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  1. Article ; Online: New nitrosyl ruthenium complexes with combined activities for multiple cardiovascular disorders.

    Gouveia Júnior, Florêncio Sousa / Silveira, João Alison de Moraes / Holanda, Thais Muratori / Marinho, Aline Diogo / Ridnour, Lisa A / Wink, David A / de Siqueira, Rodrigo José Bezerra / Monteiro, Helena Serra Azul / Sousa, Eduardo Henrique Silva de / Lopes, Luiz Gonzaga de França

    Dalton transactions (Cambridge, England : 2003)

    2023  Volume 52, Issue 16, Page(s) 5176–5191

    Abstract: Nitrosyl ruthenium complexes are promising platforms for nitric oxide (NO) and nitroxyl (HNO) release, which exert their therapeutic application. In this context, we developed two polypyridinic compounds with the general ... ...

    Abstract Nitrosyl ruthenium complexes are promising platforms for nitric oxide (NO) and nitroxyl (HNO) release, which exert their therapeutic application. In this context, we developed two polypyridinic compounds with the general formula
    MeSH term(s) Animals ; Rats ; Coordination Complexes ; Nitric Oxide/chemistry ; Nitrogen Oxides/chemistry ; Ruthenium/chemistry ; Sulfhydryl Compounds/chemistry ; Cardiovascular Diseases
    Chemical Substances Coordination Complexes ; Nitric Oxide (31C4KY9ESH) ; Nitrogen Oxides ; nitroxyl (GFQ4MMS07W) ; Ruthenium (7UI0TKC3U5) ; Sulfhydryl Compounds
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt00059a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The nitric oxide pathway is involved in the anti-inflammatory effect of the rutheniumcomplex [Ru(bpy)2(2-MIM)(NO)](PF6)3.

    Carvalho, Isadora Oliveira / Queiroz, Cléo Vanessa Gomes / Marques, Gabriela Fernandes Oliveira / Craveiro, Raquel Magalhães Castelo Branco / Xavier Júnior, Francisco Antônio Félix / Gouveia Júnior, Florêncio Sousa / Lopes, Luiz Gonzaga de França / Chaves, Edna Maria Camelo / Monteiro, Helena Serra Azul / Assreuy, Ana Maria Sampaio / Evangelista, Janaina Serra Azul Monteiro

    European journal of pharmacology

    2022  Volume 921, Page(s) 174869

    Abstract: Metal coordination complexes are chemotherapeutic and anti-inflammatory agents. The ruthenium complex FOR811A ([Ru(bpy) ...

    Abstract Metal coordination complexes are chemotherapeutic and anti-inflammatory agents. The ruthenium complex FOR811A ([Ru(bpy)
    MeSH term(s) 2,2'-Dipyridyl/analogs & derivatives ; Animals ; Anti-Inflammatory Agents/adverse effects ; Carrageenan/adverse effects ; Edema/chemically induced ; Edema/drug therapy ; Edema/metabolism ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/metabolism ; Mice ; Nitric Oxide/metabolism ; Organometallic Compounds/pharmacology ; Organometallic Compounds/therapeutic use
    Chemical Substances Anti-Inflammatory Agents ; Organometallic Compounds ; bis(bipyridyl)ruthenium(II) ; Nitric Oxide (31C4KY9ESH) ; 2,2'-Dipyridyl (551W113ZEP) ; Carrageenan (9000-07-1)
    Language English
    Publishing date 2022-03-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2022.174869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Anti-asthmatic effect of nitric oxide metallo-donor FOR811A [cis-[Ru(bpy)2(2-MIM)(NO)](PF6)3] in the respiratory mechanics of Swiss mice.

    Costa, Paula Priscila Correia / Waller, Stefanie Bressan / Dos Santos, Gilvan Ribeiro / Gondim, Fladimir de Lima / Serra, Daniel Silveira / Cavalcante, Francisco Sales Ávila / Gouveia Júnior, Florêncio Sousa / de Paula Júnior, Valdir Ferreira / Sousa, Eduardo Henrique Silva / Lopes, Luiz Gonzaga de França / Ribeiro, Wesley Lyeverton Correia / Monteiro, Helena Serra Azul

    PloS one

    2021  Volume 16, Issue 3, Page(s) e0248394

    Abstract: We aimed at evaluating the anti-asthmatic effect of cis-[Ru(bpy)2(2-MIM)(NO)](PF6)3 (FOR811A), a nitrosyl-ruthenium compound, in a murine model of allergic asthma. The anti-asthmatic effects were analyzed by measuring the mechanical lung and ... ...

