coronary Artery Bypass ; Endothelium, Vascular ; Female ; Humans ; Male ; Middle Aged ; Organ Preservation/methods ; Organ Preservation Solutions ; Prospective Studies ; Saphenous Vein/transplantation ; Temperature
Chemical Substances	Cardioplegic Solutions ; Organ Preservation Solutions
Language	English
Publishing date	2020-03-24
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.14519
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Article ; Online: One-year Non-persistence With Contemporary Antiplatelet Therapy in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention.

Goudevenos, John / Xanthopoulou, Ioanna / Deftereos, Spyridon / Alexopoulos, Dimitrios

Revista espanola de cardiologia (English ed.)

2016 Volume 69, Issue 8, Page(s) 790–793

MeSH term(s)	Acute Coronary Syndrome/therapy ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Percutaneous Coronary Intervention ; Platelet Aggregation Inhibitors/therapeutic use ; Time Factors
Chemical Substances	Platelet Aggregation Inhibitors
Language	Spanish
Publishing date	2016-08
Publishing country	Spain
Document type	Letter
ISSN	1885-5857
ISSN (online)	1885-5857
DOI	10.1016/j.rec.2016.03.028
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Article ; Online: Anticoagulation therapy in elderly patients with atrial fibrillation: results from the Registry of Atrial Fibrillation To Investigate the Implementation of New Guidelines (RAFTING).

Pipilis, Athanasios / Farmakis, Dimitrios / Kaliambakos, Sotirios / Goudevenos, John / Lekakis, John

Journal of cardiovascular medicine (Hagerstown, Md.)

2017 Volume 18, Issue 7, Page(s) 545–549

Abstract: Background: Patients with atrial fibrillation aged 75 years or older have a CHA2DS2VASc score that dictates oral anticoagulants. We recorded physicians' anticoagulation attitudes in elderly patients with atrial fibrillation and assessed the impact of ... ...

Abstract	Background: Patients with atrial fibrillation aged 75 years or older have a CHA2DS2VASc score that dictates oral anticoagulants. We recorded physicians' anticoagulation attitudes in elderly patients with atrial fibrillation and assessed the impact of stroke and bleeding risk. Methods: Atrial Fibrillation To Investigate the Implementation of New Guidelines , a countrywide prospective registry performed in Greece during 2010, a period when only vitamin-K antagonists (VKA) were available, enrolled 1127 patients with atrial fibrillation diagnosis during Emergency Departments visit in 31 representative hospitals; 807 patients had known atrial fibrillation and of those, 342 aged 75 years or older. We recorded preadmission anticoagulation treatment and associated it with clinical characteristics and stroke/bleeding risk. Results: Patients on VKA (n = 207; 61%) were younger (81 ± 4 vs. 83 ± 5; P < 0.001) but no other significant differences were noticed, including mean CHA2DS2VASc (high: 2-4, very high: >4) or modified HASBLED (low: 0-2, high: >2) scores. VKA were prescribed in 65% of patients with very high CHA2DS2VASc score as compared with 55% of those with high score (P = 0.065). VKA were used equally in low or high-modified HASBLED score (61% vs. 59%; P = 0.78). The interaction between CHA2DS2VASc and HASBLED was significant (P < 0.001) in patients on VKA; in patients with low HASBLED, VKA use was similar in high versus very high CHA2DS2VASc score (58 vs. 64%), whereas in patients with high HASBLED, VKA use tended to be higher in very high versus high CHA2DS2VASc score (66 vs. 43%). Conclusion: In this countrywide atrial fibrillation registry, 61% of elderly patients received VKA, a decision driven mainly by stroke risk. VKA use was not higher in patients with low bleeding risk.
Language	English
Publishing date	2017-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/JCM.0000000000000355
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Zs.A 5210: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 559: Show issues

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Article ; Online: CardioPulmonary Resuscitation in patients with suspected or confirmed Covid-19. A consensus of the Working group on CardioPulmonary Resuscitation of the Hellenic Society of Cardiology.

