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  1. Article ; Online: Squeezed vacuum phase control at 2  μm.

    Yap, M J / Gould, D W / McRae, T G / Altin, P A / Kijbunchoo, N / Mansell, G L / Ward, R L / Shaddock, D A / Slagmolen, B J J / McClelland, D E

    Optics letters

    2019  Volume 44, Issue 21, Page(s) 5386–5389

    Abstract: We demonstrate phase control for vacuum-squeezed light at a 2 μm wavelength, which is a necessary technology for proposed future gravitational wave observatories. The control scheme allowed examination of noise behavior at frequencies below 1 kHz and ... ...

    Abstract We demonstrate phase control for vacuum-squeezed light at a 2 μm wavelength, which is a necessary technology for proposed future gravitational wave observatories. The control scheme allowed examination of noise behavior at frequencies below 1 kHz and indicated that squeezing below this frequency was limited by dark noise and scattered light. We directly measure 3.9±0.2  dB of squeezing from 2 kHz to 80 kHz and 14.2±0.3  dB of antisqueezing relative to the shot noise level. The observed maximum level of squeezing is currently limited by photodetector quantum efficiency and laser instabilities at this new wavelength for squeezed light. Accounting for all losses, we conclude the generation of 11.3 dB of squeezing at the optical parametric oscillator.
    Language English
    Publishing date 2019-10-31
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.44.005386
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  2. Article ; Online: Associations between COVID-19 infection, tobacco smoking and nicotine use, common respiratory conditions and inhaled corticosteroids: a prospective QResearch-Case Mix Programme data linkage study January-May 2020

    Aveyard, P. / Lindson, N. / Gao, M. / Hartmann-Boyce, J. / Smith, M. / Young, D. / Coupland, C. / Tan, P. S. / Clift, A. K. / Harrison, D. / Gould, D. W. / Pavord, I. / Watkinson, P. / Hippisley-Cox, J.

    Abstract: Introduction Epidemiological and laboratory research seems to suggest that smoking and perhaps nicotine alone could reduce the severity of COVID-19. Likewise, there is some evidence that inhaled corticosteroids could also reduce its severity, opening the ...

    Abstract Introduction Epidemiological and laboratory research seems to suggest that smoking and perhaps nicotine alone could reduce the severity of COVID-19. Likewise, there is some evidence that inhaled corticosteroids could also reduce its severity, opening the possibility that nicotine and inhaled steroids could be used as treatments. Methods In this prospective cohort study, we will link English general practice records from the QResearch database to Public Health England's database of SARS-CoV-2 positive tests, Hospital Episode Statistics, admission to intensive care units, and death from COVID-19 to identify our outcomes: hospitalisation, ICU admission, and death due to COVID. Using Cox regression, we will perform sequential adjustment for potential confounders identified by separate directed acyclic graphs to: 1. Assess the association between smoking and COVID-19 disease severity, and how that changes on adjustment for smoking-related comorbidity. 2. More closely characterise the association between smoking and severe COVID-19 disease by assessing whether the association is modified by age (as a proxy of length of smoking), gender, ethnic group, and whether people have asthma or COPD. 3. Assess for evidence of a dose-response relation between smoking intensity and disease severity, which would help create a case for causality. 4. Examine the association between former smokers who are using NRT or are vaping and disease severity. 5. Examine whether pre-existing respiratory disease is associated with severe COVID-19 infection. 6. Assess whether the association between chronic obstructive pulmonary disease (COPD) and asthma and COVID-19 disease severity is modified by age, gender, ethnicity, and smoking status. 7. Assess whether the use of inhaled corticosteroids is associated with severity of COVID-19 disease. 8. To assess whether the association between use of inhaled corticosteroids and severity of COVID-19 disease is modified by the number of other airways medications used (as a proxy for severity of condition) and whether people have asthma or COPD. Conclusions This representative population sample will, to our knowledge, present the first comprehensive examination of the association between smoking, nicotine use without smoking, respiratory disease, and severity of COVID-19. We will undertake several sensitivity analyses to examine the potential for bias in these associations.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    DOI 10.1101/2020.06.05.20116624
    Database COVID19

