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  1. Book ; Thesis: Nachweis von Mikrosatelliteninstabilitäten bei Patienten mit Verdacht auf ein HNPCC-Syndrom

    Gröne, Jörn

    1997  

    Author's details vorgelegt von Jörn Gröne
    Language German
    Size 56 Bl., Ill., graph. Darst., 30 cm
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Göttingen, Univ., Diss., 1998
    HBZ-ID HT013161454
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2001 MB 2723 order for loan Magazin

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  2. Article: Proktokolektomie mit Entfernung der analen Schleimhaut. Was spricht dafür, was spricht dagegen?

    Gröne, Jörn

    Bauchredner

    2015  Volume 120, Issue 1, Page(s) 14

    Language German
    Document type Article
    ZDB-ID 1010454-9
    ISSN 1435-1862
    Database Current Contents Medicine

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  3. Article ; Online: Meist holt man die Galle durchs Schlüsselloch.

    Gröne, Jörn / Kreis, M E

    MMW Fortschritte der Medizin

    2018  Volume 160, Issue 8, Page(s) 53–56

    Title translation Indications for conversion of laparoscopic to open cholecystectomy.
    MeSH term(s) Cholecystectomy, Laparoscopic/methods ; Cholecystitis/surgery ; Humans ; Laparoscopy ; Retrospective Studies
    Language German
    Publishing date 2018-05-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1478211-x
    ISSN 1613-3560 ; 1438-3276
    ISSN (online) 1613-3560
    ISSN 1438-3276
    DOI 10.1007/s15006-018-0486-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 72: Show issues

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  4. Article ; Online: Risk factors for failure of ileal pouch-anal anastomosis in patients with refractory ulcerative colitis.

    Frese, Jan P / Gröne, Jörn / Lauscher, Johannes C / Konietschke, Frank / Kreis, Martin E / Seifarth, Claudia

    Surgery

    2021  Volume 171, Issue 2, Page(s) 299–304

    Abstract: Background: Proctocolectomy with ileal pouch-anal anastomosis is the standard surgical procedure for ulcerative colitis refractory to medical treatment. In a few cases, ileal pouch-anal anastomosis cannot be completed due to intraoperative technical ... ...

    Abstract Background: Proctocolectomy with ileal pouch-anal anastomosis is the standard surgical procedure for ulcerative colitis refractory to medical treatment. In a few cases, ileal pouch-anal anastomosis cannot be completed due to intraoperative technical problems. The aim of this single-center study was to identify risk factors for a technically failed ileal pouch-anal anastomosis.
    Methods: In total, 391 patients with ulcerative colitis who received ileal pouch-anal anastomosis were identified. Clinical and perioperative data from patients with successful ileal pouch-anal anastomosis (IPAA+) were compared to data from failed ileal pouch-anal anastomosis (IPAA-). Definition of failed ileal pouch-anal anastomosis was intraoperative failure to perform ileal pouch-anal anastomosis. Risk factors for failed ileal pouch-anal anastomosis were assessed by logistic regression. Cut-off values were calculated on the basis of receiver operating characteristic curves and the Youden Index.
    Results: The rate of failed ileal pouch-anal anastomosis was 26 of 391 (6.6%). In 22 of 26 cases (84.6%), there was an insufficient length of the small intestinal mesentery. Patients with failed ileal pouch-anal anastomosis were more often male (80.8% vs 54.5%, P = .009), older (47.1 ± 14.1 vs 39.2 ± 12.8 years, P = .007), had a higher body mass index 27.2 ± 4.5 vs 23.7 ± 4.3 kg/m
    Conclusion: Technical failure of ileal pouch-anal anastomosis is elevated in patients with higher body mass index, with refractory ulcerative colitis, and/or extended immunosuppressive medication. Three-staged ileal pouch-anal anastomosis and optimizing preoperative conditions may help to elevate the rate of successful ileoanal pouch construction in these patients.
    MeSH term(s) Adult ; Age Factors ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/adverse effects ; Body Mass Index ; Case-Control Studies ; Colitis, Ulcerative/complications ; Colitis, Ulcerative/pathology ; Colitis, Ulcerative/surgery ; Colonic Pouches/adverse effects ; Female ; Humans ; Male ; Mesentery/pathology ; Middle Aged ; Prednisolone/administration & dosage ; Prednisolone/adverse effects ; Proctocolectomy, Restorative/adverse effects ; Retrospective Studies ; Risk Factors ; Sex Factors ; Treatment Failure
    Chemical Substances Anti-Inflammatory Agents ; Prednisolone (9PHQ9Y1OLM)
    Language English
    Publishing date 2021-08-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2021.07.004
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    Uk I Zs.129: Show issues Location:
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  5. Article: Fast Track - ein neues Konzept zur beschleunigten und komplikationsärmeren Chirurgie bei CED. Was ist das, wann kommt es in Frage?

