Article ; Online: Rheumatologic and autoimmune manifestations of primary immunodeficiency disorders.
Current opinion in rheumatology
2008 Volume 21, Issue 1, Page(s) 78–84
Abstract: Purpose of review: Although it may seem paradoxical, primary immunodeficiency disorders are frequently complicated by autoimmune and inflammatory conditions. These conditions pose significant diagnostic and therapeutic challenges for clinicians caring ... ...
| Abstract | Purpose of review: Although it may seem paradoxical, primary immunodeficiency disorders are frequently complicated by autoimmune and inflammatory conditions. These conditions pose significant diagnostic and therapeutic challenges for clinicians caring for these patients. There have been a number of new insights into how immunodeficiencies can predispose to autoimmunity, and rheumatologists should understand the basis for and manifestations of autoimmunity in primary immunodeficiency disorders to more effectively care for these patients. Recent findings: A number of mechanisms have recently been found to link primary immunodeficiencies and autoimmunity, including increased homeostatic proliferation in primary immunodeficiencies associated with lymphopenia and defects in regulatory T cells in the Wiskott-Aldrich syndrome. Primary immunodeficiencies that affect the innate immune system can also lead to inappropriate inflammation through impairing negative regulatory mechanisms in innate immune cells. Summary: The realization that primary immunodeficiencies can also impair negative regulation of immune responses has provided a new framework for the understanding of autoimmunity associated with these conditions. These insights may lead to new, more targeted therapies for autoimmune complications in primary immunodeficiency patients. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Autoimmune Diseases/immunology ; Autoimmune Diseases/physiopathology ; Autoimmunity/immunology ; Feedback/physiology ; Homeostasis/immunology ; Humans ; Immunity, Innate/immunology ; Immunologic Deficiency Syndromes/complications ; Immunologic Deficiency Syndromes/physiopathology ; Rheumatic Diseases/immunology ; Rheumatic Diseases/physiopathology ; T-Lymphocytes/immunology | |||||
| Language | English | |||||
| Publishing date | 2008-11-15 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 1045317-9 | |||||
| ISSN | 1531-6963 ; 1040-8711 | |||||
| ISSN (online) | 1531-6963 | |||||
| ISSN | 1040-8711 | |||||
| DOI | 10.1097/BOR.0b013e32831cb939 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 3028: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.