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  3. Article ; Online: A UK national survey of prophylactic platelet transfusion thresholds in non-bleeding, critically ill adults

    Shah, A. / Gould, D. W. / Doidge, J. C. / Mouncey, P. / Harrison, D. A. / Young, D. / Stanworth, S. J. / Watkinson, P. J. / Investigators, Threshold for Platelets

    Abstract: Thrombocytopaenia is common in critically ill patients and associated with poor clinical outcomes. Current guideline recommendations for prophylactic platelet transfusions, to prevent bleeding in critically ill patients with thrombocytopaenia, are based ... ...

    Abstract Thrombocytopaenia is common in critically ill patients and associated with poor clinical outcomes. Current guideline recommendations for prophylactic platelet transfusions, to prevent bleeding in critically ill patients with thrombocytopaenia, are based on observational data. Recent studies conducted in non-critically ill patients have demonstrated harm associated with platelet transfusions and have also called into question the efficacy of platelet transfusion. To date, there are no well-conducted randomised controlled trials (RCTs) evaluating platelet transfusion in critically ill patients. To inform the design of such an RCT, we sought to characterise current clinical practice across four commonly encountered scenarios in non-bleeding critically ill adult patients with thrombocytopaenia. An online survey link was sent to Clinical Directors and contacts of all adult general ICUs participating in the Intensive Care National Audit and Research Centre Case Mix Programme national clinical audit (n=200). The survey collected data regarding the respondents place of work, training grade and their current individual practice and possible limits of equipoise for prescribing prophylactic platelet transfusions across four scenarios: prophylaxis but with no procedure planned (NPP); ultrasound guided insertion of a right internal jugular central venous catheter (JVI); percutaneous tracheostomy (PT); and surgery with a low bleeding risk (SLBR). After excluding nine responses with missing data on all four of the main questions, responses were received from 99 staff, covering 78 ICUs (39.0% of 200 ICUs invited to participate). While nearly all respondents (98.0%) indicated a platelet transfusion threshold of 30 x 10^9/L or less for patients with no planned procedure, thresholds for planned procedures varied widely and centred at medians of 40 x 10^9/L for JVI (range: 10 to 70), 50 x 10^9/L for SLBR (range: 10 to 100) and 70 x 10^9/L for PT (range: 20 to greater than 100). Current platelet transfusion practice in UK ICUs prior to invasive procedures with relatively low bleeding risks is highly variable. Well-designed studies are needed to determine the optimal platelet transfusion thresholds in critical care.
    Keywords covid19
    Publisher MedRxiv
    Document type Article ; Online
    DOI 10.1101/2020.09.02.20186700
    Database COVID19

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  4. Article: The behaviour of the intact ureter in dogs, rabbits and rats.

    GOULD, D W / HSIEH, A C / TINCKLER, L F

    The Journal of physiology

    2003  Volume 129, Issue 3, Page(s) 436–447

    MeSH term(s) Animals ; Dogs ; Rabbits ; Rats ; Ureter/physiology ; Urinary Tract Physiological Phenomena
    Language English
    Publishing date 2003-05-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/jphysiol.1955.sp005368
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  5. Article: The effect of posture on bladder pressure.

    GOULD, D W / HSIEH, A C / TINCKLER, L F

    The Journal of physiology

    2003  Volume 129, Issue 3, Page(s) 448–453

    MeSH term(s) Humans ; Posture ; Pressure ; Urinary Bladder/physiology ; Urinary Tract Physiological Phenomena
    Language English
    Publishing date 2003-05-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/jphysiol.1955.sp005369
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  6. Article: The behaviour of the isolated water-buffalo ureter.

