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  1. Book ; Online ; E-Book: Neuroprotection in autism, schizophrenia and Alzheimer's Disease

    Gozes, Illana / Levine, Joseph

    2020  

    Author's details edited by Illana Gozes, Joseph Levine
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xviii, 301 Seiten), Illustrationen
    Publisher Academic Press, an imprint of Elsevier
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020330269
    ISBN 978-0-12-814038-3 ; 9780128140376 ; 0-12-814038-0 ; 0128140372
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Neuroprotection in Alzheimer's disease

    Gozes, Illana

    2017  

    Author's details edited by Illana Gozes
    Keywords Alzheimer Disease / prevention & control ; Neuroprotection
    Language English
    Size 1 Online-Ressource (xv, 327 Seiten), Illustrationen
    Publisher Elsevier AP
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019391316
    ISBN 978-0-12-803712-6 ; 9780128036907 ; 0-12-803712-1 ; 0128036907
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: A novel genomic mutation in ADNP leading to intellectual disability.

    Gozes, Illana

    European journal of human genetics : EJHG

    2023  Volume 31, Issue 8, Page(s) 851–852

    MeSH term(s) Humans ; Intellectual Disability/genetics ; Intellectual Disability/physiopathology ; Autism Spectrum Disorder/genetics ; Genomics ; Mutation ; Nerve Tissue Proteins/genetics ; Homeodomain Proteins/genetics
    Chemical Substances ADNP protein, human ; Nerve Tissue Proteins ; Homeodomain Proteins
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1141470-4
    ISSN 1476-5438 ; 1018-4813
    ISSN (online) 1476-5438
    ISSN 1018-4813
    DOI 10.1038/s41431-023-01387-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3589: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Tau, ADNP, and sex.

    Gozes, Illana

    Cytoskeleton (Hoboken, N.J.)

    2023  Volume 81, Issue 1, Page(s) 16–23

    Abstract: With 50 years to the original discovery of Tau, I gave here my perspective, looking through the prism of activity-dependent neuroprotective protein (ADNP), and the influence of sex. My starting point was vasoactive intestinal peptide (VIP), a regulator ... ...

    Abstract With 50 years to the original discovery of Tau, I gave here my perspective, looking through the prism of activity-dependent neuroprotective protein (ADNP), and the influence of sex. My starting point was vasoactive intestinal peptide (VIP), a regulator of ADNP. I then moved to the original discovery of ADNP and its active neuroprotective site, NAP, drug candidate, davunetide. Tau-ADNP-NAP interactions were then explained with emphasis on sex and future translational medicine.
    Language English
    Publishing date 2023-08-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534372-5
    ISSN 1949-3592 ; 1949-3584
    ISSN (online) 1949-3592
    ISSN 1949-3584
    DOI 10.1002/cm.21776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1840: Show issues Location:
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  5. Article ; Online: From the Desk of the Editor‑in‑Chief: Excerpts from the Society for Neurochemistry (ESN) Future Perspectives for European Neurochemistry Highlighting the Symposium Asking "Autism, Epilepsy, Intellectual Disability Where Do These All Meet?"

    Gozes, Illana

    Journal of molecular neuroscience : MN

    2022  Volume 72, Issue 7, Page(s) 1527–1529

    MeSH term(s) Autism Spectrum Disorder ; Autistic Disorder ; Epilepsy ; Humans ; Intellectual Disability ; Neurochemistry
    Language English
    Publishing date 2022-07-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 1043392-2
    ISSN 1559-1166 ; 0895-8696
    ISSN (online) 1559-1166
    ISSN 0895-8696
    DOI 10.1007/s12031-022-02045-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3006: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Book: Neuropeptide techniques

    Gozes, Illana

    (Neuromethods ; 39)

    2008  

    Author's details ed. by Illana Gozes
    Series title Neuromethods ; 39
    Collection
    Keywords Neuropeptides / physiology ; Neuropeptides / chemical synthesis
    Language English
    Size XII, 160 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT015377593
    ISBN 978-1-58829-468-5 ; 9781603270991 ; 1-58829-468-4 ; 160327099X
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 A 1827 order for loan Magazin

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  7. Article ; Online: A Different Outlook at Psychiatric and Neurological Diseases: Brain Somatic Mutations Are Implicated in Schizophrenia.