Latsios, George / Synetos, Andreas / Mastrokostopoulos, Antonios / Vogiatzi, Georgia / Bounas, Pavlos / Nikitas, Georgios / Papanikolaou, Aggelos / Parisis, Charalampos / Kanakakis, Ioannis / Goudevenos, John

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

2020 Volume 62, Issue 1, Page(s) 24–28

Abstract: The unprecedented for modern medicine pandemic caused by the SARS-COV-2 virus ("coronavirus", Covid-19 disease) creates in turn new data on the management and survival of cardiac arrest victims, but mainly on the safety of CardioPulmonary Resuscitation ( ... ...

Abstract	The unprecedented for modern medicine pandemic caused by the SARS-COV-2 virus ("coronavirus", Covid-19 disease) creates in turn new data on the management and survival of cardiac arrest victims, but mainly on the safety of CardioPulmonary Resuscitation (CPR) providers. The Covid-19 pandemic resulted in losses of thousands of lives, and many more people were hospitalized in simple or in intensive care unit beds, both globally and locally in Greece. More specifically, in victims of cardiac arrest, both in- and out- of hospital, the increased mortality and high contagiousness of the SARS-CoV-2 virus posed new questions, of both medical and moral nature/ to CPR providers. What we all know in resuscitation, that we cannot harm the victim and therefore do the most/best we can, is no longer the everyday reality. What we need to know and incorporate into decision-making in the resuscitation process is the distribution of limited human and material resources, the potentially very poor outcome of patients with Covid-19 and cardiac arrest, and especially that a potential infection of health professionals can lead in the lack of health professionals in the near future. This review tries to incorporate the added skills and precautions for CPR providers in terms of both in- and out- hospital CPR.
MeSH term(s)	COVID-19/mortality ; COVID-19/prevention & control ; COVID-19/transmission ; Cardiopulmonary Resuscitation/ethics ; Cardiopulmonary Resuscitation/methods ; Cardiopulmonary Resuscitation/standards ; Heart Arrest/therapy ; Heart Arrest/virology ; Humans ; Occupational Exposure/prevention & control ; Occupational Health/ethics ; Occupational Health/standards ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-09-17
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2215027-4
ISSN	2241-5955 ; 1109-9666
ISSN (online)	2241-5955
ISSN	1109-9666
DOI	10.1016/j.hjc.2020.09.010
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Zs.A 6187: Show issues

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Article ; Online: Acute myocardial infarction in a young bodybuilder taking anabolic androgenic steroids: A case report and critical review of the literature.

Christou, Georgios A / Christou, Konstantinos A / Nikas, Dimitrios N / Goudevenos, John A

European journal of preventive cardiology

2016 Volume 23, Issue 16, Page(s) 1785–1796

Abstract: We describe a case report of a 30-year-old bodybuilder suffering acute myocardial infarction (AMI). He had been taking stanozolol and testosterone for two months. The coronary angiogram showed high thrombotic burden in the left anterior descending artery ...

Abstract	We describe a case report of a 30-year-old bodybuilder suffering acute myocardial infarction (AMI). He had been taking stanozolol and testosterone for two months. The coronary angiogram showed high thrombotic burden in the left anterior descending artery without underlying atherosclerosis. Few case reports of AMI in athletes taking anabolic androgenic steroids (AASs) have been reported so far. AAS-related AMI is possibly underreported in the medical literature due to the desire of the affected individuals to hide AAS use. Physicians should always consider the possibility of AAS abuse in the context of a young athlete suffering AMI. AASs can predispose to AMI through the acceleration of coronary atherosclerosis. Additionally, thrombosis without underlying atherosclerosis or vasospasm is highly possible to cause AMI in AAS users. Complications after AMI may be more frequent in AAS users.
Language	English
Publishing date	2016-11
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1177/2047487316651341
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Zs.A 4686: Show issues

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Article ; Online: Effects of P2Y12 receptor inhibition in patients with ST-segment elevation myocardial infarction.

Alexopoulos, Dimitrios / Xanthopoulou, Ioanna / Goudevenos, John

The American journal of cardiology

2014 Volume 113, Issue 12, Page(s) 2064–2069

Abstract: In ST-segment elevation myocardial infarction (STEMI), an effective antiplatelet treatment adjunctive to primary percutaneous coronary intervention is of utmost importance. High dose of clopidogrel, prasugrel, or ticagrelor provides a faster, more potent, ...