    GOULD, D W / HSIEH, A C / TINCKLER, L F

    The Journal of physiology

    2003  Volume 129, Issue 3, Page(s) 425–435

    MeSH term(s) Animals ; Buffaloes ; Ureter/physiology ; Urinary Tract Physiological Phenomena
    Language English
    Publishing date 2003-05-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/jphysiol.1955.sp005367
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  7. Article: Observations from the CDC. Preventing alcohol-exposed pregnancies among women of childbearing age: the necessity of a preconceptional approach.

    Floyd, R L / Ebrahim, S H / Boyle, C A / Gould, D W

    Journal of women's health & gender-based medicine

    1999  Volume 8, Issue 6, Page(s) 733–736

    MeSH term(s) Adolescent ; Adult ; Alcoholism/epidemiology ; Alcoholism/prevention & control ; Centers for Disease Control and Prevention (U.S.) ; Female ; Fetal Alcohol Spectrum Disorders/epidemiology ; Fetal Alcohol Spectrum Disorders/prevention & control ; Humans ; Population Surveillance ; Preconception Care/methods ; Pregnancy ; Pregnancy Complications/epidemiology ; Pregnancy Complications/prevention & control ; Prevalence ; Primary Health Care/methods ; United States/epidemiology
    Language English
    Publishing date 1999-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1494558-7
    ISSN 1524-6094
    ISSN 1524-6094
    DOI 10.1089/152460999319048
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  8. Article ; Online: Search for Subsolar-Mass Binaries in the First Half of Advanced LIGO's and Advanced Virgo's Third Observing Run.

