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  1. Article ; Online: Do all children in South Africa have access to dedicated paediatric intensive care?

    Goussard, Pierre

    African journal of thoracic and critical care medicine

    2022  Volume 28, Issue 3

    Language English
    Publishing date 2022-09-16
    Publishing country South Africa
    Document type Editorial
    ZDB-ID 2945902-3
    ISSN 2617-0205 ; 2617-0191
    ISSN (online) 2617-0205
    ISSN 2617-0191
    DOI 10.7196/AJTCCM.2022.v28i3.272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Endoscopic findings in children born with oesophageal atresia in an academic unit in South Africa.

    de Vos, C / Fourie, N / Banieghbal, B / Schubart, P T / Sidler, D / Goussard, P

    South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie

    2024  Volume 62, Issue 1, Page(s) 43–47

    Abstract: Background: Oesophageal atresia (OA) is one of the most common congenital gastrointestinal (GI) abnormalities. Due to advances in multidisciplinary care, early prognosis has improved with emphasis shifting to the long-term impact of this disease. ... ...

    Abstract Background: Oesophageal atresia (OA) is one of the most common congenital gastrointestinal (GI) abnormalities. Due to advances in multidisciplinary care, early prognosis has improved with emphasis shifting to the long-term impact of this disease. Literature suggests a higher incidence of Barrett's and eosinophilic oesophagitis in these children, with an increased risk of oesophageal carcinoma. Guidelines for adults born with OA include routine endoscopy and lifelong screening of the upper gastrointestinal tract (GIT). Despite this, uncertainty remains regarding the necessity and frequency of endoscopic surveillance for children born with OA. We describe our endoscopic findings in children born with OA.
    Methods: A prospective analytic cohort study was undertaken, which included all children born with OA, that were followed-up in our unit between 2020 and 2022. History regarding feeding and GI symptoms were documented after which an endoscopy was performed.
    Results: During the study period, 37 endoscopies were performed in patients born with OA at a median age of 25 months. The most common clinical appearance on endoscopy was anastomotic strictures followed by oesophagitis. Twelve patients had biopsies taken, with abnormal histology in all but one patient. The most common histological finding was oesophagitis with lymphocytes and chronic gastritis. Two patients had Helicobacter Pylori infection, and one had findings suggestive of eosinophilic oesophagitis.
    Conclusion: All patients with a clinical indication for an endoscopy had abnormal clinical or histological findings, thus concurring with the literature in highlighting the need for regular endoscopy. We recommend regular clinical follow-up and endoscopic surveillance if clinically indicated for children born with OA.
    MeSH term(s) Adult ; Child ; Humans ; Child, Preschool ; Esophageal Atresia/epidemiology ; Esophageal Atresia/surgery ; South Africa/epidemiology ; Cohort Studies ; Eosinophilic Esophagitis ; Helicobacter Infections ; Prospective Studies ; Helicobacter pylori
    Language English
    Publishing date 2024-04-03
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 416504-4
    ISSN 2078-5151 ; 0038-2361
    ISSN (online) 2078-5151
    ISSN 0038-2361
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    Zs.B 593: Show issues Location:
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  3. Article ; Online: Horseshoe lung in a young child at Tygerberg Hospital, South Africa.

    Mfingwana, L / Goussard, P / Andronikou, S / Morrison, J

    African journal of thoracic and critical care medicine

    2021  Volume 27, Issue 4

    Abstract: Horseshoe lung is a very rare congenital malformation in which the bases of the right and left lung are fused to each other by a narrow isthmus. Although rare, a hyperlucent area in the lower left lung, close to the vertebral column, may represent a ... ...

    Abstract Horseshoe lung is a very rare congenital malformation in which the bases of the right and left lung are fused to each other by a narrow isthmus. Although rare, a hyperlucent area in the lower left lung, close to the vertebral column, may represent a horseshoe lung. Horseshoe lung is often associated with scimitar syndrome. Here, we present a case of a 2-year-old girl who presented with recurrent chest infections and wheezing associated with horseshoe lung. The right lung appeared to be hypoplastic.
    Language English
    Publishing date 2021-12-31
    Publishing country South Africa
    Document type Case Reports
    ZDB-ID 2945902-3
    ISSN 2617-0205 ; 2617-0191
    ISSN (online) 2617-0205
    ISSN 2617-0191
    DOI 10.7196/AJTCCM.2021.v27i4.138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Which side are they on? Diagnosing primary ciliary dyskinesias in low- or middle-income countries: A review and case series.

    Surdut, S P / van der Merwe, E / Goussard, P / Urban, M F

    African journal of thoracic and critical care medicine

    2023  Volume 29, Issue 3

    Abstract: Background: Primary ciliary dyskinesia (PCD) is a rare genetic condition with a variable clinical presentation, making its diagnosis a challenge. We describe two unrelated sibling pairs with PCD: adult siblings in the first and perinatal/neonatal in the ...

