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  1. Book: Dealing with difficult staff in the NHS

    Gourlay, Robin

    1998  

    Author's details Robin Gourlay
    Language English
    Size IX, 146 S.
    Publisher Kogan Page
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT011121717
    ISBN 0-7494-2370-6 ; 978-0-7494-2370-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 A 6465 order for loan Magazin

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  2. Article ; Online: Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC.

    Snelling, Tom / Shpiro, Natalia / Gourlay, Robert / Lamoliatte, Frederic / Cohen, Philip

    The Biochemical journal

    2022  Volume 479, Issue 20, Page(s) 2195–2216

    Abstract: ADP-heptose activates the protein kinase ALPK1 triggering TIFA phosphorylation at Thr9, the recruitment of TRAF6 and the subsequent production of inflammatory mediators. Here, we demonstrate that ADP-heptose also stimulates the formation of Lys63- and ... ...

    Abstract ADP-heptose activates the protein kinase ALPK1 triggering TIFA phosphorylation at Thr9, the recruitment of TRAF6 and the subsequent production of inflammatory mediators. Here, we demonstrate that ADP-heptose also stimulates the formation of Lys63- and Met1-linked ubiquitin chains to activate the TAK1 and canonical IKK complexes, respectively. We further show that the E3 ligases TRAF6 and c-IAP1 operate redundantly to generate the Lys63-linked ubiquitin chains required for pathway activation, which we demonstrate are attached to TRAF6, TRAF2 and c-IAP1, and that c-IAP1 is recruited to TIFA by TRAF2. ADP-heptose also induces activation of the kinase TBK1 by a TAK1-independent mechanism, which require TRAF2 and TRAF6. We establish that ALPK1 phosphorylates TIFA directly at Thr177 as well as Thr9 in vitro. Thr177 is located within the TRAF6-binding motif and its mutation to Asp prevents TRAF6 but not TRAF2 binding, indicating a role in restricting ADP-heptose signalling. We conclude that ADP-heptose signalling is controlled by the combined actions of TRAF2/c-IAP1 and TRAF6.
    MeSH term(s) TNF Receptor-Associated Factor 6/genetics ; TNF Receptor-Associated Factor 2/genetics ; TNF Receptor-Associated Factor 2/metabolism ; Heptoses/chemistry ; Heptoses/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitin/metabolism ; Protein Kinases/metabolism ; Adenosine Diphosphate ; Inflammation Mediators ; NF-kappa B/genetics ; NF-kappa B/metabolism
    Chemical Substances TNF Receptor-Associated Factor 6 ; TNF Receptor-Associated Factor 2 ; Heptoses ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Ubiquitin ; Protein Kinases (EC 2.7.-) ; Adenosine Diphosphate (61D2G4IYVH) ; Inflammation Mediators ; NF-kappa B
    Language English
    Publishing date 2022-12-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2969-5
    ISSN 1470-8728 ; 0006-2936 ; 0306-3275 ; 0264-6021
    ISSN (online) 1470-8728
    ISSN 0006-2936 ; 0306-3275 ; 0264-6021
    DOI 10.1042/BCJ20220401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The interface.

    Gourlay, R

    International journal of health care quality assurance incorporating Leadership in health services

    2001  Volume 14, Issue 2-3, Page(s) 102–103

    MeSH term(s) Documentation ; Hospitals, Public/standards ; Humans ; Problem Solving ; Risk Management/organization & administration ; Social Responsibility ; State Medicine/standards ; United Kingdom
    Language English
    Publishing date 2001-05-09
    Publishing country England
    Document type Editorial
    ZDB-ID 645125-1
    ISSN 1366-0756 ; 0952-6862
    ISSN 1366-0756 ; 0952-6862
    DOI 10.1108/ijhcqa.2001.06214caa.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Seminars on management topics for doctors in training.

    Gourlay, R

    International journal of health care quality assurance incorporating Leadership in health services

    2001  Volume 14, Issue 6-7, Page(s) 280–281

    MeSH term(s) Education, Medical/methods ; Female ; Hospital Administration/education ; Hospital Administration/methods ; Humans ; Male ; Organizational Innovation ; Quality Assurance, Health Care ; Students, Medical
    Language English
    Publishing date 2001
    Publishing country England
    Document type Editorial
    ZDB-ID 645125-1
    ISSN 1366-0756 ; 0952-6862
    ISSN 1366-0756 ; 0952-6862
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  5. Article: The customer chain.

    Gourlay, R

    International journal of health care quality assurance incorporating Leadership in health services

    2000  Volume 13, Issue 4-5, Page(s) 198–199

    MeSH term(s) Humans ; Patient Satisfaction ; Quality Assurance, Health Care
    Language English
    Publishing date 2000
    Publishing country England
    Document type Editorial
    ZDB-ID 645125-1
    ISSN 1366-0756 ; 0952-6862
    ISSN 1366-0756 ; 0952-6862
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  6. Article: Quality and the appraisal process.

    Gourlay, R

    International journal of health care quality assurance incorporating Leadership in health services

    2000  Volume 13, Issue 6-7, Page(s) 288–289

    MeSH term(s) Employee Performance Appraisal ; Guideline Adherence ; Humans ; Quality Assurance, Health Care
    Language English
    Publishing date 2000
    Publishing country England
    Document type Editorial
    ZDB-ID 645125-1
    ISSN 1366-0756 ; 0952-6862
    ISSN 1366-0756 ; 0952-6862
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  7. Article: Objectives of a quality assurance programme.

    Gourlay, R

    International journal of health care quality assurance incorporating Leadership in health services

    2000  Volume 13, Issue 1, Page(s) 7

    MeSH term(s) Data Collection ; Quality Assurance, Health Care/organization & administration ; State Medicine/standards ; United Kingdom
    Language English
    Publishing date 2000
    Publishing country England
    Document type Editorial
    ZDB-ID 645125-1
    ISSN 1366-0756 ; 0952-6862
    ISSN 1366-0756 ; 0952-6862
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  8. Article: Clinical governance.

    Gourlay, R

    International journal of health care quality assurance incorporating Leadership in health services

    1999  Volume 12, Issue 1, Page(s) 5

    MeSH term(s) Clinical Medicine/standards ; Hospitals, Public/standards ; Social Responsibility ; State Medicine/standards ; United Kingdom
    Language English
    Publishing date 1999
    Publishing country England
    Document type Editorial
    ZDB-ID 645125-1
    ISSN 1366-0756 ; 0952-6862
    ISSN 1366-0756 ; 0952-6862
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  9. Article: Managerial governance to parallel clinical governance.

    Gourlay, R

    International journal of health care quality assurance incorporating Leadership in health services

    1999  Volume 12, Issue 6-7, Page(s) 278

    MeSH term(s) Management Audit ; Medical Audit ; State Medicine/organization & administration ; State Medicine/standards ; United Kingdom
    Language English
    Publishing date 1999
    Publishing country England
    Document type Editorial
    ZDB-ID 645125-1
    ISSN 1366-0756 ; 0952-6862
    ISSN 1366-0756 ; 0952-6862
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  10. Article: Clinical and managerial quality.

    Gourlay, R

    International journal of health care quality assurance incorporating Leadership in health services

    1998  Volume 11, Issue 6-7, Page(s) 180

    MeSH term(s) Humans ; Organizational Policy ; Staff Development ; Total Quality Management ; United Kingdom
    Language English
    Publishing date 1998
    Publishing country England
    Document type Editorial
    ZDB-ID 645125-1
    ISSN 1366-0756 ; 0952-6862
    ISSN 1366-0756 ; 0952-6862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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