    Abbott, R / Abbott, T D / Acernese, F / Ackley, K / Adams, C / Adhikari, N / Adhikari, R X / Adya, V B / Affeldt, C / Agarwal, D / Agathos, M / Agatsuma, K / Aggarwal, N / Aguiar, O D / Aiello, L / Ain, A / Ajith, P / Albanesi, S / Allocca, A /
    Altin, P A / Amato, A / Anand, C / Anand, S / Ananyeva, A / Anderson, S B / Anderson, W G / Andrade, T / Andres, N / Andrić, T / Angelova, S V / Ansoldi, S / Antelis, J M / Antier, S / Appert, S / Arai, K / Araya, M C / Areeda, J S / Arène, M / Arnaud, N / Aronson, S M / Arun, K G / Asali, Y / Ashton, G / Assiduo, M / Aston, S M / Astone, P / Aubin, F / Austin, C / Babak, S / Badaracco, F / Bader, M K M / Badger, C / Bae, S / Baer, A M / Bagnasco, S / Bai, Y / Baird, J / Ball, M / Ballardin, G / Ballmer, S W / Balsamo, A / Baltus, G / Banagiri, S / Bankar, D / Barayoga, J C / Barbieri, C / Barish, B C / Barker, D / Barneo, P / Barone, F / Barr, B / Barsotti, L / Barsuglia, M / Barta, D / Bartlett, J / Barton, M A / Bartos, I / Bassiri, R / Basti, A / Bawaj, M / Bayley, J C / Baylor, A C / Bazzan, M / Bécsy, B / Bedakihale, V M / Bejger, M / Belahcene, I / Benedetto, V / Beniwal, D / Bennett, T F / Bentley, J D / BenYaala, M / Bergamin, F / Berger, B K / Bernuzzi, S / Berry, C P L / Bersanetti, D / Bertolini, A / Betzwieser, J / Beveridge, D / Bhandare, R / Bhardwaj, U / Bhattacharjee, D / Bhaumik, S / Bilenko, I A / Billingsley, G / Bini, S / Birney, R / Birnholtz, O / Biscans, S / Bischi, M / Biscoveanu, S / Bisht, A / Biswas, B / Bitossi, M / Bizouard, M-A / Blackburn, J K / Blair, C D / Blair, D G / Blair, R M / Bobba, F / Bode, N / Boer, M / Bogaert, G / Boldrini, M / Bonavena, L D / Bondu, F / Bonilla, E / Bonnand, R / Booker, P / Boom, B A / Bork, R / Boschi, V / Bose, N / Bose, S / Bossilkov, V / Boudart, V / Bouffanais, Y / Bozzi, A / Bradaschia, C / Brady, P R / Bramley, A / Branch, A / Branchesi, M / Brau, J E / Breschi, M / Briant, T / Briggs, J H / Brillet, A / Brinkmann, M / Brockill, P / Brooks, A F / Brooks, J / Brown, D D / Brunett, S / Bruno, G / Bruntz, R / Bryant, J / Bulik, T / Bulten, H J / Buonanno, A / Buscicchio, R / Buskulic, D / Buy, C / Byer, R L / Cadonati, L / Cagnoli, G / Cahillane, C / Bustillo, J Calderón / Callaghan, J D / Callister, T A / Calloni, E / Cameron, J / Camp, J B / Canepa, M / Canevarolo, S / Cannavacciuolo, M / Cannon, K C / Cao, H / Capote, E / Carapella, G / Carbognani, F / Carlin, J B / Carney, M F / Carpinelli, M / Carrillo, G / Carullo, G / Carver, T L / Diaz, J Casanueva / Casentini, C / Castaldi, G / Caudill, S / Cavaglià, M / Cavalier, F / Cavalieri, R / Ceasar, M / Cella, G / Cerdá-Durán, P / Cesarini, E / Chaibi, W / Chakravarti, K / Subrahmanya, S Chalathadka / Champion, E / Chan, C-H / Chan, C / Chan, C L / Chan, K / Chandra, K / Chanial, P / Chao, S / Charlton, P / Chase, E A / Chassande-Mottin, E / Chatterjee, C / Chatterjee, Debarati / Chatterjee, Deep / Chaturvedi, M / Chaty, S / Chatziioannou, K / Chen, H Y / Chen, J / Chen, X / Chen, Y / Chen, Z / Cheng, H / Cheong, C K / Cheung, H Y / Chia, H Y / Chiadini, F / Chiarini, G / Chierici, R / Chincarini, A / Chiofalo, M L / Chiummo, A / Cho, G / Cho, H S / Choudhary, R K / Choudhary, S / Christensen, N / Chu, Q / Chua, S / Chung, K W / Ciani, G / Ciecielag, P / Cieślar, M / Cifaldi, M / Ciobanu, A A / Ciolfi, R / Cipriano, F / Cirone, A / Clara, F / Clark, E N / Clark, J A / Clarke, L / Clearwater, P / Clesse, S / Cleva, F / Coccia, E / Codazzo, E / Cohadon, P-F / Cohen, D E / Cohen, L / Colleoni, M / Collette, C G / Colombo, A / Colpi, M / Compton, C M / Constancio, M / Conti, L / Cooper, S J / Corban, P / Corbitt, T R / Cordero-Carrión, I / Corezzi, S / Corley, K R / Cornish, N / Corre, D / Corsi, A / Cortese, S / Costa, C A / Cotesta, R / Coughlin, M W / Coulon, J-P / Countryman, S T / Cousins, B / Couvares, P / Coward, D M / Cowart, M J / Coyne, D C / Coyne, R / Creighton, J D E / Creighton, T D / Criswell, A W / Croquette, M / Crowder, S G / Cudell, J R / Cullen, T J / Cumming, A / Cummings, R / Cunningham, L / Cuoco, E / Curyło, M / Dabadie, P / Canton, T Dal / Dall'Osso, S / Dálya, G / Dana, A / DaneshgaranBajastani, L