    Abstract We aimed at evaluating the anti-asthmatic effect of cis-[Ru(bpy)2(2-MIM)(NO)](PF6)3 (FOR811A), a nitrosyl-ruthenium compound, in a murine model of allergic asthma. The anti-asthmatic effects were analyzed by measuring the mechanical lung and morphometrical parameters in female Swiss mice allocated in the following groups: untreated control (Ctl+Sal) and control treated with FOR811A (Ctl+FOR), along asthmatic groups untreated (Ast+Sal) and treated with FOR811A (Ast+FOR). The drug-protein interaction was evaluated by in-silico assay using molecular docking. The results showed that the use of FOR811A in experimental asthma (Ast+FOR) decreased the pressure-volume curve, hysteresis, tissue elastance, tissue resistance, and airway resistance, similar to the control groups (Ctl+Sal; Ctl+FOR). However, it differed from the untreated asthmatic group (Ast+Sal, p<0.05), indicating that FOR811A corrected the lung parenchyma and relaxed the smooth muscles of the bronchi. Similar to control groups (Ctl+Sal; Ctl+FOR), FOR811A increased the inspiratory capacity and static compliance in asthmatic animals (Ast+Sal, p<0.05), showing that this metallodrug improved the capacity of inspiration during asthma. The morphometric parameters showed that FOR811A decreased the alveolar collapse and kept the bronchoconstriction during asthma. Beyond that, the molecular docking using FOR811A showed a strong interaction in the distal portion of the heme group of the soluble guanylate cyclase, particularly with cysteine residue (Cys141). In summary, FOR811A relaxed bronchial smooth muscles and improved respiratory mechanics during asthma, providing a protective effect and promising use for the development of an anti-asthmatic drug.
    MeSH term(s) Animals ; Anti-Asthmatic Agents/chemistry ; Anti-Asthmatic Agents/pharmacology ; Asthma/drug therapy ; Asthma/physiopathology ; Female ; Mice ; Nitric Oxide Donors/chemistry ; Nitric Oxide Donors/pharmacology ; Organometallic Compounds/chemistry ; Organometallic Compounds/pharmacology ; Respiratory Mechanics/drug effects ; Ruthenium/chemistry ; Ruthenium/pharmacology
    Chemical Substances Anti-Asthmatic Agents ; Nitric Oxide Donors ; Organometallic Compounds ; Ruthenium (7UI0TKC3U5)
    Language English
    Publishing date 2021-03-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0248394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Synthesis and potential vasorelaxant effect of a novel ruthenium-based nitro complex.

    de Oliveira Neto, Joselito / Marinho, Márcia Machado / Silveira, João Alison de Moraes / Rocha, Danilo Galvão / Lima, Natália Cavalcante Barbosa / Gouveia Júnior, Florêncio Sousa / Lopes, Luiz Gonzaga de França / de Sousa, Eduardo Henrique Silva / Martins, Alice Maria Costa / Marinho, Aline Diogo / Jorge, Roberta Jeane Bezerra / Monteiro, Helena Serra Azul

    Journal of inorganic biochemistry

    2021  Volume 228, Page(s) 111666

    Abstract: This study aimed to investigate the synthesis and potential vasodilator effect of a novel ruthenium complex, cis-[Ru(bpy) ...

    Abstract This study aimed to investigate the synthesis and potential vasodilator effect of a novel ruthenium complex, cis-[Ru(bpy)
    Language English
    Publishing date 2021-11-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 162843-4
    ISSN 1873-3344 ; 0162-0134
    ISSN (online) 1873-3344
    ISSN 0162-0134
    DOI 10.1016/j.jinorgbio.2021.111666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1730: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  5. Article ; Online: Nitro-imidazole-based ruthenium complexes with antioxidant and anti-inflammatory activities.

    Sasahara, Greyce Luri / Gouveia Júnior, Florêncio Sousa / Rodrigues, Raphael de Oliveira / Zampieri, Dávila Souza / Fonseca, Said Gonçalves da Cruz / Gonçalves, Rita de Cássia Ribeiro / Athaydes, Brena Ramos / Kitagawa, Rodrigo Rezende / Santos, Flávia Almeida / Sousa, Eduardo Henrique Silva / Nagao-Dias, Aparecida Tiemi / Lopes, Luiz Gonzaga de França

    Journal of inorganic biochemistry

    2020  Volume 206, Page(s) 111048

    Abstract: Inflammation is a physiological process triggered in response to tissue damage, and involves events related to cell recruitment, cytokines release and reactive oxygen species (ROS) production. Failing to control the process duration lead to ... ...

    Abstract Inflammation is a physiological process triggered in response to tissue damage, and involves events related to cell recruitment, cytokines release and reactive oxygen species (ROS) production. Failing to control the process duration lead to chronification and may be associated with the development of various pathologies, including autoimmune diseases and cancer. Considering the pharmacological potential of metal-based compounds, two new ruthenium complexes were synthesized: cis-[Ru(NO
    MeSH term(s) A549 Cells ; Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Bacteria/drug effects ; Cell Proliferation ; Coordination Complexes/chemistry ; Coordination Complexes/pharmacology ; Humans ; Imidazoles/chemistry ; Lipid Peroxidation ; MCF-7 Cells ; Mice ; Molecular Structure ; RAW 264.7 Cells ; Ruthenium/chemistry ; Superoxides/metabolism
    Chemical Substances Anti-Bacterial Agents ; Anti-Inflammatory Agents ; Antineoplastic Agents ; Antioxidants ; Coordination Complexes ; Imidazoles ; Superoxides (11062-77-4) ; Ruthenium (7UI0TKC3U5)
    Language English
    Publishing date 2020-02-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 162843-4
    ISSN 1873-3344 ; 0162-0134
    ISSN (online) 1873-3344
    ISSN 0162-0134
    DOI 10.1016/j.jinorgbio.2020.111048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1730: Show issues Location:
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