Abstract	In ST-segment elevation myocardial infarction (STEMI), an effective antiplatelet treatment adjunctive to primary percutaneous coronary intervention is of utmost importance. High dose of clopidogrel, prasugrel, or ticagrelor provides a faster, more potent, and more consistent platelet inhibition than standard clopidogrel. Oral P2Y12 inhibitors have been studied in large clinical trials and are in use in clinical practice. Intravenously administered P2Y12 inhibitors such as cangrelor have also been tested. However, statistically significant anti-ischemic superiority of stronger platelet inhibition regimens versus standard clopidogrel has not been proved exclusively in patients receiving primary percutaneous coronary intervention. Whether orally administered antiplatelet agents suffice in patients with STEMI has been recently disputed, mainly because of their delayed onset of action. Platelet reactivity variability before P2Y12 blockade and its evolution over time, genetic predisposition, antiplatelet agent used, timing, and method of platelet function testing significantly affect the rates of high on-treatment platelet reactivity. Although ominous signs of greater bleeding potential of stronger antiplatelet regimens have not appeared in STEMI, this should be carefully tested.
MeSH term(s)	Administration, Oral ; Aged ; Combined Modality Therapy ; Dose-Response Relationship, Drug ; Electrocardiography/methods ; Female ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Humans ; Infusions, Intravenous ; Male ; Middle Aged ; Myocardial Infarction/diagnosis ; Myocardial Infarction/mortality ; Myocardial Infarction/therapy ; Percutaneous Coronary Intervention/methods ; Percutaneous Coronary Intervention/mortality ; Platelet Aggregation Inhibitors/administration & dosage ; Platelet Aggregation Inhibitors/adverse effects ; Prognosis ; Purinergic P2Y Receptor Antagonists/administration & dosage ; Purinergic P2Y Receptor Antagonists/adverse effects ; Randomized Controlled Trials as Topic ; Risk Assessment ; Survival Analysis ; Ticlopidine/administration & dosage ; Ticlopidine/adverse effects ; Ticlopidine/analogs & derivatives ; Treatment Outcome
Chemical Substances	Platelet Aggregation Inhibitors ; Purinergic P2Y Receptor Antagonists ; clopidogrel (A74586SNO7) ; Ticlopidine (OM90ZUW7M1)
Language	English
Publishing date	2014-06-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2014.03.053
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Article ; Online: Frequency of inappropriate and nonrecommended prasugrel prescription: great variations.

Alexopoulos, Dimitrios / Xanthopoulou, Ioanna / Goudevenos, John

Journal of the American College of Cardiology

2014 Volume 64, Issue 22, Page(s) 2433–2434

MeSH term(s)	Cardiovascular Diseases/prevention & control ; Drug Prescriptions/standards ; Humans ; Piperazines/pharmacology ; Prescription Drugs/pharmacology ; Registries ; Thiophenes/pharmacology
Chemical Substances	Piperazines ; Prescription Drugs ; Thiophenes
Language	English
Publishing date	2014-12-09
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2014.08.043
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 196: Show issues

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Article ; Online: Aldosterone signaling in atrial fibrillation another piece in the puzzle of atrial remodeling.

Korantzopoulos, Panagiotis / Goudevenos, John A

Journal of the American College of Cardiology

2010 Volume 55, Issue 8, Page(s) 771–773

MeSH term(s)	Aldosterone/metabolism ; Animals ; Atrial Fibrillation/metabolism ; Humans ; Signal Transduction
Chemical Substances	Aldosterone (4964P6T9RB)
Language	English
Publishing date	2010-02-23
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2009.10.032
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 196: Show issues

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Article ; Online: Everolimus-eluting versus paclitaxel-eluting stents.

Kounis, Nicholas G / Goudevenos, John A

Lancet (London, England)

2010 Volume 375, Issue 9721, Page(s) 1161; author reply 1161–2

MeSH term(s)	Drug-Eluting Stents ; Equipment Design ; Everolimus ; Humans ; Hypersensitivity/etiology ; Immunosuppressive Agents ; Nickel/adverse effects ; Paclitaxel ; Sirolimus/analogs & derivatives ; Thrombosis/etiology ; Thrombosis/prevention & control
Chemical Substances	Immunosuppressive Agents ; Nickel (7OV03QG267) ; Everolimus (9HW64Q8G6G) ; Paclitaxel (P88XT4IS4D) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2010-04-03
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(10)60510-7
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Zs.MG 94: Show issues

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