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  1. Article: Cold Agglutinin Syndrome and Hemophagocytic Lymphohistiocytosis: An Unusual Combination Caused by Epstein-Barr Virus Infection.

    Sousa Nunes, Beatriz / Gouveia, Catarina / Kjollerstrom, Paula / Farela Neves, João

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52179

    Abstract: Autoimmune hemolytic anemia (AIHA) and hemophagocytic lymphohistiocytosis (HLH) are rare complications of infectious mononucleosis. The authors describe a 12-year-old male with acute infectious mononucleosis, hepatitis, cholestasis, and an autoimmune ... ...

    Abstract Autoimmune hemolytic anemia (AIHA) and hemophagocytic lymphohistiocytosis (HLH) are rare complications of infectious mononucleosis. The authors describe a 12-year-old male with acute infectious mononucleosis, hepatitis, cholestasis, and an autoimmune hemolytic disorder caused by cold agglutinins IgM (anti-i specificity). Clinical deterioration with persistent fever, anemia, and hepatosplenomegaly was consistent with cold AIHA plus concomitant HLH. The patient was treated with corticosteroids and acyclovir, with an uneventful recovery. Although rare, cold agglutinin syndrome and HLH can complicate infectious mononucleosis and should be considered in a patient with clinical deterioration. Corticosteroids are the mainstay treatment of HLH and may be beneficial in infection-associated cold agglutinin syndrome.
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Elbow septic arthritis in an infant: an unusual presentation of invasive pneumococcal disease.

    Santos, Paula / Gouveia, Catarina / Ovídio, Joana / Ribeiro, Catarina

    BMJ case reports

    2023  Volume 16, Issue 12

    Abstract: Acute septic arthritis is a rare, potentially severe infection that requires immediate treatment to avoid long-term morbidity. Most common aetiological agents are commonly used for empirical treatment, but the choice of antibiotics may be influenced by ... ...

    Abstract Acute septic arthritis is a rare, potentially severe infection that requires immediate treatment to avoid long-term morbidity. Most common aetiological agents are commonly used for empirical treatment, but the choice of antibiotics may be influenced by other factors, such as the patient's age and the epidemiological context.We report an infant with elbow arthritis, whose treatment was changed after
    MeSH term(s) Humans ; Infant ; Anti-Bacterial Agents/therapeutic use ; Arthritis, Infectious/diagnosis ; Arthritis, Infectious/drug therapy ; Arthritis, Infectious/complications ; Elbow ; Pneumococcal Infections/diagnosis ; Pneumococcal Infections/drug therapy ; Pneumococcal Vaccines ; Streptococcus pneumoniae
    Chemical Substances Anti-Bacterial Agents ; Pneumococcal Vaccines
    Language English
    Publishing date 2023-12-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-256888
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  3. Article ; Online: The pathogenicity of Plasmopara viticola: a review of evolutionary dynamics, infection strategies and effector molecules.

    Gouveia, Catarina / Santos, Rita B / Paiva-Silva, Catarina / Buchholz, Günther / Malhó, Rui / Figueiredo, Andreia

    BMC plant biology

    2024  Volume 24, Issue 1, Page(s) 327

    Abstract: Oomycetes are filamentous organisms that resemble fungi in terms of morphology and life cycle, primarily due to convergent evolution. The success of pathogenic oomycetes lies in their ability to adapt and overcome host resistance, occasionally ... ...

    Abstract Oomycetes are filamentous organisms that resemble fungi in terms of morphology and life cycle, primarily due to convergent evolution. The success of pathogenic oomycetes lies in their ability to adapt and overcome host resistance, occasionally transitioning to new hosts. During plant infection, these organisms secrete effector proteins and other compounds during plant infection, as a molecular arsenal that contributes to their pathogenic success. Genomic sequencing, transcriptomic analysis, and proteomic studies have revealed highly diverse effector repertoires among different oomycete pathogens, highlighting their adaptability and evolution potential.The obligate biotrophic oomycete Plasmopara viticola affects grapevine plants (Vitis vinifera L.) causing the downy mildew disease, with significant economic impact. This disease is devastating in Europe, leading to substantial production losses. Even though Plasmopara viticola is a well-known pathogen, to date there are scarce reviews summarising pathogenicity, virulence, the genetics and molecular mechanisms of interaction with grapevine.This review aims to explore the current knowledge of the infection strategy, lifecycle, effector molecules, and pathogenicity of Plasmopara viticola. The recent sequencing of the Plasmopara viticola genome has provided new insights into understanding the infection strategies employed by this pathogen. Additionally, we will highlight the contributions of omics technologies in unravelling the ongoing evolution of this oomycete, including the first in-plant proteome analysis of the pathogen.
    MeSH term(s) Oomycetes/pathogenicity ; Oomycetes/physiology ; Plant Diseases/microbiology ; Vitis/microbiology ; Vitis/genetics ; Virulence ; Biological Evolution ; Host-Pathogen Interactions
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2059868-3
    ISSN 1471-2229 ; 1471-2229
    ISSN (online) 1471-2229
    ISSN 1471-2229
    DOI 10.1186/s12870-024-05037-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Kingella kingae Tenosynovitis: No Need for Surgical Management?