    Gröne, Jörn

    Bauchredner

    2011  Volume 105, Issue -, Page(s) 34

    Language German
    Document type Article
    ZDB-ID 1010454-9
    ISSN 1435-1862
    Database Current Contents Medicine

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  6. Article ; Online: Inflammation of the rectal remnant endangers the outcome of ileal pouch-anal anastomosis: a case-control study.

    Frese, Jan P / Gröne, Jörn / Lauscher, Johannes C / Kreis, Martin E / Weixler, Benjamin / Beyer, Katharina / Seifarth, Claudia

    International journal of colorectal disease

    2022  Volume 37, Issue 7, Page(s) 1647–1655

    Abstract: Background: Inflammation of the rectal remnant may affect the postoperative outcome of ileal pouch-anal anastomosis (IPAA) in patients with ulcerative colitis (UC). We aimed to determine the extent of inflammation in the anastomotic area during IPAA and ...

    Abstract Background: Inflammation of the rectal remnant may affect the postoperative outcome of ileal pouch-anal anastomosis (IPAA) in patients with ulcerative colitis (UC). We aimed to determine the extent of inflammation in the anastomotic area during IPAA and to investigate the impact of proctitis on postoperative complications and long-term outcomes.
    Methods: Three hundred thirty-four UC patients with primary IPAA were included in this retrospective case-control study. The histopathologic degree of inflammation in the anastomotic area was graded into three stages of no proctitis ("NOP"), mild to medium proctitis ("MIP"), and severe proctitis ("SEP"). Preoperative risk factors, 30-day morbidity, and follow-up data were assessed. Kaplan-Meier analysis was performed in the event of pouch failure.
    Results: The prevalence of proctitis was high (MIP 40.4%, and SEP 42.8%). During follow-up, the incidence of complications was highest among SEP: resulting in re-intervention (n = 40; 28.2%, p = 0.017), pouchitis (n = 36; 25.2%, p < 0.01), and pouch failure (n = 32; 22.4%, p = 0.032). The time interval to pouch failure was 5.0 (4.0-6.9) years among NOP, and 1.2 (0.5-2.3) years in SEP (p = 0.036). ASA 3, pouchitis, and pouch fistula were independent risk factors for pouch failure.
    Conclusion: Proctitis at the time of IPAA is common. A high degree of inflammation is associated with poor long-term outcomes, an effect that declines over time. In addition, a higher degree of proctitis leads to earlier pouch failure.
    MeSH term(s) Anastomosis, Surgical/adverse effects ; Anastomosis, Surgical/methods ; Case-Control Studies ; Colitis, Ulcerative/complications ; Colitis, Ulcerative/surgery ; Colonic Pouches/adverse effects ; Humans ; Inflammation/complications ; Postoperative Complications/epidemiology ; Pouchitis/etiology ; Proctitis/surgery ; Proctocolectomy, Restorative/adverse effects ; Retrospective Studies
    Language English
    Publishing date 2022-06-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-022-04195-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2121: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Book ; Online ; Thesis: Untersuchung des Zusammenhangs zwischen differentieller Genexpression und phänotypischen Veränderungen solider Karzinome am Beispiel des kolorektalen Karzinoms

    Gröne, Jörn [Verfasser]

    2012  

    Author's details Jörn Gröne
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Medizinische Fakultät Charité - Universitätsmedizin Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  8. Article: Wann kommt es zu Inkontinenz bei CED?