    Abstract Background: Primary ciliary dyskinesia (PCD) is a rare genetic condition with a variable clinical presentation, making its diagnosis a challenge. We describe two unrelated sibling pairs with PCD: adult siblings in the first and perinatal/neonatal in the second. Both families highlight the more common and rarer clinical manifestations of PCD. We use these cases to highlight: (
    Study synopsis: What the study adds.
    Language English
    Publishing date 2023-09-19
    Publishing country South Africa
    Document type Journal Article ; Review
    ZDB-ID 2945902-3
    ISSN 2617-0205 ; 2617-0191
    ISSN (online) 2617-0205
    ISSN 2617-0191
    DOI 10.7196/AJTCCM.2023.v29i3.425
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  5. Article ; Online: Disease-specific quality of life as part of the long-term follow-up for children born with esophageal atresia in an academic unit in South Africa-a pilot study.

    de Vos, C / Dellenmark-Blom, M / Sikwete, F M / Sidler, D / van Wyk, L / Goussard, P

    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    2024  

    Abstract: As neonatal mortality rates have decreased in esophageal atresia (EA), there is a growing focus on quality of life (QoL) in these children. No study from Africa has reported on this topic. This pilot study aimed to describe disease-specific QoL in EA ... ...

    Abstract As neonatal mortality rates have decreased in esophageal atresia (EA), there is a growing focus on quality of life (QoL) in these children. No study from Africa has reported on this topic. This pilot study aimed to describe disease-specific QoL in EA children and its applicability as part of long-term follow-up in an academic facility in South Africa. Disease-specific QoL in children born with EA was assessed utilizing the EA-QoL questionnaire for children aged 2-17 years during a patient-encounter. The parent-report for children aged 2-7 years compromised 17 items categorized into three domains: eating, physical health and treatment, and social isolation/stress. The 24-item EA-QL questionnaire for children aged 8-18 (child- and parent-report) explored four domains: eating, body perception, social relationships, and health and well-being. A total of 13 questionnaires for children aged 2-7 years were completed by five parents. A negative perceived impact on their child's eating was reported by 46-92% of parents, and less impact in the other two domains. A total of 27 questionnaires were completed by eight children aged 8-17 years and 10 parents. Similar percentages children and parents reported a negative impact in the eating, social relationships, and body perception domains. More than half reported a negative impact on the child's health and well-being. This study supports the concept that assessment of disease-specific QoL should play a vital role in the comprehensive follow-up approach for children born with EA. We identified that parents of younger children were more likely to report eating disorders, whereas parents of older children were more likely to report health difficulties with different perceptions when it came to the child's scar.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639470-x
    ISSN 1442-2050 ; 1120-8694
    ISSN (online) 1442-2050
    ISSN 1120-8694
    DOI 10.1093/dote/doae016
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    Zs.A 2378: Show issues Location:
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  6. Article ; Online: Cytomegalovirus viral load as predictor of the clinical course of hypoxic pneumonia in children.

    Lakhan, A / Gie, A / Rhode, D / Mfingwana, L / Parker, N / Goussard, P

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2023  Volume 27, Issue 1, Page(s) 49–54

    Abstract: BACKGROUND: ...

    Abstract BACKGROUND:
    MeSH term(s) Child ; Humans ; Infant ; Cytomegalovirus ; Retrospective Studies ; Viral Load ; South Africa/epidemiology ; Pneumonia/diagnosis ; Oxygen ; Cytomegalovirus Infections/diagnosis ; Disease Progression
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-03-30
    Publishing country France
    Document type Journal Article
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.22.0428
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    Zs.A 4776: Show issues Location:
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    Zs.MO 261: Show issues

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  7. Article ; Online: Tonsillar hypertrophy and prolapse in a child - is epiglottitis a predisposing factor for sudden unexpected death?

    Nieuwoudt, I / Goussard, P / Verster, J / Dempers, J

    BMC pediatrics

    2020  Volume 20, Issue 1, Page(s) 22

    Abstract: Background: Tonsillitis, with associated tonsillar hypertrophy, is a common disease of childhood, yet it is rarely associated with sudden death due to airway obstruction. Lethal complications involving the inflamed tonsils include haemorrhage, ... ...