    Gozes, Illana

    Biological psychiatry

    2021  Volume 90, Issue 1, Page(s) 6–8

    MeSH term(s) Brain ; Humans ; Mutation ; Nervous System Diseases ; Schizophrenia/genetics
    Language English
    Publishing date 2021-06-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2021.04.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 720: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article: The ADNP Syndrome and CP201 (NAP) Potential and Hope.

    Gozes, Illana

    Frontiers in neurology

    2020  Volume 11, Page(s) 608444

    Abstract: Activity-dependent neuroprotective protein ( ...

    Abstract Activity-dependent neuroprotective protein (
    Language English
    Publishing date 2020-11-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2020.608444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A novel davunetide (NAPVSIPQQ to NAPVSIPQE) point mutation in activity-dependent neuroprotective protein (ADNP) causes a mild developmental syndrome.

    Gozes, Illana / Shazman, Shula

    The European journal of neuroscience

    2023  Volume 58, Issue 2, Page(s) 2641–2652

    Abstract: NAP (NAPVSIPQ, drug candidate name, davunetide) is the neuroprotective fragment of activity-dependent neuroprotective protein (ADNP). Recent studies identified NAPVSIP as a Src homology 3 (SH3) domain-ligand association site, responsible for controlling ... ...

    Abstract NAP (NAPVSIPQ, drug candidate name, davunetide) is the neuroprotective fragment of activity-dependent neuroprotective protein (ADNP). Recent studies identified NAPVSIP as a Src homology 3 (SH3) domain-ligand association site, responsible for controlling signalling pathways regulating the cytoskeleton. Furthermore, the SIP motif in NAP/ADNP was identified as crucial for direct microtubule end-binding protein interaction facilitating microtubule dynamics and Tau microtubule interaction, at the microtubule end-binding protein site EB1 and EB3. Most de novo ADNP mutations reveal heterozygous STOP or frameshift STOP aberrations, driving the autistic/intellectual disability-related ADNP syndrome. Here, we report for the first time on a de novo missense mutation, resulting in ADNP containing NAPVISPQE instead of NAPVSIPQQ, in a child presenting developmental hypotonia, possibly associated with inflammation affecting food intake in early life coupled with fear of peer interactions and suggestive of a novel case of the ADNP syndrome. In silico modelling showed that the mutation Q (polar side chain) to E (negative side chain) affected the electrostatic characteristics of ADNP (reducing, while scattering the electrostatic positive patch). Comparison with the most prevalent pathogenic ADNP mutation, p.Tyr719*, indicated a further reduction in the electrostatic patch. Previously, exogenous NAP partially ameliorated deficits associated with ADNP p.Tyr719* mutations in transfected cells and in CRISPR/Cas9 genome edited cell and mouse models. These findings stress the importance of the NAP sequence in ADNP and as a future putative therapy for the ADNP syndrome.
    MeSH term(s) Mice ; Animals ; Nerve Tissue Proteins/genetics ; Point Mutation ; Oligopeptides/genetics ; Oligopeptides/metabolism ; Oligopeptides/therapeutic use ; Microtubules/metabolism ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism
    Chemical Substances davunetide (GF00K3IIWE) ; Nerve Tissue Proteins ; Oligopeptides ; Homeodomain Proteins
    Language English
    Publishing date 2023-02-09
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/ejn.15920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2548: Show issues Location:
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  10. Article: ADNP Regulates Cognition: A Multitasking Protein.

    Gozes, Illana

    Frontiers in neuroscience

    2018  Volume 12, Page(s) 873

    Language English
    Publishing date 2018-11-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2018.00873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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