M / D'Angelo, B / Danilishin, S / D'Antonio, S / Danzmann, K / Darsow-Fromm, C / Dasgupta, A / Datrier, L E H / Datta, S / Dattilo, V / Dave, I / Davier, M / Davies, G S / Davis, D / Davis, M C / Daw, E J / Dean, R / DeBra, D / Deenadayalan, M / Degallaix, J / De Laurentis, M / Deléglise, S / Del Favero, V / De Lillo, F / De Lillo, N / Del Pozzo, W / DeMarchi, L M / De Matteis, F / D'Emilio, V / Demos, N / Dent, T / Depasse, A / De Pietri, R / De Rosa, R / De Rossi, C / DeSalvo, R / De Simone, R / Dhurandhar, S / Díaz, M C / Diaz-Ortiz, M / Didio, N A / Dietrich, T / Di Fiore, L / Di Fronzo, C / Di Giorgio, C / Di Giovanni, F / Di Giovanni, M / Di Girolamo, T / Di Lieto, A / Ding, B / Di Pace, S / Di Palma, I / Di Renzo, F / Divakarla, A K / Dmitriev, A / Doctor, Z / D'Onofrio, L / Donovan, F / Dooley, K L / Doravari, S / Dorrington, I / Drago, M / Driggers, J C / Drori, Y / Ducoin, J-G / Dupej, P / Durante, O / D'Urso, D / Duverne, P-A / Dwyer, S E / Eassa, C / Easter, P J / Ebersold, M / Eckhardt, T / Eddolls, G / Edelman, B / Edo, T B / Edy, O / Effler, A / Eichholz, J / Eikenberry, S S / Eisenmann, M / Eisenstein, R A / Ejlli, A / Engelby, E / Errico, L / Essick, R C / Estellés, H / Estevez, D / Etienne, Z / Etzel, T / Evans, M / Evans, T M / Ewing, B E / Fafone, V / Fair, H / Fairhurst, S / Farah, A M / Farinon, S / Farr, B / Farr, W M / Farrow, N W / Fauchon-Jones, E J / Favaro, G / Favata, M / Fays, M / Fazio, M / Feicht, J / Fejer, M M / Fekecs, B / Fenyvesi, E / Ferguson, D L / Fernandez-Galiana, A / Ferrante, I / Ferreira, T A / Fidecaro, F / Figura, P / Fiori, I / Fishbach, M / Fisher, R P / Fittipaldi, R / Fiumara, V / Flaminio, R / Floden, E / Fong, H / Font, J A / Fornal, B / Forsyth, P W F / Franke, A / Frasca, S / Frasconi, F / Frederick, C / Freed, J P / Frei, Z / Freise, A / Frey, R / Fritschel, P / Frolov, V V / Fronzé, G G / Fulda, P / Fyffe, M / Gabbard, H A / Gadre, B U / Gair, J R / Gais, J / Galaudage, S / Gamba, R / Ganapathy, D / Ganguly, A / Gaonkar, S G / Garaventa, B / García-Núñez, C / García-Quirós, C / Garufi, F / Gateley, B / Gaudio, S / Gayathri, V / Gemme, G / Gennai, A / George, J / Gerberding, O / Gergely, L / Gewecke, P / Ghonge, S / Ghosh, Abhirup / Ghosh, Archisman / Ghosh, Shaon / Ghosh, Shrobana / Giacomazzo, B / Giacoppo, L / Giaime, J A / Giardina, K D / Gibson, D R / Gier, C / Giesler, M / Giri, P / Gissi, F / Glanzer, J / Gleckl, A E / Godwin, P / Goetz, E / Goetz, R / Gohlke, N / Goncharov, B / González, G / Gopakumar, A / Gosselin, M / Gouaty, R / Gould, D W / Grace, B / Grado, A / Granata, M / Granata, V / Grant, A / Gras, S / Grassia, P / Gray, C / Gray, R / Greco, G / Green, A C / Green, R / Gretarsson, A M / Gretarsson, E M / Griffith, D / Griffiths, W / Griggs, H L / Grignani, G / Grimaldi, A / Grimm, S J / Grote, H / Grunewald, S / Gruning, P / Guerra, D / Guidi, G M / Guimaraes, A R / Guixé, G / Gulati, H K / Guo, H-K / Guo, Y / Gupta, Anchal / Gupta, Anuradha / Gupta, P / Gustafson, E K / Gustafson, R / Guzman, F / Haegel, L / Halim, O / Hall, E D / Hamilton, E Z / Hammond, G / Haney, M / Hanks, J / Hanna, C / Hannam, M D / Hannuksela, O / Hansen, H / Hansen, T J / Hanson, J / Harder, T / Hardwick, T / Haris, K / Harms, J / Harry, G M / Harry, I W / Hartwig, D / Haskell, B / Hasskew, R K / Haster, C-J / Haughian, K / Hayes, F J / Healy, J / Heidmann, A / Heidt, A / Heintze, M C / Heinze, J / Heinzel, J / Heitmann, H / Hellman, F / Hello, P / Helmling-Cornell, A F / Hemming, G / Hendry, M / Heng, I S / Hennes, E / Hennig, J / Hennig, M H / Hernandez, A G / Vivanco, F Hernandez / Heurs, M / Hild, S / Hill, P / Hines, A S / Hochheim, S / Hofman, D / Hohmann, J N / Holcomb, D G / Holland, N A / Hollows, I J / Holmes, Z J / Holt, K / Holz, D E / Hopkins, P / Hough, J / Hourihane, S / Howell, E J / Hoy, C G / Hoyland, D / Hreibi, A / Hsu, Y / Huang, Y / Hübner, M T / Huddart, A D / Hughey, B / Hui, V / Husa, S / Huttner, S H / Huxford, R / Huynh-Dinh, T / Idzkowski, B / Iess, A / Ingram, C / Isi, M / Isleif, K / Iyer, B R / JaberianHamedan, V / 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    Physical review letters