    Abstract Background: Tonsillitis, with associated tonsillar hypertrophy, is a common disease of childhood, yet it is rarely associated with sudden death due to airway obstruction. Lethal complications involving the inflamed tonsils include haemorrhage, retropharyngeal abscess and disseminated sepsis.
    Case presentation: We report on a case of sudden and unexpected death in an 8-year-old female who was diagnosed with and treated for tonsillitis. The child was diagnosed with acute tonsillitis 2 days prior to her collapse and was placed on a course of oral antibiotics. There were no signs of upper or lower airway obstruction. She was found to be unresponsive by her caregiver and gasping for air in her bed in the early hours of the second morning after the start of treatment. Autopsy showed massive and symmetrically enlarged palatine tonsils. The tonsils filled the pharynx almost completely. The epiglottis and laryngeal mucosa at the base of the epiglottis in the vicinity of the aryepiglottic membrane and the superior aspect of the larynx displayed red-purple discoloration, with mucosal swelling and edema. Histological examination of the palatine tonsils revealed prominent lymphoid hyperplasia, but no evidence of acute inflammation.
    Conclusion: Palatine tonsillar hypertrophy in infants is a common feature of both viral and bacterial tonsillitis and has been postulated as a possible risk factor for Sudden and Unexplained Death in Infancy (SUDI), based on the theory of mechanical impediment of breathing by narrowing of the upper airway. The rounded shape of the tonsils may facilitate some airflow past the enlarged structures and hence protect against asphyxial death when the enlarged tonsils fill the laryngo-pharynx. Epiglottal and proximal laryngeal edema may play a more significant role in asphyxial unexpected deaths in cases of tonsillitis with tonsillar hypertrophy than previously suspected. This focusses the importance of careful examination of the epiglottis and proximal laryngeal mucosa, as part of a thorough examination of the laryngo-pharynx in cases of sudden death associated with tonsillar hypertrophy.
    MeSH term(s) Child ; Death, Sudden/etiology ; Epiglottitis/complications ; Epiglottitis/diagnosis ; Female ; Humans ; Hypertrophy/etiology ; Infant ; Palatine Tonsil ; Prolapse
    Keywords covid19
    Language English
    Publishing date 2020-01-20
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2041342-7
    ISSN 1471-2431 ; 1471-2431
    ISSN (online) 1471-2431
    ISSN 1471-2431
    DOI 10.1186/s12887-020-1927-3
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  8. Article ; Online: Modified full-face snorkel masks as personal protective equipment for COVID-19 in South Africa.

    Van Wyk, L / Goussard, P / Meintjes, W A J

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

    2020  Volume 110, Issue 11, Page(s) 13087

    MeSH term(s) COVID-19 ; Delivery of Health Care ; Humans ; Masks ; Pandemics ; Personal Protective Equipment ; SARS-CoV-2 ; South Africa
    Language English
    Publishing date 2020-09-29
    Publishing country South Africa
    Document type Letter ; Comment
    ZDB-ID 390968-2
    ISSN 2078-5135 ; 0038-2469 ; 0256-9574
    ISSN (online) 2078-5135
    ISSN 0038-2469 ; 0256-9574
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    Ua VI Zs.406: Show issues Location:
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  9. Article ; Online: Bronchoscopy precautions and recommendations in the COVID-19 pandemic.

    Eber, Ernst / Goussard, Pierre

    Paediatric respiratory reviews

    2021  Volume 37, Page(s) 68–73

    Abstract: As the airways of SARS-CoV-2 infected patients contain a high viral load, bronchoscopy is associated with increased risk of patient to health care worker transmission due to aerosolised viral particles and contamination of surfaces during bronchoscopy. ... ...

    Abstract As the airways of SARS-CoV-2 infected patients contain a high viral load, bronchoscopy is associated with increased risk of patient to health care worker transmission due to aerosolised viral particles and contamination of surfaces during bronchoscopy. Bronchoscopy is not appropriate for diagnosing SARS-CoV-2 infection and, as an aerosol generating procedure involving a significant risk of transmission, has a very limited role in the management of SARS-CoV-2 infected patients including children. During the SARS-CoV-2 pandemic rigid bronchoscopy should be avoided due to the increased risk of droplet spread. Flexible bronchoscopy should be performed first in SARS-CoV-2 positive individuals or in unknown cases, to determine if rigid bronchoscopy is indicated. When available single-use flexible bronchoscopes may be considered for use; devices are available with a range of diameters, and improved image quality and degrees of angulation. When rigid bronchoscopy is necessary, jet ventilation must be avoided and conventional ventilation be used to reduce the risk of aerosolisation. Adequate personal protection equipment is key, as is training of health care workers in correct donning and doffing. Modified full face masks are a practical and safe alternative to filtering facepieces for use in bronchoscopy. When anaesthetic and infection prevention control protocols are strictly adhered to, bronchoscopy can be performed in SARS-CoV-2 positive children.
    MeSH term(s) Bronchoscopy/standards ; COVID-19/epidemiology ; COVID-19/transmission ; Disease Transmission, Infectious/prevention & control ; Health Personnel ; Humans ; Infection Control/methods ; Pandemics ; Personal Protective Equipment ; Practice Guidelines as Topic
    Language English
    Publishing date 2021-01-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2147664-0
    ISSN 1526-0550 ; 1526-0542
    ISSN (online) 1526-0550
    ISSN 1526-0542
    DOI 10.1016/j.prrv.2021.01.001
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    Zs.A 5919: Show issues Location:
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  10. Article ; Online: Adjunctive therapy for severe hypoxic pneumonia in HIV-infected and HIV-exposed children in low- and middle-income countries.

    Goussard, P / Gie, R P

    Paediatrics and international child health

    2017  Volume 37, Issue 2, Page(s) 82–83

    MeSH term(s) Adrenal Cortex Hormones ; Child ; Double-Blind Method ; HIV ; Humans ; Infant ; Malawi ; Pneumocystis carinii ; Pneumonia, Pneumocystis
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2017-02-06
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2649065-1
    ISSN 2046-9055 ; 2046-9047
    ISSN (online) 2046-9055
    ISSN 2046-9047
    DOI 10.1080/20469047.2017.1287552
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