    Gröne, Jörn

    Bauchredner

    2009  Volume 96, Issue -, Page(s) 26

    Language German
    Document type Article
    ZDB-ID 1010454-9
    ISSN 1435-1862
    Database Current Contents Medicine

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    Zs.A 6881: Show issues Location:
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  9. Article ; Online: Implication of FDG-PET/CT in patients with potentially operable colorectal lung metastases.

    Uporov, Anton / Taber, Samantha / Estèvez Schwarz, Lope / Groene, Joern / Pilz, Lothar R / Foerster, Gregor / Bittner, Roland / Pfannschmidt, Joachim

    Innovative surgical sciences

    2021  Volume 6, Issue 3, Page(s) 89–95

    Abstract: Objectives: This prospective study assessed the role of F-18-FDG-PET/CT in clinical staging for patients with colorectal cancer planned for pulmonary metastasectomy by thoracotomy or video-assisted surgery.: Patients and methods: In addition to ... ...

    Abstract Objectives: This prospective study assessed the role of F-18-FDG-PET/CT in clinical staging for patients with colorectal cancer planned for pulmonary metastasectomy by thoracotomy or video-assisted surgery.
    Patients and methods: In addition to conventional imaging, we performed 86 F-18-FDG-PET/CT studies in 76 patients with potentially resectable metastatic colorectal lung metastases. We then investigated the effect that PET/CT had on further clinical management. Based on the results from the 47 thoracotomies performed, we compared the number of pulmonary metastases discovered after histologic examination with the number predicted by the conventional computed tomography (CT) as an independent part of the F-18-FDG-PET/CT examination and by the F-18-FDG-PET component.
    Results: F-18-FDG-PET/CT led to changes in treatment regime and diagnostic planning in many patients. In five patients PET/CT revealed previously undetected local recurrence of the primary colorectal cancer, in four patients hepatic metastases, in three patients bone metastases, in two patients soft-tissue metastases, and in three patients histologically preoperatively proven N2 or N3 station lymph node involvement. These all constituted exclusion criteria, and consequently the previously planned pulmonary metastasectomy was not performed. The sensitivity and positive predictive value (PPV) for detection of pulmonary metastases were 84.2% and 36.4% for CT and 75.0% and 61.6% for F-18-FDG-PET study. The calculated sensitivity, specificity, PPV, and NPV of F-18-FDG-PET/CT for detecting thoracic lymph node involvement were 85.7%, 93.0%, 66.7%, and 97.5%, respectively. Furthermore, we found that F-18-FDG-PET/CT may predict thoracic lymph node involvement based on the SUV of pulmonary nodules.
    Conclusions: F-18-FDG-PET/CT has a clear role in the diagnostic workup for pulmonary metastatic colorectal cancer and may save patients from futile surgery. It cannot, however, be relied on to detect all possible pulmonary and nodal metastases, which surgeons must always consider when making treatment decisions.
    Language English
    Publishing date 2021-12-24
    Publishing country Germany
    Document type Journal Article
    ISSN 2364-7485
    ISSN (online) 2364-7485
    DOI 10.1515/iss-2021-0029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Sources of Support and Information During Disease: An Exploratory Study, Comparing Migrant and Nonmigrant Colorectal Cancer Patients in Germany.

    Leonhardt, Marja / Aschenbrenner, Katja / Gröne, Jörn / Kreis, Martin E / Lauscher, Johannes C

    Journal of transcultural nursing : official journal of the Transcultural Nursing Society

    2019  Volume 31, Issue 4, Page(s) 387–396

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Colorectal Neoplasms/psychology ; Colorectal Neoplasms/therapy ; Cross-Sectional Studies ; Emigrants and Immigrants/psychology ; Female ; Germany ; Health Services Accessibility/standards ; Humans ; Male ; Middle Aged ; Social Support ; Socioeconomic Factors ; Surveys and Questionnaires
    Language English
    Publishing date 2019-09-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1291524-5
    ISSN 1552-7832 ; 1043-6596
    ISSN (online) 1552-7832
    ISSN 1043-6596
    DOI 10.1177/1043659619875197
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