    Gouveia, Catarina / Norte, Susana / Arcângelo, Joana / Tavares, Delfin / Alves, Pedro

    The Pediatric infectious disease journal

    2022  Volume 41, Issue 7, Page(s) e302–e303

    MeSH term(s) Arthritis, Infectious ; Humans ; Infant ; Kingella kingae/genetics ; Neisseriaceae Infections/diagnosis ; Neisseriaceae Infections/surgery ; Polymerase Chain Reaction ; Tenosynovitis/surgery
    Language English
    Publishing date 2022-06-07
    Publishing country United States
    Document type Letter
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000003547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1852: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Uncovering the burden of Influenza in children in Portugal, 2008-2018.

    Caldas Afonso, Alberto / Gouveia, Catarina / Januário, Gustavo / Carmo, Mafalda / Lopes, Hugo / Bricout, Hélène / Gomes, Catarina / Froes, Filipe

    BMC infectious diseases

    2024  Volume 24, Issue 1, Page(s) 100

    Abstract: Background: Despite their higher risk of developing severe disease, little is known about the burden of influenza in Portugal in children aged < 5 years old. This study aims to cover this gap by estimating the clinical and economic burden of severe ... ...

    Abstract Background: Despite their higher risk of developing severe disease, little is known about the burden of influenza in Portugal in children aged < 5 years old. This study aims to cover this gap by estimating the clinical and economic burden of severe influenza in children, in Portugal, during ten consecutive influenza seasons (2008/09-2017/18).
    Methods: We reviewed hospitalizations in children aged < 5 years old using anonymized administrative data covering all public hospitals discharges in mainland Portugal. The burden of hospitalization and in-hospital mortality directly coded as due to influenza was supplemented by the indirect burden calculated from excess hospitalization and mortality (influenza-associated), estimated for four groups of diagnoses (pneumonia or influenza, respiratory, respiratory or cardiovascular, and all-cause), through cyclic regression models integrating the incidence of influenza. Means were reported excluding the H1N1pdm09 pandemic (2009/10).
    Results: The mean annual number of hospitalizations coded as due to influenza was 189 (41.3 cases per 100,000 children aged < 5 years old). Hospitalization rates decreased with increasing age. Nine-in-ten children were previously healthy, but the presence of comorbidities increased with age. Children stayed, on average, 6.1 days at the hospital. Invasive mechanical ventilation was used in 2.4% of hospitalizations and non-invasive in 3.1%. Influenza-associated excess hospitalizations between 2008 and 2018 were estimated at 1,850 in pneumonia or influenza, 1,760 in respiratory, 1,787 in respiratory or cardiovascular, and 1,879 in all-cause models. A total of 95 influenza-associated excess deaths were estimated in all-cause, 14 in respiratory or cardiovascular, and 9 in respiratory models. Over ten years, influenza hospitalizations were estimated to have cost the National Health Service at least €2.9 million, of which 66.5% from healthy children.
    Conclusions: Influenza viruses led to a high number of hospitalizations in children. Most were previously healthy. Results should lead to a reflection on the adequate preventive measures to protect this age group.
    MeSH term(s) Child, Preschool ; Humans ; Infant ; Hospitalization ; Influenza, Human ; Pneumonia/epidemiology ; Portugal/epidemiology ; Seasons ; State Medicine
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-023-08685-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cerebral Malaria and Cytotoxic Lesions of the Corpus Callosum.