    2022  Volume 129, Issue 6, Page(s) 61104

    Abstract: We report on a search for compact binary coalescences where at least one binary component has a mass between 0.2  M_{⊙} and 1.0  M_{⊙} in Advanced LIGO and Advanced Virgo data collected between 1 April 2019 1500 UTC and 1 October 2019 1500 UTC. We extend ...

    Abstract We report on a search for compact binary coalescences where at least one binary component has a mass between 0.2  M_{⊙} and 1.0  M_{⊙} in Advanced LIGO and Advanced Virgo data collected between 1 April 2019 1500 UTC and 1 October 2019 1500 UTC. We extend our previous analyses in two main ways: we include data from the Virgo detector and we allow for more unequal mass systems, with mass ratio q≥0.1. We do not report any gravitational-wave candidates. The most significant trigger has a false alarm rate of 0.14  yr^{-1}. This implies an upper limit on the merger rate of subsolar binaries in the range [220-24200]  Gpc^{-3} yr^{-1}, depending on the chirp mass of the binary. We use this upper limit to derive astrophysical constraints on two phenomenological models that could produce subsolar-mass compact objects. One is an isotropic distribution of equal-mass primordial black holes. Using this model, we find that the fraction of dark matter in primordial black holes in the mass range 0.2  M_{⊙}<m_{PBH}<1.0  M_{⊙} is f_{PBH}≡Ω_{PBH}/Ω_{DM}≲6%. This improves existing constraints on primordial black hole abundance by a factor of ∼3. The other is a dissipative dark matter model, in which fermionic dark matter can collapse and form black holes. The upper limit on the fraction of dark matter black holes depends on the minimum mass of the black holes that can be formed: the most constraining result is obtained at M_{min}=1  M_{⊙}, where f_{DBH}≡Ω_{DBH}/Ω_{DM}≲0.003%. These are the first constraints placed on dissipative dark models by subsolar-mass analyses.<br />
    Language English
    Publishing date 2022-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.129.061104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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