    Sousa, Afonso / Silva, Tiago Milheiro / Conceição, Carla / Vieira, José Pedro / Gouveia, Catarina / Varandas, Luís

    The Pediatric infectious disease journal

    2023  Volume 42, Issue 9, Page(s) e358–e359

    MeSH term(s) Humans ; Corpus Callosum/diagnostic imaging ; Corpus Callosum/pathology ; Malaria, Cerebral/diagnosis ; Magnetic Resonance Imaging
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Letter
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000003963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1852: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Grapevine-Associated Lipid Signalling Is Specifically Activated in an

    Laureano, Gonçalo / Santos, Catarina / Gouveia, Catarina / Matos, Ana Rita / Figueiredo, Andreia

    Cells

    2023  Volume 12, Issue 3

    Abstract: ... Vitis ... ...

    Abstract Vitis vinifera
    MeSH term(s) Humans ; Disease Resistance/genetics ; Oomycetes/physiology ; Peronospora ; Fatty Acids ; Lipids
    Chemical Substances Fatty Acids ; Lipids
    Language English
    Publishing date 2023-01-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12030394
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  8. Article ; Online: Dysphagia and Tongue Deviation: An Unexpected Cause.

    Almendra, Margarida / Pedro Vieira, José / Conceição, Carla / Delgado, Inês / Gouveia, Catarina

    The Pediatric infectious disease journal

    2022  Volume 41, Issue 12, Page(s) 1032–1034

    MeSH term(s) Humans ; Deglutition Disorders/diagnosis ; Deglutition Disorders/etiology ; Tongue ; Tongue Diseases/diagnosis ; Tongue Diseases/etiology
    Language English
    Publishing date 2022-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000003507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1852: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Recurrent pyogenic infections caused by a novel Gln1420* mutation in the C3 gene.

    Coelho, Pedro Simão / Gouveia, Catarina / Pinto, Marta Valente / Neves, Conceição / Cordeiro, Ana Isabel / Neves, João Farela

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 1017195

    Abstract: C3 is a crucial protein of the complement system. Congenital C3 deficiency is extremely rare and manifests through recurrent, severe infections and should always be considered as a differential diagnosis of recurrent pyogenic infections. We report a case ...

    Abstract C3 is a crucial protein of the complement system. Congenital C3 deficiency is extremely rare and manifests through recurrent, severe infections and should always be considered as a differential diagnosis of recurrent pyogenic infections. We report a case of a patient with a novel C3 gene mutation, responsible for complete C3 deficiency with impaired complement system activation and recurrent infections.
    Language English
    Publishing date 2022-10-05
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.1017195
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  10. Article ; Online: COVID-19 in a tertiary paediatric centre in Portugal: a single-centre retrospective study.

    Silva, Tiago Milheiro / Garcia, Ana Margarida / Gouveia, Catarina / Candeias, Flora / Brito, Maria João

    BMJ paediatrics open

    2022  Volume 6, Issue 1

    Abstract: Objective: To describe the demographic, clinical, laboratory and imaging features of the first 300 SARS-CoV-2-infected children presenting to a tertiary paediatric centre in Portugal.: Design: Single-centre, retrospective, descriptive study of ... ...

    Abstract Objective: To describe the demographic, clinical, laboratory and imaging features of the first 300 SARS-CoV-2-infected children presenting to a tertiary paediatric centre in Portugal.
    Design: Single-centre, retrospective, descriptive study of paediatric patients who had a confirmed SARS-CoV-2 infection from 7 March to 20 September 2020.
    Setting: Tertiary paediatric referral centre (Hospital Dona Estefânia, Lisbon, Portugal).
    Patients: 18 years or younger.
    Main outcome measures: Incidence, mortality, age of infection, clinical characteristics, treatment prescribed and outcome.
    Results: Three hundred patients with confirmed COVID-19 presented to the centre. One hundred and seventeen (39%) patients were admitted to the hospital: 69 with COVID-19 and 48 for other reasons. The most common symptoms in children admitted with COVID-19 were fever (49) and cough (38). Six patients required intensive care. Two children died and seven reported short-term sequelae.
    Conclusions: COVID-19 is usually a mild disease in children, but a small proportion of patients develop severe and critical disease. Fatal outcomes were rare and only occurred in children with severe previous medical conditions.
    MeSH term(s) COVID-19/epidemiology ; Child ; Humans ; Portugal/epidemiology ; Retrospective Studies ; SARS-CoV-2 ; Tertiary Care Centers
    Language English
    Publishing date 2022-09-02
    Publishing country England
    Document type Journal Article
    ISSN 2399-9772
    ISSN (online) 2399-9772
    DOI 10.1136/bmjpo-2021-001252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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